Symptom variability over the course of the day in patients with stable COPD in Brazil: A real-world observational study

Detalhes bibliográficos
Autor(a) principal: Cukier, Alberto
Data de Publicação: 2020
Outros Autores: De Godoy, Irma [UNESP], Costa, Claudia Henrique da, Rubin, Adalberto Sperb, Gregorio, Marcelo Gervilla, Neto, Aldo Agra de Albuquerque, Lima, Marina Andrade, Pereira, Monica Corso, Tanni, Suzana Erico [UNESP], Athanazio, Rodrigo Abensur, Bessa, Elizabeth Jauhar Cardoso, Wehrmeister, Fernando Cesar, Lourenco, Cristina Bassi, Menezes, Ana Maria Baptista
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.36416/1806-3756/e20190223
http://hdl.handle.net/11449/199859
Resumo: Objective: To analyze symptoms at different times of day in patients with COPD. Methods: This was a multicenter, cross-sectional observational study conducted at eight centers in Brazil. We evaluated morning, daytime, and nighttime symptoms in patients with stable COPD. Results: We included 593 patients under regular treatment, of whom 309 (52.1%) were male and 92 (15.5%) were active smokers. The mean age was 67.7 years, and the mean FEV1 was 49.4% of the predicted value. In comparison with the patients who had mild or moderate symptoms, the 183 (30.8%) with severe symptoms were less physically active (p = 0.002), had greater airflow limitation (p < 0.001), had more outpatient exacerbations (p = 0.002) and more inpatient exacerbations (p = 0.043), as well as scoring worse on specific instruments. The most common morning and nighttime symptoms were dyspnea (in 45.2% and 33.1%, respectively), cough (in 37.5% and 33.3%, respectively), and wheezing (in 24.4% and 27.0%, respectively). The intensity of daytime symptoms correlated strongly with that of morning symptoms (r = 0.65, p < 0.001) and that of nighttime symptoms (r = 0.60, p < 0.001), as well as with the COPD Assessment Test score (r = 0.62; p < 0.001), although it showed only a weak correlation with FEV1 (r = −0.205; p < 0.001). Conclusions: Dyspnea was more common in the morning than at night. Having morning or nighttime symptoms was associated with greater daytime symptom severity. Symptom intensity was strongly associated with poor quality of life and with the frequency of exacerbations, although it was weakly associated with airflow limitation.
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spelling Symptom variability over the course of the day in patients with stable COPD in Brazil: A real-world observational studyBrazilChronic obstructiveDisease progressionPulmonary diseaseQuality of lifeRespiratorySigns and symptomsObjective: To analyze symptoms at different times of day in patients with COPD. Methods: This was a multicenter, cross-sectional observational study conducted at eight centers in Brazil. We evaluated morning, daytime, and nighttime symptoms in patients with stable COPD. Results: We included 593 patients under regular treatment, of whom 309 (52.1%) were male and 92 (15.5%) were active smokers. The mean age was 67.7 years, and the mean FEV1 was 49.4% of the predicted value. In comparison with the patients who had mild or moderate symptoms, the 183 (30.8%) with severe symptoms were less physically active (p = 0.002), had greater airflow limitation (p < 0.001), had more outpatient exacerbations (p = 0.002) and more inpatient exacerbations (p = 0.043), as well as scoring worse on specific instruments. The most common morning and nighttime symptoms were dyspnea (in 45.2% and 33.1%, respectively), cough (in 37.5% and 33.3%, respectively), and wheezing (in 24.4% and 27.0%, respectively). The intensity of daytime symptoms correlated strongly with that of morning symptoms (r = 0.65, p < 0.001) and that of nighttime symptoms (r = 0.60, p < 0.001), as well as with the COPD Assessment Test score (r = 0.62; p < 0.001), although it showed only a weak correlation with FEV1 (r = −0.205; p < 0.001). Conclusions: Dyspnea was more common in the morning than at night. Having morning or nighttime symptoms was associated with greater daytime symptom severity. Symptom intensity was strongly associated with poor quality of life and with the frequency of exacerbations, although it was weakly associated with airflow limitation.Divisão de Pneumologia Instituto do Coração – InCor – Hospital das Clínicas Faculdade de Medicina Universidade de São PauloDisciplina de Pneumologia Faculdade de Medicina de Botucatu Universidade Estadual Paulista – UNESPDisciplina de Pneumologia Universidade do Estado do Rio de Janeiro – UERJUniversidade Federal de Ciências da Saúde de Porto Alegre Santa Casa de Misericórdia de Porto AlegreClínica Médica NetspiroDepartamento de Pneumologia Centro de Reabilitação Pulmonar Universidade Federal de São Paulo – UNIFESPHospital Dia do PulmãoDisciplina de Pneumologia Departamento de Clínica Médica Faculdade de Ciências Médicas Universidade Estadual de CampinasUniversidade Federal de PelotasAstraZeneca do BrasilDisciplina de Pneumologia Faculdade de Medicina de Botucatu Universidade Estadual Paulista – UNESPUniversidade de São Paulo (USP)Universidade Estadual Paulista (Unesp)Universidade do Estado do Rio de Janeiro (UERJ)Santa Casa de Misericórdia de Porto AlegreClínica Médica NetspiroUniversidade Federal de São Paulo (UNIFESP)Hospital Dia do PulmãoUniversidade Estadual de Campinas (UNICAMP)Universidade Federal de PelotasAstraZeneca do BrasilCukier, AlbertoDe Godoy, Irma [UNESP]Costa, Claudia Henrique daRubin, Adalberto SperbGregorio, Marcelo GervillaNeto, Aldo Agra de AlbuquerqueLima, Marina AndradePereira, Monica CorsoTanni, Suzana Erico [UNESP]Athanazio, Rodrigo AbensurBessa, Elizabeth Jauhar CardosoWehrmeister, Fernando CesarLourenco, Cristina BassiMenezes, Ana Maria Baptista2020-12-12T01:51:18Z2020-12-12T01:51:18Z2020-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://dx.doi.org/10.36416/1806-3756/e20190223Jornal Brasileiro de Pneumologia, v. 46, n. 3, 2020.1806-37561806-3713http://hdl.handle.net/11449/19985910.36416/1806-3756/e20190223S1806-371320200003002002-s2.0-85077032608S1806-37132020000300200.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJornal Brasileiro de Pneumologiainfo:eu-repo/semantics/openAccess2024-08-14T17:22:26Zoai:repositorio.unesp.br:11449/199859Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-14T17:22:26Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Symptom variability over the course of the day in patients with stable COPD in Brazil: A real-world observational study
title Symptom variability over the course of the day in patients with stable COPD in Brazil: A real-world observational study
spellingShingle Symptom variability over the course of the day in patients with stable COPD in Brazil: A real-world observational study
Cukier, Alberto
Brazil
Chronic obstructive
Disease progression
Pulmonary disease
Quality of life
Respiratory
Signs and symptoms
title_short Symptom variability over the course of the day in patients with stable COPD in Brazil: A real-world observational study
title_full Symptom variability over the course of the day in patients with stable COPD in Brazil: A real-world observational study
title_fullStr Symptom variability over the course of the day in patients with stable COPD in Brazil: A real-world observational study
title_full_unstemmed Symptom variability over the course of the day in patients with stable COPD in Brazil: A real-world observational study
title_sort Symptom variability over the course of the day in patients with stable COPD in Brazil: A real-world observational study
author Cukier, Alberto
author_facet Cukier, Alberto
De Godoy, Irma [UNESP]
Costa, Claudia Henrique da
Rubin, Adalberto Sperb
Gregorio, Marcelo Gervilla
Neto, Aldo Agra de Albuquerque
Lima, Marina Andrade
Pereira, Monica Corso
Tanni, Suzana Erico [UNESP]
Athanazio, Rodrigo Abensur
Bessa, Elizabeth Jauhar Cardoso
Wehrmeister, Fernando Cesar
Lourenco, Cristina Bassi
Menezes, Ana Maria Baptista
author_role author
author2 De Godoy, Irma [UNESP]
Costa, Claudia Henrique da
Rubin, Adalberto Sperb
Gregorio, Marcelo Gervilla
Neto, Aldo Agra de Albuquerque
Lima, Marina Andrade
Pereira, Monica Corso
Tanni, Suzana Erico [UNESP]
Athanazio, Rodrigo Abensur
Bessa, Elizabeth Jauhar Cardoso
Wehrmeister, Fernando Cesar
Lourenco, Cristina Bassi
Menezes, Ana Maria Baptista
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade de São Paulo (USP)
Universidade Estadual Paulista (Unesp)
Universidade do Estado do Rio de Janeiro (UERJ)
Santa Casa de Misericórdia de Porto Alegre
Clínica Médica Netspiro
Universidade Federal de São Paulo (UNIFESP)
Hospital Dia do Pulmão
Universidade Estadual de Campinas (UNICAMP)
Universidade Federal de Pelotas
AstraZeneca do Brasil
dc.contributor.author.fl_str_mv Cukier, Alberto
De Godoy, Irma [UNESP]
Costa, Claudia Henrique da
Rubin, Adalberto Sperb
Gregorio, Marcelo Gervilla
Neto, Aldo Agra de Albuquerque
Lima, Marina Andrade
Pereira, Monica Corso
Tanni, Suzana Erico [UNESP]
Athanazio, Rodrigo Abensur
Bessa, Elizabeth Jauhar Cardoso
Wehrmeister, Fernando Cesar
Lourenco, Cristina Bassi
Menezes, Ana Maria Baptista
dc.subject.por.fl_str_mv Brazil
Chronic obstructive
Disease progression
Pulmonary disease
Quality of life
Respiratory
Signs and symptoms
topic Brazil
Chronic obstructive
Disease progression
Pulmonary disease
Quality of life
Respiratory
Signs and symptoms
description Objective: To analyze symptoms at different times of day in patients with COPD. Methods: This was a multicenter, cross-sectional observational study conducted at eight centers in Brazil. We evaluated morning, daytime, and nighttime symptoms in patients with stable COPD. Results: We included 593 patients under regular treatment, of whom 309 (52.1%) were male and 92 (15.5%) were active smokers. The mean age was 67.7 years, and the mean FEV1 was 49.4% of the predicted value. In comparison with the patients who had mild or moderate symptoms, the 183 (30.8%) with severe symptoms were less physically active (p = 0.002), had greater airflow limitation (p < 0.001), had more outpatient exacerbations (p = 0.002) and more inpatient exacerbations (p = 0.043), as well as scoring worse on specific instruments. The most common morning and nighttime symptoms were dyspnea (in 45.2% and 33.1%, respectively), cough (in 37.5% and 33.3%, respectively), and wheezing (in 24.4% and 27.0%, respectively). The intensity of daytime symptoms correlated strongly with that of morning symptoms (r = 0.65, p < 0.001) and that of nighttime symptoms (r = 0.60, p < 0.001), as well as with the COPD Assessment Test score (r = 0.62; p < 0.001), although it showed only a weak correlation with FEV1 (r = −0.205; p < 0.001). Conclusions: Dyspnea was more common in the morning than at night. Having morning or nighttime symptoms was associated with greater daytime symptom severity. Symptom intensity was strongly associated with poor quality of life and with the frequency of exacerbations, although it was weakly associated with airflow limitation.
publishDate 2020
dc.date.none.fl_str_mv 2020-12-12T01:51:18Z
2020-12-12T01:51:18Z
2020-01-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.36416/1806-3756/e20190223
Jornal Brasileiro de Pneumologia, v. 46, n. 3, 2020.
1806-3756
1806-3713
http://hdl.handle.net/11449/199859
10.36416/1806-3756/e20190223
S1806-37132020000300200
2-s2.0-85077032608
S1806-37132020000300200.pdf
url http://dx.doi.org/10.36416/1806-3756/e20190223
http://hdl.handle.net/11449/199859
identifier_str_mv Jornal Brasileiro de Pneumologia, v. 46, n. 3, 2020.
1806-3756
1806-3713
10.36416/1806-3756/e20190223
S1806-37132020000300200
2-s2.0-85077032608
S1806-37132020000300200.pdf
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Jornal Brasileiro de Pneumologia
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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