Symptom variability over the course of the day in patients with stable COPD in Brazil: A real-world observational study
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.36416/1806-3756/e20190223 http://hdl.handle.net/11449/199859 |
Resumo: | Objective: To analyze symptoms at different times of day in patients with COPD. Methods: This was a multicenter, cross-sectional observational study conducted at eight centers in Brazil. We evaluated morning, daytime, and nighttime symptoms in patients with stable COPD. Results: We included 593 patients under regular treatment, of whom 309 (52.1%) were male and 92 (15.5%) were active smokers. The mean age was 67.7 years, and the mean FEV1 was 49.4% of the predicted value. In comparison with the patients who had mild or moderate symptoms, the 183 (30.8%) with severe symptoms were less physically active (p = 0.002), had greater airflow limitation (p < 0.001), had more outpatient exacerbations (p = 0.002) and more inpatient exacerbations (p = 0.043), as well as scoring worse on specific instruments. The most common morning and nighttime symptoms were dyspnea (in 45.2% and 33.1%, respectively), cough (in 37.5% and 33.3%, respectively), and wheezing (in 24.4% and 27.0%, respectively). The intensity of daytime symptoms correlated strongly with that of morning symptoms (r = 0.65, p < 0.001) and that of nighttime symptoms (r = 0.60, p < 0.001), as well as with the COPD Assessment Test score (r = 0.62; p < 0.001), although it showed only a weak correlation with FEV1 (r = −0.205; p < 0.001). Conclusions: Dyspnea was more common in the morning than at night. Having morning or nighttime symptoms was associated with greater daytime symptom severity. Symptom intensity was strongly associated with poor quality of life and with the frequency of exacerbations, although it was weakly associated with airflow limitation. |
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Symptom variability over the course of the day in patients with stable COPD in Brazil: A real-world observational studyBrazilChronic obstructiveDisease progressionPulmonary diseaseQuality of lifeRespiratorySigns and symptomsObjective: To analyze symptoms at different times of day in patients with COPD. Methods: This was a multicenter, cross-sectional observational study conducted at eight centers in Brazil. We evaluated morning, daytime, and nighttime symptoms in patients with stable COPD. Results: We included 593 patients under regular treatment, of whom 309 (52.1%) were male and 92 (15.5%) were active smokers. The mean age was 67.7 years, and the mean FEV1 was 49.4% of the predicted value. In comparison with the patients who had mild or moderate symptoms, the 183 (30.8%) with severe symptoms were less physically active (p = 0.002), had greater airflow limitation (p < 0.001), had more outpatient exacerbations (p = 0.002) and more inpatient exacerbations (p = 0.043), as well as scoring worse on specific instruments. The most common morning and nighttime symptoms were dyspnea (in 45.2% and 33.1%, respectively), cough (in 37.5% and 33.3%, respectively), and wheezing (in 24.4% and 27.0%, respectively). The intensity of daytime symptoms correlated strongly with that of morning symptoms (r = 0.65, p < 0.001) and that of nighttime symptoms (r = 0.60, p < 0.001), as well as with the COPD Assessment Test score (r = 0.62; p < 0.001), although it showed only a weak correlation with FEV1 (r = −0.205; p < 0.001). Conclusions: Dyspnea was more common in the morning than at night. Having morning or nighttime symptoms was associated with greater daytime symptom severity. Symptom intensity was strongly associated with poor quality of life and with the frequency of exacerbations, although it was weakly associated with airflow limitation.Divisão de Pneumologia Instituto do Coração – InCor – Hospital das Clínicas Faculdade de Medicina Universidade de São PauloDisciplina de Pneumologia Faculdade de Medicina de Botucatu Universidade Estadual Paulista – UNESPDisciplina de Pneumologia Universidade do Estado do Rio de Janeiro – UERJUniversidade Federal de Ciências da Saúde de Porto Alegre Santa Casa de Misericórdia de Porto AlegreClínica Médica NetspiroDepartamento de Pneumologia Centro de Reabilitação Pulmonar Universidade Federal de São Paulo – UNIFESPHospital Dia do PulmãoDisciplina de Pneumologia Departamento de Clínica Médica Faculdade de Ciências Médicas Universidade Estadual de CampinasUniversidade Federal de PelotasAstraZeneca do BrasilDisciplina de Pneumologia Faculdade de Medicina de Botucatu Universidade Estadual Paulista – UNESPUniversidade de São Paulo (USP)Universidade Estadual Paulista (Unesp)Universidade do Estado do Rio de Janeiro (UERJ)Santa Casa de Misericórdia de Porto AlegreClínica Médica NetspiroUniversidade Federal de São Paulo (UNIFESP)Hospital Dia do PulmãoUniversidade Estadual de Campinas (UNICAMP)Universidade Federal de PelotasAstraZeneca do BrasilCukier, AlbertoDe Godoy, Irma [UNESP]Costa, Claudia Henrique daRubin, Adalberto SperbGregorio, Marcelo GervillaNeto, Aldo Agra de AlbuquerqueLima, Marina AndradePereira, Monica CorsoTanni, Suzana Erico [UNESP]Athanazio, Rodrigo AbensurBessa, Elizabeth Jauhar CardosoWehrmeister, Fernando CesarLourenco, Cristina BassiMenezes, Ana Maria Baptista2020-12-12T01:51:18Z2020-12-12T01:51:18Z2020-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://dx.doi.org/10.36416/1806-3756/e20190223Jornal Brasileiro de Pneumologia, v. 46, n. 3, 2020.1806-37561806-3713http://hdl.handle.net/11449/19985910.36416/1806-3756/e20190223S1806-371320200003002002-s2.0-85077032608S1806-37132020000300200.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJornal Brasileiro de Pneumologiainfo:eu-repo/semantics/openAccess2024-08-14T17:22:26Zoai:repositorio.unesp.br:11449/199859Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-14T17:22:26Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Symptom variability over the course of the day in patients with stable COPD in Brazil: A real-world observational study |
title |
Symptom variability over the course of the day in patients with stable COPD in Brazil: A real-world observational study |
spellingShingle |
Symptom variability over the course of the day in patients with stable COPD in Brazil: A real-world observational study Cukier, Alberto Brazil Chronic obstructive Disease progression Pulmonary disease Quality of life Respiratory Signs and symptoms |
title_short |
Symptom variability over the course of the day in patients with stable COPD in Brazil: A real-world observational study |
title_full |
Symptom variability over the course of the day in patients with stable COPD in Brazil: A real-world observational study |
title_fullStr |
Symptom variability over the course of the day in patients with stable COPD in Brazil: A real-world observational study |
title_full_unstemmed |
Symptom variability over the course of the day in patients with stable COPD in Brazil: A real-world observational study |
title_sort |
Symptom variability over the course of the day in patients with stable COPD in Brazil: A real-world observational study |
author |
Cukier, Alberto |
author_facet |
Cukier, Alberto De Godoy, Irma [UNESP] Costa, Claudia Henrique da Rubin, Adalberto Sperb Gregorio, Marcelo Gervilla Neto, Aldo Agra de Albuquerque Lima, Marina Andrade Pereira, Monica Corso Tanni, Suzana Erico [UNESP] Athanazio, Rodrigo Abensur Bessa, Elizabeth Jauhar Cardoso Wehrmeister, Fernando Cesar Lourenco, Cristina Bassi Menezes, Ana Maria Baptista |
author_role |
author |
author2 |
De Godoy, Irma [UNESP] Costa, Claudia Henrique da Rubin, Adalberto Sperb Gregorio, Marcelo Gervilla Neto, Aldo Agra de Albuquerque Lima, Marina Andrade Pereira, Monica Corso Tanni, Suzana Erico [UNESP] Athanazio, Rodrigo Abensur Bessa, Elizabeth Jauhar Cardoso Wehrmeister, Fernando Cesar Lourenco, Cristina Bassi Menezes, Ana Maria Baptista |
author2_role |
author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade de São Paulo (USP) Universidade Estadual Paulista (Unesp) Universidade do Estado do Rio de Janeiro (UERJ) Santa Casa de Misericórdia de Porto Alegre Clínica Médica Netspiro Universidade Federal de São Paulo (UNIFESP) Hospital Dia do Pulmão Universidade Estadual de Campinas (UNICAMP) Universidade Federal de Pelotas AstraZeneca do Brasil |
dc.contributor.author.fl_str_mv |
Cukier, Alberto De Godoy, Irma [UNESP] Costa, Claudia Henrique da Rubin, Adalberto Sperb Gregorio, Marcelo Gervilla Neto, Aldo Agra de Albuquerque Lima, Marina Andrade Pereira, Monica Corso Tanni, Suzana Erico [UNESP] Athanazio, Rodrigo Abensur Bessa, Elizabeth Jauhar Cardoso Wehrmeister, Fernando Cesar Lourenco, Cristina Bassi Menezes, Ana Maria Baptista |
dc.subject.por.fl_str_mv |
Brazil Chronic obstructive Disease progression Pulmonary disease Quality of life Respiratory Signs and symptoms |
topic |
Brazil Chronic obstructive Disease progression Pulmonary disease Quality of life Respiratory Signs and symptoms |
description |
Objective: To analyze symptoms at different times of day in patients with COPD. Methods: This was a multicenter, cross-sectional observational study conducted at eight centers in Brazil. We evaluated morning, daytime, and nighttime symptoms in patients with stable COPD. Results: We included 593 patients under regular treatment, of whom 309 (52.1%) were male and 92 (15.5%) were active smokers. The mean age was 67.7 years, and the mean FEV1 was 49.4% of the predicted value. In comparison with the patients who had mild or moderate symptoms, the 183 (30.8%) with severe symptoms were less physically active (p = 0.002), had greater airflow limitation (p < 0.001), had more outpatient exacerbations (p = 0.002) and more inpatient exacerbations (p = 0.043), as well as scoring worse on specific instruments. The most common morning and nighttime symptoms were dyspnea (in 45.2% and 33.1%, respectively), cough (in 37.5% and 33.3%, respectively), and wheezing (in 24.4% and 27.0%, respectively). The intensity of daytime symptoms correlated strongly with that of morning symptoms (r = 0.65, p < 0.001) and that of nighttime symptoms (r = 0.60, p < 0.001), as well as with the COPD Assessment Test score (r = 0.62; p < 0.001), although it showed only a weak correlation with FEV1 (r = −0.205; p < 0.001). Conclusions: Dyspnea was more common in the morning than at night. Having morning or nighttime symptoms was associated with greater daytime symptom severity. Symptom intensity was strongly associated with poor quality of life and with the frequency of exacerbations, although it was weakly associated with airflow limitation. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-12-12T01:51:18Z 2020-12-12T01:51:18Z 2020-01-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.36416/1806-3756/e20190223 Jornal Brasileiro de Pneumologia, v. 46, n. 3, 2020. 1806-3756 1806-3713 http://hdl.handle.net/11449/199859 10.36416/1806-3756/e20190223 S1806-37132020000300200 2-s2.0-85077032608 S1806-37132020000300200.pdf |
url |
http://dx.doi.org/10.36416/1806-3756/e20190223 http://hdl.handle.net/11449/199859 |
identifier_str_mv |
Jornal Brasileiro de Pneumologia, v. 46, n. 3, 2020. 1806-3756 1806-3713 10.36416/1806-3756/e20190223 S1806-37132020000300200 2-s2.0-85077032608 S1806-37132020000300200.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Jornal Brasileiro de Pneumologia |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1808128121449218048 |