Hemostatic profile and thromboembolic risk in healthy dogs treated with prednisone: a randomized controlled trial
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1186/1746-6148-9-268 http://hdl.handle.net/11449/112337 |
Resumo: | Background: Thrombosis has been associated to some diseases like hyperadrenocorticism (HAC). Several drugs can alter the balance, such as the corticosteroid prednisone, used mainly for its anti-inflammatory and immunosuppressive effects. It is known that hypercortisolism can stimulate thrombi formation by increasing coagulation factors and decreasing fibrinolysis. However it is not known how prednisone administration affects hemostasis in dogs and if it is dose dependent. The aim of this study, therefore, was to demonstrate the effects of prednisone administration on dogs' hemostatic profile.Results: Significant decrease of antithrombin levels was observed in both groups (anti-inflammatory and immunosuppressive doses) after 15 days of treatment. An increase of platelet aggregation was observed in dogs receiving immunosuppressive doses of prednisone (Group II).Conclusions: From the results obtained in our study, it is not possible to infer that hypercortisolism can increase the thromboembolic risk, despite the decreased anticoagulant factors (antithrombin levels). |
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Repositório Institucional da UNESP |
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Hemostatic profile and thromboembolic risk in healthy dogs treated with prednisone: a randomized controlled trialPlateletsHemostasisPrednisoneThromboembolismBackground: Thrombosis has been associated to some diseases like hyperadrenocorticism (HAC). Several drugs can alter the balance, such as the corticosteroid prednisone, used mainly for its anti-inflammatory and immunosuppressive effects. It is known that hypercortisolism can stimulate thrombi formation by increasing coagulation factors and decreasing fibrinolysis. However it is not known how prednisone administration affects hemostasis in dogs and if it is dose dependent. The aim of this study, therefore, was to demonstrate the effects of prednisone administration on dogs' hemostatic profile.Results: Significant decrease of antithrombin levels was observed in both groups (anti-inflammatory and immunosuppressive doses) after 15 days of treatment. An increase of platelet aggregation was observed in dogs receiving immunosuppressive doses of prednisone (Group II).Conclusions: From the results obtained in our study, it is not possible to infer that hypercortisolism can increase the thromboembolic risk, despite the decreased anticoagulant factors (antithrombin levels).Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Univ Estadual Paulista UNESP, Dept Vet Clin, Botucatu Vet Med Sch, Botucatu, SP, BrazilUniv Estado Santa Catarina UDESC, Lages Vet Med Sch, Dept Vet Med, Lages, BrazilUniv Estadual Paulista UNESP, Dept Vet Clin, Botucatu Vet Med Sch, Botucatu, SP, BrazilBiomed Central Ltd.Universidade Estadual Paulista (Unesp)Universidade do Estado de Santa Catarina (UDESC)Romao, Felipe Gazza [UNESP]Campos, Elza Fernanda [UNESP]Scabelo Mattoso, Claudio RobertoTakahira, Regina Kiomi [UNESP]2014-12-03T13:10:38Z2014-12-03T13:10:38Z2013-12-31info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article6application/pdfhttp://dx.doi.org/10.1186/1746-6148-9-268Bmc Veterinary Research. London: Biomed Central Ltd, v. 9, 6 p., 2013.1746-6148http://hdl.handle.net/11449/11233710.1186/1746-6148-9-268WOS:000329634500001WOS000329634500001.pdf35178254101788130000-0003-3323-4199Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBMC Veterinary Research1.9580,934info:eu-repo/semantics/openAccess2023-11-13T06:16:28Zoai:repositorio.unesp.br:11449/112337Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T17:36:40.138206Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Hemostatic profile and thromboembolic risk in healthy dogs treated with prednisone: a randomized controlled trial |
title |
Hemostatic profile and thromboembolic risk in healthy dogs treated with prednisone: a randomized controlled trial |
spellingShingle |
Hemostatic profile and thromboembolic risk in healthy dogs treated with prednisone: a randomized controlled trial Romao, Felipe Gazza [UNESP] Platelets Hemostasis Prednisone Thromboembolism |
title_short |
Hemostatic profile and thromboembolic risk in healthy dogs treated with prednisone: a randomized controlled trial |
title_full |
Hemostatic profile and thromboembolic risk in healthy dogs treated with prednisone: a randomized controlled trial |
title_fullStr |
Hemostatic profile and thromboembolic risk in healthy dogs treated with prednisone: a randomized controlled trial |
title_full_unstemmed |
Hemostatic profile and thromboembolic risk in healthy dogs treated with prednisone: a randomized controlled trial |
title_sort |
Hemostatic profile and thromboembolic risk in healthy dogs treated with prednisone: a randomized controlled trial |
author |
Romao, Felipe Gazza [UNESP] |
author_facet |
Romao, Felipe Gazza [UNESP] Campos, Elza Fernanda [UNESP] Scabelo Mattoso, Claudio Roberto Takahira, Regina Kiomi [UNESP] |
author_role |
author |
author2 |
Campos, Elza Fernanda [UNESP] Scabelo Mattoso, Claudio Roberto Takahira, Regina Kiomi [UNESP] |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Universidade do Estado de Santa Catarina (UDESC) |
dc.contributor.author.fl_str_mv |
Romao, Felipe Gazza [UNESP] Campos, Elza Fernanda [UNESP] Scabelo Mattoso, Claudio Roberto Takahira, Regina Kiomi [UNESP] |
dc.subject.por.fl_str_mv |
Platelets Hemostasis Prednisone Thromboembolism |
topic |
Platelets Hemostasis Prednisone Thromboembolism |
description |
Background: Thrombosis has been associated to some diseases like hyperadrenocorticism (HAC). Several drugs can alter the balance, such as the corticosteroid prednisone, used mainly for its anti-inflammatory and immunosuppressive effects. It is known that hypercortisolism can stimulate thrombi formation by increasing coagulation factors and decreasing fibrinolysis. However it is not known how prednisone administration affects hemostasis in dogs and if it is dose dependent. The aim of this study, therefore, was to demonstrate the effects of prednisone administration on dogs' hemostatic profile.Results: Significant decrease of antithrombin levels was observed in both groups (anti-inflammatory and immunosuppressive doses) after 15 days of treatment. An increase of platelet aggregation was observed in dogs receiving immunosuppressive doses of prednisone (Group II).Conclusions: From the results obtained in our study, it is not possible to infer that hypercortisolism can increase the thromboembolic risk, despite the decreased anticoagulant factors (antithrombin levels). |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-12-31 2014-12-03T13:10:38Z 2014-12-03T13:10:38Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1186/1746-6148-9-268 Bmc Veterinary Research. London: Biomed Central Ltd, v. 9, 6 p., 2013. 1746-6148 http://hdl.handle.net/11449/112337 10.1186/1746-6148-9-268 WOS:000329634500001 WOS000329634500001.pdf 3517825410178813 0000-0003-3323-4199 |
url |
http://dx.doi.org/10.1186/1746-6148-9-268 http://hdl.handle.net/11449/112337 |
identifier_str_mv |
Bmc Veterinary Research. London: Biomed Central Ltd, v. 9, 6 p., 2013. 1746-6148 10.1186/1746-6148-9-268 WOS:000329634500001 WOS000329634500001.pdf 3517825410178813 0000-0003-3323-4199 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
BMC Veterinary Research 1.958 0,934 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
6 application/pdf |
dc.publisher.none.fl_str_mv |
Biomed Central Ltd. |
publisher.none.fl_str_mv |
Biomed Central Ltd. |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128834190442496 |