Aquatic Pollution and Risks to Biodiversity: The Example of Cocaine Effects on the Ovaries of Anguilla anguilla
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.3390/ani12141766 http://hdl.handle.net/11449/241518 |
Resumo: | Pollution is one of the main causes of the loss of biodiversity, currently one of the most important environmental problems. Important sources of aquatic pollution are illicit drugs, whose presence in waters is closely related to human consumption; their psychoactive properties and biological activity suggest potential adverse effects on non-target organisms, such as aquatic biota. In this study, we evaluated the effect of an environmentally relevant concentration of cocaine (20 ng L−1), an illicit drug widely found in surface waters, on the ovaries of Anguilla anguilla, a species critically endangered and able to accumulate cocaine in its tissues following chronic exposure. The following parameters were evaluated: (1) the morphology of the ovaries; (2) the presence and distribution of enzymes involved in oogenesis; (3) serum cortisol, FSH, and LH levels. The eels exposed to cocaine showed a smaller follicular area and a higher percentage of connective tissue than controls (p < 0.05), as well as many previtellogenic oocytes compared with controls having numerous fully vitellogenic and early vitellogenic oocytes. In addition, the presence and location of 3β-hydroxysteroid dehydrogenase, 17β-hydroxysteroid dehydrogenase, and P450 aromatase differed in the two groups. Finally, cocaine exposure decreased FSH and LH levels, while it increased cortisol levels. These findings show that even a low environmental concentration of cocaine affects the ovarian morphology and activity of A. anguilla, suggesting a potential impact on reproduction in this species. |
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Aquatic Pollution and Risks to Biodiversity: The Example of Cocaine Effects on the Ovaries of Anguilla anguillaAnguilla anguillacocainegonadotropinsoogenesis enzymesovaryPollution is one of the main causes of the loss of biodiversity, currently one of the most important environmental problems. Important sources of aquatic pollution are illicit drugs, whose presence in waters is closely related to human consumption; their psychoactive properties and biological activity suggest potential adverse effects on non-target organisms, such as aquatic biota. In this study, we evaluated the effect of an environmentally relevant concentration of cocaine (20 ng L−1), an illicit drug widely found in surface waters, on the ovaries of Anguilla anguilla, a species critically endangered and able to accumulate cocaine in its tissues following chronic exposure. The following parameters were evaluated: (1) the morphology of the ovaries; (2) the presence and distribution of enzymes involved in oogenesis; (3) serum cortisol, FSH, and LH levels. The eels exposed to cocaine showed a smaller follicular area and a higher percentage of connective tissue than controls (p < 0.05), as well as many previtellogenic oocytes compared with controls having numerous fully vitellogenic and early vitellogenic oocytes. In addition, the presence and location of 3β-hydroxysteroid dehydrogenase, 17β-hydroxysteroid dehydrogenase, and P450 aromatase differed in the two groups. Finally, cocaine exposure decreased FSH and LH levels, while it increased cortisol levels. These findings show that even a low environmental concentration of cocaine affects the ovarian morphology and activity of A. anguilla, suggesting a potential impact on reproduction in this species.Institute of Biosciences São Paulo State University “Júlio de Mesquita Filho,”, Litoral Paulista Campus, Praça Infante Dom Henrique s/nDepartment of Marine Sciences Federal University of São Paulo, Rua Maria Máximo, 168Department of Biology University of Naples Federico II, Via, Cinthia, Edificio 7Center for Studies on Bioinspired Agro-Environmental Technology (BAT Center)Morphofunctional Laboratory University of Rio Preto-UNAERP, Campus Guarujá, Av. D. Pedro I, 3.300 Enseada Guarujá-SP CEPInstitute of Biosciences São Paulo State University “Júlio de Mesquita Filho,”, Litoral Paulista Campus, Praça Infante Dom Henrique s/nUniversidade Estadual Paulista (UNESP)Universidade de São Paulo (USP)University of Naples Federico IICenter for Studies on Bioinspired Agro-Environmental Technology (BAT Center)University of Rio Preto-UNAERPFontes, Mayana Karoline [UNESP]Rosati, LuigiDi Lorenzo, MarianaPereira, Camilo Dias SeabraMaranho, Luciane AlvesLaforgia, VincenzaCapaldo, Anna2023-03-01T21:07:34Z2023-03-01T21:07:34Z2022-07-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.3390/ani12141766Animals, v. 12, n. 14, 2022.2076-2615http://hdl.handle.net/11449/24151810.3390/ani121417662-s2.0-85136162407Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengAnimalsinfo:eu-repo/semantics/openAccess2023-03-01T21:07:34Zoai:repositorio.unesp.br:11449/241518Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-03-01T21:07:34Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Aquatic Pollution and Risks to Biodiversity: The Example of Cocaine Effects on the Ovaries of Anguilla anguilla |
title |
Aquatic Pollution and Risks to Biodiversity: The Example of Cocaine Effects on the Ovaries of Anguilla anguilla |
spellingShingle |
Aquatic Pollution and Risks to Biodiversity: The Example of Cocaine Effects on the Ovaries of Anguilla anguilla Fontes, Mayana Karoline [UNESP] Anguilla anguilla cocaine gonadotropins oogenesis enzymes ovary |
title_short |
Aquatic Pollution and Risks to Biodiversity: The Example of Cocaine Effects on the Ovaries of Anguilla anguilla |
title_full |
Aquatic Pollution and Risks to Biodiversity: The Example of Cocaine Effects on the Ovaries of Anguilla anguilla |
title_fullStr |
Aquatic Pollution and Risks to Biodiversity: The Example of Cocaine Effects on the Ovaries of Anguilla anguilla |
title_full_unstemmed |
Aquatic Pollution and Risks to Biodiversity: The Example of Cocaine Effects on the Ovaries of Anguilla anguilla |
title_sort |
Aquatic Pollution and Risks to Biodiversity: The Example of Cocaine Effects on the Ovaries of Anguilla anguilla |
author |
Fontes, Mayana Karoline [UNESP] |
author_facet |
Fontes, Mayana Karoline [UNESP] Rosati, Luigi Di Lorenzo, Mariana Pereira, Camilo Dias Seabra Maranho, Luciane Alves Laforgia, Vincenza Capaldo, Anna |
author_role |
author |
author2 |
Rosati, Luigi Di Lorenzo, Mariana Pereira, Camilo Dias Seabra Maranho, Luciane Alves Laforgia, Vincenza Capaldo, Anna |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) Universidade de São Paulo (USP) University of Naples Federico II Center for Studies on Bioinspired Agro-Environmental Technology (BAT Center) University of Rio Preto-UNAERP |
dc.contributor.author.fl_str_mv |
Fontes, Mayana Karoline [UNESP] Rosati, Luigi Di Lorenzo, Mariana Pereira, Camilo Dias Seabra Maranho, Luciane Alves Laforgia, Vincenza Capaldo, Anna |
dc.subject.por.fl_str_mv |
Anguilla anguilla cocaine gonadotropins oogenesis enzymes ovary |
topic |
Anguilla anguilla cocaine gonadotropins oogenesis enzymes ovary |
description |
Pollution is one of the main causes of the loss of biodiversity, currently one of the most important environmental problems. Important sources of aquatic pollution are illicit drugs, whose presence in waters is closely related to human consumption; their psychoactive properties and biological activity suggest potential adverse effects on non-target organisms, such as aquatic biota. In this study, we evaluated the effect of an environmentally relevant concentration of cocaine (20 ng L−1), an illicit drug widely found in surface waters, on the ovaries of Anguilla anguilla, a species critically endangered and able to accumulate cocaine in its tissues following chronic exposure. The following parameters were evaluated: (1) the morphology of the ovaries; (2) the presence and distribution of enzymes involved in oogenesis; (3) serum cortisol, FSH, and LH levels. The eels exposed to cocaine showed a smaller follicular area and a higher percentage of connective tissue than controls (p < 0.05), as well as many previtellogenic oocytes compared with controls having numerous fully vitellogenic and early vitellogenic oocytes. In addition, the presence and location of 3β-hydroxysteroid dehydrogenase, 17β-hydroxysteroid dehydrogenase, and P450 aromatase differed in the two groups. Finally, cocaine exposure decreased FSH and LH levels, while it increased cortisol levels. These findings show that even a low environmental concentration of cocaine affects the ovarian morphology and activity of A. anguilla, suggesting a potential impact on reproduction in this species. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-07-01 2023-03-01T21:07:34Z 2023-03-01T21:07:34Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.3390/ani12141766 Animals, v. 12, n. 14, 2022. 2076-2615 http://hdl.handle.net/11449/241518 10.3390/ani12141766 2-s2.0-85136162407 |
url |
http://dx.doi.org/10.3390/ani12141766 http://hdl.handle.net/11449/241518 |
identifier_str_mv |
Animals, v. 12, n. 14, 2022. 2076-2615 10.3390/ani12141766 2-s2.0-85136162407 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Animals |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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1803046488978227200 |