Exercise training in the aerobic/anaerobic metabolic transition prevents glucose intolerance in alloxan-treated rats
Autor(a) principal: | |
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Data de Publicação: | 2008 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1186/1472-6823-8-11 http://hdl.handle.net/11449/70607 |
Resumo: | Background: Ninety percent of cases of diabetes are of the slowly evolving non-insulin-dependent type, or Type 2 diabetes. Lack of exercise is regarded as one of the main causes of this disorder. In this study we analyzed the effects of physical exercise on glucose homeostasis in adult rats with type 2 diabetes induced by a neonatal injection of alloxan. Methods: Female Wistar rats aged 6 days were injected with either 250 mg/ kg of body weight of alloxan or citrate buffer 0.01 M (controls). After weaning, half of the animals in each group were subjected to physical training adjusted to meet the aerobic-anaerobic metabolic transition by swimming 1 h/day for 5 days a week with weight overloads. The necessary overload used was set and periodically readjusted for each rat through effort tests based on the maximal lactate steady state procedure. When aged 28, 60, 90, and 120 days, the rats underwent glucose tolerance tests (GTT) and their peripheral insulin sensitivity was evaluated using the HOMA index. Results: The area under the serum glucose curve obtained through GTT was always higher in alloxan-treated animals than in controls. A decrease in this area was observed in trained alloxan-treated rats at 90 and 120 days old compared with non-trained animals. At 90 days old the trained controls showed lower HOMA indices than the non-trained controls. Conclusion: Neonatal administration of alloxan induced a persistent glucose intolerance in all injected rats, which was successfully counteracted by physical training in the aerobic/anaerobic metabolic transition. © 2008 Mota et al; licensee BioMed Central Ltd. |
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Exercise training in the aerobic/anaerobic metabolic transition prevents glucose intolerance in alloxan-treated ratsalloxanglucoselactic acidaerobic metabolismalloxan diabetes mellitusanaerobic metabolismanimal experimentanimal modelcontrolled studyfemaleglucose blood levelglucose homeostasisglucose intoleranceglucose tolerance testinsulin sensitivitykinesiotherapylactate blood levelnon insulin dependent diabetes mellitusnonhumanphysical activityratsteady stateswimmingWistar ratBackground: Ninety percent of cases of diabetes are of the slowly evolving non-insulin-dependent type, or Type 2 diabetes. Lack of exercise is regarded as one of the main causes of this disorder. In this study we analyzed the effects of physical exercise on glucose homeostasis in adult rats with type 2 diabetes induced by a neonatal injection of alloxan. Methods: Female Wistar rats aged 6 days were injected with either 250 mg/ kg of body weight of alloxan or citrate buffer 0.01 M (controls). After weaning, half of the animals in each group were subjected to physical training adjusted to meet the aerobic-anaerobic metabolic transition by swimming 1 h/day for 5 days a week with weight overloads. The necessary overload used was set and periodically readjusted for each rat through effort tests based on the maximal lactate steady state procedure. When aged 28, 60, 90, and 120 days, the rats underwent glucose tolerance tests (GTT) and their peripheral insulin sensitivity was evaluated using the HOMA index. Results: The area under the serum glucose curve obtained through GTT was always higher in alloxan-treated animals than in controls. A decrease in this area was observed in trained alloxan-treated rats at 90 and 120 days old compared with non-trained animals. At 90 days old the trained controls showed lower HOMA indices than the non-trained controls. Conclusion: Neonatal administration of alloxan induced a persistent glucose intolerance in all injected rats, which was successfully counteracted by physical training in the aerobic/anaerobic metabolic transition. © 2008 Mota et al; licensee BioMed Central Ltd.Institute of Biosciences Department of Physical Education São Paulo State University, Unesp, SPInstitute of Biosciences Department of Physiology and Biophysical Campinas State University, Unicamp, SPInstitute of Biosciences Department of Physical Education São Paulo State University, Unesp, SPUniversidade Estadual Paulista (Unesp)Universidade Estadual de Campinas (UNICAMP)Soares de Alencar Mota, Clécia [UNESP]Ribeiro, Carla [UNESP]de Araújo, Gustavo Gomes [UNESP]de Araújo, Michel Barbosa [UNESP]de Barros Manchado-Gobatto, Fúlvia [UNESP]Voltarelli, Fabrício Azevedo [UNESP]de Oliveira, Camila Aparecida MachadoLuciano, Eliete [UNESP]de Mello, Maria Alice Rostom [UNESP]2014-05-27T11:23:41Z2014-05-27T11:23:41Z2008-10-02info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://dx.doi.org/10.1186/1472-6823-8-11BMC Endocrine Disorders, v. 8.1472-6823http://hdl.handle.net/11449/7060710.1186/1472-6823-8-112-s2.0-540491508242-s2.0-54049150824.pdf2933779830637191Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBMC Endocrine Disorders2.0270,965info:eu-repo/semantics/openAccess2023-10-11T06:07:50Zoai:repositorio.unesp.br:11449/70607Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T14:37:46.760081Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Exercise training in the aerobic/anaerobic metabolic transition prevents glucose intolerance in alloxan-treated rats |
title |
Exercise training in the aerobic/anaerobic metabolic transition prevents glucose intolerance in alloxan-treated rats |
spellingShingle |
Exercise training in the aerobic/anaerobic metabolic transition prevents glucose intolerance in alloxan-treated rats Soares de Alencar Mota, Clécia [UNESP] alloxan glucose lactic acid aerobic metabolism alloxan diabetes mellitus anaerobic metabolism animal experiment animal model controlled study female glucose blood level glucose homeostasis glucose intolerance glucose tolerance test insulin sensitivity kinesiotherapy lactate blood level non insulin dependent diabetes mellitus nonhuman physical activity rat steady state swimming Wistar rat |
title_short |
Exercise training in the aerobic/anaerobic metabolic transition prevents glucose intolerance in alloxan-treated rats |
title_full |
Exercise training in the aerobic/anaerobic metabolic transition prevents glucose intolerance in alloxan-treated rats |
title_fullStr |
Exercise training in the aerobic/anaerobic metabolic transition prevents glucose intolerance in alloxan-treated rats |
title_full_unstemmed |
Exercise training in the aerobic/anaerobic metabolic transition prevents glucose intolerance in alloxan-treated rats |
title_sort |
Exercise training in the aerobic/anaerobic metabolic transition prevents glucose intolerance in alloxan-treated rats |
author |
Soares de Alencar Mota, Clécia [UNESP] |
author_facet |
Soares de Alencar Mota, Clécia [UNESP] Ribeiro, Carla [UNESP] de Araújo, Gustavo Gomes [UNESP] de Araújo, Michel Barbosa [UNESP] de Barros Manchado-Gobatto, Fúlvia [UNESP] Voltarelli, Fabrício Azevedo [UNESP] de Oliveira, Camila Aparecida Machado Luciano, Eliete [UNESP] de Mello, Maria Alice Rostom [UNESP] |
author_role |
author |
author2 |
Ribeiro, Carla [UNESP] de Araújo, Gustavo Gomes [UNESP] de Araújo, Michel Barbosa [UNESP] de Barros Manchado-Gobatto, Fúlvia [UNESP] Voltarelli, Fabrício Azevedo [UNESP] de Oliveira, Camila Aparecida Machado Luciano, Eliete [UNESP] de Mello, Maria Alice Rostom [UNESP] |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Universidade Estadual de Campinas (UNICAMP) |
dc.contributor.author.fl_str_mv |
Soares de Alencar Mota, Clécia [UNESP] Ribeiro, Carla [UNESP] de Araújo, Gustavo Gomes [UNESP] de Araújo, Michel Barbosa [UNESP] de Barros Manchado-Gobatto, Fúlvia [UNESP] Voltarelli, Fabrício Azevedo [UNESP] de Oliveira, Camila Aparecida Machado Luciano, Eliete [UNESP] de Mello, Maria Alice Rostom [UNESP] |
dc.subject.por.fl_str_mv |
alloxan glucose lactic acid aerobic metabolism alloxan diabetes mellitus anaerobic metabolism animal experiment animal model controlled study female glucose blood level glucose homeostasis glucose intolerance glucose tolerance test insulin sensitivity kinesiotherapy lactate blood level non insulin dependent diabetes mellitus nonhuman physical activity rat steady state swimming Wistar rat |
topic |
alloxan glucose lactic acid aerobic metabolism alloxan diabetes mellitus anaerobic metabolism animal experiment animal model controlled study female glucose blood level glucose homeostasis glucose intolerance glucose tolerance test insulin sensitivity kinesiotherapy lactate blood level non insulin dependent diabetes mellitus nonhuman physical activity rat steady state swimming Wistar rat |
description |
Background: Ninety percent of cases of diabetes are of the slowly evolving non-insulin-dependent type, or Type 2 diabetes. Lack of exercise is regarded as one of the main causes of this disorder. In this study we analyzed the effects of physical exercise on glucose homeostasis in adult rats with type 2 diabetes induced by a neonatal injection of alloxan. Methods: Female Wistar rats aged 6 days were injected with either 250 mg/ kg of body weight of alloxan or citrate buffer 0.01 M (controls). After weaning, half of the animals in each group were subjected to physical training adjusted to meet the aerobic-anaerobic metabolic transition by swimming 1 h/day for 5 days a week with weight overloads. The necessary overload used was set and periodically readjusted for each rat through effort tests based on the maximal lactate steady state procedure. When aged 28, 60, 90, and 120 days, the rats underwent glucose tolerance tests (GTT) and their peripheral insulin sensitivity was evaluated using the HOMA index. Results: The area under the serum glucose curve obtained through GTT was always higher in alloxan-treated animals than in controls. A decrease in this area was observed in trained alloxan-treated rats at 90 and 120 days old compared with non-trained animals. At 90 days old the trained controls showed lower HOMA indices than the non-trained controls. Conclusion: Neonatal administration of alloxan induced a persistent glucose intolerance in all injected rats, which was successfully counteracted by physical training in the aerobic/anaerobic metabolic transition. © 2008 Mota et al; licensee BioMed Central Ltd. |
publishDate |
2008 |
dc.date.none.fl_str_mv |
2008-10-02 2014-05-27T11:23:41Z 2014-05-27T11:23:41Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1186/1472-6823-8-11 BMC Endocrine Disorders, v. 8. 1472-6823 http://hdl.handle.net/11449/70607 10.1186/1472-6823-8-11 2-s2.0-54049150824 2-s2.0-54049150824.pdf 2933779830637191 |
url |
http://dx.doi.org/10.1186/1472-6823-8-11 http://hdl.handle.net/11449/70607 |
identifier_str_mv |
BMC Endocrine Disorders, v. 8. 1472-6823 10.1186/1472-6823-8-11 2-s2.0-54049150824 2-s2.0-54049150824.pdf 2933779830637191 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
BMC Endocrine Disorders 2.027 0,965 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1808128391163936768 |