Evaluation of Two Beta-Tricalcium Phosphates with Different Particle Dimensions in Human Maxillary Sinus Floor Elevation: A Prospective, Randomized Clinical Trial
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.3390/ma15051824 http://hdl.handle.net/11449/230513 |
Resumo: | This study aimed to compare two beta-tricalcium phosphates with different particle sizes in human maxillary sinuses lifting. The immunolabeling of cells for RUNX2 and VEGF were performed to evaluate the osteoblast precursor cells and the vascular formation after 6 months of bone repair. Ten maxillary sinuses were grafted with autogenous bone graft (Group 1), 10 were grafted with ChronOs® (Group 2), and 10 were grafted with BETA-TCP® (Group 3). After 6 months of bone healing, biopsies were obtained to assess the new bone formed by histomorphometric and immunohistochemical evaluation for RUNX2 and VEGF. The mean bone formation for Group 1 was 51.4 ± 17.4%. Group 2 presented 45.5 ± 9.9%, and Group 3 conferred 35.4 ± 8.0% of new bone formation. The RUNX2 offered low for Groups 1 and 2 with high cellular activity for osteoblast in Group 3. The VEGF immunolabeling was moderate for Groups 1 and 2 and intense for Group 3. In conclusion, it was possible to show that the bone substitutes evaluated in the present study presented suitable outcomes for bone regeneration, being an alternative for the autogenous bone graft in maxillary sinus bone height reconstruction. |
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spelling |
Evaluation of Two Beta-Tricalcium Phosphates with Different Particle Dimensions in Human Maxillary Sinus Floor Elevation: A Prospective, Randomized Clinical TrialBiomaterialsBone substitutesSinus floor augmentationThis study aimed to compare two beta-tricalcium phosphates with different particle sizes in human maxillary sinuses lifting. The immunolabeling of cells for RUNX2 and VEGF were performed to evaluate the osteoblast precursor cells and the vascular formation after 6 months of bone repair. Ten maxillary sinuses were grafted with autogenous bone graft (Group 1), 10 were grafted with ChronOs® (Group 2), and 10 were grafted with BETA-TCP® (Group 3). After 6 months of bone healing, biopsies were obtained to assess the new bone formed by histomorphometric and immunohistochemical evaluation for RUNX2 and VEGF. The mean bone formation for Group 1 was 51.4 ± 17.4%. Group 2 presented 45.5 ± 9.9%, and Group 3 conferred 35.4 ± 8.0% of new bone formation. The RUNX2 offered low for Groups 1 and 2 with high cellular activity for osteoblast in Group 3. The VEGF immunolabeling was moderate for Groups 1 and 2 and intense for Group 3. In conclusion, it was possible to show that the bone substitutes evaluated in the present study presented suitable outcomes for bone regeneration, being an alternative for the autogenous bone graft in maxillary sinus bone height reconstruction.Department of Oral & Maxillofacial Surgery Aracatuba School of Dentistry Sao Paulo State UniversityDepartment of Oral & Maxillofacial Surgery University of Grande Rio—UNIGRANRIOClinical Research Unit of the Antonio Pedro Hospital Fluminense Federal UniversityDepartment of Dental Prosthesis Aracatuba School of Dentistry Sao Paulo State UniversityDepartment of Human Anatomy Aracatuba School of Dentistry Sao Paulo State UniversityDepartment of Oral & Maxillofacial Surgery Aracatuba School of Dentistry Sao Paulo State UniversityDepartment of Dental Prosthesis Aracatuba School of Dentistry Sao Paulo State UniversityDepartment of Human Anatomy Aracatuba School of Dentistry Sao Paulo State UniversityUniversidade Estadual Paulista (UNESP)University of Grande Rio—UNIGRANRIOFluminense Federal UniversityMendes, Bruno Coelho [UNESP]Pereira, Rodrigo Dos SantosMourão, Carlos Fernando de Almeida BarrosMontemezzi, PietroSantos, Anderson Maikon de Souza [UNESP]Moreno, Jéssica Monique Lopes [UNESP]Okamoto, Roberta [UNESP]Hochuli-Vieira, Eduardo [UNESP]2022-04-29T08:40:34Z2022-04-29T08:40:34Z2022-03-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.3390/ma15051824Materials, v. 15, n. 5, 2022.1996-1944http://hdl.handle.net/11449/23051310.3390/ma150518242-s2.0-85125806166Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengMaterialsinfo:eu-repo/semantics/openAccess2024-09-19T13:30:17Zoai:repositorio.unesp.br:11449/230513Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-19T13:30:17Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Evaluation of Two Beta-Tricalcium Phosphates with Different Particle Dimensions in Human Maxillary Sinus Floor Elevation: A Prospective, Randomized Clinical Trial |
title |
Evaluation of Two Beta-Tricalcium Phosphates with Different Particle Dimensions in Human Maxillary Sinus Floor Elevation: A Prospective, Randomized Clinical Trial |
spellingShingle |
Evaluation of Two Beta-Tricalcium Phosphates with Different Particle Dimensions in Human Maxillary Sinus Floor Elevation: A Prospective, Randomized Clinical Trial Mendes, Bruno Coelho [UNESP] Biomaterials Bone substitutes Sinus floor augmentation |
title_short |
Evaluation of Two Beta-Tricalcium Phosphates with Different Particle Dimensions in Human Maxillary Sinus Floor Elevation: A Prospective, Randomized Clinical Trial |
title_full |
Evaluation of Two Beta-Tricalcium Phosphates with Different Particle Dimensions in Human Maxillary Sinus Floor Elevation: A Prospective, Randomized Clinical Trial |
title_fullStr |
Evaluation of Two Beta-Tricalcium Phosphates with Different Particle Dimensions in Human Maxillary Sinus Floor Elevation: A Prospective, Randomized Clinical Trial |
title_full_unstemmed |
Evaluation of Two Beta-Tricalcium Phosphates with Different Particle Dimensions in Human Maxillary Sinus Floor Elevation: A Prospective, Randomized Clinical Trial |
title_sort |
Evaluation of Two Beta-Tricalcium Phosphates with Different Particle Dimensions in Human Maxillary Sinus Floor Elevation: A Prospective, Randomized Clinical Trial |
author |
Mendes, Bruno Coelho [UNESP] |
author_facet |
Mendes, Bruno Coelho [UNESP] Pereira, Rodrigo Dos Santos Mourão, Carlos Fernando de Almeida Barros Montemezzi, Pietro Santos, Anderson Maikon de Souza [UNESP] Moreno, Jéssica Monique Lopes [UNESP] Okamoto, Roberta [UNESP] Hochuli-Vieira, Eduardo [UNESP] |
author_role |
author |
author2 |
Pereira, Rodrigo Dos Santos Mourão, Carlos Fernando de Almeida Barros Montemezzi, Pietro Santos, Anderson Maikon de Souza [UNESP] Moreno, Jéssica Monique Lopes [UNESP] Okamoto, Roberta [UNESP] Hochuli-Vieira, Eduardo [UNESP] |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) University of Grande Rio—UNIGRANRIO Fluminense Federal University |
dc.contributor.author.fl_str_mv |
Mendes, Bruno Coelho [UNESP] Pereira, Rodrigo Dos Santos Mourão, Carlos Fernando de Almeida Barros Montemezzi, Pietro Santos, Anderson Maikon de Souza [UNESP] Moreno, Jéssica Monique Lopes [UNESP] Okamoto, Roberta [UNESP] Hochuli-Vieira, Eduardo [UNESP] |
dc.subject.por.fl_str_mv |
Biomaterials Bone substitutes Sinus floor augmentation |
topic |
Biomaterials Bone substitutes Sinus floor augmentation |
description |
This study aimed to compare two beta-tricalcium phosphates with different particle sizes in human maxillary sinuses lifting. The immunolabeling of cells for RUNX2 and VEGF were performed to evaluate the osteoblast precursor cells and the vascular formation after 6 months of bone repair. Ten maxillary sinuses were grafted with autogenous bone graft (Group 1), 10 were grafted with ChronOs® (Group 2), and 10 were grafted with BETA-TCP® (Group 3). After 6 months of bone healing, biopsies were obtained to assess the new bone formed by histomorphometric and immunohistochemical evaluation for RUNX2 and VEGF. The mean bone formation for Group 1 was 51.4 ± 17.4%. Group 2 presented 45.5 ± 9.9%, and Group 3 conferred 35.4 ± 8.0% of new bone formation. The RUNX2 offered low for Groups 1 and 2 with high cellular activity for osteoblast in Group 3. The VEGF immunolabeling was moderate for Groups 1 and 2 and intense for Group 3. In conclusion, it was possible to show that the bone substitutes evaluated in the present study presented suitable outcomes for bone regeneration, being an alternative for the autogenous bone graft in maxillary sinus bone height reconstruction. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-04-29T08:40:34Z 2022-04-29T08:40:34Z 2022-03-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.3390/ma15051824 Materials, v. 15, n. 5, 2022. 1996-1944 http://hdl.handle.net/11449/230513 10.3390/ma15051824 2-s2.0-85125806166 |
url |
http://dx.doi.org/10.3390/ma15051824 http://hdl.handle.net/11449/230513 |
identifier_str_mv |
Materials, v. 15, n. 5, 2022. 1996-1944 10.3390/ma15051824 2-s2.0-85125806166 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Materials |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
repositoriounesp@unesp.br |
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1813546413603160064 |