Evaluation of Two Beta-Tricalcium Phosphates with Different Particle Dimensions in Human Maxillary Sinus Floor Elevation: A Prospective, Randomized Clinical Trial

Detalhes bibliográficos
Autor(a) principal: Mendes, Bruno Coelho [UNESP]
Data de Publicação: 2022
Outros Autores: Pereira, Rodrigo Dos Santos, Mourão, Carlos Fernando de Almeida Barros, Montemezzi, Pietro, Santos, Anderson Maikon de Souza [UNESP], Moreno, Jéssica Monique Lopes [UNESP], Okamoto, Roberta [UNESP], Hochuli-Vieira, Eduardo [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.3390/ma15051824
http://hdl.handle.net/11449/230513
Resumo: This study aimed to compare two beta-tricalcium phosphates with different particle sizes in human maxillary sinuses lifting. The immunolabeling of cells for RUNX2 and VEGF were performed to evaluate the osteoblast precursor cells and the vascular formation after 6 months of bone repair. Ten maxillary sinuses were grafted with autogenous bone graft (Group 1), 10 were grafted with ChronOs® (Group 2), and 10 were grafted with BETA-TCP® (Group 3). After 6 months of bone healing, biopsies were obtained to assess the new bone formed by histomorphometric and immunohistochemical evaluation for RUNX2 and VEGF. The mean bone formation for Group 1 was 51.4 ± 17.4%. Group 2 presented 45.5 ± 9.9%, and Group 3 conferred 35.4 ± 8.0% of new bone formation. The RUNX2 offered low for Groups 1 and 2 with high cellular activity for osteoblast in Group 3. The VEGF immunolabeling was moderate for Groups 1 and 2 and intense for Group 3. In conclusion, it was possible to show that the bone substitutes evaluated in the present study presented suitable outcomes for bone regeneration, being an alternative for the autogenous bone graft in maxillary sinus bone height reconstruction.
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spelling Evaluation of Two Beta-Tricalcium Phosphates with Different Particle Dimensions in Human Maxillary Sinus Floor Elevation: A Prospective, Randomized Clinical TrialBiomaterialsBone substitutesSinus floor augmentationThis study aimed to compare two beta-tricalcium phosphates with different particle sizes in human maxillary sinuses lifting. The immunolabeling of cells for RUNX2 and VEGF were performed to evaluate the osteoblast precursor cells and the vascular formation after 6 months of bone repair. Ten maxillary sinuses were grafted with autogenous bone graft (Group 1), 10 were grafted with ChronOs® (Group 2), and 10 were grafted with BETA-TCP® (Group 3). After 6 months of bone healing, biopsies were obtained to assess the new bone formed by histomorphometric and immunohistochemical evaluation for RUNX2 and VEGF. The mean bone formation for Group 1 was 51.4 ± 17.4%. Group 2 presented 45.5 ± 9.9%, and Group 3 conferred 35.4 ± 8.0% of new bone formation. The RUNX2 offered low for Groups 1 and 2 with high cellular activity for osteoblast in Group 3. The VEGF immunolabeling was moderate for Groups 1 and 2 and intense for Group 3. In conclusion, it was possible to show that the bone substitutes evaluated in the present study presented suitable outcomes for bone regeneration, being an alternative for the autogenous bone graft in maxillary sinus bone height reconstruction.Department of Oral & Maxillofacial Surgery Aracatuba School of Dentistry Sao Paulo State UniversityDepartment of Oral & Maxillofacial Surgery University of Grande Rio—UNIGRANRIOClinical Research Unit of the Antonio Pedro Hospital Fluminense Federal UniversityDepartment of Dental Prosthesis Aracatuba School of Dentistry Sao Paulo State UniversityDepartment of Human Anatomy Aracatuba School of Dentistry Sao Paulo State UniversityDepartment of Oral & Maxillofacial Surgery Aracatuba School of Dentistry Sao Paulo State UniversityDepartment of Dental Prosthesis Aracatuba School of Dentistry Sao Paulo State UniversityDepartment of Human Anatomy Aracatuba School of Dentistry Sao Paulo State UniversityUniversidade Estadual Paulista (UNESP)University of Grande Rio—UNIGRANRIOFluminense Federal UniversityMendes, Bruno Coelho [UNESP]Pereira, Rodrigo Dos SantosMourão, Carlos Fernando de Almeida BarrosMontemezzi, PietroSantos, Anderson Maikon de Souza [UNESP]Moreno, Jéssica Monique Lopes [UNESP]Okamoto, Roberta [UNESP]Hochuli-Vieira, Eduardo [UNESP]2022-04-29T08:40:34Z2022-04-29T08:40:34Z2022-03-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.3390/ma15051824Materials, v. 15, n. 5, 2022.1996-1944http://hdl.handle.net/11449/23051310.3390/ma150518242-s2.0-85125806166Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengMaterialsinfo:eu-repo/semantics/openAccess2024-09-19T13:30:17Zoai:repositorio.unesp.br:11449/230513Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-19T13:30:17Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Evaluation of Two Beta-Tricalcium Phosphates with Different Particle Dimensions in Human Maxillary Sinus Floor Elevation: A Prospective, Randomized Clinical Trial
title Evaluation of Two Beta-Tricalcium Phosphates with Different Particle Dimensions in Human Maxillary Sinus Floor Elevation: A Prospective, Randomized Clinical Trial
spellingShingle Evaluation of Two Beta-Tricalcium Phosphates with Different Particle Dimensions in Human Maxillary Sinus Floor Elevation: A Prospective, Randomized Clinical Trial
Mendes, Bruno Coelho [UNESP]
Biomaterials
Bone substitutes
Sinus floor augmentation
title_short Evaluation of Two Beta-Tricalcium Phosphates with Different Particle Dimensions in Human Maxillary Sinus Floor Elevation: A Prospective, Randomized Clinical Trial
title_full Evaluation of Two Beta-Tricalcium Phosphates with Different Particle Dimensions in Human Maxillary Sinus Floor Elevation: A Prospective, Randomized Clinical Trial
title_fullStr Evaluation of Two Beta-Tricalcium Phosphates with Different Particle Dimensions in Human Maxillary Sinus Floor Elevation: A Prospective, Randomized Clinical Trial
title_full_unstemmed Evaluation of Two Beta-Tricalcium Phosphates with Different Particle Dimensions in Human Maxillary Sinus Floor Elevation: A Prospective, Randomized Clinical Trial
title_sort Evaluation of Two Beta-Tricalcium Phosphates with Different Particle Dimensions in Human Maxillary Sinus Floor Elevation: A Prospective, Randomized Clinical Trial
author Mendes, Bruno Coelho [UNESP]
author_facet Mendes, Bruno Coelho [UNESP]
Pereira, Rodrigo Dos Santos
Mourão, Carlos Fernando de Almeida Barros
Montemezzi, Pietro
Santos, Anderson Maikon de Souza [UNESP]
Moreno, Jéssica Monique Lopes [UNESP]
Okamoto, Roberta [UNESP]
Hochuli-Vieira, Eduardo [UNESP]
author_role author
author2 Pereira, Rodrigo Dos Santos
Mourão, Carlos Fernando de Almeida Barros
Montemezzi, Pietro
Santos, Anderson Maikon de Souza [UNESP]
Moreno, Jéssica Monique Lopes [UNESP]
Okamoto, Roberta [UNESP]
Hochuli-Vieira, Eduardo [UNESP]
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (UNESP)
University of Grande Rio—UNIGRANRIO
Fluminense Federal University
dc.contributor.author.fl_str_mv Mendes, Bruno Coelho [UNESP]
Pereira, Rodrigo Dos Santos
Mourão, Carlos Fernando de Almeida Barros
Montemezzi, Pietro
Santos, Anderson Maikon de Souza [UNESP]
Moreno, Jéssica Monique Lopes [UNESP]
Okamoto, Roberta [UNESP]
Hochuli-Vieira, Eduardo [UNESP]
dc.subject.por.fl_str_mv Biomaterials
Bone substitutes
Sinus floor augmentation
topic Biomaterials
Bone substitutes
Sinus floor augmentation
description This study aimed to compare two beta-tricalcium phosphates with different particle sizes in human maxillary sinuses lifting. The immunolabeling of cells for RUNX2 and VEGF were performed to evaluate the osteoblast precursor cells and the vascular formation after 6 months of bone repair. Ten maxillary sinuses were grafted with autogenous bone graft (Group 1), 10 were grafted with ChronOs® (Group 2), and 10 were grafted with BETA-TCP® (Group 3). After 6 months of bone healing, biopsies were obtained to assess the new bone formed by histomorphometric and immunohistochemical evaluation for RUNX2 and VEGF. The mean bone formation for Group 1 was 51.4 ± 17.4%. Group 2 presented 45.5 ± 9.9%, and Group 3 conferred 35.4 ± 8.0% of new bone formation. The RUNX2 offered low for Groups 1 and 2 with high cellular activity for osteoblast in Group 3. The VEGF immunolabeling was moderate for Groups 1 and 2 and intense for Group 3. In conclusion, it was possible to show that the bone substitutes evaluated in the present study presented suitable outcomes for bone regeneration, being an alternative for the autogenous bone graft in maxillary sinus bone height reconstruction.
publishDate 2022
dc.date.none.fl_str_mv 2022-04-29T08:40:34Z
2022-04-29T08:40:34Z
2022-03-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.3390/ma15051824
Materials, v. 15, n. 5, 2022.
1996-1944
http://hdl.handle.net/11449/230513
10.3390/ma15051824
2-s2.0-85125806166
url http://dx.doi.org/10.3390/ma15051824
http://hdl.handle.net/11449/230513
identifier_str_mv Materials, v. 15, n. 5, 2022.
1996-1944
10.3390/ma15051824
2-s2.0-85125806166
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Materials
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv repositoriounesp@unesp.br
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