Clinical Symptoms, Imaging Features and Cyst Distribution in the Cerebrospinal Fluid Compartments in Patients with Extraparenchymal Neurocysticercosis
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1371/journal.pntd.0005115 http://hdl.handle.net/11449/162349 |
Resumo: | Extraparenchymal neurocysticercosis has an aggressive course because cysts in the cerebrospinal fluid compartments induce acute inflammatory reactions. The relationships between symptoms, imaging findings, lesion type and location remain poorly understood. In this retrospective clinical records-based study, we describe the clinical symptoms, magnetic resonance imaging features, and cyst distribution in the CSF compartments of 36 patients with extraparenchymal neurocysticercosis. Patients were recruited between 1995 and 2010 and median follow up was 38 months. During all the follow up time we found that 75% (27/36) of the patients had symptoms related to raised intracranial pressure sometime, 72.2% (26/36) cysticercotic meningitis, 61.1% (22/36) seizures, and 50.0% (18/36) headaches unrelated to intracranial pressure. Regarding lesion types, 77.8% (28/36) of patients presented with grape-like cysts, 22.2% (8/36) giant cysts, and 61.1% (22/36) contrast-enhancing lesions. Hydrocephalus occurred in 72.2% (26/36) of patients during the follow-up period. All patients had cysts in the subarachnoid space and 41.7% (15/36) had at least one cyst in some ventricle. Cysts were predominantly located in the posterior fossa (31 patients) and supratentorial basal cisterns (19 patients). The fourth ventricle was the main compromised ventricle (10 patients). Spinal cysts were more frequent than previously reported (11.1%, 4/36). Our findings are useful for both diagnosis and treatment selection in patients with neurocysticercosis. |
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Clinical Symptoms, Imaging Features and Cyst Distribution in the Cerebrospinal Fluid Compartments in Patients with Extraparenchymal NeurocysticercosisExtraparenchymal neurocysticercosis has an aggressive course because cysts in the cerebrospinal fluid compartments induce acute inflammatory reactions. The relationships between symptoms, imaging findings, lesion type and location remain poorly understood. In this retrospective clinical records-based study, we describe the clinical symptoms, magnetic resonance imaging features, and cyst distribution in the CSF compartments of 36 patients with extraparenchymal neurocysticercosis. Patients were recruited between 1995 and 2010 and median follow up was 38 months. During all the follow up time we found that 75% (27/36) of the patients had symptoms related to raised intracranial pressure sometime, 72.2% (26/36) cysticercotic meningitis, 61.1% (22/36) seizures, and 50.0% (18/36) headaches unrelated to intracranial pressure. Regarding lesion types, 77.8% (28/36) of patients presented with grape-like cysts, 22.2% (8/36) giant cysts, and 61.1% (22/36) contrast-enhancing lesions. Hydrocephalus occurred in 72.2% (26/36) of patients during the follow-up period. All patients had cysts in the subarachnoid space and 41.7% (15/36) had at least one cyst in some ventricle. Cysts were predominantly located in the posterior fossa (31 patients) and supratentorial basal cisterns (19 patients). The fourth ventricle was the main compromised ventricle (10 patients). Spinal cysts were more frequent than previously reported (11.1%, 4/36). Our findings are useful for both diagnosis and treatment selection in patients with neurocysticercosis.Univ Estadual Paulista, Botucatu Med Sch, Dept Neurol Psychol & Psychiat, Botucatu, BrazilUniv Sao Paulo, Ribeirao Preto Sch Med, Dept Neurosci & Behav Sci, Ribeirao Preto, BrazilUniv Sao Paulo, Ribeirao Preto Sch Med, Dept Internal Med, Ribeirao Preto, BrazilUniv Nacl Autonoma Mexico, Inst Biomed Invest, Mexico City, DF, MexicoUniv Estadual Paulista, Botucatu Med Sch, Dept Neurol Psychol & Psychiat, Botucatu, BrazilPublic Library ScienceUniversidade Estadual Paulista (Unesp)Universidade de São Paulo (USP)Univ Nacl Autonoma MexicoBazan, Rodrigo [UNESP]Hamamoto Filho, Pedro Tadao [UNESP]Luvizutto, Gustavo Jose [UNESP]Carvalho Nunes, Helio Rubens de [UNESP]Odashima, Newton SatoruSantos, Antonio Carlos dosElias Junior, JorgeZanini, Marco Antonio [UNESP]Fleury, AgnesTakayanagui, Osvaldo Massaiti2018-11-26T17:15:43Z2018-11-26T17:15:43Z2016-11-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article14application/pdfhttp://dx.doi.org/10.1371/journal.pntd.0005115Plos Neglected Tropical Diseases. San Francisco: Public Library Science, v. 10, n. 11, 14 p., 2016.1935-2735http://hdl.handle.net/11449/16234910.1371/journal.pntd.0005115WOS:000392154400037WOS000392154400037.pdf28949751418951892894975141895189Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengPlos Neglected Tropical Diseasesinfo:eu-repo/semantics/openAccess2024-08-16T15:45:16Zoai:repositorio.unesp.br:11449/162349Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-16T15:45:16Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Clinical Symptoms, Imaging Features and Cyst Distribution in the Cerebrospinal Fluid Compartments in Patients with Extraparenchymal Neurocysticercosis |
title |
Clinical Symptoms, Imaging Features and Cyst Distribution in the Cerebrospinal Fluid Compartments in Patients with Extraparenchymal Neurocysticercosis |
spellingShingle |
Clinical Symptoms, Imaging Features and Cyst Distribution in the Cerebrospinal Fluid Compartments in Patients with Extraparenchymal Neurocysticercosis Bazan, Rodrigo [UNESP] |
title_short |
Clinical Symptoms, Imaging Features and Cyst Distribution in the Cerebrospinal Fluid Compartments in Patients with Extraparenchymal Neurocysticercosis |
title_full |
Clinical Symptoms, Imaging Features and Cyst Distribution in the Cerebrospinal Fluid Compartments in Patients with Extraparenchymal Neurocysticercosis |
title_fullStr |
Clinical Symptoms, Imaging Features and Cyst Distribution in the Cerebrospinal Fluid Compartments in Patients with Extraparenchymal Neurocysticercosis |
title_full_unstemmed |
Clinical Symptoms, Imaging Features and Cyst Distribution in the Cerebrospinal Fluid Compartments in Patients with Extraparenchymal Neurocysticercosis |
title_sort |
Clinical Symptoms, Imaging Features and Cyst Distribution in the Cerebrospinal Fluid Compartments in Patients with Extraparenchymal Neurocysticercosis |
author |
Bazan, Rodrigo [UNESP] |
author_facet |
Bazan, Rodrigo [UNESP] Hamamoto Filho, Pedro Tadao [UNESP] Luvizutto, Gustavo Jose [UNESP] Carvalho Nunes, Helio Rubens de [UNESP] Odashima, Newton Satoru Santos, Antonio Carlos dos Elias Junior, Jorge Zanini, Marco Antonio [UNESP] Fleury, Agnes Takayanagui, Osvaldo Massaiti |
author_role |
author |
author2 |
Hamamoto Filho, Pedro Tadao [UNESP] Luvizutto, Gustavo Jose [UNESP] Carvalho Nunes, Helio Rubens de [UNESP] Odashima, Newton Satoru Santos, Antonio Carlos dos Elias Junior, Jorge Zanini, Marco Antonio [UNESP] Fleury, Agnes Takayanagui, Osvaldo Massaiti |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Universidade de São Paulo (USP) Univ Nacl Autonoma Mexico |
dc.contributor.author.fl_str_mv |
Bazan, Rodrigo [UNESP] Hamamoto Filho, Pedro Tadao [UNESP] Luvizutto, Gustavo Jose [UNESP] Carvalho Nunes, Helio Rubens de [UNESP] Odashima, Newton Satoru Santos, Antonio Carlos dos Elias Junior, Jorge Zanini, Marco Antonio [UNESP] Fleury, Agnes Takayanagui, Osvaldo Massaiti |
description |
Extraparenchymal neurocysticercosis has an aggressive course because cysts in the cerebrospinal fluid compartments induce acute inflammatory reactions. The relationships between symptoms, imaging findings, lesion type and location remain poorly understood. In this retrospective clinical records-based study, we describe the clinical symptoms, magnetic resonance imaging features, and cyst distribution in the CSF compartments of 36 patients with extraparenchymal neurocysticercosis. Patients were recruited between 1995 and 2010 and median follow up was 38 months. During all the follow up time we found that 75% (27/36) of the patients had symptoms related to raised intracranial pressure sometime, 72.2% (26/36) cysticercotic meningitis, 61.1% (22/36) seizures, and 50.0% (18/36) headaches unrelated to intracranial pressure. Regarding lesion types, 77.8% (28/36) of patients presented with grape-like cysts, 22.2% (8/36) giant cysts, and 61.1% (22/36) contrast-enhancing lesions. Hydrocephalus occurred in 72.2% (26/36) of patients during the follow-up period. All patients had cysts in the subarachnoid space and 41.7% (15/36) had at least one cyst in some ventricle. Cysts were predominantly located in the posterior fossa (31 patients) and supratentorial basal cisterns (19 patients). The fourth ventricle was the main compromised ventricle (10 patients). Spinal cysts were more frequent than previously reported (11.1%, 4/36). Our findings are useful for both diagnosis and treatment selection in patients with neurocysticercosis. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-11-01 2018-11-26T17:15:43Z 2018-11-26T17:15:43Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1371/journal.pntd.0005115 Plos Neglected Tropical Diseases. San Francisco: Public Library Science, v. 10, n. 11, 14 p., 2016. 1935-2735 http://hdl.handle.net/11449/162349 10.1371/journal.pntd.0005115 WOS:000392154400037 WOS000392154400037.pdf 2894975141895189 2894975141895189 |
url |
http://dx.doi.org/10.1371/journal.pntd.0005115 http://hdl.handle.net/11449/162349 |
identifier_str_mv |
Plos Neglected Tropical Diseases. San Francisco: Public Library Science, v. 10, n. 11, 14 p., 2016. 1935-2735 10.1371/journal.pntd.0005115 WOS:000392154400037 WOS000392154400037.pdf 2894975141895189 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Plos Neglected Tropical Diseases |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
14 application/pdf |
dc.publisher.none.fl_str_mv |
Public Library Science |
publisher.none.fl_str_mv |
Public Library Science |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
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UNESP |
reponame_str |
Repositório Institucional da UNESP |
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Repositório Institucional da UNESP |
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Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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1808128116454850560 |