Heparin prevents Zika virus induced-cytopathic effects in human neural progenitor cells

Detalhes bibliográficos
Autor(a) principal: Ghezzi, Silvia
Data de Publicação: 2017
Outros Autores: Cooper, Lynsay, Rubio, Alicia, Pagani, Isabel, Capobianchi, Maria Rosaria, Ippolito, Giuseppe, Pelletier, Julien [UNESP], Meneghetti, Maria Cecilia Z., Lima, Marcelo A., Skidmore, Mark A., Broccoli, Vania, Yates, Edwin A., Vicenzi, Elisa
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1016/j.antiviral.2016.12.023
http://hdl.handle.net/11449/159451
Resumo: The recent Zika virus (ZIKV) outbreak, which mainly affected Brazil and neighbouring states, demonstrated the paucity of information concerning the epidemiology of several flaviruses, but also highlighted the lack of available agents with which to treat such emerging diseases. Here, we show that heparin, a widely used anticoagulant, while exerting a modest inhibitory effect on Zika Virus replication, fully prevents virus-induced cell death of human neural progenitor cells (NPCs). (C) 2017 Elsevier B.V. All rights reserved.
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spelling Heparin prevents Zika virus induced-cytopathic effects in human neural progenitor cellsZika virus (ZIKV)Neural progenitor cellsHeparinCell deathThe recent Zika virus (ZIKV) outbreak, which mainly affected Brazil and neighbouring states, demonstrated the paucity of information concerning the epidemiology of several flaviruses, but also highlighted the lack of available agents with which to treat such emerging diseases. Here, we show that heparin, a widely used anticoagulant, while exerting a modest inhibitory effect on Zika Virus replication, fully prevents virus-induced cell death of human neural progenitor cells (NPCs). (C) 2017 Elsevier B.V. All rights reserved.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)BBSRC/EPSRC for a New Investigator AwardKeele University for Seed Funding AwardBiotechnology and Biological Sciences Research CouncilIst Sci San Raffaele, Via Olgettina, I-20132 Milan, ItalyKeele Univ, Sch Life Sci, Keele ST5 5BG, Staffs, EnglandLazzaro Spallanzani Natl Inst Infect Dis, Rome, ItalyUniv Estadual Paulista Julio de Mesquito Filho, Inst Biotecnol, BR-18607440 Botucatu, SP, BrazilUniv Fed Sao Paulo, Dept Biochem, Rua Tres de Maio, BR-04044020 Sao Paulo, SP, BrazilUniv Liverpool, Dept Biochem, Inst Integrat Biol, Liverpool L69 7ZB, Merseyside, EnglandCNR, CNR, Inst Neurosci, Milan, ItalyUniv Estadual Paulista Julio de Mesquito Filho, Inst Biotecnol, BR-18607440 Botucatu, SP, BrazilFAPESP: 15/08782-3BBSRC/EPSRC for a New Investigator Award: BB/L023717/1Biotechnology and Biological Sciences Research Council: BB/L023717/1Elsevier B.V.Ist Sci San RaffaeleKeele UnivLazzaro Spallanzani Natl Inst Infect DisUniversidade Estadual Paulista (Unesp)Universidade Federal de São Paulo (UNIFESP)Univ LiverpoolCNRGhezzi, SilviaCooper, LynsayRubio, AliciaPagani, IsabelCapobianchi, Maria RosariaIppolito, GiuseppePelletier, Julien [UNESP]Meneghetti, Maria Cecilia Z.Lima, Marcelo A.Skidmore, Mark A.Broccoli, VaniaYates, Edwin A.Vicenzi, Elisa2018-11-26T15:43:51Z2018-11-26T15:43:51Z2017-04-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article13-17application/pdfhttp://dx.doi.org/10.1016/j.antiviral.2016.12.023Antiviral Research. Amsterdam: Elsevier Science Bv, v. 140, p. 13-17, 2017.0166-3542http://hdl.handle.net/11449/15945110.1016/j.antiviral.2016.12.023WOS:000397076600002WOS000397076600002.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengAntiviral Research1,925info:eu-repo/semantics/openAccess2023-12-21T06:24:37Zoai:repositorio.unesp.br:11449/159451Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T20:57:04.657958Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Heparin prevents Zika virus induced-cytopathic effects in human neural progenitor cells
title Heparin prevents Zika virus induced-cytopathic effects in human neural progenitor cells
spellingShingle Heparin prevents Zika virus induced-cytopathic effects in human neural progenitor cells
Ghezzi, Silvia
Zika virus (ZIKV)
Neural progenitor cells
Heparin
Cell death
title_short Heparin prevents Zika virus induced-cytopathic effects in human neural progenitor cells
title_full Heparin prevents Zika virus induced-cytopathic effects in human neural progenitor cells
title_fullStr Heparin prevents Zika virus induced-cytopathic effects in human neural progenitor cells
title_full_unstemmed Heparin prevents Zika virus induced-cytopathic effects in human neural progenitor cells
title_sort Heparin prevents Zika virus induced-cytopathic effects in human neural progenitor cells
author Ghezzi, Silvia
author_facet Ghezzi, Silvia
Cooper, Lynsay
Rubio, Alicia
Pagani, Isabel
Capobianchi, Maria Rosaria
Ippolito, Giuseppe
Pelletier, Julien [UNESP]
Meneghetti, Maria Cecilia Z.
Lima, Marcelo A.
Skidmore, Mark A.
Broccoli, Vania
Yates, Edwin A.
Vicenzi, Elisa
author_role author
author2 Cooper, Lynsay
Rubio, Alicia
Pagani, Isabel
Capobianchi, Maria Rosaria
Ippolito, Giuseppe
Pelletier, Julien [UNESP]
Meneghetti, Maria Cecilia Z.
Lima, Marcelo A.
Skidmore, Mark A.
Broccoli, Vania
Yates, Edwin A.
Vicenzi, Elisa
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Ist Sci San Raffaele
Keele Univ
Lazzaro Spallanzani Natl Inst Infect Dis
Universidade Estadual Paulista (Unesp)
Universidade Federal de São Paulo (UNIFESP)
Univ Liverpool
CNR
dc.contributor.author.fl_str_mv Ghezzi, Silvia
Cooper, Lynsay
Rubio, Alicia
Pagani, Isabel
Capobianchi, Maria Rosaria
Ippolito, Giuseppe
Pelletier, Julien [UNESP]
Meneghetti, Maria Cecilia Z.
Lima, Marcelo A.
Skidmore, Mark A.
Broccoli, Vania
Yates, Edwin A.
Vicenzi, Elisa
dc.subject.por.fl_str_mv Zika virus (ZIKV)
Neural progenitor cells
Heparin
Cell death
topic Zika virus (ZIKV)
Neural progenitor cells
Heparin
Cell death
description The recent Zika virus (ZIKV) outbreak, which mainly affected Brazil and neighbouring states, demonstrated the paucity of information concerning the epidemiology of several flaviruses, but also highlighted the lack of available agents with which to treat such emerging diseases. Here, we show that heparin, a widely used anticoagulant, while exerting a modest inhibitory effect on Zika Virus replication, fully prevents virus-induced cell death of human neural progenitor cells (NPCs). (C) 2017 Elsevier B.V. All rights reserved.
publishDate 2017
dc.date.none.fl_str_mv 2017-04-01
2018-11-26T15:43:51Z
2018-11-26T15:43:51Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/j.antiviral.2016.12.023
Antiviral Research. Amsterdam: Elsevier Science Bv, v. 140, p. 13-17, 2017.
0166-3542
http://hdl.handle.net/11449/159451
10.1016/j.antiviral.2016.12.023
WOS:000397076600002
WOS000397076600002.pdf
url http://dx.doi.org/10.1016/j.antiviral.2016.12.023
http://hdl.handle.net/11449/159451
identifier_str_mv Antiviral Research. Amsterdam: Elsevier Science Bv, v. 140, p. 13-17, 2017.
0166-3542
10.1016/j.antiviral.2016.12.023
WOS:000397076600002
WOS000397076600002.pdf
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Antiviral Research
1,925
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 13-17
application/pdf
dc.publisher.none.fl_str_mv Elsevier B.V.
publisher.none.fl_str_mv Elsevier B.V.
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1808129265903861760

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