Mir-513a-3p contributes to the controlling of cellular migration processes in the A549 lung tumor cells by modulating integrin beta-8 expression
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1007/s11010-017-3229-0 http://hdl.handle.net/11449/164323 |
Resumo: | Lung tumors are a frequent type of cancer in humans and a leading cause of death, and the late diagnostic contributes to high mortality rates. New therapeutic strategies are needed, and the heptapeptide angiotensin-(1-7) [ang-(1-7)] demonstrated the ability to control cancer growth rates and migration in vitro and in vivo. However, the possible use of the heptapeptide in clinical trials demands deeper analyses to elucidate molecular mechanisms of its effect in the target cells. In this study, we investigated relevant elements that control pro-inflammatory environment and cellular migration, focusing in the post-transcription mechanism using lung tumor cell line. In our cellular model, the microRNA-513a-3p was identified as a novel element targeting ITG-beta 8, thereby controlling the protein level and its molecular function in the controlling of migration and pro-inflammatory environment. These findings provide useful information for future studies, using miR-513a-3p as an innovative molecular tool to control lung tumor cell migration, which will support more effective clinical treatment of the patients with the widely used chemotherapeutic agents, increasing survival rates. |
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Mir-513a-3p contributes to the controlling of cellular migration processes in the A549 lung tumor cells by modulating integrin beta-8 expressionCellular migration processesPro-inflammatory environmentSmall non-coding RNAsTumorigenesesVasoactive peptideLung tumors are a frequent type of cancer in humans and a leading cause of death, and the late diagnostic contributes to high mortality rates. New therapeutic strategies are needed, and the heptapeptide angiotensin-(1-7) [ang-(1-7)] demonstrated the ability to control cancer growth rates and migration in vitro and in vivo. However, the possible use of the heptapeptide in clinical trials demands deeper analyses to elucidate molecular mechanisms of its effect in the target cells. In this study, we investigated relevant elements that control pro-inflammatory environment and cellular migration, focusing in the post-transcription mechanism using lung tumor cell line. In our cellular model, the microRNA-513a-3p was identified as a novel element targeting ITG-beta 8, thereby controlling the protein level and its molecular function in the controlling of migration and pro-inflammatory environment. These findings provide useful information for future studies, using miR-513a-3p as an innovative molecular tool to control lung tumor cell migration, which will support more effective clinical treatment of the patients with the widely used chemotherapeutic agents, increasing survival rates.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)INCT-Nano-BiofarmaceuticaUniv Estadual Paulista, Inst Biociencias, Dept Biol, Lab Biol Mol, BR-13506900 Sao Paulo, BrazilUniv Estadual Paulista, Inst Quim, Sao Paulo, BrazilUniv Fed Ouro Preto, Nucleo Pesquisa Biol, Ouro Preto, MG, BrazilUniv Fed Minas Gerais, Dept Fisiol & Biofis, Lab Fisiol, Belo Horizonte, MG, BrazilUniv Estadual Paulista, Inst Biociencias, Dept Biol, Lab Biol Mol, BR-13506900 Sao Paulo, BrazilUniv Estadual Paulista, Inst Quim, Sao Paulo, BrazilCNPq: 474060/2012-8FAPESP: FAPESP-2014/21645-2FAPESP: 2013/21186-5SpringerUniversidade Estadual Paulista (Unesp)Univ Fed Ouro PretoUniversidade Federal de Minas Gerais (UFMG)Silveira, Marina Bonfogo da [UNESP]Lima, Kelvin Furtado [UNESP]Silva, Andrea Renata daSouza dos Santos, Robson AugustoMoraes, Karen C. M. [UNESP]2018-11-26T17:52:08Z2018-11-26T17:52:08Z2018-07-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article43-52application/pdfhttp://dx.doi.org/10.1007/s11010-017-3229-0Molecular And Cellular Biochemistry. Dordrecht: Springer, v. 444, n. 1-2, p. 43-52, 2018.0300-8177http://hdl.handle.net/11449/16432310.1007/s11010-017-3229-0WOS:000435411600006WOS000435411600006.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengMolecular And Cellular Biochemistry1,003info:eu-repo/semantics/openAccess2024-01-12T06:27:08Zoai:repositorio.unesp.br:11449/164323Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T22:46:41.069378Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Mir-513a-3p contributes to the controlling of cellular migration processes in the A549 lung tumor cells by modulating integrin beta-8 expression |
title |
Mir-513a-3p contributes to the controlling of cellular migration processes in the A549 lung tumor cells by modulating integrin beta-8 expression |
spellingShingle |
Mir-513a-3p contributes to the controlling of cellular migration processes in the A549 lung tumor cells by modulating integrin beta-8 expression Silveira, Marina Bonfogo da [UNESP] Cellular migration processes Pro-inflammatory environment Small non-coding RNAs Tumorigeneses Vasoactive peptide |
title_short |
Mir-513a-3p contributes to the controlling of cellular migration processes in the A549 lung tumor cells by modulating integrin beta-8 expression |
title_full |
Mir-513a-3p contributes to the controlling of cellular migration processes in the A549 lung tumor cells by modulating integrin beta-8 expression |
title_fullStr |
Mir-513a-3p contributes to the controlling of cellular migration processes in the A549 lung tumor cells by modulating integrin beta-8 expression |
title_full_unstemmed |
Mir-513a-3p contributes to the controlling of cellular migration processes in the A549 lung tumor cells by modulating integrin beta-8 expression |
title_sort |
Mir-513a-3p contributes to the controlling of cellular migration processes in the A549 lung tumor cells by modulating integrin beta-8 expression |
author |
Silveira, Marina Bonfogo da [UNESP] |
author_facet |
Silveira, Marina Bonfogo da [UNESP] Lima, Kelvin Furtado [UNESP] Silva, Andrea Renata da Souza dos Santos, Robson Augusto Moraes, Karen C. M. [UNESP] |
author_role |
author |
author2 |
Lima, Kelvin Furtado [UNESP] Silva, Andrea Renata da Souza dos Santos, Robson Augusto Moraes, Karen C. M. [UNESP] |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Univ Fed Ouro Preto Universidade Federal de Minas Gerais (UFMG) |
dc.contributor.author.fl_str_mv |
Silveira, Marina Bonfogo da [UNESP] Lima, Kelvin Furtado [UNESP] Silva, Andrea Renata da Souza dos Santos, Robson Augusto Moraes, Karen C. M. [UNESP] |
dc.subject.por.fl_str_mv |
Cellular migration processes Pro-inflammatory environment Small non-coding RNAs Tumorigeneses Vasoactive peptide |
topic |
Cellular migration processes Pro-inflammatory environment Small non-coding RNAs Tumorigeneses Vasoactive peptide |
description |
Lung tumors are a frequent type of cancer in humans and a leading cause of death, and the late diagnostic contributes to high mortality rates. New therapeutic strategies are needed, and the heptapeptide angiotensin-(1-7) [ang-(1-7)] demonstrated the ability to control cancer growth rates and migration in vitro and in vivo. However, the possible use of the heptapeptide in clinical trials demands deeper analyses to elucidate molecular mechanisms of its effect in the target cells. In this study, we investigated relevant elements that control pro-inflammatory environment and cellular migration, focusing in the post-transcription mechanism using lung tumor cell line. In our cellular model, the microRNA-513a-3p was identified as a novel element targeting ITG-beta 8, thereby controlling the protein level and its molecular function in the controlling of migration and pro-inflammatory environment. These findings provide useful information for future studies, using miR-513a-3p as an innovative molecular tool to control lung tumor cell migration, which will support more effective clinical treatment of the patients with the widely used chemotherapeutic agents, increasing survival rates. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-11-26T17:52:08Z 2018-11-26T17:52:08Z 2018-07-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1007/s11010-017-3229-0 Molecular And Cellular Biochemistry. Dordrecht: Springer, v. 444, n. 1-2, p. 43-52, 2018. 0300-8177 http://hdl.handle.net/11449/164323 10.1007/s11010-017-3229-0 WOS:000435411600006 WOS000435411600006.pdf |
url |
http://dx.doi.org/10.1007/s11010-017-3229-0 http://hdl.handle.net/11449/164323 |
identifier_str_mv |
Molecular And Cellular Biochemistry. Dordrecht: Springer, v. 444, n. 1-2, p. 43-52, 2018. 0300-8177 10.1007/s11010-017-3229-0 WOS:000435411600006 WOS000435411600006.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Molecular And Cellular Biochemistry 1,003 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
43-52 application/pdf |
dc.publisher.none.fl_str_mv |
Springer |
publisher.none.fl_str_mv |
Springer |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129461621620736 |