Uso de plasma rico em plaquetas em úlceras de córnea em cães

• Autor(a) principal: Merlini, N.B. [UNESP]
• Data de Publicação: 2014
• Outros Autores: Fonzar, J.F. [UNESP], Perches, C.S. [UNESP], Sereno, M.G. [UNESP], Souza, V.l. [UNESP], Estanislau, C.A. [UNESP], Rodas, N.r., Ranzani [UNESP], J J.T. [UNESP], Maia, L. [UNESP], Padovani, C.R. [UNESP], Brandão, C. V. S. [UNESP]
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352014000601742&lng=pt&nrm=iso&tlng=en; http://hdl.handle.net/11449/127311
• topic: Dogs; Epithelial defect; Growth factors; PRP; Cão; Defeito epitelial; Fatores de crescimento; PRP

This study aims to clinically and macroscopically evaluate the adjuvant therapy withplatelet-rich plasma in the form of eyedrops or clot, for corneal ulcers in dogtreated at the Veterinary Ophthalmology Service. We analyzed 20 eyes diagnosed withulcerative keratitis, divided into two experimental groups. The eyedrop group (GC)was composed of eyes treated topically with eyedrops of autologous platelet-richplasma (PRP), and the clot group (GT) was composed of eyes treated with aplatelet-rich clot and covered with a third eyelid for retention of the clot. Thegroups were evaluated by clinical and macroscopic analysis and by the analysis ofepithelial defect reduction, at different times, at three, five, ten, 15 and 30 days,except for the third day in GT. The coverage of the third eyelid was removed on thefifth day. In both groups the inflammation signs reduced, there was an improvement inocular sensibility and proper repair of epithelial defect. All GT eyes and 70% GCeyes showed complete healing on the fifth day, the remainder of GC completed healingon the tenth day. PRP in the form of eyedrops and clot is an excellent adjuvanttherapy to be instituted in the clinical treatment for corneal ulcer in dogs, becauseit decreases the inflammatory signs and the ocular pain and it potentially assists inhealing epithelial defects.