Mixture of vitamin C, hesperidin and piperidol exposure in pregnancy: Maternal-fetal repercussions

• Autor(a) principal: Volpato, Gustavo Tadeu [UNESP]
• Data de Publicação: 2006
• Outros Autores: Damasceno, Débora Cristina [UNESP], Miranda, Márcia Regina F. [UNESP], Sabbag Filho, Daher, De Mattos Paranhos Calderon, Iracema [UNESP], Rudge, Marilza Vieira Cunha [UNESP]
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://dx.doi.org/10.1590/S1516-93322006000100008; http://hdl.handle.net/11449/68722
• topic: Hesperidin and piperidol mixture; Maternal repercussions; Pregnancy; Rats; Vitamin C; ascorbic acid; hesperidin; piperidine derivative; animal experiment; atrophy; bladder sphincter; controlled study; embryo resorption; female; fetus death; fetus malformation; hydronephrosis; nonhuman; organogenesis; ossification; percussion; pregnancy; prenatal drug exposure; progeny; rat; sexual behavior; vagina smear

To evaluate the reproductive performance and the development of their offspring on rat pregnancy. Wistar pregnant rats were gavaged with 0 mg/kg wb/day (control group, n = 20) and 166.5 mg/kg/day of a mixture of vitamin C, hesperidin and piperidol (experimental group, n = 20) during the organogenic period (from day 5 to 14 of pregnancy; positive vaginal smear = day 0). The female rats were killed on day 21 of pregnancy. The number of implantations, resorptions (dead embryos), and live/dead fetuses were counted for the analysis of the postimplantation loss rates. There was neither alteration in maternal reproductive performance, but it was verified an increase of the number of fetuses presenting dilated urether, hydronephrosis, and reduced ossification of skull due to the treatment of female rats with a mixture of vitamin C, hesperidin and piperidol, these abnormalities were considered transitory and may not interfere on offspring development. It was not verified other type of major malformation neither the appearance of fetuses presenting atrophy of upper limbs that it could be associated to use of this drug.