Chick embryo chorioallantoic membrane as a suitable in vivo model to evaluate drug delivery systems for cancer treatment: A review
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.ejpb.2020.06.010 http://hdl.handle.net/11449/200675 |
Resumo: | Cancer represents a significant public health problem. More than 18.1 million people are annually diagnosed with cancer and 9.6 million die mainly due to metastatic disease. Chemotherapy has been one of the main cancer treatment modalities; however, most of the chemotherapeutic agents are non-specific, exhibiting several toxic side effects, which compromises the patient's quality of life. Therefore, it is necessary to search for new therapeutic alternatives, using for example, drug delivery systems (DDS) to target cancer cells, increasing the selectivity of chemotherapeutic drugs. This approach is promising; however, it is crucial to evaluate the biological performance of the systems. Although mammalian models continue to be explored for clinical applications, they are time-consuming and very restrictive from the ethical and legal perspectives. Hence, the chick embryo chorioallantoic membrane (CAM) has been shown to be a suitable in vivo model since it allows a more appropriate model for the study of drugs and/or DDS performance than in vitro tests. Thereby, this article revises the recent advances of DDS for cancer therapy, evaluating the feasibility of the CAM model. |
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Chick embryo chorioallantoic membrane as a suitable in vivo model to evaluate drug delivery systems for cancer treatment: A reviewAngiogenesisAnti-angiogenicCAM modelCancerChicken embryosDrug delivery systemsCancer represents a significant public health problem. More than 18.1 million people are annually diagnosed with cancer and 9.6 million die mainly due to metastatic disease. Chemotherapy has been one of the main cancer treatment modalities; however, most of the chemotherapeutic agents are non-specific, exhibiting several toxic side effects, which compromises the patient's quality of life. Therefore, it is necessary to search for new therapeutic alternatives, using for example, drug delivery systems (DDS) to target cancer cells, increasing the selectivity of chemotherapeutic drugs. This approach is promising; however, it is crucial to evaluate the biological performance of the systems. Although mammalian models continue to be explored for clinical applications, they are time-consuming and very restrictive from the ethical and legal perspectives. Hence, the chick embryo chorioallantoic membrane (CAM) has been shown to be a suitable in vivo model since it allows a more appropriate model for the study of drugs and/or DDS performance than in vitro tests. Thereby, this article revises the recent advances of DDS for cancer therapy, evaluating the feasibility of the CAM model.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)UNESP São Paulo State University School of Pharmaceutical Sciences Department of Drugs and MedicinesUNESP São Paulo State University School of Pharmaceutical Sciences Department of Clinical AnalysisLife and Health Sciences Research Institute (ICVS) School of Medicine University of MinhoICVS/3B's-PT Government Associate LaboratoryUNICAMP University of Campinas Piracicaba Dental School Department of BiosciencesUNESP São Paulo State University School of Pharmaceutical Sciences Department of Drugs and MedicinesUNESP São Paulo State University School of Pharmaceutical Sciences Department of Clinical AnalysisFAPESP: #2013/01565-1FAPESP: #2015/21412-0FAPESP: #2016/06337-5, #2019/07245-5FAPESP: #2016/09671-3FAPESP: #2017/10016-2FAPESP: #2017/23357-2FAPESP: #2018/04546-1Universidade Estadual Paulista (Unesp)University of MinhoICVS/3B's-PT Government Associate LaboratoryUniversidade Estadual de Campinas (UNICAMP)Victorelli, Francesca Damiani [UNESP]Cardoso, Valéria Maria de Oliveira [UNESP]Ferreira, Natália Noronha [UNESP]Calixto, Giovana Maria Fioramonti [UNESP]Fontana, Carla Raquel [UNESP]Baltazar, FátimaGremião, Maria Palmira Daflon [UNESP]Chorilli, Marlus [UNESP]2020-12-12T02:13:05Z2020-12-12T02:13:05Z2020-08-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article273-284http://dx.doi.org/10.1016/j.ejpb.2020.06.010European Journal of Pharmaceutics and Biopharmaceutics, v. 153, p. 273-284.1873-34410939-6411http://hdl.handle.net/11449/20067510.1016/j.ejpb.2020.06.0102-s2.0-85087220347Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengEuropean Journal of Pharmaceutics and Biopharmaceuticsinfo:eu-repo/semantics/openAccess2024-06-24T13:46:23Zoai:repositorio.unesp.br:11449/200675Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T22:11:45.905293Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Chick embryo chorioallantoic membrane as a suitable in vivo model to evaluate drug delivery systems for cancer treatment: A review |
title |
Chick embryo chorioallantoic membrane as a suitable in vivo model to evaluate drug delivery systems for cancer treatment: A review |
spellingShingle |
Chick embryo chorioallantoic membrane as a suitable in vivo model to evaluate drug delivery systems for cancer treatment: A review Victorelli, Francesca Damiani [UNESP] Angiogenesis Anti-angiogenic CAM model Cancer Chicken embryos Drug delivery systems |
title_short |
Chick embryo chorioallantoic membrane as a suitable in vivo model to evaluate drug delivery systems for cancer treatment: A review |
title_full |
Chick embryo chorioallantoic membrane as a suitable in vivo model to evaluate drug delivery systems for cancer treatment: A review |
title_fullStr |
Chick embryo chorioallantoic membrane as a suitable in vivo model to evaluate drug delivery systems for cancer treatment: A review |
title_full_unstemmed |
Chick embryo chorioallantoic membrane as a suitable in vivo model to evaluate drug delivery systems for cancer treatment: A review |
title_sort |
Chick embryo chorioallantoic membrane as a suitable in vivo model to evaluate drug delivery systems for cancer treatment: A review |
author |
Victorelli, Francesca Damiani [UNESP] |
author_facet |
Victorelli, Francesca Damiani [UNESP] Cardoso, Valéria Maria de Oliveira [UNESP] Ferreira, Natália Noronha [UNESP] Calixto, Giovana Maria Fioramonti [UNESP] Fontana, Carla Raquel [UNESP] Baltazar, Fátima Gremião, Maria Palmira Daflon [UNESP] Chorilli, Marlus [UNESP] |
author_role |
author |
author2 |
Cardoso, Valéria Maria de Oliveira [UNESP] Ferreira, Natália Noronha [UNESP] Calixto, Giovana Maria Fioramonti [UNESP] Fontana, Carla Raquel [UNESP] Baltazar, Fátima Gremião, Maria Palmira Daflon [UNESP] Chorilli, Marlus [UNESP] |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) University of Minho ICVS/3B's-PT Government Associate Laboratory Universidade Estadual de Campinas (UNICAMP) |
dc.contributor.author.fl_str_mv |
Victorelli, Francesca Damiani [UNESP] Cardoso, Valéria Maria de Oliveira [UNESP] Ferreira, Natália Noronha [UNESP] Calixto, Giovana Maria Fioramonti [UNESP] Fontana, Carla Raquel [UNESP] Baltazar, Fátima Gremião, Maria Palmira Daflon [UNESP] Chorilli, Marlus [UNESP] |
dc.subject.por.fl_str_mv |
Angiogenesis Anti-angiogenic CAM model Cancer Chicken embryos Drug delivery systems |
topic |
Angiogenesis Anti-angiogenic CAM model Cancer Chicken embryos Drug delivery systems |
description |
Cancer represents a significant public health problem. More than 18.1 million people are annually diagnosed with cancer and 9.6 million die mainly due to metastatic disease. Chemotherapy has been one of the main cancer treatment modalities; however, most of the chemotherapeutic agents are non-specific, exhibiting several toxic side effects, which compromises the patient's quality of life. Therefore, it is necessary to search for new therapeutic alternatives, using for example, drug delivery systems (DDS) to target cancer cells, increasing the selectivity of chemotherapeutic drugs. This approach is promising; however, it is crucial to evaluate the biological performance of the systems. Although mammalian models continue to be explored for clinical applications, they are time-consuming and very restrictive from the ethical and legal perspectives. Hence, the chick embryo chorioallantoic membrane (CAM) has been shown to be a suitable in vivo model since it allows a more appropriate model for the study of drugs and/or DDS performance than in vitro tests. Thereby, this article revises the recent advances of DDS for cancer therapy, evaluating the feasibility of the CAM model. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-12-12T02:13:05Z 2020-12-12T02:13:05Z 2020-08-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.ejpb.2020.06.010 European Journal of Pharmaceutics and Biopharmaceutics, v. 153, p. 273-284. 1873-3441 0939-6411 http://hdl.handle.net/11449/200675 10.1016/j.ejpb.2020.06.010 2-s2.0-85087220347 |
url |
http://dx.doi.org/10.1016/j.ejpb.2020.06.010 http://hdl.handle.net/11449/200675 |
identifier_str_mv |
European Journal of Pharmaceutics and Biopharmaceutics, v. 153, p. 273-284. 1873-3441 0939-6411 10.1016/j.ejpb.2020.06.010 2-s2.0-85087220347 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
European Journal of Pharmaceutics and Biopharmaceutics |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
273-284 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129403024048128 |