Applications of the hexanic fraction of Agave sisalana Perrine ex Engelm (Asparagaceae): control of inflammation and pain screening
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/S0074-02762013000300002 http://hdl.handle.net/11449/27220 |
Resumo: | The present study evaluated the anti-inflammatory and analgesic properties of Agave sisalana Perrine in classic models of inflammation and pain. The hexanic fraction of A. sisalana (HFAS) was obtained by acid hydrolysis followed by hexanic reflux. Anti-inflammatory properties were examined in three acute mouse models (xylene ear oedema, hind paw oedema and pleurisy) and a chronic mouse model (granuloma cotton pellet). The antinociceptive potential was evaluated in chemical (acetic-acid) and thermal (tail-flick and hot-plate test) models of pain. When given orally, HFAS (5, 10, 25 and 50 mg/kg) reduced ear oedema (p < 0.0001; 52%, 71%, 62% and 42%, respectively). HFAS also reduced hind paw oedema at doses of 10 mg/kg and 25 mg/kg (p < 0.05; 42% and 58%, respectively) and pleurisy at doses of 10 mg/kg and 25 mg/kg (41% and 50%, respectively). In a chronic model, HFAS reduced inflammation by 46% and 58% at doses of 10 mg/kg and 25 mg/kg, respectively. Moreover, this fraction showed analgesic properties against the abdominal writhing in an acetic acid model (at doses of 5-25 mg/kg) with inhibitory rates of 24%, 54% and 48%. The HFAS also showed an increased latency time in the hot-plate (23% and 28%) and tail-flick tests (61% and 66%) for the 25 mg/kg and 50 mg/kg doses, respectively. These results suggest that HFAS has anti-inflammatory and analgesic properties. |
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Applications of the hexanic fraction of Agave sisalana Perrine ex Engelm (Asparagaceae): control of inflammation and pain screeningAgave sisalana Perrine ex Engelmhecogenintigogeninanti-inflammatory activityanalgesic activityThe present study evaluated the anti-inflammatory and analgesic properties of Agave sisalana Perrine in classic models of inflammation and pain. The hexanic fraction of A. sisalana (HFAS) was obtained by acid hydrolysis followed by hexanic reflux. Anti-inflammatory properties were examined in three acute mouse models (xylene ear oedema, hind paw oedema and pleurisy) and a chronic mouse model (granuloma cotton pellet). The antinociceptive potential was evaluated in chemical (acetic-acid) and thermal (tail-flick and hot-plate test) models of pain. When given orally, HFAS (5, 10, 25 and 50 mg/kg) reduced ear oedema (p < 0.0001; 52%, 71%, 62% and 42%, respectively). HFAS also reduced hind paw oedema at doses of 10 mg/kg and 25 mg/kg (p < 0.05; 42% and 58%, respectively) and pleurisy at doses of 10 mg/kg and 25 mg/kg (41% and 50%, respectively). In a chronic model, HFAS reduced inflammation by 46% and 58% at doses of 10 mg/kg and 25 mg/kg, respectively. Moreover, this fraction showed analgesic properties against the abdominal writhing in an acetic acid model (at doses of 5-25 mg/kg) with inhibitory rates of 24%, 54% and 48%. The HFAS also showed an increased latency time in the hot-plate (23% and 28%) and tail-flick tests (61% and 66%) for the 25 mg/kg and 50 mg/kg doses, respectively. These results suggest that HFAS has anti-inflammatory and analgesic properties.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Departamento de Biologia Estrutural e FuncionalUniversidade Estadual de Campinas Faculdade de Ciências Médicas Departamento de FarmacologiaInstituto de Biologia Departamento de Biologia VegetalUniversidade Estadual Paulista Faculdade de Ciências e Letras de Assis Departamento de BiologiaUniversidade Federal de Goiás (UFG) Departamento de Ciências BiológicasUniversidade Estadual Paulista Faculdade de Ciências e Letras de Assis Departamento de BiologiaInstituto Oswaldo Cruz, Ministério da SaúdeDepartamento de Biologia Estrutural e FuncionalUniversidade Estadual de Campinas (UNICAMP)Instituto de Biologia Departamento de Biologia VegetalUniversidade Estadual Paulista (Unesp)Universidade Federal de Goiás (UFG)Dunder, Ricardo JoséLuiz-Ferreira, AndersonAlmeida, Ana Cristina Alves deFaria, Felipe Meira deTakayama, ChristianeSocca, Eduardo Augusto RabeloSalvador, Marcos JoséMello, Gláucia CoelhoSantos, Catarina dos [UNESP]Oliva-Neto, Pedro deSouza-Brito, Alba Regina Monteiro2014-05-20T15:09:26Z2014-05-20T15:09:26Z2013-05-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article263-271http://dx.doi.org/10.1590/S0074-02762013000300002Memórias do Instituto Oswaldo Cruz. Instituto Oswaldo Cruz, Ministério da Saúde, v. 108, n. 3, p. 263-271, 2013.0074-0276http://hdl.handle.net/11449/2722010.1590/S0074-02762013000300002S0074-02762013000300263WOS:000320501000002S0074-02762013000300263.pdfSciELOreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengMemórias do Instituto Oswaldo Cruz2.8331,172info:eu-repo/semantics/openAccess2021-10-23T17:16:50Zoai:repositorio.unesp.br:11449/27220Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T16:36:41.953019Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Applications of the hexanic fraction of Agave sisalana Perrine ex Engelm (Asparagaceae): control of inflammation and pain screening |
title |
Applications of the hexanic fraction of Agave sisalana Perrine ex Engelm (Asparagaceae): control of inflammation and pain screening |
spellingShingle |
Applications of the hexanic fraction of Agave sisalana Perrine ex Engelm (Asparagaceae): control of inflammation and pain screening Dunder, Ricardo José Agave sisalana Perrine ex Engelm hecogenin tigogenin anti-inflammatory activity analgesic activity |
title_short |
Applications of the hexanic fraction of Agave sisalana Perrine ex Engelm (Asparagaceae): control of inflammation and pain screening |
title_full |
Applications of the hexanic fraction of Agave sisalana Perrine ex Engelm (Asparagaceae): control of inflammation and pain screening |
title_fullStr |
Applications of the hexanic fraction of Agave sisalana Perrine ex Engelm (Asparagaceae): control of inflammation and pain screening |
title_full_unstemmed |
Applications of the hexanic fraction of Agave sisalana Perrine ex Engelm (Asparagaceae): control of inflammation and pain screening |
title_sort |
Applications of the hexanic fraction of Agave sisalana Perrine ex Engelm (Asparagaceae): control of inflammation and pain screening |
author |
Dunder, Ricardo José |
author_facet |
Dunder, Ricardo José Luiz-Ferreira, Anderson Almeida, Ana Cristina Alves de Faria, Felipe Meira de Takayama, Christiane Socca, Eduardo Augusto Rabelo Salvador, Marcos José Mello, Gláucia Coelho Santos, Catarina dos [UNESP] Oliva-Neto, Pedro de Souza-Brito, Alba Regina Monteiro |
author_role |
author |
author2 |
Luiz-Ferreira, Anderson Almeida, Ana Cristina Alves de Faria, Felipe Meira de Takayama, Christiane Socca, Eduardo Augusto Rabelo Salvador, Marcos José Mello, Gláucia Coelho Santos, Catarina dos [UNESP] Oliva-Neto, Pedro de Souza-Brito, Alba Regina Monteiro |
author2_role |
author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Departamento de Biologia Estrutural e Funcional Universidade Estadual de Campinas (UNICAMP) Instituto de Biologia Departamento de Biologia Vegetal Universidade Estadual Paulista (Unesp) Universidade Federal de Goiás (UFG) |
dc.contributor.author.fl_str_mv |
Dunder, Ricardo José Luiz-Ferreira, Anderson Almeida, Ana Cristina Alves de Faria, Felipe Meira de Takayama, Christiane Socca, Eduardo Augusto Rabelo Salvador, Marcos José Mello, Gláucia Coelho Santos, Catarina dos [UNESP] Oliva-Neto, Pedro de Souza-Brito, Alba Regina Monteiro |
dc.subject.por.fl_str_mv |
Agave sisalana Perrine ex Engelm hecogenin tigogenin anti-inflammatory activity analgesic activity |
topic |
Agave sisalana Perrine ex Engelm hecogenin tigogenin anti-inflammatory activity analgesic activity |
description |
The present study evaluated the anti-inflammatory and analgesic properties of Agave sisalana Perrine in classic models of inflammation and pain. The hexanic fraction of A. sisalana (HFAS) was obtained by acid hydrolysis followed by hexanic reflux. Anti-inflammatory properties were examined in three acute mouse models (xylene ear oedema, hind paw oedema and pleurisy) and a chronic mouse model (granuloma cotton pellet). The antinociceptive potential was evaluated in chemical (acetic-acid) and thermal (tail-flick and hot-plate test) models of pain. When given orally, HFAS (5, 10, 25 and 50 mg/kg) reduced ear oedema (p < 0.0001; 52%, 71%, 62% and 42%, respectively). HFAS also reduced hind paw oedema at doses of 10 mg/kg and 25 mg/kg (p < 0.05; 42% and 58%, respectively) and pleurisy at doses of 10 mg/kg and 25 mg/kg (41% and 50%, respectively). In a chronic model, HFAS reduced inflammation by 46% and 58% at doses of 10 mg/kg and 25 mg/kg, respectively. Moreover, this fraction showed analgesic properties against the abdominal writhing in an acetic acid model (at doses of 5-25 mg/kg) with inhibitory rates of 24%, 54% and 48%. The HFAS also showed an increased latency time in the hot-plate (23% and 28%) and tail-flick tests (61% and 66%) for the 25 mg/kg and 50 mg/kg doses, respectively. These results suggest that HFAS has anti-inflammatory and analgesic properties. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-05-01 2014-05-20T15:09:26Z 2014-05-20T15:09:26Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S0074-02762013000300002 Memórias do Instituto Oswaldo Cruz. Instituto Oswaldo Cruz, Ministério da Saúde, v. 108, n. 3, p. 263-271, 2013. 0074-0276 http://hdl.handle.net/11449/27220 10.1590/S0074-02762013000300002 S0074-02762013000300263 WOS:000320501000002 S0074-02762013000300263.pdf |
url |
http://dx.doi.org/10.1590/S0074-02762013000300002 http://hdl.handle.net/11449/27220 |
identifier_str_mv |
Memórias do Instituto Oswaldo Cruz. Instituto Oswaldo Cruz, Ministério da Saúde, v. 108, n. 3, p. 263-271, 2013. 0074-0276 10.1590/S0074-02762013000300002 S0074-02762013000300263 WOS:000320501000002 S0074-02762013000300263.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Memórias do Instituto Oswaldo Cruz 2.833 1,172 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
263-271 |
dc.publisher.none.fl_str_mv |
Instituto Oswaldo Cruz, Ministério da Saúde |
publisher.none.fl_str_mv |
Instituto Oswaldo Cruz, Ministério da Saúde |
dc.source.none.fl_str_mv |
SciELO reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128678443352064 |