Therapeutic dose of Ginkgo biloba extract 761 may alter the urine excretion of Wistar rats
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/S0102-695X2012005000093 http://hdl.handle.net/11449/211394 |
Resumo: | Wistar rats (n=20) were divided in two groups: G1 received 2 mg/kg of GBE (Ginkgo biloba extract 761), whereas G2 received the same volume of a sodium chloride solution (0.9%), both for 10 days. After a 7-day interval, the treatment was repeated for 8 days. Urine volume and food and water intake were measured daily during this protocol. Histological assessments were performed. No significant difference (p>0.05) was observed in food and water intake of animals during treatment with GBE. Animals who received GBE had a smaller urine volume and increase of weight with a significance difference (p<0.05) during the first and second exposure period. No histological alteration was observed in tissues, except for the kidney of the experimental group, which revealed a higher concentration of red cells in the glomerulus with a strong staining for Vascular Endothelial Growth Factor (VEGF). The introduction of GBE (therapeutic dose) in health rats may promote alterations in the physiology of the kidney, but no sufficient to modify the glomerulus architecture, including at ultra structural level (electron microscopy). |
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Therapeutic dose of Ginkgo biloba extract 761 may alter the urine excretion of Wistar ratselectron microscopeGinkgo bilobakidneyVEGFWistar rats (n=20) were divided in two groups: G1 received 2 mg/kg of GBE (Ginkgo biloba extract 761), whereas G2 received the same volume of a sodium chloride solution (0.9%), both for 10 days. After a 7-day interval, the treatment was repeated for 8 days. Urine volume and food and water intake were measured daily during this protocol. Histological assessments were performed. No significant difference (p>0.05) was observed in food and water intake of animals during treatment with GBE. Animals who received GBE had a smaller urine volume and increase of weight with a significance difference (p<0.05) during the first and second exposure period. No histological alteration was observed in tissues, except for the kidney of the experimental group, which revealed a higher concentration of red cells in the glomerulus with a strong staining for Vascular Endothelial Growth Factor (VEGF). The introduction of GBE (therapeutic dose) in health rats may promote alterations in the physiology of the kidney, but no sufficient to modify the glomerulus architecture, including at ultra structural level (electron microscopy).Universidade Federal Fluminense, Hospital Universitário Antônio PedroUniversidade Estadual Paulista, Hospital da CriançaUniversidade do Estado do Rio de Janeiro, Departamento de Histologia e EmbriologiaUniversidade Estadual Paulista, Hospital da CriançaSociedade Brasileira de FarmacognosiaUniversidade Federal FluminenseUniversidade Estadual Paulista (Unesp)Universidade do Estado do Rio de JaneiroDalmacio, Monica S. C.Campos, Sylvia M. N.Carvalho, Jorge J. J.Pereira, Mário J. S.Nascimento, Ana LúciaPaschoal, Patricia O. [UNESP]Sobrinho, Andrea P.Pedruzzi, Monique M. B.Garrido, ValeriaMoreno, Silvana R. F.Teixeira, Gerlinde A. P. B.Cardoso, Gilberto P.2021-07-14T10:23:45Z2021-07-14T10:23:45Z2012-10info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1060-1069application/pdfhttp://dx.doi.org/10.1590/S0102-695X2012005000093Revista Brasileira de Farmacognosia. Curitiba, PR, Brazil: Sociedade Brasileira de Farmacognosia, v. 22, n. 5, p. 1060-1069, 2012.0102-695X1981-528Xhttp://hdl.handle.net/11449/21139410.1590/S0102-695X2012005000093S0102-695X2012000500018S0102-695X2012000500018.pdfSciELOreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengRevista Brasileira de Farmacognosiainfo:eu-repo/semantics/openAccess2023-10-16T06:09:28Zoai:repositorio.unesp.br:11449/211394Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T15:08:13.832729Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Therapeutic dose of Ginkgo biloba extract 761 may alter the urine excretion of Wistar rats |
title |
Therapeutic dose of Ginkgo biloba extract 761 may alter the urine excretion of Wistar rats |
spellingShingle |
Therapeutic dose of Ginkgo biloba extract 761 may alter the urine excretion of Wistar rats Dalmacio, Monica S. C. electron microscope Ginkgo biloba kidney VEGF |
title_short |
Therapeutic dose of Ginkgo biloba extract 761 may alter the urine excretion of Wistar rats |
title_full |
Therapeutic dose of Ginkgo biloba extract 761 may alter the urine excretion of Wistar rats |
title_fullStr |
Therapeutic dose of Ginkgo biloba extract 761 may alter the urine excretion of Wistar rats |
title_full_unstemmed |
Therapeutic dose of Ginkgo biloba extract 761 may alter the urine excretion of Wistar rats |
title_sort |
Therapeutic dose of Ginkgo biloba extract 761 may alter the urine excretion of Wistar rats |
author |
Dalmacio, Monica S. C. |
author_facet |
Dalmacio, Monica S. C. Campos, Sylvia M. N. Carvalho, Jorge J. J. Pereira, Mário J. S. Nascimento, Ana Lúcia Paschoal, Patricia O. [UNESP] Sobrinho, Andrea P. Pedruzzi, Monique M. B. Garrido, Valeria Moreno, Silvana R. F. Teixeira, Gerlinde A. P. B. Cardoso, Gilberto P. |
author_role |
author |
author2 |
Campos, Sylvia M. N. Carvalho, Jorge J. J. Pereira, Mário J. S. Nascimento, Ana Lúcia Paschoal, Patricia O. [UNESP] Sobrinho, Andrea P. Pedruzzi, Monique M. B. Garrido, Valeria Moreno, Silvana R. F. Teixeira, Gerlinde A. P. B. Cardoso, Gilberto P. |
author2_role |
author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal Fluminense Universidade Estadual Paulista (Unesp) Universidade do Estado do Rio de Janeiro |
dc.contributor.author.fl_str_mv |
Dalmacio, Monica S. C. Campos, Sylvia M. N. Carvalho, Jorge J. J. Pereira, Mário J. S. Nascimento, Ana Lúcia Paschoal, Patricia O. [UNESP] Sobrinho, Andrea P. Pedruzzi, Monique M. B. Garrido, Valeria Moreno, Silvana R. F. Teixeira, Gerlinde A. P. B. Cardoso, Gilberto P. |
dc.subject.por.fl_str_mv |
electron microscope Ginkgo biloba kidney VEGF |
topic |
electron microscope Ginkgo biloba kidney VEGF |
description |
Wistar rats (n=20) were divided in two groups: G1 received 2 mg/kg of GBE (Ginkgo biloba extract 761), whereas G2 received the same volume of a sodium chloride solution (0.9%), both for 10 days. After a 7-day interval, the treatment was repeated for 8 days. Urine volume and food and water intake were measured daily during this protocol. Histological assessments were performed. No significant difference (p>0.05) was observed in food and water intake of animals during treatment with GBE. Animals who received GBE had a smaller urine volume and increase of weight with a significance difference (p<0.05) during the first and second exposure period. No histological alteration was observed in tissues, except for the kidney of the experimental group, which revealed a higher concentration of red cells in the glomerulus with a strong staining for Vascular Endothelial Growth Factor (VEGF). The introduction of GBE (therapeutic dose) in health rats may promote alterations in the physiology of the kidney, but no sufficient to modify the glomerulus architecture, including at ultra structural level (electron microscopy). |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-10 2021-07-14T10:23:45Z 2021-07-14T10:23:45Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S0102-695X2012005000093 Revista Brasileira de Farmacognosia. Curitiba, PR, Brazil: Sociedade Brasileira de Farmacognosia, v. 22, n. 5, p. 1060-1069, 2012. 0102-695X 1981-528X http://hdl.handle.net/11449/211394 10.1590/S0102-695X2012005000093 S0102-695X2012000500018 S0102-695X2012000500018.pdf |
url |
http://dx.doi.org/10.1590/S0102-695X2012005000093 http://hdl.handle.net/11449/211394 |
identifier_str_mv |
Revista Brasileira de Farmacognosia. Curitiba, PR, Brazil: Sociedade Brasileira de Farmacognosia, v. 22, n. 5, p. 1060-1069, 2012. 0102-695X 1981-528X 10.1590/S0102-695X2012005000093 S0102-695X2012000500018 S0102-695X2012000500018.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Revista Brasileira de Farmacognosia |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
1060-1069 application/pdf |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Farmacognosia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Farmacognosia |
dc.source.none.fl_str_mv |
SciELO reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1808128466170675200 |