Evaluation of the anti-inflammatory, analgesic and antipyretic activities of the natural polyphenol chlorogenic acid
Autor(a) principal: | |
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Data de Publicação: | 2006 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1248/bpb.29.2236 http://hdl.handle.net/11449/69193 |
Resumo: | Phenolic compounds are numerous and ubiquitous in the plant kingdom, being particularly present in health-promoting foods. Epidemiological evidences suggest that the consumption of polyphenol-rich foods reduces the incidence of cancer, coronary heart disease and inflammation. Chlorogenic acid (CGA) is one of the most abundant polyphenol compounds in human diet. Data obtained from in vivo and in vitro experiments show that CGA mostly presents antioxidant and anti-carcinogenic activities. However, the effects of CGA on the inflammatory reaction and on the related pain and fever processes have been explored less so far. Therefore, this study was designed to evaluate the anti-inflammatory, antinociceptive and antipyretic activities of CGA in rats. In comparison to control, CGA at doses 50 and 100 mg/kg inhibited carrageenin-induced paw edema beginning at the 2nd hour of the experimental procedure. Furthermore, at doses 50 and 100 mg/kg CGA also inhibited the number of flinches in the late phase of formalin-induced pain test. Such activities may be derived from the inhibitory action of CGA in the peripheral synthesis/release of inflammatory mediators involved in these responses. On the other hand, even at the highest tested dose (200 mg/kg), CGA did not inhibit the febrile response induced by lipopolysaccharide (LPS) in rats. Additional experiments are necessary in order to clarify the true target for the anti-inflammatory and analgesic effects of CGA. © 2006 Pharmaceutical Society of Japan. |
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Evaluation of the anti-inflammatory, analgesic and antipyretic activities of the natural polyphenol chlorogenic acidAnalgesicAnti-inflammatoryCarrageeninChlorogenic acidFormalinLipopolysaccharide (LPS)chlorogenic acidlipopolysaccharidepolyphenol derivativeanalgesic activityanimal experimentanimal modelantiinflammatory activityantineoplastic activityantinociceptionantioxidant activityantipyretic activitycontrolled studydose responsedrug effectdrug inhibitionfeverinflammationmalenonhumanpain assessmentpaw edemaratAdministration, OralAnalgesicsAnalgesics, Non-NarcoticAnimalsAnti-Inflammatory Agents, Non-SteroidalCarrageenanChlorogenic AcidDisease Models, AnimalDose-Response Relationship, DrugDrug Evaluation, PreclinicalEdemaFeverFlavonoidsFormaldehydeHindlimbInflammationLipopolysaccharidesMaleMolecular StructurePainPhenolsRatsRats, WistarTime FactorsPhenolic compounds are numerous and ubiquitous in the plant kingdom, being particularly present in health-promoting foods. Epidemiological evidences suggest that the consumption of polyphenol-rich foods reduces the incidence of cancer, coronary heart disease and inflammation. Chlorogenic acid (CGA) is one of the most abundant polyphenol compounds in human diet. Data obtained from in vivo and in vitro experiments show that CGA mostly presents antioxidant and anti-carcinogenic activities. However, the effects of CGA on the inflammatory reaction and on the related pain and fever processes have been explored less so far. Therefore, this study was designed to evaluate the anti-inflammatory, antinociceptive and antipyretic activities of CGA in rats. In comparison to control, CGA at doses 50 and 100 mg/kg inhibited carrageenin-induced paw edema beginning at the 2nd hour of the experimental procedure. Furthermore, at doses 50 and 100 mg/kg CGA also inhibited the number of flinches in the late phase of formalin-induced pain test. Such activities may be derived from the inhibitory action of CGA in the peripheral synthesis/release of inflammatory mediators involved in these responses. On the other hand, even at the highest tested dose (200 mg/kg), CGA did not inhibit the febrile response induced by lipopolysaccharide (LPS) in rats. Additional experiments are necessary in order to clarify the true target for the anti-inflammatory and analgesic effects of CGA. © 2006 Pharmaceutical Society of Japan.University of São Paulo Faculty of Pharmaceutical Sciences of Ribeirão Preto Campus Universitário da USP, Avenida do Café s/n, Ribeirão Preto-SP 14040-903University of São Paulo Medical School of Ribeirão Preto Campus Universitário da USP, Avenida dos Bandeirantes 3900, Ribeirão Preto-SP 14049-900São Paulo State University at Rio Claro Department of Zoology, Avenida 24A, 1515, Rio Claro-SP 13506-900São Paulo State University at Rio Claro Department of Zoology, Avenida 24A, 1515, Rio Claro-SP 13506-900Universidade de São Paulo (USP)Universidade Estadual Paulista (Unesp)Dos Santos, Michel DavidAlmeida, Maria Camila [UNESP]Lopes, Norberto PeporineDe Souza, Glória Emília Petto2014-05-27T11:22:01Z2014-05-27T11:22:01Z2006-11-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2236-2240http://dx.doi.org/10.1248/bpb.29.2236Biological and Pharmaceutical Bulletin, v. 29, n. 11, p. 2236-2240, 2006.0918-61581347-5215http://hdl.handle.net/11449/6919310.1248/bpb.29.22362-s2.0-33750632133Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBiological and Pharmaceutical Bulletin1.6940,6260,626info:eu-repo/semantics/openAccess2021-10-22T17:02:26Zoai:repositorio.unesp.br:11449/69193Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T14:34:12.565603Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Evaluation of the anti-inflammatory, analgesic and antipyretic activities of the natural polyphenol chlorogenic acid |
title |
Evaluation of the anti-inflammatory, analgesic and antipyretic activities of the natural polyphenol chlorogenic acid |
spellingShingle |
Evaluation of the anti-inflammatory, analgesic and antipyretic activities of the natural polyphenol chlorogenic acid Dos Santos, Michel David Analgesic Anti-inflammatory Carrageenin Chlorogenic acid Formalin Lipopolysaccharide (LPS) chlorogenic acid lipopolysaccharide polyphenol derivative analgesic activity animal experiment animal model antiinflammatory activity antineoplastic activity antinociception antioxidant activity antipyretic activity controlled study dose response drug effect drug inhibition fever inflammation male nonhuman pain assessment paw edema rat Administration, Oral Analgesics Analgesics, Non-Narcotic Animals Anti-Inflammatory Agents, Non-Steroidal Carrageenan Chlorogenic Acid Disease Models, Animal Dose-Response Relationship, Drug Drug Evaluation, Preclinical Edema Fever Flavonoids Formaldehyde Hindlimb Inflammation Lipopolysaccharides Male Molecular Structure Pain Phenols Rats Rats, Wistar Time Factors |
title_short |
Evaluation of the anti-inflammatory, analgesic and antipyretic activities of the natural polyphenol chlorogenic acid |
title_full |
Evaluation of the anti-inflammatory, analgesic and antipyretic activities of the natural polyphenol chlorogenic acid |
title_fullStr |
Evaluation of the anti-inflammatory, analgesic and antipyretic activities of the natural polyphenol chlorogenic acid |
title_full_unstemmed |
Evaluation of the anti-inflammatory, analgesic and antipyretic activities of the natural polyphenol chlorogenic acid |
title_sort |
Evaluation of the anti-inflammatory, analgesic and antipyretic activities of the natural polyphenol chlorogenic acid |
author |
Dos Santos, Michel David |
author_facet |
Dos Santos, Michel David Almeida, Maria Camila [UNESP] Lopes, Norberto Peporine De Souza, Glória Emília Petto |
author_role |
author |
author2 |
Almeida, Maria Camila [UNESP] Lopes, Norberto Peporine De Souza, Glória Emília Petto |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Universidade de São Paulo (USP) Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Dos Santos, Michel David Almeida, Maria Camila [UNESP] Lopes, Norberto Peporine De Souza, Glória Emília Petto |
dc.subject.por.fl_str_mv |
Analgesic Anti-inflammatory Carrageenin Chlorogenic acid Formalin Lipopolysaccharide (LPS) chlorogenic acid lipopolysaccharide polyphenol derivative analgesic activity animal experiment animal model antiinflammatory activity antineoplastic activity antinociception antioxidant activity antipyretic activity controlled study dose response drug effect drug inhibition fever inflammation male nonhuman pain assessment paw edema rat Administration, Oral Analgesics Analgesics, Non-Narcotic Animals Anti-Inflammatory Agents, Non-Steroidal Carrageenan Chlorogenic Acid Disease Models, Animal Dose-Response Relationship, Drug Drug Evaluation, Preclinical Edema Fever Flavonoids Formaldehyde Hindlimb Inflammation Lipopolysaccharides Male Molecular Structure Pain Phenols Rats Rats, Wistar Time Factors |
topic |
Analgesic Anti-inflammatory Carrageenin Chlorogenic acid Formalin Lipopolysaccharide (LPS) chlorogenic acid lipopolysaccharide polyphenol derivative analgesic activity animal experiment animal model antiinflammatory activity antineoplastic activity antinociception antioxidant activity antipyretic activity controlled study dose response drug effect drug inhibition fever inflammation male nonhuman pain assessment paw edema rat Administration, Oral Analgesics Analgesics, Non-Narcotic Animals Anti-Inflammatory Agents, Non-Steroidal Carrageenan Chlorogenic Acid Disease Models, Animal Dose-Response Relationship, Drug Drug Evaluation, Preclinical Edema Fever Flavonoids Formaldehyde Hindlimb Inflammation Lipopolysaccharides Male Molecular Structure Pain Phenols Rats Rats, Wistar Time Factors |
description |
Phenolic compounds are numerous and ubiquitous in the plant kingdom, being particularly present in health-promoting foods. Epidemiological evidences suggest that the consumption of polyphenol-rich foods reduces the incidence of cancer, coronary heart disease and inflammation. Chlorogenic acid (CGA) is one of the most abundant polyphenol compounds in human diet. Data obtained from in vivo and in vitro experiments show that CGA mostly presents antioxidant and anti-carcinogenic activities. However, the effects of CGA on the inflammatory reaction and on the related pain and fever processes have been explored less so far. Therefore, this study was designed to evaluate the anti-inflammatory, antinociceptive and antipyretic activities of CGA in rats. In comparison to control, CGA at doses 50 and 100 mg/kg inhibited carrageenin-induced paw edema beginning at the 2nd hour of the experimental procedure. Furthermore, at doses 50 and 100 mg/kg CGA also inhibited the number of flinches in the late phase of formalin-induced pain test. Such activities may be derived from the inhibitory action of CGA in the peripheral synthesis/release of inflammatory mediators involved in these responses. On the other hand, even at the highest tested dose (200 mg/kg), CGA did not inhibit the febrile response induced by lipopolysaccharide (LPS) in rats. Additional experiments are necessary in order to clarify the true target for the anti-inflammatory and analgesic effects of CGA. © 2006 Pharmaceutical Society of Japan. |
publishDate |
2006 |
dc.date.none.fl_str_mv |
2006-11-01 2014-05-27T11:22:01Z 2014-05-27T11:22:01Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1248/bpb.29.2236 Biological and Pharmaceutical Bulletin, v. 29, n. 11, p. 2236-2240, 2006. 0918-6158 1347-5215 http://hdl.handle.net/11449/69193 10.1248/bpb.29.2236 2-s2.0-33750632133 |
url |
http://dx.doi.org/10.1248/bpb.29.2236 http://hdl.handle.net/11449/69193 |
identifier_str_mv |
Biological and Pharmaceutical Bulletin, v. 29, n. 11, p. 2236-2240, 2006. 0918-6158 1347-5215 10.1248/bpb.29.2236 2-s2.0-33750632133 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Biological and Pharmaceutical Bulletin 1.694 0,626 0,626 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
2236-2240 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1808128379576123392 |