The Higher Plasma Malondialdehyde Concentrations Are Determined by Metabolic Syndrome-Related Glucolipotoxicity

Detalhes bibliográficos
Autor(a) principal: Moreto, Fernando [UNESP]
Data de Publicação: 2014
Outros Autores: Oliveira, Erick P. de [UNESP], Manda, Rodrigo M. [UNESP], Burini, Roberto Carlos [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1155/2014/505368
http://hdl.handle.net/11449/111198
Resumo: This study aimed to elucidate the determinants of higher plasma malondialdehyde (MDA) in free-living adults. In a cross-sectional study we evaluated 148 free-living subjects (54 +/- 11 years, 78% women) at high risk for or with metabolic syndrome (MetS). They were assessed by anthropometry and body composition, dietary intake, and clinical and laboratorial analysis. The analysis of plasma MDA was performed by HPLC, and concentration values were used to provide four groups according to percentile distribution. Subjects with higher plasma MDA showed higher prevalence of MetS and higher values of waist circumference (WC), glucose, triglycerides (TG), gamma-glutamyltransferase (gamma-GT), and higher energy intake. Multiadjusted logistic regression analysis identified as determinants of higher plasma MDA the altered values of WC and gamma-GT followed by hypertriglyceridemia, hyperglycemia, insulin resistance, higher dietary sugar-intake, and presence of MetS. In conclusion, the glucolipotoxic state predisposed by the presence of MetS seems to be the major determinant of higher plasma MDA concentrations.
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spelling The Higher Plasma Malondialdehyde Concentrations Are Determined by Metabolic Syndrome-Related GlucolipotoxicityThis study aimed to elucidate the determinants of higher plasma malondialdehyde (MDA) in free-living adults. In a cross-sectional study we evaluated 148 free-living subjects (54 +/- 11 years, 78% women) at high risk for or with metabolic syndrome (MetS). They were assessed by anthropometry and body composition, dietary intake, and clinical and laboratorial analysis. The analysis of plasma MDA was performed by HPLC, and concentration values were used to provide four groups according to percentile distribution. Subjects with higher plasma MDA showed higher prevalence of MetS and higher values of waist circumference (WC), glucose, triglycerides (TG), gamma-glutamyltransferase (gamma-GT), and higher energy intake. Multiadjusted logistic regression analysis identified as determinants of higher plasma MDA the altered values of WC and gamma-GT followed by hypertriglyceridemia, hyperglycemia, insulin resistance, higher dietary sugar-intake, and presence of MetS. In conclusion, the glucolipotoxic state predisposed by the presence of MetS seems to be the major determinant of higher plasma MDA concentrations.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Sao Paulo State Univ, Botucatu Sch Med, Ctr Nutr & Exercise Metab CeMENutri, Botucatu, SP, BrazilUniv Fed Uberlandia, Sch Med, BR-38400 Uberlandia, MG, BrazilSao Paulo State Univ, Botucatu Sch Med, Ctr Nutr & Exercise Metab CeMENutri, Botucatu, SP, BrazilHindawi Publishing CorporationUniversidade Estadual Paulista (Unesp)Universidade Federal de Uberlândia (UFU)Moreto, Fernando [UNESP]Oliveira, Erick P. de [UNESP]Manda, Rodrigo M. [UNESP]Burini, Roberto Carlos [UNESP]2014-12-03T13:07:03Z2014-12-03T13:07:03Z2014-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article7application/pdfhttp://dx.doi.org/10.1155/2014/505368Oxidative Medicine And Cellular Longevity. New York: Hindawi Publishing Corporation, 7 p., 2014.1942-0900http://hdl.handle.net/11449/11119810.1155/2014/505368WOS:000338551500001WOS000338551500001.pdf2287552780901172Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengOxidative Medicine and Cellular Longevity4.9361,558info:eu-repo/semantics/openAccess2024-01-20T06:35:34Zoai:repositorio.unesp.br:11449/111198Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-01-20T06:35:34Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv The Higher Plasma Malondialdehyde Concentrations Are Determined by Metabolic Syndrome-Related Glucolipotoxicity
title The Higher Plasma Malondialdehyde Concentrations Are Determined by Metabolic Syndrome-Related Glucolipotoxicity
spellingShingle The Higher Plasma Malondialdehyde Concentrations Are Determined by Metabolic Syndrome-Related Glucolipotoxicity
Moreto, Fernando [UNESP]
title_short The Higher Plasma Malondialdehyde Concentrations Are Determined by Metabolic Syndrome-Related Glucolipotoxicity
title_full The Higher Plasma Malondialdehyde Concentrations Are Determined by Metabolic Syndrome-Related Glucolipotoxicity
title_fullStr The Higher Plasma Malondialdehyde Concentrations Are Determined by Metabolic Syndrome-Related Glucolipotoxicity
title_full_unstemmed The Higher Plasma Malondialdehyde Concentrations Are Determined by Metabolic Syndrome-Related Glucolipotoxicity
title_sort The Higher Plasma Malondialdehyde Concentrations Are Determined by Metabolic Syndrome-Related Glucolipotoxicity
author Moreto, Fernando [UNESP]
author_facet Moreto, Fernando [UNESP]
Oliveira, Erick P. de [UNESP]
Manda, Rodrigo M. [UNESP]
Burini, Roberto Carlos [UNESP]
author_role author
author2 Oliveira, Erick P. de [UNESP]
Manda, Rodrigo M. [UNESP]
Burini, Roberto Carlos [UNESP]
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
Universidade Federal de Uberlândia (UFU)
dc.contributor.author.fl_str_mv Moreto, Fernando [UNESP]
Oliveira, Erick P. de [UNESP]
Manda, Rodrigo M. [UNESP]
Burini, Roberto Carlos [UNESP]
description This study aimed to elucidate the determinants of higher plasma malondialdehyde (MDA) in free-living adults. In a cross-sectional study we evaluated 148 free-living subjects (54 +/- 11 years, 78% women) at high risk for or with metabolic syndrome (MetS). They were assessed by anthropometry and body composition, dietary intake, and clinical and laboratorial analysis. The analysis of plasma MDA was performed by HPLC, and concentration values were used to provide four groups according to percentile distribution. Subjects with higher plasma MDA showed higher prevalence of MetS and higher values of waist circumference (WC), glucose, triglycerides (TG), gamma-glutamyltransferase (gamma-GT), and higher energy intake. Multiadjusted logistic regression analysis identified as determinants of higher plasma MDA the altered values of WC and gamma-GT followed by hypertriglyceridemia, hyperglycemia, insulin resistance, higher dietary sugar-intake, and presence of MetS. In conclusion, the glucolipotoxic state predisposed by the presence of MetS seems to be the major determinant of higher plasma MDA concentrations.
publishDate 2014
dc.date.none.fl_str_mv 2014-12-03T13:07:03Z
2014-12-03T13:07:03Z
2014-01-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1155/2014/505368
Oxidative Medicine And Cellular Longevity. New York: Hindawi Publishing Corporation, 7 p., 2014.
1942-0900
http://hdl.handle.net/11449/111198
10.1155/2014/505368
WOS:000338551500001
WOS000338551500001.pdf
2287552780901172
url http://dx.doi.org/10.1155/2014/505368
http://hdl.handle.net/11449/111198
identifier_str_mv Oxidative Medicine And Cellular Longevity. New York: Hindawi Publishing Corporation, 7 p., 2014.
1942-0900
10.1155/2014/505368
WOS:000338551500001
WOS000338551500001.pdf
2287552780901172
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Oxidative Medicine and Cellular Longevity
4.936
1,558
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 7
application/pdf
dc.publisher.none.fl_str_mv Hindawi Publishing Corporation
publisher.none.fl_str_mv Hindawi Publishing Corporation
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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