The Higher Plasma Malondialdehyde Concentrations Are Determined by Metabolic Syndrome-Related Glucolipotoxicity
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1155/2014/505368 http://hdl.handle.net/11449/111198 |
Resumo: | This study aimed to elucidate the determinants of higher plasma malondialdehyde (MDA) in free-living adults. In a cross-sectional study we evaluated 148 free-living subjects (54 +/- 11 years, 78% women) at high risk for or with metabolic syndrome (MetS). They were assessed by anthropometry and body composition, dietary intake, and clinical and laboratorial analysis. The analysis of plasma MDA was performed by HPLC, and concentration values were used to provide four groups according to percentile distribution. Subjects with higher plasma MDA showed higher prevalence of MetS and higher values of waist circumference (WC), glucose, triglycerides (TG), gamma-glutamyltransferase (gamma-GT), and higher energy intake. Multiadjusted logistic regression analysis identified as determinants of higher plasma MDA the altered values of WC and gamma-GT followed by hypertriglyceridemia, hyperglycemia, insulin resistance, higher dietary sugar-intake, and presence of MetS. In conclusion, the glucolipotoxic state predisposed by the presence of MetS seems to be the major determinant of higher plasma MDA concentrations. |
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Repositório Institucional da UNESP |
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The Higher Plasma Malondialdehyde Concentrations Are Determined by Metabolic Syndrome-Related GlucolipotoxicityThis study aimed to elucidate the determinants of higher plasma malondialdehyde (MDA) in free-living adults. In a cross-sectional study we evaluated 148 free-living subjects (54 +/- 11 years, 78% women) at high risk for or with metabolic syndrome (MetS). They were assessed by anthropometry and body composition, dietary intake, and clinical and laboratorial analysis. The analysis of plasma MDA was performed by HPLC, and concentration values were used to provide four groups according to percentile distribution. Subjects with higher plasma MDA showed higher prevalence of MetS and higher values of waist circumference (WC), glucose, triglycerides (TG), gamma-glutamyltransferase (gamma-GT), and higher energy intake. Multiadjusted logistic regression analysis identified as determinants of higher plasma MDA the altered values of WC and gamma-GT followed by hypertriglyceridemia, hyperglycemia, insulin resistance, higher dietary sugar-intake, and presence of MetS. In conclusion, the glucolipotoxic state predisposed by the presence of MetS seems to be the major determinant of higher plasma MDA concentrations.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Sao Paulo State Univ, Botucatu Sch Med, Ctr Nutr & Exercise Metab CeMENutri, Botucatu, SP, BrazilUniv Fed Uberlandia, Sch Med, BR-38400 Uberlandia, MG, BrazilSao Paulo State Univ, Botucatu Sch Med, Ctr Nutr & Exercise Metab CeMENutri, Botucatu, SP, BrazilHindawi Publishing CorporationUniversidade Estadual Paulista (Unesp)Universidade Federal de Uberlândia (UFU)Moreto, Fernando [UNESP]Oliveira, Erick P. de [UNESP]Manda, Rodrigo M. [UNESP]Burini, Roberto Carlos [UNESP]2014-12-03T13:07:03Z2014-12-03T13:07:03Z2014-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article7application/pdfhttp://dx.doi.org/10.1155/2014/505368Oxidative Medicine And Cellular Longevity. New York: Hindawi Publishing Corporation, 7 p., 2014.1942-0900http://hdl.handle.net/11449/11119810.1155/2014/505368WOS:000338551500001WOS000338551500001.pdf2287552780901172Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengOxidative Medicine and Cellular Longevity4.9361,558info:eu-repo/semantics/openAccess2024-09-03T14:12:30Zoai:repositorio.unesp.br:11449/111198Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-03T14:12:30Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
The Higher Plasma Malondialdehyde Concentrations Are Determined by Metabolic Syndrome-Related Glucolipotoxicity |
title |
The Higher Plasma Malondialdehyde Concentrations Are Determined by Metabolic Syndrome-Related Glucolipotoxicity |
spellingShingle |
The Higher Plasma Malondialdehyde Concentrations Are Determined by Metabolic Syndrome-Related Glucolipotoxicity Moreto, Fernando [UNESP] |
title_short |
The Higher Plasma Malondialdehyde Concentrations Are Determined by Metabolic Syndrome-Related Glucolipotoxicity |
title_full |
The Higher Plasma Malondialdehyde Concentrations Are Determined by Metabolic Syndrome-Related Glucolipotoxicity |
title_fullStr |
The Higher Plasma Malondialdehyde Concentrations Are Determined by Metabolic Syndrome-Related Glucolipotoxicity |
title_full_unstemmed |
The Higher Plasma Malondialdehyde Concentrations Are Determined by Metabolic Syndrome-Related Glucolipotoxicity |
title_sort |
The Higher Plasma Malondialdehyde Concentrations Are Determined by Metabolic Syndrome-Related Glucolipotoxicity |
author |
Moreto, Fernando [UNESP] |
author_facet |
Moreto, Fernando [UNESP] Oliveira, Erick P. de [UNESP] Manda, Rodrigo M. [UNESP] Burini, Roberto Carlos [UNESP] |
author_role |
author |
author2 |
Oliveira, Erick P. de [UNESP] Manda, Rodrigo M. [UNESP] Burini, Roberto Carlos [UNESP] |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Universidade Federal de Uberlândia (UFU) |
dc.contributor.author.fl_str_mv |
Moreto, Fernando [UNESP] Oliveira, Erick P. de [UNESP] Manda, Rodrigo M. [UNESP] Burini, Roberto Carlos [UNESP] |
description |
This study aimed to elucidate the determinants of higher plasma malondialdehyde (MDA) in free-living adults. In a cross-sectional study we evaluated 148 free-living subjects (54 +/- 11 years, 78% women) at high risk for or with metabolic syndrome (MetS). They were assessed by anthropometry and body composition, dietary intake, and clinical and laboratorial analysis. The analysis of plasma MDA was performed by HPLC, and concentration values were used to provide four groups according to percentile distribution. Subjects with higher plasma MDA showed higher prevalence of MetS and higher values of waist circumference (WC), glucose, triglycerides (TG), gamma-glutamyltransferase (gamma-GT), and higher energy intake. Multiadjusted logistic regression analysis identified as determinants of higher plasma MDA the altered values of WC and gamma-GT followed by hypertriglyceridemia, hyperglycemia, insulin resistance, higher dietary sugar-intake, and presence of MetS. In conclusion, the glucolipotoxic state predisposed by the presence of MetS seems to be the major determinant of higher plasma MDA concentrations. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-12-03T13:07:03Z 2014-12-03T13:07:03Z 2014-01-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1155/2014/505368 Oxidative Medicine And Cellular Longevity. New York: Hindawi Publishing Corporation, 7 p., 2014. 1942-0900 http://hdl.handle.net/11449/111198 10.1155/2014/505368 WOS:000338551500001 WOS000338551500001.pdf 2287552780901172 |
url |
http://dx.doi.org/10.1155/2014/505368 http://hdl.handle.net/11449/111198 |
identifier_str_mv |
Oxidative Medicine And Cellular Longevity. New York: Hindawi Publishing Corporation, 7 p., 2014. 1942-0900 10.1155/2014/505368 WOS:000338551500001 WOS000338551500001.pdf 2287552780901172 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Oxidative Medicine and Cellular Longevity 4.936 1,558 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
7 application/pdf |
dc.publisher.none.fl_str_mv |
Hindawi Publishing Corporation |
publisher.none.fl_str_mv |
Hindawi Publishing Corporation |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
repositoriounesp@unesp.br |
_version_ |
1810021422799519744 |