Exercise counteracts fatty liver disease in rats fed on fructose-rich diet
Autor(a) principal: | |
---|---|
Data de Publicação: | 2010 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1186/1476-511X-9-116 http://hdl.handle.net/11449/20890 |
Resumo: | Background: This study aimed to analyze the effects of exercise at the aerobic/anaerobic transition on the markers of non-alcoholic fatty liver disease (NAFLD), insulin sensitivity and the blood chemistry of rats kept on a fructose-rich diet.Methods: We separated 48 Wistar rats into two groups according to diet: a control group (balanced diet AIN-93 G) and a fructose-rich diet group (60% fructose). The animals were tested for maximal lactate-steady state (MLSS) in order to identify the aerobic/anaerobic metabolic transition during swimming exercises at 28 and 90 days of age. One third of the animals of each group were submitted to swimming training at an intensity equivalent to the individual MLSS for 1 hours/day, 5 days/week from 28 to 120 days (early protocol). Another third were submitted to the training from 90 to 120 days (late protocol), and the others remained sedentary. The main assays performed included an insulin tolerance test (ITT) and tests of serum alanine aminotransferase [ALT] and aspartate aminotransferase [AST] activities, serum triglyceride concentrations [TG] and liver total lipid concentrations.Results: The fructose-fed rats showed decreased insulin sensitivity, and the late-exercise training protocol counteracted this alteration. There was no difference between the groups in levels of serum ALT, whereas AST and liver lipids increased in the fructose-fed sedentary group when compared with the other groups. Serum triglycerides concentrations were higher in the fructose-fed trained groups when compared with the corresponding control group.Conclusions: The late-training protocol was effective in restoring insulin sensitivity to acceptable standards. Considering the markers here evaluated, both training protocols were successful in preventing the emergence of non-alcoholic fatty liver status disease. |
id |
UNSP_92b7c273c6fa5f0b772662ca54e91bfe |
---|---|
oai_identifier_str |
oai:repositorio.unesp.br:11449/20890 |
network_acronym_str |
UNSP |
network_name_str |
Repositório Institucional da UNESP |
repository_id_str |
2946 |
spelling |
Exercise counteracts fatty liver disease in rats fed on fructose-rich dietBackground: This study aimed to analyze the effects of exercise at the aerobic/anaerobic transition on the markers of non-alcoholic fatty liver disease (NAFLD), insulin sensitivity and the blood chemistry of rats kept on a fructose-rich diet.Methods: We separated 48 Wistar rats into two groups according to diet: a control group (balanced diet AIN-93 G) and a fructose-rich diet group (60% fructose). The animals were tested for maximal lactate-steady state (MLSS) in order to identify the aerobic/anaerobic metabolic transition during swimming exercises at 28 and 90 days of age. One third of the animals of each group were submitted to swimming training at an intensity equivalent to the individual MLSS for 1 hours/day, 5 days/week from 28 to 120 days (early protocol). Another third were submitted to the training from 90 to 120 days (late protocol), and the others remained sedentary. The main assays performed included an insulin tolerance test (ITT) and tests of serum alanine aminotransferase [ALT] and aspartate aminotransferase [AST] activities, serum triglyceride concentrations [TG] and liver total lipid concentrations.Results: The fructose-fed rats showed decreased insulin sensitivity, and the late-exercise training protocol counteracted this alteration. There was no difference between the groups in levels of serum ALT, whereas AST and liver lipids increased in the fructose-fed sedentary group when compared with the other groups. Serum triglycerides concentrations were higher in the fructose-fed trained groups when compared with the corresponding control group.Conclusions: The late-training protocol was effective in restoring insulin sensitivity to acceptable standards. Considering the markers here evaluated, both training protocols were successful in preventing the emergence of non-alcoholic fatty liver status disease.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)São Paulo State Univ UNESP, Dept Phys Educ, BR-13506900 Rio Claro, SP, BrazilUniv Fed Mato Grosso, Dept Phys Educ, BR-78060900 Cuiaba, Mato Grosso, BrazilSão Paulo State Univ UNESP, Dept Phys Educ, BR-13506900 Rio Claro, SP, BrazilBiomed Central Ltd.Universidade Estadual Paulista (Unesp)Univ Fed Mato GrossoBotezelli, Jose D. [UNESP]Mora, Rodrigo F. [UNESP]Dalia, Rodrigo A. [UNESP]Moura, Leandro P. [UNESP]Cambri, Lucieli T. [UNESP]Ghezzi, Ana C. [UNESP]Voltarelli, Fabricio A.Mello, Maria A. R. [UNESP]2013-09-30T18:49:21Z2014-05-20T13:58:47Z2013-09-30T18:49:21Z2014-05-20T13:58:47Z2010-10-14info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article9application/pdfhttp://dx.doi.org/10.1186/1476-511X-9-116Lipids In Health and Disease. London: Biomed Central Ltd., v. 9, p. 9, 2010.1476-511Xhttp://hdl.handle.net/11449/2089010.1186/1476-511X-9-116WOS:000283536700001WOS000283536700001.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengLipids in Health and Disease2.663info:eu-repo/semantics/openAccess2023-10-29T06:06:19Zoai:repositorio.unesp.br:11449/20890Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T16:20:17.094118Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Exercise counteracts fatty liver disease in rats fed on fructose-rich diet |
title |
Exercise counteracts fatty liver disease in rats fed on fructose-rich diet |
spellingShingle |
Exercise counteracts fatty liver disease in rats fed on fructose-rich diet Botezelli, Jose D. [UNESP] |
title_short |
Exercise counteracts fatty liver disease in rats fed on fructose-rich diet |
title_full |
Exercise counteracts fatty liver disease in rats fed on fructose-rich diet |
title_fullStr |
Exercise counteracts fatty liver disease in rats fed on fructose-rich diet |
title_full_unstemmed |
Exercise counteracts fatty liver disease in rats fed on fructose-rich diet |
title_sort |
Exercise counteracts fatty liver disease in rats fed on fructose-rich diet |
author |
Botezelli, Jose D. [UNESP] |
author_facet |
Botezelli, Jose D. [UNESP] Mora, Rodrigo F. [UNESP] Dalia, Rodrigo A. [UNESP] Moura, Leandro P. [UNESP] Cambri, Lucieli T. [UNESP] Ghezzi, Ana C. [UNESP] Voltarelli, Fabricio A. Mello, Maria A. R. [UNESP] |
author_role |
author |
author2 |
Mora, Rodrigo F. [UNESP] Dalia, Rodrigo A. [UNESP] Moura, Leandro P. [UNESP] Cambri, Lucieli T. [UNESP] Ghezzi, Ana C. [UNESP] Voltarelli, Fabricio A. Mello, Maria A. R. [UNESP] |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Univ Fed Mato Grosso |
dc.contributor.author.fl_str_mv |
Botezelli, Jose D. [UNESP] Mora, Rodrigo F. [UNESP] Dalia, Rodrigo A. [UNESP] Moura, Leandro P. [UNESP] Cambri, Lucieli T. [UNESP] Ghezzi, Ana C. [UNESP] Voltarelli, Fabricio A. Mello, Maria A. R. [UNESP] |
description |
Background: This study aimed to analyze the effects of exercise at the aerobic/anaerobic transition on the markers of non-alcoholic fatty liver disease (NAFLD), insulin sensitivity and the blood chemistry of rats kept on a fructose-rich diet.Methods: We separated 48 Wistar rats into two groups according to diet: a control group (balanced diet AIN-93 G) and a fructose-rich diet group (60% fructose). The animals were tested for maximal lactate-steady state (MLSS) in order to identify the aerobic/anaerobic metabolic transition during swimming exercises at 28 and 90 days of age. One third of the animals of each group were submitted to swimming training at an intensity equivalent to the individual MLSS for 1 hours/day, 5 days/week from 28 to 120 days (early protocol). Another third were submitted to the training from 90 to 120 days (late protocol), and the others remained sedentary. The main assays performed included an insulin tolerance test (ITT) and tests of serum alanine aminotransferase [ALT] and aspartate aminotransferase [AST] activities, serum triglyceride concentrations [TG] and liver total lipid concentrations.Results: The fructose-fed rats showed decreased insulin sensitivity, and the late-exercise training protocol counteracted this alteration. There was no difference between the groups in levels of serum ALT, whereas AST and liver lipids increased in the fructose-fed sedentary group when compared with the other groups. Serum triglycerides concentrations were higher in the fructose-fed trained groups when compared with the corresponding control group.Conclusions: The late-training protocol was effective in restoring insulin sensitivity to acceptable standards. Considering the markers here evaluated, both training protocols were successful in preventing the emergence of non-alcoholic fatty liver status disease. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-10-14 2013-09-30T18:49:21Z 2013-09-30T18:49:21Z 2014-05-20T13:58:47Z 2014-05-20T13:58:47Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1186/1476-511X-9-116 Lipids In Health and Disease. London: Biomed Central Ltd., v. 9, p. 9, 2010. 1476-511X http://hdl.handle.net/11449/20890 10.1186/1476-511X-9-116 WOS:000283536700001 WOS000283536700001.pdf |
url |
http://dx.doi.org/10.1186/1476-511X-9-116 http://hdl.handle.net/11449/20890 |
identifier_str_mv |
Lipids In Health and Disease. London: Biomed Central Ltd., v. 9, p. 9, 2010. 1476-511X 10.1186/1476-511X-9-116 WOS:000283536700001 WOS000283536700001.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Lipids in Health and Disease 2.663 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
9 application/pdf |
dc.publisher.none.fl_str_mv |
Biomed Central Ltd. |
publisher.none.fl_str_mv |
Biomed Central Ltd. |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128635278721024 |