Spondias mombin supplementation attenuated cardiac remodelling process induced by tobacco smoke
Main Author: | |
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Publication Date: | 2018 |
Other Authors: | , , , , , , , , , , , , , , |
Format: | Article |
Language: | eng |
Source: | Repositório Institucional da UNESP |
Download full: | http://dx.doi.org/10.1111/jcmm.13683 http://hdl.handle.net/11449/176378 |
Summary: | The objective of this study was to investigate the influence of Spondias mombin (SM) supplementation on the cardiac remodelling process induced by exposure to tobacco smoke (ETS) in rats. Male Wistar rats were divided into 4 groups: group C (control, n = 20) comprised animals not exposed to cigarette smoke and received standard chow; group ETS (n = 20) comprised animals exposed to cigarette smoke and received standard chow; group ETS100 (n = 20) received standard chow supplemented with 100 mg/kg body weight/d of SM; and group ETS250 (n = 20) received standard chow supplemented with 250 mg/kg body weight/d of SM. The observation period was 2 months. The ETS animals had higher values of left cardiac chamber diameters and of left ventricular mass index. SM supplementation attenuated these changes. In addition, the myocyte cross-sectional area (CSA) was lower in group C compared with the ETS groups; however, the ETS250 group had lower values of CSA compared with the ETS group. The ETS group also showed higher cardiac levels of lipid hydroperoxide (LH) compared with group C; and, groups ETS100 and ETS250 had lower concentrations of LH compared with the ETS group. Regarding energy metabolism, SM supplementation decreased glycolysis and increased the β-oxidation and the oxidative phosphorylation. There were no differences in the expression of Nrf-2, SIRT-1, NF-κB, interferon-gamma and interleukin 10. In conclusion, our results suggest that ETS induced the cardiac remodelling process. In addition, SM supplementation attenuated this process, along with oxidative stress reduction and energy metabolism modulation. |
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Spondias mombin supplementation attenuated cardiac remodelling process induced by tobacco smokecardiac remodellingcigarette smokeenergy metabolismfruitoxidative stressThe objective of this study was to investigate the influence of Spondias mombin (SM) supplementation on the cardiac remodelling process induced by exposure to tobacco smoke (ETS) in rats. Male Wistar rats were divided into 4 groups: group C (control, n = 20) comprised animals not exposed to cigarette smoke and received standard chow; group ETS (n = 20) comprised animals exposed to cigarette smoke and received standard chow; group ETS100 (n = 20) received standard chow supplemented with 100 mg/kg body weight/d of SM; and group ETS250 (n = 20) received standard chow supplemented with 250 mg/kg body weight/d of SM. The observation period was 2 months. The ETS animals had higher values of left cardiac chamber diameters and of left ventricular mass index. SM supplementation attenuated these changes. In addition, the myocyte cross-sectional area (CSA) was lower in group C compared with the ETS groups; however, the ETS250 group had lower values of CSA compared with the ETS group. The ETS group also showed higher cardiac levels of lipid hydroperoxide (LH) compared with group C; and, groups ETS100 and ETS250 had lower concentrations of LH compared with the ETS group. Regarding energy metabolism, SM supplementation decreased glycolysis and increased the β-oxidation and the oxidative phosphorylation. There were no differences in the expression of Nrf-2, SIRT-1, NF-κB, interferon-gamma and interleukin 10. In conclusion, our results suggest that ETS induced the cardiac remodelling process. In addition, SM supplementation attenuated this process, along with oxidative stress reduction and energy metabolism modulation.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Internal Medicine Department Botucatu Medical School UNESP—São Paulo State UniversityDepartment of Anesthesiology Botucatu Medical School UNESP—São Paulo State UniversityChemistry and Biochemistry Department Institute of Biological Sciences Botucatu Medical School UNESP—São Paulo State UniversityInternal Medicine Department Botucatu Medical School UNESP—São Paulo State UniversityDepartment of Anesthesiology Botucatu Medical School UNESP—São Paulo State UniversityChemistry and Biochemistry Department Institute of Biological Sciences Botucatu Medical School UNESP—São Paulo State UniversityFAPESP: 2014/21310-0Universidade Estadual Paulista (Unesp)Lourenço, Maria Angélica Martins [UNESP]Braz, Mariana Gobbo [UNESP]Aun, Aline Garcia [UNESP]Pereira, Bruna Letícia Buzati [UNESP]Figueiredo, Amanda Menezes [UNESP]da Silva, Renata Aparecida Cândido [UNESP]Kazmarek, Elisa Moya [UNESP]Alegre, Patrícia Helena Correa [UNESP]Bachiega, Tatiana Fernanda [UNESP]Zanati, Silmeia Garcia [UNESP]Azevedo, Paula Schmidt [UNESP]Polegato, Bertha Furlan [UNESP]Fernandes, Ana Angélica Henrique [UNESP]de Paiva, Sergio Alberto Rupp [UNESP]Zornoff, Leonardo Antonio Mamede [UNESP]Minicucci, Marcos Ferreira [UNESP]2018-12-11T17:20:33Z2018-12-11T17:20:33Z2018-08-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article3996-4004application/pdfhttp://dx.doi.org/10.1111/jcmm.13683Journal of Cellular and Molecular Medicine, v. 22, n. 8, p. 3996-4004, 2018.1582-1838http://hdl.handle.net/11449/17637810.1111/jcmm.136832-s2.0-850477722322-s2.0-85047772232.pdf50168390153945471213140801402647743870403447167355300230102038040000-0002-5843-6232Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Cellular and Molecular Medicine1,647info:eu-repo/semantics/openAccess2024-08-14T17:21:53Zoai:repositorio.unesp.br:11449/176378Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-14T17:21:53Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Spondias mombin supplementation attenuated cardiac remodelling process induced by tobacco smoke |
title |
Spondias mombin supplementation attenuated cardiac remodelling process induced by tobacco smoke |
spellingShingle |
Spondias mombin supplementation attenuated cardiac remodelling process induced by tobacco smoke Lourenço, Maria Angélica Martins [UNESP] cardiac remodelling cigarette smoke energy metabolism fruit oxidative stress |
title_short |
Spondias mombin supplementation attenuated cardiac remodelling process induced by tobacco smoke |
title_full |
Spondias mombin supplementation attenuated cardiac remodelling process induced by tobacco smoke |
title_fullStr |
Spondias mombin supplementation attenuated cardiac remodelling process induced by tobacco smoke |
title_full_unstemmed |
Spondias mombin supplementation attenuated cardiac remodelling process induced by tobacco smoke |
title_sort |
Spondias mombin supplementation attenuated cardiac remodelling process induced by tobacco smoke |
author |
Lourenço, Maria Angélica Martins [UNESP] |
author_facet |
Lourenço, Maria Angélica Martins [UNESP] Braz, Mariana Gobbo [UNESP] Aun, Aline Garcia [UNESP] Pereira, Bruna Letícia Buzati [UNESP] Figueiredo, Amanda Menezes [UNESP] da Silva, Renata Aparecida Cândido [UNESP] Kazmarek, Elisa Moya [UNESP] Alegre, Patrícia Helena Correa [UNESP] Bachiega, Tatiana Fernanda [UNESP] Zanati, Silmeia Garcia [UNESP] Azevedo, Paula Schmidt [UNESP] Polegato, Bertha Furlan [UNESP] Fernandes, Ana Angélica Henrique [UNESP] de Paiva, Sergio Alberto Rupp [UNESP] Zornoff, Leonardo Antonio Mamede [UNESP] Minicucci, Marcos Ferreira [UNESP] |
author_role |
author |
author2 |
Braz, Mariana Gobbo [UNESP] Aun, Aline Garcia [UNESP] Pereira, Bruna Letícia Buzati [UNESP] Figueiredo, Amanda Menezes [UNESP] da Silva, Renata Aparecida Cândido [UNESP] Kazmarek, Elisa Moya [UNESP] Alegre, Patrícia Helena Correa [UNESP] Bachiega, Tatiana Fernanda [UNESP] Zanati, Silmeia Garcia [UNESP] Azevedo, Paula Schmidt [UNESP] Polegato, Bertha Furlan [UNESP] Fernandes, Ana Angélica Henrique [UNESP] de Paiva, Sergio Alberto Rupp [UNESP] Zornoff, Leonardo Antonio Mamede [UNESP] Minicucci, Marcos Ferreira [UNESP] |
author2_role |
author author author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Lourenço, Maria Angélica Martins [UNESP] Braz, Mariana Gobbo [UNESP] Aun, Aline Garcia [UNESP] Pereira, Bruna Letícia Buzati [UNESP] Figueiredo, Amanda Menezes [UNESP] da Silva, Renata Aparecida Cândido [UNESP] Kazmarek, Elisa Moya [UNESP] Alegre, Patrícia Helena Correa [UNESP] Bachiega, Tatiana Fernanda [UNESP] Zanati, Silmeia Garcia [UNESP] Azevedo, Paula Schmidt [UNESP] Polegato, Bertha Furlan [UNESP] Fernandes, Ana Angélica Henrique [UNESP] de Paiva, Sergio Alberto Rupp [UNESP] Zornoff, Leonardo Antonio Mamede [UNESP] Minicucci, Marcos Ferreira [UNESP] |
dc.subject.por.fl_str_mv |
cardiac remodelling cigarette smoke energy metabolism fruit oxidative stress |
topic |
cardiac remodelling cigarette smoke energy metabolism fruit oxidative stress |
description |
The objective of this study was to investigate the influence of Spondias mombin (SM) supplementation on the cardiac remodelling process induced by exposure to tobacco smoke (ETS) in rats. Male Wistar rats were divided into 4 groups: group C (control, n = 20) comprised animals not exposed to cigarette smoke and received standard chow; group ETS (n = 20) comprised animals exposed to cigarette smoke and received standard chow; group ETS100 (n = 20) received standard chow supplemented with 100 mg/kg body weight/d of SM; and group ETS250 (n = 20) received standard chow supplemented with 250 mg/kg body weight/d of SM. The observation period was 2 months. The ETS animals had higher values of left cardiac chamber diameters and of left ventricular mass index. SM supplementation attenuated these changes. In addition, the myocyte cross-sectional area (CSA) was lower in group C compared with the ETS groups; however, the ETS250 group had lower values of CSA compared with the ETS group. The ETS group also showed higher cardiac levels of lipid hydroperoxide (LH) compared with group C; and, groups ETS100 and ETS250 had lower concentrations of LH compared with the ETS group. Regarding energy metabolism, SM supplementation decreased glycolysis and increased the β-oxidation and the oxidative phosphorylation. There were no differences in the expression of Nrf-2, SIRT-1, NF-κB, interferon-gamma and interleukin 10. In conclusion, our results suggest that ETS induced the cardiac remodelling process. In addition, SM supplementation attenuated this process, along with oxidative stress reduction and energy metabolism modulation. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-12-11T17:20:33Z 2018-12-11T17:20:33Z 2018-08-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1111/jcmm.13683 Journal of Cellular and Molecular Medicine, v. 22, n. 8, p. 3996-4004, 2018. 1582-1838 http://hdl.handle.net/11449/176378 10.1111/jcmm.13683 2-s2.0-85047772232 2-s2.0-85047772232.pdf 5016839015394547 1213140801402647 7438704034471673 5530023010203804 0000-0002-5843-6232 |
url |
http://dx.doi.org/10.1111/jcmm.13683 http://hdl.handle.net/11449/176378 |
identifier_str_mv |
Journal of Cellular and Molecular Medicine, v. 22, n. 8, p. 3996-4004, 2018. 1582-1838 10.1111/jcmm.13683 2-s2.0-85047772232 2-s2.0-85047772232.pdf 5016839015394547 1213140801402647 7438704034471673 5530023010203804 0000-0002-5843-6232 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of Cellular and Molecular Medicine 1,647 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
3996-4004 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128103564705792 |