Induction of mitotic crossing-over in diploid strains of Aspergillus nidulans using low-dose X-rays

Detalhes bibliográficos
Autor(a) principal: Stoll, L. B.
Data de Publicação: 2008
Outros Autores: Cremonesi, F. C. A., Pires, L. T. A., Zucchi, T. D., Zucchi, T. M. A. D.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.4238/vol7-2gmr414
http://hdl.handle.net/11449/70498
Resumo: As a contribution towards detecting the genetic effects of low doses of genotoxic physical agents, this paper deals with the consequences of low-dose X-rays in the Aspergillus nidulans genome. The irradiation doses studied were those commonly used in dental clinics (1-5 cGy). Even very low doses promoted increased mitotic crossing-over frequencies in diploid strains heterozygous for several genetic markers including the ones involved in DNA repair and recombination mechanisms. Genetic markers of several heterozygous strains were individually analyzed disclosing that some markers were especially sensitive to the treatments. These markers should be chosen as bio-indicators in the homozygotization index assay to better detect the recombinogenic/ carcinogenic genomic effects of low-dose X-rays. ©FUNPEC-RP.
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spelling Induction of mitotic crossing-over in diploid strains of Aspergillus nidulans using low-dose X-raysAspergillus nidulansDNA damageGenotoxicity testsHomozygotization index assayLow-dose X-raysMitotic crossing-overcontrolled studycrossing overdiploidyDNA recombinationDNA repairfungal genefungal straingenotoxicitylow energy radiationmitosisnonhumanradiation mutagenesisX irradiationCrossing Over, GeneticDiploidyDNA DamageDose-Response Relationship, RadiationHomozygoteMitosisMutagenicity TestsX-RaysEmericella nidulansAs a contribution towards detecting the genetic effects of low doses of genotoxic physical agents, this paper deals with the consequences of low-dose X-rays in the Aspergillus nidulans genome. The irradiation doses studied were those commonly used in dental clinics (1-5 cGy). Even very low doses promoted increased mitotic crossing-over frequencies in diploid strains heterozygous for several genetic markers including the ones involved in DNA repair and recombination mechanisms. Genetic markers of several heterozygous strains were individually analyzed disclosing that some markers were especially sensitive to the treatments. These markers should be chosen as bio-indicators in the homozygotization index assay to better detect the recombinogenic/ carcinogenic genomic effects of low-dose X-rays. ©FUNPEC-RP.Faculdade de Odontologia Universidade de Franca, Franca, SPFaculdade de Odontologia Universidade de São Paulo, Ribeirão Preto, SPCentro Universitário Moura Lacerda, Ribeirão Preto, SPDepartamento de Parasitologia Instituto de Ciências Biomédicas Universidade de São Paulo, São Paulo, SPDepartamento de Ciências Biológicas and Biotecnologia Universidade do Estado de São Paulo, Assis, SPUniversidade de Franca (UNIFRAN)Universidade de São Paulo (USP)Centro Universitário Moura LacerdaUniversidade Estadual Paulista (Unesp)Stoll, L. B.Cremonesi, F. C. A.Pires, L. T. A.Zucchi, T. D.Zucchi, T. M. A. D.2014-05-27T11:23:37Z2014-05-27T11:23:37Z2008-07-30info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article467-475application/pdfhttp://dx.doi.org/10.4238/vol7-2gmr414Genetics and Molecular Research, v. 7, n. 2, p. 467-475, 2008.1676-5680http://hdl.handle.net/11449/7049810.4238/vol7-2gmr4142-s2.0-479490950902-s2.0-47949095090.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengGenetics and Molecular Research0,439info:eu-repo/semantics/openAccess2023-10-26T06:10:08Zoai:repositorio.unesp.br:11449/70498Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T16:02:52.386462Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Induction of mitotic crossing-over in diploid strains of Aspergillus nidulans using low-dose X-rays
title Induction of mitotic crossing-over in diploid strains of Aspergillus nidulans using low-dose X-rays
spellingShingle Induction of mitotic crossing-over in diploid strains of Aspergillus nidulans using low-dose X-rays
Stoll, L. B.
Aspergillus nidulans
DNA damage
Genotoxicity tests
Homozygotization index assay
Low-dose X-rays
Mitotic crossing-over
controlled study
crossing over
diploidy
DNA recombination
DNA repair
fungal gene
fungal strain
genotoxicity
low energy radiation
mitosis
nonhuman
radiation mutagenesis
X irradiation
Crossing Over, Genetic
Diploidy
DNA Damage
Dose-Response Relationship, Radiation
Homozygote
Mitosis
Mutagenicity Tests
X-Rays
Emericella nidulans
title_short Induction of mitotic crossing-over in diploid strains of Aspergillus nidulans using low-dose X-rays
title_full Induction of mitotic crossing-over in diploid strains of Aspergillus nidulans using low-dose X-rays
title_fullStr Induction of mitotic crossing-over in diploid strains of Aspergillus nidulans using low-dose X-rays
title_full_unstemmed Induction of mitotic crossing-over in diploid strains of Aspergillus nidulans using low-dose X-rays
title_sort Induction of mitotic crossing-over in diploid strains of Aspergillus nidulans using low-dose X-rays
author Stoll, L. B.
author_facet Stoll, L. B.
Cremonesi, F. C. A.
Pires, L. T. A.
Zucchi, T. D.
Zucchi, T. M. A. D.
author_role author
author2 Cremonesi, F. C. A.
Pires, L. T. A.
Zucchi, T. D.
Zucchi, T. M. A. D.
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade de Franca (UNIFRAN)
Universidade de São Paulo (USP)
Centro Universitário Moura Lacerda
Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Stoll, L. B.
Cremonesi, F. C. A.
Pires, L. T. A.
Zucchi, T. D.
Zucchi, T. M. A. D.
dc.subject.por.fl_str_mv Aspergillus nidulans
DNA damage
Genotoxicity tests
Homozygotization index assay
Low-dose X-rays
Mitotic crossing-over
controlled study
crossing over
diploidy
DNA recombination
DNA repair
fungal gene
fungal strain
genotoxicity
low energy radiation
mitosis
nonhuman
radiation mutagenesis
X irradiation
Crossing Over, Genetic
Diploidy
DNA Damage
Dose-Response Relationship, Radiation
Homozygote
Mitosis
Mutagenicity Tests
X-Rays
Emericella nidulans
topic Aspergillus nidulans
DNA damage
Genotoxicity tests
Homozygotization index assay
Low-dose X-rays
Mitotic crossing-over
controlled study
crossing over
diploidy
DNA recombination
DNA repair
fungal gene
fungal strain
genotoxicity
low energy radiation
mitosis
nonhuman
radiation mutagenesis
X irradiation
Crossing Over, Genetic
Diploidy
DNA Damage
Dose-Response Relationship, Radiation
Homozygote
Mitosis
Mutagenicity Tests
X-Rays
Emericella nidulans
description As a contribution towards detecting the genetic effects of low doses of genotoxic physical agents, this paper deals with the consequences of low-dose X-rays in the Aspergillus nidulans genome. The irradiation doses studied were those commonly used in dental clinics (1-5 cGy). Even very low doses promoted increased mitotic crossing-over frequencies in diploid strains heterozygous for several genetic markers including the ones involved in DNA repair and recombination mechanisms. Genetic markers of several heterozygous strains were individually analyzed disclosing that some markers were especially sensitive to the treatments. These markers should be chosen as bio-indicators in the homozygotization index assay to better detect the recombinogenic/ carcinogenic genomic effects of low-dose X-rays. ©FUNPEC-RP.
publishDate 2008
dc.date.none.fl_str_mv 2008-07-30
2014-05-27T11:23:37Z
2014-05-27T11:23:37Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.4238/vol7-2gmr414
Genetics and Molecular Research, v. 7, n. 2, p. 467-475, 2008.
1676-5680
http://hdl.handle.net/11449/70498
10.4238/vol7-2gmr414
2-s2.0-47949095090
2-s2.0-47949095090.pdf
url http://dx.doi.org/10.4238/vol7-2gmr414
http://hdl.handle.net/11449/70498
identifier_str_mv Genetics and Molecular Research, v. 7, n. 2, p. 467-475, 2008.
1676-5680
10.4238/vol7-2gmr414
2-s2.0-47949095090
2-s2.0-47949095090.pdf
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Genetics and Molecular Research
0,439
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 467-475
application/pdf
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1808128599382818816

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