Doença periodontal em pacientes com Diabetes Mellitus: influência de polimorfismos genéticos?

• Autor(a) principal: Oliveira, Rafael Nepomuceno de [UNESP]
• Data de Publicação: 2011
• Outros Autores: Corbi, Samia Cruz Tfaile [UNESP], Bastos, Alliny de Souza [UNESP], Orrico, Silvana Regina Perez [UNESP], Scarel-Caminaga, Raquel Mantuanelli [UNESP]
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://www.revodontolunesp.com.br/article/51ae4aa81ef1faca3d0037e1; http://hdl.handle.net/11449/125594
• topic: Periodontitis; Diabetes mellitus; Genetic polymorphism; Periodontite; Diabetes mellitus; Polimorfismo genético

Currently it is clear that there are several factors that can act as modifiers of diseases, without causing them directly, but having the potential to make these conditions to progress faster and more severe. There is a growing number of studies investigating the relationship between Diabetes Mellitus (DM) and Periodontal Disease (PD), including some studies focusing on the influence of genetic factors in this process. The aim of this study was to verify through a literature review, the influence of genetic polymorphisms in the development of PD in patients with DM. PubMed and BIREME were used as databases and the terms Periodontitis or Periodontal Disease, Polymorphism, Diabetes Mellitus were searched. After a refinement in the literature, five studies were selected and they were related to chronic PD with DM and polymorphisms in cytokine genes, especially interleukin 1 (IL1) e IL6. Polymorphisms were associated with a higher concentration of pro-inflammatory cytokines in the gingival crevicular fluid of diabetic patients when compared to non-diabetic. In conclusion, it is necessary to confirm this association with longitudinal studies that must investigate a larger number of cytokine genes in order to understand the cause-effect relationship between genetic polymorphisms, DM and PD.