Efeitos hipotensivo e diurético dos extratos aquosos de pitanga (Eugenia uniflora L.) e jambolão (Eugenia jambolana Lam.) em ratos normotensos anestesiados

Detalhes bibliográficos
Autor(a) principal: Cirqueira, R. T.
Data de Publicação: 2005
Outros Autores: Alves, M. J Q F [UNESP]
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://www.ibb.unesp.br/Home/Departamentos/Botanica/RBPM-RevistaBrasileiradePlantasMedicinais/artigo_12_v7_n2.pdf
http://hdl.handle.net/11449/68131
Resumo: Plants that possess a diuretic effect are widely used by people in the treatment of some important diseases as edema and hypertension. The objective of this work was to study the effects of pitanga and jambos aqueous extracts (AE) about the arterial pressure (AP) and urinary flow (V) in normotensive and anesthetized rats. The AE were prepared for the decoction method and administrated for intragastric way in different concentrations: 10%, 15%, 20% and 25%. These concentrations corresponded respectively at doses of 56, 94, 145, 172 mg of pitanga dried extract /Kg and 44, 73, 83, 95 mg of jambos dried extract/Kg. The animals were divided in nine groups with seven individuals (n=7): control (C), P-10%, P-15%, P-20%, P-25%, J-10%, J-15%, J-20% and J-25%. The rats were anesthetized (hypnol 3%) and submitted to tracheotomy. The left carotide artery was catheterized to measure the AP through a mercury manometer, in periods of 15 minutes. The bladder was catheterized for urine collection and to measure the V, in periods of 30 minutes. The experimental protocol was divided in four periods of 30 minutes each: basal (to evaluate of the basal parameters) and experimental (Exp) 1, 2 and 3 (after the administration of the AE). The results were analyzed for ANOVA and Tukey (X±SD, p<0.05). In the C group did have not alteration of the AP basal but the V basal increased. In the experimental groups (AE of P and J) had significative decline in the AP basal: 34% (P-10%), 20% (P-15%), 21% (P-20%), 31% (P-25%), 24% (J-10%), 20% (J-15%) 16% (J-20%) and 29% (J-25%). Moreover, the administration of AE increased the V basal in: 280% (P-15%) and 192% (J-20%). The results showed that the plants evaluated are hypotensive and diuretic.
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spelling Efeitos hipotensivo e diurético dos extratos aquosos de pitanga (Eugenia uniflora L.) e jambolão (Eugenia jambolana Lam.) em ratos normotensos anestesiadosHypotensive and diuretic effects of pitanga (Eugenia uniflora L.) and jambos (Eugenia jambolana Lam.) aqueous extracts in normotensive anesthetized ratsDiureticHypotensiveJambosMedicinal plantsPitangaEugenia uniflora extractplant extractSyzygium cumini extractunclassified druganimal experimentantihypertensive activityarterial pressurecontrolled studydiuresisdiuretic activityEugeniaeugenia jambolanaeugenia unifloramedicinal plantmicturitionnonhumanratAnimaliaEugenia unifloraSyzygium cuminiPlants that possess a diuretic effect are widely used by people in the treatment of some important diseases as edema and hypertension. The objective of this work was to study the effects of pitanga and jambos aqueous extracts (AE) about the arterial pressure (AP) and urinary flow (V) in normotensive and anesthetized rats. The AE were prepared for the decoction method and administrated for intragastric way in different concentrations: 10%, 15%, 20% and 25%. These concentrations corresponded respectively at doses of 56, 94, 145, 172 mg of pitanga dried extract /Kg and 44, 73, 83, 95 mg of jambos dried extract/Kg. The animals were divided in nine groups with seven individuals (n=7): control (C), P-10%, P-15%, P-20%, P-25%, J-10%, J-15%, J-20% and J-25%. The rats were anesthetized (hypnol 3%) and submitted to tracheotomy. The left carotide artery was catheterized to measure the AP through a mercury manometer, in periods of 15 minutes. The bladder was catheterized for urine collection and to measure the V, in periods of 30 minutes. The experimental protocol was divided in four periods of 30 minutes each: basal (to evaluate of the basal parameters) and experimental (Exp) 1, 2 and 3 (after the administration of the AE). The results were analyzed for ANOVA and Tukey (X±SD, p<0.05). In the C group did have not alteration of the AP basal but the V basal increased. In the experimental groups (AE of P and J) had significative decline in the AP basal: 34% (P-10%), 20% (P-15%), 21% (P-20%), 31% (P-25%), 24% (J-10%), 20% (J-15%) 16% (J-20%) and 29% (J-25%). Moreover, the administration of AE increased the V basal in: 280% (P-15%) and 192% (J-20%). The results showed that the plants evaluated are hypotensive and diuretic.Departamento de Biologia Faculdade de Filosofia, Ciências e Letras USP, Avenida Bandeirantes, 3900, CEP14040-901, Ribeirao Preto, SPDepartamento de Fisiologia Instituto de Biociências UNESP, Rubião Júnior s/nDepartamento de Fisiologia Instituto de Biociências UNESP, Rubião Júnior s/nUniversidade de São Paulo (USP)Universidade Estadual Paulista (Unesp)Cirqueira, R. T.Alves, M. J Q F [UNESP]2014-05-27T11:21:16Z2014-05-27T11:21:16Z2005-02-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article86-91application/pdfhttp://www.ibb.unesp.br/Home/Departamentos/Botanica/RBPM-RevistaBrasileiradePlantasMedicinais/artigo_12_v7_n2.pdfRevista Brasileira de Plantas Medicinais, v. 7, n. 2, p. 86-91, 2005.1516-0572http://hdl.handle.net/11449/681312-s2.0-213444459692-s2.0-21344445969.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPporRevista Brasileira de Plantas Medicinais0,199info:eu-repo/semantics/openAccess2023-12-04T06:10:39Zoai:repositorio.unesp.br:11449/68131Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T19:26:12.434213Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Efeitos hipotensivo e diurético dos extratos aquosos de pitanga (Eugenia uniflora L.) e jambolão (Eugenia jambolana Lam.) em ratos normotensos anestesiados
Hypotensive and diuretic effects of pitanga (Eugenia uniflora L.) and jambos (Eugenia jambolana Lam.) aqueous extracts in normotensive anesthetized rats
title Efeitos hipotensivo e diurético dos extratos aquosos de pitanga (Eugenia uniflora L.) e jambolão (Eugenia jambolana Lam.) em ratos normotensos anestesiados
spellingShingle Efeitos hipotensivo e diurético dos extratos aquosos de pitanga (Eugenia uniflora L.) e jambolão (Eugenia jambolana Lam.) em ratos normotensos anestesiados
Cirqueira, R. T.
Diuretic
Hypotensive
Jambos
Medicinal plants
Pitanga
Eugenia uniflora extract
plant extract
Syzygium cumini extract
unclassified drug
animal experiment
antihypertensive activity
arterial pressure
controlled study
diuresis
diuretic activity
Eugenia
eugenia jambolana
eugenia uniflora
medicinal plant
micturition
nonhuman
rat
Animalia
Eugenia uniflora
Syzygium cumini
title_short Efeitos hipotensivo e diurético dos extratos aquosos de pitanga (Eugenia uniflora L.) e jambolão (Eugenia jambolana Lam.) em ratos normotensos anestesiados
title_full Efeitos hipotensivo e diurético dos extratos aquosos de pitanga (Eugenia uniflora L.) e jambolão (Eugenia jambolana Lam.) em ratos normotensos anestesiados
title_fullStr Efeitos hipotensivo e diurético dos extratos aquosos de pitanga (Eugenia uniflora L.) e jambolão (Eugenia jambolana Lam.) em ratos normotensos anestesiados
title_full_unstemmed Efeitos hipotensivo e diurético dos extratos aquosos de pitanga (Eugenia uniflora L.) e jambolão (Eugenia jambolana Lam.) em ratos normotensos anestesiados
title_sort Efeitos hipotensivo e diurético dos extratos aquosos de pitanga (Eugenia uniflora L.) e jambolão (Eugenia jambolana Lam.) em ratos normotensos anestesiados
author Cirqueira, R. T.
author_facet Cirqueira, R. T.
Alves, M. J Q F [UNESP]
author_role author
author2 Alves, M. J Q F [UNESP]
author2_role author
dc.contributor.none.fl_str_mv Universidade de São Paulo (USP)
Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Cirqueira, R. T.
Alves, M. J Q F [UNESP]
dc.subject.por.fl_str_mv Diuretic
Hypotensive
Jambos
Medicinal plants
Pitanga
Eugenia uniflora extract
plant extract
Syzygium cumini extract
unclassified drug
animal experiment
antihypertensive activity
arterial pressure
controlled study
diuresis
diuretic activity
Eugenia
eugenia jambolana
eugenia uniflora
medicinal plant
micturition
nonhuman
rat
Animalia
Eugenia uniflora
Syzygium cumini
topic Diuretic
Hypotensive
Jambos
Medicinal plants
Pitanga
Eugenia uniflora extract
plant extract
Syzygium cumini extract
unclassified drug
animal experiment
antihypertensive activity
arterial pressure
controlled study
diuresis
diuretic activity
Eugenia
eugenia jambolana
eugenia uniflora
medicinal plant
micturition
nonhuman
rat
Animalia
Eugenia uniflora
Syzygium cumini
description Plants that possess a diuretic effect are widely used by people in the treatment of some important diseases as edema and hypertension. The objective of this work was to study the effects of pitanga and jambos aqueous extracts (AE) about the arterial pressure (AP) and urinary flow (V) in normotensive and anesthetized rats. The AE were prepared for the decoction method and administrated for intragastric way in different concentrations: 10%, 15%, 20% and 25%. These concentrations corresponded respectively at doses of 56, 94, 145, 172 mg of pitanga dried extract /Kg and 44, 73, 83, 95 mg of jambos dried extract/Kg. The animals were divided in nine groups with seven individuals (n=7): control (C), P-10%, P-15%, P-20%, P-25%, J-10%, J-15%, J-20% and J-25%. The rats were anesthetized (hypnol 3%) and submitted to tracheotomy. The left carotide artery was catheterized to measure the AP through a mercury manometer, in periods of 15 minutes. The bladder was catheterized for urine collection and to measure the V, in periods of 30 minutes. The experimental protocol was divided in four periods of 30 minutes each: basal (to evaluate of the basal parameters) and experimental (Exp) 1, 2 and 3 (after the administration of the AE). The results were analyzed for ANOVA and Tukey (X±SD, p<0.05). In the C group did have not alteration of the AP basal but the V basal increased. In the experimental groups (AE of P and J) had significative decline in the AP basal: 34% (P-10%), 20% (P-15%), 21% (P-20%), 31% (P-25%), 24% (J-10%), 20% (J-15%) 16% (J-20%) and 29% (J-25%). Moreover, the administration of AE increased the V basal in: 280% (P-15%) and 192% (J-20%). The results showed that the plants evaluated are hypotensive and diuretic.
publishDate 2005
dc.date.none.fl_str_mv 2005-02-01
2014-05-27T11:21:16Z
2014-05-27T11:21:16Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.ibb.unesp.br/Home/Departamentos/Botanica/RBPM-RevistaBrasileiradePlantasMedicinais/artigo_12_v7_n2.pdf
Revista Brasileira de Plantas Medicinais, v. 7, n. 2, p. 86-91, 2005.
1516-0572
http://hdl.handle.net/11449/68131
2-s2.0-21344445969
2-s2.0-21344445969.pdf
url http://www.ibb.unesp.br/Home/Departamentos/Botanica/RBPM-RevistaBrasileiradePlantasMedicinais/artigo_12_v7_n2.pdf
http://hdl.handle.net/11449/68131
identifier_str_mv Revista Brasileira de Plantas Medicinais, v. 7, n. 2, p. 86-91, 2005.
1516-0572
2-s2.0-21344445969
2-s2.0-21344445969.pdf
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv Revista Brasileira de Plantas Medicinais
0,199
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 86-91
application/pdf
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
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