Dysbiosis and probiotic applications in autoimmune diseases
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , |
Tipo de documento: | Capítulo de livro |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/B978-0-12-824390-9.00004-9 http://hdl.handle.net/11449/240927 |
Resumo: | Several evidence in animal models and humans pointed to the involvement of oral and intestinal dysbiosis in the development of autoimmune diseases. Dysbiosis is associated with decreased bacterial function and diversity, as well as decreased beneficial microbes, increased pathobionts, impaired barrier function, bacterial translocation, systemic inflammation, and decreased immune regulatory mechanisms in the gut mucosa. The mechanisms proposed to link dysbiosis with autoimmune diseases include molecular mimicry, bystander T-cell activation, T helper cell skewing, epitope spreading, dual T-cell receptors, posttranslational modification of luminal proteins by dysbiotic microbiota, and amplification by inflammatory cytokines. Studies suggest that probiotics influence systemic immune responses, ensure the homeostasis of the healthy microbiota in the intestinal mucosa, and therefore, could be used as adjuvant therapy to treat immune-mediated diseases. The mechanisms to achieve these effects include mucus secretion, antimicrobial peptide production, cross-feeding other resident microbes, production of organic acids and enzymes, gastrointestinal epithelial barrier maintenance, decreasing oxidative stress, competition with pathogens, and finally, modulation of the host immunity. Here, we described several reports concerning dysbiosis and probiotic applications in animal models of autoimmune diseases, human studies, and clinical trials concerning the applicability of probiotics in autoimmune diabetes, autoimmune thyroid diseases, rheumatoid arthritis, systemic lupus erythematosus, and Sjögren syndrome. |
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Dysbiosis and probiotic applications in autoimmune diseasesAutoimmunityDysbiosisInflammationMicrobiotaProbioticsSeveral evidence in animal models and humans pointed to the involvement of oral and intestinal dysbiosis in the development of autoimmune diseases. Dysbiosis is associated with decreased bacterial function and diversity, as well as decreased beneficial microbes, increased pathobionts, impaired barrier function, bacterial translocation, systemic inflammation, and decreased immune regulatory mechanisms in the gut mucosa. The mechanisms proposed to link dysbiosis with autoimmune diseases include molecular mimicry, bystander T-cell activation, T helper cell skewing, epitope spreading, dual T-cell receptors, posttranslational modification of luminal proteins by dysbiotic microbiota, and amplification by inflammatory cytokines. Studies suggest that probiotics influence systemic immune responses, ensure the homeostasis of the healthy microbiota in the intestinal mucosa, and therefore, could be used as adjuvant therapy to treat immune-mediated diseases. The mechanisms to achieve these effects include mucus secretion, antimicrobial peptide production, cross-feeding other resident microbes, production of organic acids and enzymes, gastrointestinal epithelial barrier maintenance, decreasing oxidative stress, competition with pathogens, and finally, modulation of the host immunity. Here, we described several reports concerning dysbiosis and probiotic applications in animal models of autoimmune diseases, human studies, and clinical trials concerning the applicability of probiotics in autoimmune diabetes, autoimmune thyroid diseases, rheumatoid arthritis, systemic lupus erythematosus, and Sjögren syndrome.Microbiology Program Institute of Biosciences Humanities and Exact Sciences (IBILCE) São Paulo State University (UNESP)Department of Pediatrics Hospital from School of Medicine from Botucatu (HCFMB) São Paulo State University (UNESP)Department of Food Engineering and Technology Institute of Biosciences Humanities and Exact Sciences São Paulo State University (UNESP)Microbiology Program Institute of Biosciences Humanities and Exact Sciences (IBILCE) São Paulo State University (UNESP)Department of Pediatrics Hospital from School of Medicine from Botucatu (HCFMB) São Paulo State University (UNESP)Department of Food Engineering and Technology Institute of Biosciences Humanities and Exact Sciences São Paulo State University (UNESP)Universidade Estadual Paulista (UNESP)Salis, Larissa Vedovato Vilela de [UNESP]Martins, Luísa Sales [UNESP]Rodrigues, Guilherme Siqueira Pardo [UNESP]Oliveira, Gislane Lelis Vilela de [UNESP]2023-03-01T20:38:53Z2023-03-01T20:38:53Z2022-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/bookPart269-294http://dx.doi.org/10.1016/B978-0-12-824390-9.00004-9Translational Autoimmunity: Treatment of Autoimmune Diseases, p. 269-294.http://hdl.handle.net/11449/24092710.1016/B978-0-12-824390-9.00004-92-s2.0-85129382234Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengTranslational Autoimmunity: Treatment of Autoimmune Diseasesinfo:eu-repo/semantics/openAccess2024-09-03T13:47:05Zoai:repositorio.unesp.br:11449/240927Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-03T13:47:05Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Dysbiosis and probiotic applications in autoimmune diseases |
title |
Dysbiosis and probiotic applications in autoimmune diseases |
spellingShingle |
Dysbiosis and probiotic applications in autoimmune diseases Salis, Larissa Vedovato Vilela de [UNESP] Autoimmunity Dysbiosis Inflammation Microbiota Probiotics |
title_short |
Dysbiosis and probiotic applications in autoimmune diseases |
title_full |
Dysbiosis and probiotic applications in autoimmune diseases |
title_fullStr |
Dysbiosis and probiotic applications in autoimmune diseases |
title_full_unstemmed |
Dysbiosis and probiotic applications in autoimmune diseases |
title_sort |
Dysbiosis and probiotic applications in autoimmune diseases |
author |
Salis, Larissa Vedovato Vilela de [UNESP] |
author_facet |
Salis, Larissa Vedovato Vilela de [UNESP] Martins, Luísa Sales [UNESP] Rodrigues, Guilherme Siqueira Pardo [UNESP] Oliveira, Gislane Lelis Vilela de [UNESP] |
author_role |
author |
author2 |
Martins, Luísa Sales [UNESP] Rodrigues, Guilherme Siqueira Pardo [UNESP] Oliveira, Gislane Lelis Vilela de [UNESP] |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) |
dc.contributor.author.fl_str_mv |
Salis, Larissa Vedovato Vilela de [UNESP] Martins, Luísa Sales [UNESP] Rodrigues, Guilherme Siqueira Pardo [UNESP] Oliveira, Gislane Lelis Vilela de [UNESP] |
dc.subject.por.fl_str_mv |
Autoimmunity Dysbiosis Inflammation Microbiota Probiotics |
topic |
Autoimmunity Dysbiosis Inflammation Microbiota Probiotics |
description |
Several evidence in animal models and humans pointed to the involvement of oral and intestinal dysbiosis in the development of autoimmune diseases. Dysbiosis is associated with decreased bacterial function and diversity, as well as decreased beneficial microbes, increased pathobionts, impaired barrier function, bacterial translocation, systemic inflammation, and decreased immune regulatory mechanisms in the gut mucosa. The mechanisms proposed to link dysbiosis with autoimmune diseases include molecular mimicry, bystander T-cell activation, T helper cell skewing, epitope spreading, dual T-cell receptors, posttranslational modification of luminal proteins by dysbiotic microbiota, and amplification by inflammatory cytokines. Studies suggest that probiotics influence systemic immune responses, ensure the homeostasis of the healthy microbiota in the intestinal mucosa, and therefore, could be used as adjuvant therapy to treat immune-mediated diseases. The mechanisms to achieve these effects include mucus secretion, antimicrobial peptide production, cross-feeding other resident microbes, production of organic acids and enzymes, gastrointestinal epithelial barrier maintenance, decreasing oxidative stress, competition with pathogens, and finally, modulation of the host immunity. Here, we described several reports concerning dysbiosis and probiotic applications in animal models of autoimmune diseases, human studies, and clinical trials concerning the applicability of probiotics in autoimmune diabetes, autoimmune thyroid diseases, rheumatoid arthritis, systemic lupus erythematosus, and Sjögren syndrome. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-01-01 2023-03-01T20:38:53Z 2023-03-01T20:38:53Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/bookPart |
format |
bookPart |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/B978-0-12-824390-9.00004-9 Translational Autoimmunity: Treatment of Autoimmune Diseases, p. 269-294. http://hdl.handle.net/11449/240927 10.1016/B978-0-12-824390-9.00004-9 2-s2.0-85129382234 |
url |
http://dx.doi.org/10.1016/B978-0-12-824390-9.00004-9 http://hdl.handle.net/11449/240927 |
identifier_str_mv |
Translational Autoimmunity: Treatment of Autoimmune Diseases, p. 269-294. 10.1016/B978-0-12-824390-9.00004-9 2-s2.0-85129382234 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Translational Autoimmunity: Treatment of Autoimmune Diseases |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
269-294 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
repositoriounesp@unesp.br |
_version_ |
1810021367385423872 |