A systematic literature review on the European, African and Amerindian genetic ancestry components on Brazilian health outcomes
Autor(a) principal: | |
---|---|
Data de Publicação: | 2019 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1038/s41598-019-45081-7 http://hdl.handle.net/11449/189301 |
Resumo: | The variables such as race, skin colour and ethnicity have become intensely discussed in medicine research, as a response to the rising debate over the importance of the ethnic-racial dimension in the scope of health-disease processes. The aim of this study was to identify the European (EUR), African (AFR) and Amerindian (AMR) ancestries on Brazilian health outcomes through a systematic literature review. This study was carried out by searching in three electronic databases, for studies published between 2005 and 2017. A total of 13 papers were eligible. The search identified the following health outcomes: visceral leishmaniosis, malaria, Alzheimer’s disease, neuromyelitis optica, multiple sclerosis, prostate cancer, non-syndromic cleft lip/palate, chronic heart failure, sickle cell disease, primary congenital glaucoma, preterm labour, preterm premature rupture of membranes, systemic lupus erythematosus and type 1 diabetes mellitus. Research paper assessments were guided by the STROBE instrument, and agreements between results were determined by comparing the points attributed by two authors. Increased EUR ancestry was identified from preterm labour (PTL), type 1 diabetes (T1D) and non-syndromic cleft lip with or without cleft palate (NSCL), as well as in patients presenting aggressive prostate cancer prognoses. On the other hand, the highest AFR ancestral component was verified from systemic lupus erythematosus (SLE) and primary congenital glaucoma (PCG) cases, presenting worse prognoses. AMR ancestry may be a protective factor in the development of Alzheimer’s disease (AD). The worst hemodynamic parameters in cases of heart failure (HF) were identified among individuals with greater AMR and AFR ancestry indices. |
id |
UNSP_ba74a1c8e5af3cb2289a7dfbeab76f11 |
---|---|
oai_identifier_str |
oai:repositorio.unesp.br:11449/189301 |
network_acronym_str |
UNSP |
network_name_str |
Repositório Institucional da UNESP |
repository_id_str |
2946 |
spelling |
A systematic literature review on the European, African and Amerindian genetic ancestry components on Brazilian health outcomesThe variables such as race, skin colour and ethnicity have become intensely discussed in medicine research, as a response to the rising debate over the importance of the ethnic-racial dimension in the scope of health-disease processes. The aim of this study was to identify the European (EUR), African (AFR) and Amerindian (AMR) ancestries on Brazilian health outcomes through a systematic literature review. This study was carried out by searching in three electronic databases, for studies published between 2005 and 2017. A total of 13 papers were eligible. The search identified the following health outcomes: visceral leishmaniosis, malaria, Alzheimer’s disease, neuromyelitis optica, multiple sclerosis, prostate cancer, non-syndromic cleft lip/palate, chronic heart failure, sickle cell disease, primary congenital glaucoma, preterm labour, preterm premature rupture of membranes, systemic lupus erythematosus and type 1 diabetes mellitus. Research paper assessments were guided by the STROBE instrument, and agreements between results were determined by comparing the points attributed by two authors. Increased EUR ancestry was identified from preterm labour (PTL), type 1 diabetes (T1D) and non-syndromic cleft lip with or without cleft palate (NSCL), as well as in patients presenting aggressive prostate cancer prognoses. On the other hand, the highest AFR ancestral component was verified from systemic lupus erythematosus (SLE) and primary congenital glaucoma (PCG) cases, presenting worse prognoses. AMR ancestry may be a protective factor in the development of Alzheimer’s disease (AD). The worst hemodynamic parameters in cases of heart failure (HF) were identified among individuals with greater AMR and AFR ancestry indices.Department of Neurology Graduate Program in Neurology (PPGNEURO) – Universidade Federal do Estado do Rio de Janeiro UNIRIOResearch Center for Population and Public Policies Studies Rio de Janeiro Brazil. Oswaldo Cruz FoundationDepartamento de Neurologia Psicologia e Psiquiatria Faculdade de Medicina de Botucatu Universidade Estadual Paulista -UNESPDepartment of Genetics and Molecular Biology UNIRIOGraduate Program in Molecular and Cell Biology (PPGBMC). UNIRIODepartamento de Neurologia Psicologia e Psiquiatria Faculdade de Medicina de Botucatu Universidade Estadual Paulista -UNESPUNIRIOBrazil. Oswaldo Cruz FoundationUniversidade Estadual Paulista (Unesp)Graduate Program in Molecular and Cell Biology (PPGBMC). UNIRIOPereira, Fabiana dos Santos Carolino FirmoGuimarães, Raphael MendonçaLucidi, Alexandre RamosBrum, Doralina Guimarães [UNESP]Paiva, Carmen Lucia AntãoAlvarenga, Regina Maria Papais2019-10-06T16:36:18Z2019-10-06T16:36:18Z2019-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1038/s41598-019-45081-7Scientific Reports, v. 9, n. 1, 2019.2045-2322http://hdl.handle.net/11449/18930110.1038/s41598-019-45081-72-s2.0-85067642124Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengScientific Reportsinfo:eu-repo/semantics/openAccess2024-08-16T15:45:52Zoai:repositorio.unesp.br:11449/189301Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-16T15:45:52Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
A systematic literature review on the European, African and Amerindian genetic ancestry components on Brazilian health outcomes |
title |
A systematic literature review on the European, African and Amerindian genetic ancestry components on Brazilian health outcomes |
spellingShingle |
A systematic literature review on the European, African and Amerindian genetic ancestry components on Brazilian health outcomes Pereira, Fabiana dos Santos Carolino Firmo |
title_short |
A systematic literature review on the European, African and Amerindian genetic ancestry components on Brazilian health outcomes |
title_full |
A systematic literature review on the European, African and Amerindian genetic ancestry components on Brazilian health outcomes |
title_fullStr |
A systematic literature review on the European, African and Amerindian genetic ancestry components on Brazilian health outcomes |
title_full_unstemmed |
A systematic literature review on the European, African and Amerindian genetic ancestry components on Brazilian health outcomes |
title_sort |
A systematic literature review on the European, African and Amerindian genetic ancestry components on Brazilian health outcomes |
author |
Pereira, Fabiana dos Santos Carolino Firmo |
author_facet |
Pereira, Fabiana dos Santos Carolino Firmo Guimarães, Raphael Mendonça Lucidi, Alexandre Ramos Brum, Doralina Guimarães [UNESP] Paiva, Carmen Lucia Antão Alvarenga, Regina Maria Papais |
author_role |
author |
author2 |
Guimarães, Raphael Mendonça Lucidi, Alexandre Ramos Brum, Doralina Guimarães [UNESP] Paiva, Carmen Lucia Antão Alvarenga, Regina Maria Papais |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
UNIRIO Brazil. Oswaldo Cruz Foundation Universidade Estadual Paulista (Unesp) Graduate Program in Molecular and Cell Biology (PPGBMC). UNIRIO |
dc.contributor.author.fl_str_mv |
Pereira, Fabiana dos Santos Carolino Firmo Guimarães, Raphael Mendonça Lucidi, Alexandre Ramos Brum, Doralina Guimarães [UNESP] Paiva, Carmen Lucia Antão Alvarenga, Regina Maria Papais |
description |
The variables such as race, skin colour and ethnicity have become intensely discussed in medicine research, as a response to the rising debate over the importance of the ethnic-racial dimension in the scope of health-disease processes. The aim of this study was to identify the European (EUR), African (AFR) and Amerindian (AMR) ancestries on Brazilian health outcomes through a systematic literature review. This study was carried out by searching in three electronic databases, for studies published between 2005 and 2017. A total of 13 papers were eligible. The search identified the following health outcomes: visceral leishmaniosis, malaria, Alzheimer’s disease, neuromyelitis optica, multiple sclerosis, prostate cancer, non-syndromic cleft lip/palate, chronic heart failure, sickle cell disease, primary congenital glaucoma, preterm labour, preterm premature rupture of membranes, systemic lupus erythematosus and type 1 diabetes mellitus. Research paper assessments were guided by the STROBE instrument, and agreements between results were determined by comparing the points attributed by two authors. Increased EUR ancestry was identified from preterm labour (PTL), type 1 diabetes (T1D) and non-syndromic cleft lip with or without cleft palate (NSCL), as well as in patients presenting aggressive prostate cancer prognoses. On the other hand, the highest AFR ancestral component was verified from systemic lupus erythematosus (SLE) and primary congenital glaucoma (PCG) cases, presenting worse prognoses. AMR ancestry may be a protective factor in the development of Alzheimer’s disease (AD). The worst hemodynamic parameters in cases of heart failure (HF) were identified among individuals with greater AMR and AFR ancestry indices. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-10-06T16:36:18Z 2019-10-06T16:36:18Z 2019-12-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1038/s41598-019-45081-7 Scientific Reports, v. 9, n. 1, 2019. 2045-2322 http://hdl.handle.net/11449/189301 10.1038/s41598-019-45081-7 2-s2.0-85067642124 |
url |
http://dx.doi.org/10.1038/s41598-019-45081-7 http://hdl.handle.net/11449/189301 |
identifier_str_mv |
Scientific Reports, v. 9, n. 1, 2019. 2045-2322 10.1038/s41598-019-45081-7 2-s2.0-85067642124 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Scientific Reports |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128161284620288 |