Avaliação da resposta tecidual à dispersão de nanoparticula de prata

• Autor(a) principal: Silva, Fernando Oliveira [UNESP]
• Data de Publicação: 2011
• Tipo de documento: Trabalho de conclusão de curso
• Idioma: por
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://hdl.handle.net/11449/149397; http://www.athena.biblioteca.unesp.br/exlibris/bd/capelo/2017-01-26/000846228.pdf
• topic: Biocompatibilidade; Nanopartículas; Irrigantes do canal radicular; Nanoparticles

Nanomaterials have been used to create new consumer products as well as applications for life sciences and biotechnology. The aim of this study was to evaluate the tissue response to implanted polyethylene tubes filled with fibrin sponge embedded with silver nanoparticles dispersion. Methods: Thirty rats received individually four polyethylene tubes, filled with sponge embedded in 47ppm, 23ppm silver nanoparticles dispersion, 2.5% sodium hypochlorite or with no embedding as control. The observation periods were 7, 15, 30, 60 e 90 days. After each period of time, six animals were killed and the tubes and surrounding tissue removed, fixed and prepared to be analyzed in light microscope with glycol methacrylate embedding, 3 m serial cutting and HE stain. Qualitative and quantitative evaluations of the reaction were performed. Results: Both materials caused moderate reactions at 7 days. The response was similar to the control on the 15th day with 23ppm silver nanoparticles dispersion and 2.5% sodium hypochlorite and on the 30th day with 47ppm silver nanoparticles dispersion. Conclusions: It was possible to conclude that silver nanoparticles dispersion was biocompatible especially in a lower concentration