Resposta tecidual a tubos de dentina irrigados com nanopartícula de prata na concentração de 23ppm ou hipoclorito de sódio a 2,5%

• Autor(a) principal: Melo, Fernanda Fragoso Ferreira de [UNESP]
• Data de Publicação: 2011
• Tipo de documento: Trabalho de conclusão de curso
• Idioma: por
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://hdl.handle.net/11449/149395; http://www.athena.biblioteca.unesp.br/exlibris/bd/capelo/2017-01-26/000846042.pdf
• topic: Biocompatibilidade; Nanopartículas; Hipoclorito de sódio; Nanoparticles

The aim of this study was to evaluate the tissue response to implanted dentine tubes irrigated with silver nanoparticles dispersion or 2.5% sodium hyppochlorite. Thirty rats will individually received two dentine tubes irrigated with 23ppm silver nanoparticles dispersion, 2.5% sodium hypochlorite or saline as controle. The observation periods were 7 and 30 days. After each period of time, fifteen animals were killed and the tubes and surrounding tissue removed, fixed and prepared to be analyzed in light microscope with glycol methacrylate embedding, 3 m serial cutting and HE staining. Scores were defined as follows: 0, none or few inflammatory cells, no reaction; 1, <25 cells, mild reaction; 2, 25 to 125 cells, moderate reaction; 3, >125 cells, severe reaction. Fibrous capsule was categorized as thin when thickness was < 150 μm and thick at > 150 μm. Necrosis and formation of calcification were recorded. The data were statistically analyzed using Kruskal Wallis test. All groups showed a thin fibrous capsule and mild inflammatory infiltrate specially on the 30th day. This study concluded that the dispersion of silver nanoparticles was biocompatible when compared with sodium hypochlorite solution, but further studies are needed to better analyze the properties of this material and confirm the data observed