Development and in vitro evaluation of lyotropic liquid crystals for the controlled release of dexamethasone
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.3390/polym9080330 http://hdl.handle.net/11449/179072 |
Resumo: | In this study, amphiphilic polymers were investigated as biomaterials that can control dexamethasone (DXM) release. Such materials present interfacial properties in the presence of water and an oily phase that can result in lyotropic liquid crystalline systems (LLCS). In addition, they can form colloidal nanostructures similar to those in living organisms, such as bilayers and hexagonal and cubic phases, which can be exploited to solubilize lipophilic drugs to sustain their release and enhance bioavailability. It was possible to obtain lamellar and hexagonal phases when combining polyoxyethylene (20) cetyl ether (CETETH-20) polymer with oleic acid (OA), N-methylpyrrolidone (P), isopropyl myristate (IM), and water. The phases were characterized by polarized light microscopy (PLM), small-angle X-ray scattering (SAXS), rheological, textural, and bioadhesion analyses followed by an in vitro release assay. All samples showed elastic behavior in the rheology studies and hexagonal samples containing P and IM showed the highest adhesiveness. The drug release profile of all LLCS presented an average lag time of 3 h and was best fitted to the Korsmeyer-Peppas and Weibull models, with controlled release governed by a combination of diffusion and erosion mechanisms. These systems are potential carriers for DXM and can be explored in several routes of administration, providing potential advantages over conventional pharmaceutical forms. |
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Development and in vitro evaluation of lyotropic liquid crystals for the controlled release of dexamethasoneAmphiphilic polymersControlled releaseDexamethasoneDrug releaseKinetic modelLyotropic liquid crystalsNanostructured systemsIn this study, amphiphilic polymers were investigated as biomaterials that can control dexamethasone (DXM) release. Such materials present interfacial properties in the presence of water and an oily phase that can result in lyotropic liquid crystalline systems (LLCS). In addition, they can form colloidal nanostructures similar to those in living organisms, such as bilayers and hexagonal and cubic phases, which can be exploited to solubilize lipophilic drugs to sustain their release and enhance bioavailability. It was possible to obtain lamellar and hexagonal phases when combining polyoxyethylene (20) cetyl ether (CETETH-20) polymer with oleic acid (OA), N-methylpyrrolidone (P), isopropyl myristate (IM), and water. The phases were characterized by polarized light microscopy (PLM), small-angle X-ray scattering (SAXS), rheological, textural, and bioadhesion analyses followed by an in vitro release assay. All samples showed elastic behavior in the rheology studies and hexagonal samples containing P and IM showed the highest adhesiveness. The drug release profile of all LLCS presented an average lag time of 3 h and was best fitted to the Korsmeyer-Peppas and Weibull models, with controlled release governed by a combination of diffusion and erosion mechanisms. These systems are potential carriers for DXM and can be explored in several routes of administration, providing potential advantages over conventional pharmaceutical forms.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)School of Pharmaceutical Sciences São Paulo State University (UNESP)School of Pharmaceutical Sciences Federal University of Alfenas UNIFAL-MGHuman and Natural Sciences Center Federal University of ABCInstituto Interuniversitario Reconocimiento Molecular y Desarrollo Tecnológico Departamento de Farmacia y Tecnología Farmacéutica y Parasitología Universidad de ValenciaSchool of Pharmaceutical Sciences São Paulo State University (UNESP)CAPES: #1241/2014Universidade Estadual Paulista (Unesp)UNIFAL-MGFederal University of ABCUniversidad de ValenciaOyafuso, Márcia H. [UNESP]Carvalho, Flávia C.Takeshita, Tatiane M. [UNESP]de Souza, Ana L. Ribeiro [UNESP]Araújo, Daniele R.Merino, VirginiaGremião, Maria Palmira D. [UNESP]Chorilli, Marlus [UNESP]2018-12-11T17:33:26Z2018-12-11T17:33:26Z2017-08-02info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://dx.doi.org/10.3390/polym9080330Polymers, v. 9, n. 8, 2017.2073-4360http://hdl.handle.net/11449/17907210.3390/polym90803302-s2.0-850267437272-s2.0-85026743727.pdf1427125996716282Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengPolymers0,852info:eu-repo/semantics/openAccess2024-06-24T13:45:03Zoai:repositorio.unesp.br:11449/179072Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T14:35:01.147873Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Development and in vitro evaluation of lyotropic liquid crystals for the controlled release of dexamethasone |
title |
Development and in vitro evaluation of lyotropic liquid crystals for the controlled release of dexamethasone |
spellingShingle |
Development and in vitro evaluation of lyotropic liquid crystals for the controlled release of dexamethasone Oyafuso, Márcia H. [UNESP] Amphiphilic polymers Controlled release Dexamethasone Drug release Kinetic model Lyotropic liquid crystals Nanostructured systems |
title_short |
Development and in vitro evaluation of lyotropic liquid crystals for the controlled release of dexamethasone |
title_full |
Development and in vitro evaluation of lyotropic liquid crystals for the controlled release of dexamethasone |
title_fullStr |
Development and in vitro evaluation of lyotropic liquid crystals for the controlled release of dexamethasone |
title_full_unstemmed |
Development and in vitro evaluation of lyotropic liquid crystals for the controlled release of dexamethasone |
title_sort |
Development and in vitro evaluation of lyotropic liquid crystals for the controlled release of dexamethasone |
author |
Oyafuso, Márcia H. [UNESP] |
author_facet |
Oyafuso, Márcia H. [UNESP] Carvalho, Flávia C. Takeshita, Tatiane M. [UNESP] de Souza, Ana L. Ribeiro [UNESP] Araújo, Daniele R. Merino, Virginia Gremião, Maria Palmira D. [UNESP] Chorilli, Marlus [UNESP] |
author_role |
author |
author2 |
Carvalho, Flávia C. Takeshita, Tatiane M. [UNESP] de Souza, Ana L. Ribeiro [UNESP] Araújo, Daniele R. Merino, Virginia Gremião, Maria Palmira D. [UNESP] Chorilli, Marlus [UNESP] |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) UNIFAL-MG Federal University of ABC Universidad de Valencia |
dc.contributor.author.fl_str_mv |
Oyafuso, Márcia H. [UNESP] Carvalho, Flávia C. Takeshita, Tatiane M. [UNESP] de Souza, Ana L. Ribeiro [UNESP] Araújo, Daniele R. Merino, Virginia Gremião, Maria Palmira D. [UNESP] Chorilli, Marlus [UNESP] |
dc.subject.por.fl_str_mv |
Amphiphilic polymers Controlled release Dexamethasone Drug release Kinetic model Lyotropic liquid crystals Nanostructured systems |
topic |
Amphiphilic polymers Controlled release Dexamethasone Drug release Kinetic model Lyotropic liquid crystals Nanostructured systems |
description |
In this study, amphiphilic polymers were investigated as biomaterials that can control dexamethasone (DXM) release. Such materials present interfacial properties in the presence of water and an oily phase that can result in lyotropic liquid crystalline systems (LLCS). In addition, they can form colloidal nanostructures similar to those in living organisms, such as bilayers and hexagonal and cubic phases, which can be exploited to solubilize lipophilic drugs to sustain their release and enhance bioavailability. It was possible to obtain lamellar and hexagonal phases when combining polyoxyethylene (20) cetyl ether (CETETH-20) polymer with oleic acid (OA), N-methylpyrrolidone (P), isopropyl myristate (IM), and water. The phases were characterized by polarized light microscopy (PLM), small-angle X-ray scattering (SAXS), rheological, textural, and bioadhesion analyses followed by an in vitro release assay. All samples showed elastic behavior in the rheology studies and hexagonal samples containing P and IM showed the highest adhesiveness. The drug release profile of all LLCS presented an average lag time of 3 h and was best fitted to the Korsmeyer-Peppas and Weibull models, with controlled release governed by a combination of diffusion and erosion mechanisms. These systems are potential carriers for DXM and can be explored in several routes of administration, providing potential advantages over conventional pharmaceutical forms. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-08-02 2018-12-11T17:33:26Z 2018-12-11T17:33:26Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.3390/polym9080330 Polymers, v. 9, n. 8, 2017. 2073-4360 http://hdl.handle.net/11449/179072 10.3390/polym9080330 2-s2.0-85026743727 2-s2.0-85026743727.pdf 1427125996716282 |
url |
http://dx.doi.org/10.3390/polym9080330 http://hdl.handle.net/11449/179072 |
identifier_str_mv |
Polymers, v. 9, n. 8, 2017. 2073-4360 10.3390/polym9080330 2-s2.0-85026743727 2-s2.0-85026743727.pdf 1427125996716282 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Polymers 0,852 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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1808128383245090816 |