Exploration of avocado by-products as natural sources of bioactive compounds
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1371/journal.pone.0192577 http://hdl.handle.net/11449/160094 |
Resumo: | This study aimed to evaluate the antioxidant, anti-inflammatory, and cytotoxic properties and phenolic composition of peel and seed of avocado varieties Hass and Fuerte using green solvents. Ethanol soluble compounds were identified in peel and seed of both varieties using HPLC-MS/MS and quantified using HPLC-DAD. Agro-industrial by-products of both varieties exhibited high radical scavenging activity against synthetic free radicals (DPPH and ABTS) and reactive oxygen species (peroxyl, superoxide, and hypochlorous acid) and high ability to reduce Fe3+ to Fe2+. The main compounds with significant contribution to the antioxidant activity determined by online HPLC-ABTS(center dot+) analyses were procyanidin B-2 and epicatechin in the peel and trans-5-O-caffeoyl-D-quinic acid, procyanidin B-1, catechin, and epicatechin in the seed. Peel of Fuerte significantly suppressed TNF-alpha and nitric oxide (NO) release (459.3 pg/mL and 8.5 mu M, respectively), possibly because of the high phenolic content and antioxidant activity detected. Avocado agro-industrial by-products can be used for food and pharmaceutical purposes due to their antioxidant and anti-inflammatory properties. |
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Repositório Institucional da UNESP |
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spelling |
Exploration of avocado by-products as natural sources of bioactive compoundsThis study aimed to evaluate the antioxidant, anti-inflammatory, and cytotoxic properties and phenolic composition of peel and seed of avocado varieties Hass and Fuerte using green solvents. Ethanol soluble compounds were identified in peel and seed of both varieties using HPLC-MS/MS and quantified using HPLC-DAD. Agro-industrial by-products of both varieties exhibited high radical scavenging activity against synthetic free radicals (DPPH and ABTS) and reactive oxygen species (peroxyl, superoxide, and hypochlorous acid) and high ability to reduce Fe3+ to Fe2+. The main compounds with significant contribution to the antioxidant activity determined by online HPLC-ABTS(center dot+) analyses were procyanidin B-2 and epicatechin in the peel and trans-5-O-caffeoyl-D-quinic acid, procyanidin B-1, catechin, and epicatechin in the seed. Peel of Fuerte significantly suppressed TNF-alpha and nitric oxide (NO) release (459.3 pg/mL and 8.5 mu M, respectively), possibly because of the high phenolic content and antioxidant activity detected. Avocado agro-industrial by-products can be used for food and pharmaceutical purposes due to their antioxidant and anti-inflammatory properties.Fundacao do Amparo a Pesquisa do Estado de Sao PauloUniv Sao Paulo, Dept Agrifood Ind Food & Nutr, Luiz de Queiroz Coll Agr, Piracicaba, SP, BrazilUniv Estadual Campinas, Piracicaba Dent Sch, Dept Physiol Sci, Piracicaba, SP, BrazilState Univ Paulista Julio de Mesquita Filho, Sch Agr Sci, Rua Jose Barbosa de Barros, Botucatu, SP, BrazilUniv Sao Paulo, Sch Pharmaceut Sci Ribeirao Preto, Dept Phys & Chem, Vila Monte Alegre, Ribeirao Preto, SP, BrazilState Univ Paulista Julio de Mesquita Filho, Sch Agr Sci, Rua Jose Barbosa de Barros, Botucatu, SP, BrazilFundacao do Amparo a Pesquisa do Estado de Sao Paulo: 2010/52671-8Public Library ScienceUniversidade de São Paulo (USP)Universidade Estadual de Campinas (UNICAMP)Universidade Estadual Paulista (Unesp)Tremocoldi, Maria AugustaRosalen, Pedro LuizFranchin, MarceloMassarioli, Adna PradoDenny, CarinaDaiuto, Erica Regina [UNESP]Rizzato Paschoal, Jonas AugustoMelo, Priscilla SiqueiraAlencar, Severino Matias de2018-11-26T15:47:27Z2018-11-26T15:47:27Z2018-02-14info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article12application/pdfhttp://dx.doi.org/10.1371/journal.pone.0192577Plos One. San Francisco: Public Library Science, v. 13, n. 2, 12 p., 2018.1932-6203http://hdl.handle.net/11449/16009410.1371/journal.pone.0192577WOS:000425183500074WOS000425183500074.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengPlos One1,164info:eu-repo/semantics/openAccess2023-12-26T06:16:07Zoai:repositorio.unesp.br:11449/160094Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T21:19:41.575748Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Exploration of avocado by-products as natural sources of bioactive compounds |
title |
Exploration of avocado by-products as natural sources of bioactive compounds |
spellingShingle |
Exploration of avocado by-products as natural sources of bioactive compounds Tremocoldi, Maria Augusta |
title_short |
Exploration of avocado by-products as natural sources of bioactive compounds |
title_full |
Exploration of avocado by-products as natural sources of bioactive compounds |
title_fullStr |
Exploration of avocado by-products as natural sources of bioactive compounds |
title_full_unstemmed |
Exploration of avocado by-products as natural sources of bioactive compounds |
title_sort |
Exploration of avocado by-products as natural sources of bioactive compounds |
author |
Tremocoldi, Maria Augusta |
author_facet |
Tremocoldi, Maria Augusta Rosalen, Pedro Luiz Franchin, Marcelo Massarioli, Adna Prado Denny, Carina Daiuto, Erica Regina [UNESP] Rizzato Paschoal, Jonas Augusto Melo, Priscilla Siqueira Alencar, Severino Matias de |
author_role |
author |
author2 |
Rosalen, Pedro Luiz Franchin, Marcelo Massarioli, Adna Prado Denny, Carina Daiuto, Erica Regina [UNESP] Rizzato Paschoal, Jonas Augusto Melo, Priscilla Siqueira Alencar, Severino Matias de |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade de São Paulo (USP) Universidade Estadual de Campinas (UNICAMP) Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Tremocoldi, Maria Augusta Rosalen, Pedro Luiz Franchin, Marcelo Massarioli, Adna Prado Denny, Carina Daiuto, Erica Regina [UNESP] Rizzato Paschoal, Jonas Augusto Melo, Priscilla Siqueira Alencar, Severino Matias de |
description |
This study aimed to evaluate the antioxidant, anti-inflammatory, and cytotoxic properties and phenolic composition of peel and seed of avocado varieties Hass and Fuerte using green solvents. Ethanol soluble compounds were identified in peel and seed of both varieties using HPLC-MS/MS and quantified using HPLC-DAD. Agro-industrial by-products of both varieties exhibited high radical scavenging activity against synthetic free radicals (DPPH and ABTS) and reactive oxygen species (peroxyl, superoxide, and hypochlorous acid) and high ability to reduce Fe3+ to Fe2+. The main compounds with significant contribution to the antioxidant activity determined by online HPLC-ABTS(center dot+) analyses were procyanidin B-2 and epicatechin in the peel and trans-5-O-caffeoyl-D-quinic acid, procyanidin B-1, catechin, and epicatechin in the seed. Peel of Fuerte significantly suppressed TNF-alpha and nitric oxide (NO) release (459.3 pg/mL and 8.5 mu M, respectively), possibly because of the high phenolic content and antioxidant activity detected. Avocado agro-industrial by-products can be used for food and pharmaceutical purposes due to their antioxidant and anti-inflammatory properties. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-11-26T15:47:27Z 2018-11-26T15:47:27Z 2018-02-14 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1371/journal.pone.0192577 Plos One. San Francisco: Public Library Science, v. 13, n. 2, 12 p., 2018. 1932-6203 http://hdl.handle.net/11449/160094 10.1371/journal.pone.0192577 WOS:000425183500074 WOS000425183500074.pdf |
url |
http://dx.doi.org/10.1371/journal.pone.0192577 http://hdl.handle.net/11449/160094 |
identifier_str_mv |
Plos One. San Francisco: Public Library Science, v. 13, n. 2, 12 p., 2018. 1932-6203 10.1371/journal.pone.0192577 WOS:000425183500074 WOS000425183500074.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Plos One 1,164 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
12 application/pdf |
dc.publisher.none.fl_str_mv |
Public Library Science |
publisher.none.fl_str_mv |
Public Library Science |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1808129309524623360 |