Role of the lateral preoptic area in cardiovascular and neuroendocrine responses to acute restraint stress in rats

Detalhes bibliográficos
Autor(a) principal: Duarte, Josiane O. [UNESP]
Data de Publicação: 2017
Outros Autores: Gomes, Karina S. [UNESP], Nunes-de-Souza, Ricardo L. [UNESP], Crestani, Carlos C. [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1016/j.physbeh.2017.03.030
http://hdl.handle.net/11449/169569
Resumo: The lateral preoptic area (LPO) is connected with limbic structures involved in physiological and behavioral responses to stress. Accordingly, exposure to stressors stimuli activates neurons within the LPO. In spite of these evidence, an involvement of the LPO on cardiovascular and neuroendocrine adjustments during aversive threats has not yet been investigated. Therefore, in the present study we tested the hypothesis that the LPO is involved in the control of cardiovascular and neuroendocrine responses to acute restraint stress in rats. Bilateral microinjection of the nonselective synaptic blocker CoCl2 (0.1 nmol/100 nl) into the LPO did not affect basal values of either arterial pressure, heart rate, tail skin temperature, or plasma corticosterone concentration. However, LPO treatment with CoCl2 enhanced the tachycardiac response and the increase in plasma corticosterone concentration caused by restraint stress. Conversely, LPO synaptic blockade decreased restraint-evoked pressor response. Sympathetic-mediated cutaneous vasoconstriction during restraint stress was not affected by LPO pharmacological treatment. These findings indicate an inhibitory influence of LPO on tachycardiac and plasma corticosterone responses evoked during aversive threats. Additionally, data suggest that LPO plays a facilitatory influence on stress-evoked pressor response.
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spelling Role of the lateral preoptic area in cardiovascular and neuroendocrine responses to acute restraint stress in ratsBlood pressureCorticosteroneHeart rateHPA axisHypothalamusLPOStressThe lateral preoptic area (LPO) is connected with limbic structures involved in physiological and behavioral responses to stress. Accordingly, exposure to stressors stimuli activates neurons within the LPO. In spite of these evidence, an involvement of the LPO on cardiovascular and neuroendocrine adjustments during aversive threats has not yet been investigated. Therefore, in the present study we tested the hypothesis that the LPO is involved in the control of cardiovascular and neuroendocrine responses to acute restraint stress in rats. Bilateral microinjection of the nonselective synaptic blocker CoCl2 (0.1 nmol/100 nl) into the LPO did not affect basal values of either arterial pressure, heart rate, tail skin temperature, or plasma corticosterone concentration. However, LPO treatment with CoCl2 enhanced the tachycardiac response and the increase in plasma corticosterone concentration caused by restraint stress. Conversely, LPO synaptic blockade decreased restraint-evoked pressor response. Sympathetic-mediated cutaneous vasoconstriction during restraint stress was not affected by LPO pharmacological treatment. These findings indicate an inhibitory influence of LPO on tachycardiac and plasma corticosterone responses evoked during aversive threats. Additionally, data suggest that LPO plays a facilitatory influence on stress-evoked pressor response.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Laboratory of Pharmacology São Paulo State University (UNESP) School of Pharmaceutical SciencesJoint UFSCar-UNESP Graduate Program in Physiological SciencesLaboratory of Pharmacology São Paulo State University (UNESP) School of Pharmaceutical SciencesJoint UFSCar-UNESP Graduate Program in Physiological SciencesFAPESP: 2012/14376-0FAPESP: 2012/50549-6FAPESP: 2015/05922-9Universidade Estadual Paulista (Unesp)Duarte, Josiane O. [UNESP]Gomes, Karina S. [UNESP]Nunes-de-Souza, Ricardo L. [UNESP]Crestani, Carlos C. [UNESP]2018-12-11T16:46:28Z2018-12-11T16:46:28Z2017-06-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article16-21application/pdfhttp://dx.doi.org/10.1016/j.physbeh.2017.03.030Physiology and Behavior, v. 175, p. 16-21.1873-507X0031-9384http://hdl.handle.net/11449/16956910.1016/j.physbeh.2017.03.0302-s2.0-850160646952-s2.0-85016064695.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengPhysiology and Behavior1,088info:eu-repo/semantics/openAccess2023-12-12T06:20:38Zoai:repositorio.unesp.br:11449/169569Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T20:08:53.408882Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Role of the lateral preoptic area in cardiovascular and neuroendocrine responses to acute restraint stress in rats
title Role of the lateral preoptic area in cardiovascular and neuroendocrine responses to acute restraint stress in rats
spellingShingle Role of the lateral preoptic area in cardiovascular and neuroendocrine responses to acute restraint stress in rats
Duarte, Josiane O. [UNESP]
Blood pressure
Corticosterone
Heart rate
HPA axis
Hypothalamus
LPO
Stress
title_short Role of the lateral preoptic area in cardiovascular and neuroendocrine responses to acute restraint stress in rats
title_full Role of the lateral preoptic area in cardiovascular and neuroendocrine responses to acute restraint stress in rats
title_fullStr Role of the lateral preoptic area in cardiovascular and neuroendocrine responses to acute restraint stress in rats
title_full_unstemmed Role of the lateral preoptic area in cardiovascular and neuroendocrine responses to acute restraint stress in rats
title_sort Role of the lateral preoptic area in cardiovascular and neuroendocrine responses to acute restraint stress in rats
author Duarte, Josiane O. [UNESP]
author_facet Duarte, Josiane O. [UNESP]
Gomes, Karina S. [UNESP]
Nunes-de-Souza, Ricardo L. [UNESP]
Crestani, Carlos C. [UNESP]
author_role author
author2 Gomes, Karina S. [UNESP]
Nunes-de-Souza, Ricardo L. [UNESP]
Crestani, Carlos C. [UNESP]
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Duarte, Josiane O. [UNESP]
Gomes, Karina S. [UNESP]
Nunes-de-Souza, Ricardo L. [UNESP]
Crestani, Carlos C. [UNESP]
dc.subject.por.fl_str_mv Blood pressure
Corticosterone
Heart rate
HPA axis
Hypothalamus
LPO
Stress
topic Blood pressure
Corticosterone
Heart rate
HPA axis
Hypothalamus
LPO
Stress
description The lateral preoptic area (LPO) is connected with limbic structures involved in physiological and behavioral responses to stress. Accordingly, exposure to stressors stimuli activates neurons within the LPO. In spite of these evidence, an involvement of the LPO on cardiovascular and neuroendocrine adjustments during aversive threats has not yet been investigated. Therefore, in the present study we tested the hypothesis that the LPO is involved in the control of cardiovascular and neuroendocrine responses to acute restraint stress in rats. Bilateral microinjection of the nonselective synaptic blocker CoCl2 (0.1 nmol/100 nl) into the LPO did not affect basal values of either arterial pressure, heart rate, tail skin temperature, or plasma corticosterone concentration. However, LPO treatment with CoCl2 enhanced the tachycardiac response and the increase in plasma corticosterone concentration caused by restraint stress. Conversely, LPO synaptic blockade decreased restraint-evoked pressor response. Sympathetic-mediated cutaneous vasoconstriction during restraint stress was not affected by LPO pharmacological treatment. These findings indicate an inhibitory influence of LPO on tachycardiac and plasma corticosterone responses evoked during aversive threats. Additionally, data suggest that LPO plays a facilitatory influence on stress-evoked pressor response.
publishDate 2017
dc.date.none.fl_str_mv 2017-06-01
2018-12-11T16:46:28Z
2018-12-11T16:46:28Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/j.physbeh.2017.03.030
Physiology and Behavior, v. 175, p. 16-21.
1873-507X
0031-9384
http://hdl.handle.net/11449/169569
10.1016/j.physbeh.2017.03.030
2-s2.0-85016064695
2-s2.0-85016064695.pdf
url http://dx.doi.org/10.1016/j.physbeh.2017.03.030
http://hdl.handle.net/11449/169569
identifier_str_mv Physiology and Behavior, v. 175, p. 16-21.
1873-507X
0031-9384
10.1016/j.physbeh.2017.03.030
2-s2.0-85016064695
2-s2.0-85016064695.pdf
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Physiology and Behavior
1,088
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 16-21
application/pdf
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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