Role of the lateral preoptic area in cardiovascular and neuroendocrine responses to acute restraint stress in rats
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.physbeh.2017.03.030 http://hdl.handle.net/11449/169569 |
Resumo: | The lateral preoptic area (LPO) is connected with limbic structures involved in physiological and behavioral responses to stress. Accordingly, exposure to stressors stimuli activates neurons within the LPO. In spite of these evidence, an involvement of the LPO on cardiovascular and neuroendocrine adjustments during aversive threats has not yet been investigated. Therefore, in the present study we tested the hypothesis that the LPO is involved in the control of cardiovascular and neuroendocrine responses to acute restraint stress in rats. Bilateral microinjection of the nonselective synaptic blocker CoCl2 (0.1 nmol/100 nl) into the LPO did not affect basal values of either arterial pressure, heart rate, tail skin temperature, or plasma corticosterone concentration. However, LPO treatment with CoCl2 enhanced the tachycardiac response and the increase in plasma corticosterone concentration caused by restraint stress. Conversely, LPO synaptic blockade decreased restraint-evoked pressor response. Sympathetic-mediated cutaneous vasoconstriction during restraint stress was not affected by LPO pharmacological treatment. These findings indicate an inhibitory influence of LPO on tachycardiac and plasma corticosterone responses evoked during aversive threats. Additionally, data suggest that LPO plays a facilitatory influence on stress-evoked pressor response. |
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Role of the lateral preoptic area in cardiovascular and neuroendocrine responses to acute restraint stress in ratsBlood pressureCorticosteroneHeart rateHPA axisHypothalamusLPOStressThe lateral preoptic area (LPO) is connected with limbic structures involved in physiological and behavioral responses to stress. Accordingly, exposure to stressors stimuli activates neurons within the LPO. In spite of these evidence, an involvement of the LPO on cardiovascular and neuroendocrine adjustments during aversive threats has not yet been investigated. Therefore, in the present study we tested the hypothesis that the LPO is involved in the control of cardiovascular and neuroendocrine responses to acute restraint stress in rats. Bilateral microinjection of the nonselective synaptic blocker CoCl2 (0.1 nmol/100 nl) into the LPO did not affect basal values of either arterial pressure, heart rate, tail skin temperature, or plasma corticosterone concentration. However, LPO treatment with CoCl2 enhanced the tachycardiac response and the increase in plasma corticosterone concentration caused by restraint stress. Conversely, LPO synaptic blockade decreased restraint-evoked pressor response. Sympathetic-mediated cutaneous vasoconstriction during restraint stress was not affected by LPO pharmacological treatment. These findings indicate an inhibitory influence of LPO on tachycardiac and plasma corticosterone responses evoked during aversive threats. Additionally, data suggest that LPO plays a facilitatory influence on stress-evoked pressor response.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Laboratory of Pharmacology São Paulo State University (UNESP) School of Pharmaceutical SciencesJoint UFSCar-UNESP Graduate Program in Physiological SciencesLaboratory of Pharmacology São Paulo State University (UNESP) School of Pharmaceutical SciencesJoint UFSCar-UNESP Graduate Program in Physiological SciencesFAPESP: 2012/14376-0FAPESP: 2012/50549-6FAPESP: 2015/05922-9Universidade Estadual Paulista (Unesp)Duarte, Josiane O. [UNESP]Gomes, Karina S. [UNESP]Nunes-de-Souza, Ricardo L. [UNESP]Crestani, Carlos C. [UNESP]2018-12-11T16:46:28Z2018-12-11T16:46:28Z2017-06-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article16-21application/pdfhttp://dx.doi.org/10.1016/j.physbeh.2017.03.030Physiology and Behavior, v. 175, p. 16-21.1873-507X0031-9384http://hdl.handle.net/11449/16956910.1016/j.physbeh.2017.03.0302-s2.0-850160646952-s2.0-85016064695.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengPhysiology and Behavior1,088info:eu-repo/semantics/openAccess2023-12-12T06:20:38Zoai:repositorio.unesp.br:11449/169569Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T20:08:53.408882Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Role of the lateral preoptic area in cardiovascular and neuroendocrine responses to acute restraint stress in rats |
title |
Role of the lateral preoptic area in cardiovascular and neuroendocrine responses to acute restraint stress in rats |
spellingShingle |
Role of the lateral preoptic area in cardiovascular and neuroendocrine responses to acute restraint stress in rats Duarte, Josiane O. [UNESP] Blood pressure Corticosterone Heart rate HPA axis Hypothalamus LPO Stress |
title_short |
Role of the lateral preoptic area in cardiovascular and neuroendocrine responses to acute restraint stress in rats |
title_full |
Role of the lateral preoptic area in cardiovascular and neuroendocrine responses to acute restraint stress in rats |
title_fullStr |
Role of the lateral preoptic area in cardiovascular and neuroendocrine responses to acute restraint stress in rats |
title_full_unstemmed |
Role of the lateral preoptic area in cardiovascular and neuroendocrine responses to acute restraint stress in rats |
title_sort |
Role of the lateral preoptic area in cardiovascular and neuroendocrine responses to acute restraint stress in rats |
author |
Duarte, Josiane O. [UNESP] |
author_facet |
Duarte, Josiane O. [UNESP] Gomes, Karina S. [UNESP] Nunes-de-Souza, Ricardo L. [UNESP] Crestani, Carlos C. [UNESP] |
author_role |
author |
author2 |
Gomes, Karina S. [UNESP] Nunes-de-Souza, Ricardo L. [UNESP] Crestani, Carlos C. [UNESP] |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Duarte, Josiane O. [UNESP] Gomes, Karina S. [UNESP] Nunes-de-Souza, Ricardo L. [UNESP] Crestani, Carlos C. [UNESP] |
dc.subject.por.fl_str_mv |
Blood pressure Corticosterone Heart rate HPA axis Hypothalamus LPO Stress |
topic |
Blood pressure Corticosterone Heart rate HPA axis Hypothalamus LPO Stress |
description |
The lateral preoptic area (LPO) is connected with limbic structures involved in physiological and behavioral responses to stress. Accordingly, exposure to stressors stimuli activates neurons within the LPO. In spite of these evidence, an involvement of the LPO on cardiovascular and neuroendocrine adjustments during aversive threats has not yet been investigated. Therefore, in the present study we tested the hypothesis that the LPO is involved in the control of cardiovascular and neuroendocrine responses to acute restraint stress in rats. Bilateral microinjection of the nonselective synaptic blocker CoCl2 (0.1 nmol/100 nl) into the LPO did not affect basal values of either arterial pressure, heart rate, tail skin temperature, or plasma corticosterone concentration. However, LPO treatment with CoCl2 enhanced the tachycardiac response and the increase in plasma corticosterone concentration caused by restraint stress. Conversely, LPO synaptic blockade decreased restraint-evoked pressor response. Sympathetic-mediated cutaneous vasoconstriction during restraint stress was not affected by LPO pharmacological treatment. These findings indicate an inhibitory influence of LPO on tachycardiac and plasma corticosterone responses evoked during aversive threats. Additionally, data suggest that LPO plays a facilitatory influence on stress-evoked pressor response. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-06-01 2018-12-11T16:46:28Z 2018-12-11T16:46:28Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.physbeh.2017.03.030 Physiology and Behavior, v. 175, p. 16-21. 1873-507X 0031-9384 http://hdl.handle.net/11449/169569 10.1016/j.physbeh.2017.03.030 2-s2.0-85016064695 2-s2.0-85016064695.pdf |
url |
http://dx.doi.org/10.1016/j.physbeh.2017.03.030 http://hdl.handle.net/11449/169569 |
identifier_str_mv |
Physiology and Behavior, v. 175, p. 16-21. 1873-507X 0031-9384 10.1016/j.physbeh.2017.03.030 2-s2.0-85016064695 2-s2.0-85016064695.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Physiology and Behavior 1,088 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
16-21 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129165575061504 |