Cytokine and antibody production during murine leptospirosis

Detalhes bibliográficos
Autor(a) principal: Marinho, Márcia [UNESP]
Data de Publicação: 2006
Outros Autores: Silva, C. [UNESP], Lima, Valéria Marçal Felix de [UNESP], Peiró, Juliana Regina [UNESP], Perri, Silvia Helena Venturoli [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1590/S1678-91992006000400006
http://hdl.handle.net/11449/69207
Resumo: The aim of the present study was to investigate the kinetics of humoral and cellular responses during leptospirosis. We observed that the presence of tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6) was associated with antibody production and bacterial recovery, and the compromising of both TNF-α and IL-6 in the immunopathogenesis of leptospirosis during an experimental infection of BALB/c mice inoculated with Leptospira interrogans serovar Canicola was verified. Results showed higher levels of TNF-α and IL-6 in the initial phase of infection, in which the greatest bacterial clearance was observed. However, when the bacterial recovery was compared with the kinetics of the production of antibodies, the results revealed a kinetics proportionally inverted to antibody production. This fact may be related to some inhibitory factor which could be responsible for the selective suppression of the cellular immune response. We concluded that during leptospirosis there was a greater mobilization of the cellular immune response activity, mainly in the initial phase of the infectious process, for posterior involvement of the humoral response, and that both TNF-α and IL-6 could be associated with the immunopathogenesis of the disease.
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spelling Cytokine and antibody production during murine leptospirosisBALB/c miceCellular immune responseCytokinesLeptospirosisBacteria (microorganisms)Leptospira interrogansLeptospira interrogans serovar CanicolaMurinaeThe aim of the present study was to investigate the kinetics of humoral and cellular responses during leptospirosis. We observed that the presence of tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6) was associated with antibody production and bacterial recovery, and the compromising of both TNF-α and IL-6 in the immunopathogenesis of leptospirosis during an experimental infection of BALB/c mice inoculated with Leptospira interrogans serovar Canicola was verified. Results showed higher levels of TNF-α and IL-6 in the initial phase of infection, in which the greatest bacterial clearance was observed. However, when the bacterial recovery was compared with the kinetics of the production of antibodies, the results revealed a kinetics proportionally inverted to antibody production. This fact may be related to some inhibitory factor which could be responsible for the selective suppression of the cellular immune response. We concluded that during leptospirosis there was a greater mobilization of the cellular immune response activity, mainly in the initial phase of the infectious process, for posterior involvement of the humoral response, and that both TNF-α and IL-6 could be associated with the immunopathogenesis of the disease.Department of Animal Production and Health Araçatuba School of Dental Medicine São Paulo State University, Araçatuba, SP StateDepartment for Clinic and Surgery and Animal Reproduction Araçatuba School of Dental Medicine São Paulo State University, Araçatuba, SP State, R. C. Pestana, 703, Bairro D. Amelia, 16050-690, Araçatuba, SPDepartment of Animal Production and Health Araçatuba School of Dental Medicine São Paulo State University, Araçatuba, SP StateDepartment for Clinic and Surgery and Animal Reproduction Araçatuba School of Dental Medicine São Paulo State University, Araçatuba, SP StateUniversidade Estadual Paulista (Unesp)Marinho, Márcia [UNESP]Silva, C. [UNESP]Lima, Valéria Marçal Felix de [UNESP]Peiró, Juliana Regina [UNESP]Perri, Silvia Helena Venturoli [UNESP]2014-05-27T11:22:02Z2014-05-27T11:22:02Z2006-11-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article595-603application/pdfhttp://dx.doi.org/10.1590/S1678-91992006000400006Journal of Venomous Animals and Toxins Including Tropical Diseases, v. 12, n. 4, p. 595-603, 2006.1678-9199http://hdl.handle.net/11449/6920710.1590/S1678-91992006000400006S1678-91992006000400006WOS:0002462821000062-s2.0-338462841542-s2.0-33846284154.pdf5071093931017493487535233786003629761298745546980810837598202634Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Venomous Animals and Toxins Including Tropical Diseases1.7820,573info:eu-repo/semantics/openAccess2024-09-04T18:04:23Zoai:repositorio.unesp.br:11449/69207Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-04T18:04:23Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Cytokine and antibody production during murine leptospirosis
title Cytokine and antibody production during murine leptospirosis
spellingShingle Cytokine and antibody production during murine leptospirosis
Marinho, Márcia [UNESP]
BALB/c mice
Cellular immune response
Cytokines
Leptospirosis
Bacteria (microorganisms)
Leptospira interrogans
Leptospira interrogans serovar Canicola
Murinae
title_short Cytokine and antibody production during murine leptospirosis
title_full Cytokine and antibody production during murine leptospirosis
title_fullStr Cytokine and antibody production during murine leptospirosis
title_full_unstemmed Cytokine and antibody production during murine leptospirosis
title_sort Cytokine and antibody production during murine leptospirosis
author Marinho, Márcia [UNESP]
author_facet Marinho, Márcia [UNESP]
Silva, C. [UNESP]
Lima, Valéria Marçal Felix de [UNESP]
Peiró, Juliana Regina [UNESP]
Perri, Silvia Helena Venturoli [UNESP]
author_role author
author2 Silva, C. [UNESP]
Lima, Valéria Marçal Felix de [UNESP]
Peiró, Juliana Regina [UNESP]
Perri, Silvia Helena Venturoli [UNESP]
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Marinho, Márcia [UNESP]
Silva, C. [UNESP]
Lima, Valéria Marçal Felix de [UNESP]
Peiró, Juliana Regina [UNESP]
Perri, Silvia Helena Venturoli [UNESP]
dc.subject.por.fl_str_mv BALB/c mice
Cellular immune response
Cytokines
Leptospirosis
Bacteria (microorganisms)
Leptospira interrogans
Leptospira interrogans serovar Canicola
Murinae
topic BALB/c mice
Cellular immune response
Cytokines
Leptospirosis
Bacteria (microorganisms)
Leptospira interrogans
Leptospira interrogans serovar Canicola
Murinae
description The aim of the present study was to investigate the kinetics of humoral and cellular responses during leptospirosis. We observed that the presence of tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6) was associated with antibody production and bacterial recovery, and the compromising of both TNF-α and IL-6 in the immunopathogenesis of leptospirosis during an experimental infection of BALB/c mice inoculated with Leptospira interrogans serovar Canicola was verified. Results showed higher levels of TNF-α and IL-6 in the initial phase of infection, in which the greatest bacterial clearance was observed. However, when the bacterial recovery was compared with the kinetics of the production of antibodies, the results revealed a kinetics proportionally inverted to antibody production. This fact may be related to some inhibitory factor which could be responsible for the selective suppression of the cellular immune response. We concluded that during leptospirosis there was a greater mobilization of the cellular immune response activity, mainly in the initial phase of the infectious process, for posterior involvement of the humoral response, and that both TNF-α and IL-6 could be associated with the immunopathogenesis of the disease.
publishDate 2006
dc.date.none.fl_str_mv 2006-11-01
2014-05-27T11:22:02Z
2014-05-27T11:22:02Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S1678-91992006000400006
Journal of Venomous Animals and Toxins Including Tropical Diseases, v. 12, n. 4, p. 595-603, 2006.
1678-9199
http://hdl.handle.net/11449/69207
10.1590/S1678-91992006000400006
S1678-91992006000400006
WOS:000246282100006
2-s2.0-33846284154
2-s2.0-33846284154.pdf
5071093931017493
4875352337860036
2976129874554698
0810837598202634
url http://dx.doi.org/10.1590/S1678-91992006000400006
http://hdl.handle.net/11449/69207
identifier_str_mv Journal of Venomous Animals and Toxins Including Tropical Diseases, v. 12, n. 4, p. 595-603, 2006.
1678-9199
10.1590/S1678-91992006000400006
S1678-91992006000400006
WOS:000246282100006
2-s2.0-33846284154
2-s2.0-33846284154.pdf
5071093931017493
4875352337860036
2976129874554698
0810837598202634
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Journal of Venomous Animals and Toxins Including Tropical Diseases
1.782
0,573
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 595-603
application/pdf
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv repositoriounesp@unesp.br
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