The role of probiotics in maintaining immune homeostasis

Detalhes bibliográficos
Autor(a) principal: Thipe, Velaphi C.
Data de Publicação: 2022
Outros Autores: Lima, Caroline S.A., Freitas, Lucas F., Nogueira, Kamila M., Rodrigues, Adriana S., Batista, Jorge G.S., Ferreira, Aryel H., Lugão, Ademar B., Mentor, Shireen, Fonseca, Ana C.M.
Tipo de documento: Capítulo de livro
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1016/B978-0-12-823733-5.00024-6
http://hdl.handle.net/11449/245983
Resumo: The immune system is a complex architecture of a collective and coordinated network regulated by various pathways to thermodynamically maintain immune homeostasis. The gut microbiota plays a pivotal role that offers significant stimuli (i.e., gut-brain, gut-lung, and gut-liver axis) for both innate and adaptive immunity, mediating immune and metabolic homeostasis. An intricate correlation between changes in the gut microbiota (dysbiosis) and common diseases/disorders have been attributed to the invasion of pathogens, constant use of antibiotics, and hypercytokinemia—a hallmark of immune homeostasis imbalance. These factors contribute to the severity of inflammatory diseases such as cardiovascular diseases, neurological disorders, and of late the coronavirus disease, Covid-19. Probiotics (Lactobacillus spp. and Bifidobacterium spp.) have been considered as alternative and/or adjuvant therapeutic in restoring the balance of gut microbiota for maintaining immune homeostasis and integrity. The probiotics catalyze dietary fibers and proteins to generate short-chain fatty acids and tryptophan to promote antiinflammatory cytokines, reduce epithelium permeability, reinforcing immunity in the gut mucosa, and regulating the systemic immune response. Herein, we review our overarching understanding of current applications of probiotics in amelioration of gut microbiome, and the improvement of gut barrier function and maintaining immune homeostasis. We also highlight clinical trials on probiotics with reported results for the treatment of inflammatory diseases. Additionally, the looming global Covid-19 pandemic makes it prudent to highlight the role of probiotics in both the innate and adaptive human immune responses, especially amid the Covid-19 vaccination paradigm.
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spelling The role of probiotics in maintaining immune homeostasiscytokinesdysbiosisgut microbiotahomeostasisImmuneprobioticsThe immune system is a complex architecture of a collective and coordinated network regulated by various pathways to thermodynamically maintain immune homeostasis. The gut microbiota plays a pivotal role that offers significant stimuli (i.e., gut-brain, gut-lung, and gut-liver axis) for both innate and adaptive immunity, mediating immune and metabolic homeostasis. An intricate correlation between changes in the gut microbiota (dysbiosis) and common diseases/disorders have been attributed to the invasion of pathogens, constant use of antibiotics, and hypercytokinemia—a hallmark of immune homeostasis imbalance. These factors contribute to the severity of inflammatory diseases such as cardiovascular diseases, neurological disorders, and of late the coronavirus disease, Covid-19. Probiotics (Lactobacillus spp. and Bifidobacterium spp.) have been considered as alternative and/or adjuvant therapeutic in restoring the balance of gut microbiota for maintaining immune homeostasis and integrity. The probiotics catalyze dietary fibers and proteins to generate short-chain fatty acids and tryptophan to promote antiinflammatory cytokines, reduce epithelium permeability, reinforcing immunity in the gut mucosa, and regulating the systemic immune response. Herein, we review our overarching understanding of current applications of probiotics in amelioration of gut microbiome, and the improvement of gut barrier function and maintaining immune homeostasis. We also highlight clinical trials on probiotics with reported results for the treatment of inflammatory diseases. Additionally, the looming global Covid-19 pandemic makes it prudent to highlight the role of probiotics in both the innate and adaptive human immune responses, especially amid the Covid-19 vaccination paradigm.Energy and Nuclear Research Institute (IPEN) University of São PauloDepartment of Medical Biosciences University of the Western CapeVirtual University of the State of Sao Paulo (UNIVESP)Universidade de São Paulo (USP)University of the Western CapeVirtual University of the State of Sao Paulo (UNIVESP)Thipe, Velaphi C.Lima, Caroline S.A.Freitas, Lucas F.Nogueira, Kamila M.Rodrigues, Adriana S.Batista, Jorge G.S.Ferreira, Aryel H.Lugão, Ademar B.Mentor, ShireenFonseca, Ana C.M.2023-07-29T12:28:33Z2023-07-29T12:28:33Z2022-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/bookPart41-58http://dx.doi.org/10.1016/B978-0-12-823733-5.00024-6Probiotics in the Prevention and Management of Human Diseases: A Scientific Perspective, p. 41-58.http://hdl.handle.net/11449/24598310.1016/B978-0-12-823733-5.00024-62-s2.0-85138917595Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengProbiotics in the Prevention and Management of Human Diseases: A Scientific Perspectiveinfo:eu-repo/semantics/openAccess2023-07-29T12:28:33Zoai:repositorio.unesp.br:11449/245983Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T14:49:43.360146Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv The role of probiotics in maintaining immune homeostasis
title The role of probiotics in maintaining immune homeostasis
spellingShingle The role of probiotics in maintaining immune homeostasis
Thipe, Velaphi C.
cytokines
dysbiosis
gut microbiota
homeostasis
Immune
probiotics
title_short The role of probiotics in maintaining immune homeostasis
title_full The role of probiotics in maintaining immune homeostasis
title_fullStr The role of probiotics in maintaining immune homeostasis
title_full_unstemmed The role of probiotics in maintaining immune homeostasis
title_sort The role of probiotics in maintaining immune homeostasis
author Thipe, Velaphi C.
author_facet Thipe, Velaphi C.
Lima, Caroline S.A.
Freitas, Lucas F.
Nogueira, Kamila M.
Rodrigues, Adriana S.
Batista, Jorge G.S.
Ferreira, Aryel H.
Lugão, Ademar B.
Mentor, Shireen
Fonseca, Ana C.M.
author_role author
author2 Lima, Caroline S.A.
Freitas, Lucas F.
Nogueira, Kamila M.
Rodrigues, Adriana S.
Batista, Jorge G.S.
Ferreira, Aryel H.
Lugão, Ademar B.
Mentor, Shireen
Fonseca, Ana C.M.
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade de São Paulo (USP)
University of the Western Cape
Virtual University of the State of Sao Paulo (UNIVESP)
dc.contributor.author.fl_str_mv Thipe, Velaphi C.
Lima, Caroline S.A.
Freitas, Lucas F.
Nogueira, Kamila M.
Rodrigues, Adriana S.
Batista, Jorge G.S.
Ferreira, Aryel H.
Lugão, Ademar B.
Mentor, Shireen
Fonseca, Ana C.M.
dc.subject.por.fl_str_mv cytokines
dysbiosis
gut microbiota
homeostasis
Immune
probiotics
topic cytokines
dysbiosis
gut microbiota
homeostasis
Immune
probiotics
description The immune system is a complex architecture of a collective and coordinated network regulated by various pathways to thermodynamically maintain immune homeostasis. The gut microbiota plays a pivotal role that offers significant stimuli (i.e., gut-brain, gut-lung, and gut-liver axis) for both innate and adaptive immunity, mediating immune and metabolic homeostasis. An intricate correlation between changes in the gut microbiota (dysbiosis) and common diseases/disorders have been attributed to the invasion of pathogens, constant use of antibiotics, and hypercytokinemia—a hallmark of immune homeostasis imbalance. These factors contribute to the severity of inflammatory diseases such as cardiovascular diseases, neurological disorders, and of late the coronavirus disease, Covid-19. Probiotics (Lactobacillus spp. and Bifidobacterium spp.) have been considered as alternative and/or adjuvant therapeutic in restoring the balance of gut microbiota for maintaining immune homeostasis and integrity. The probiotics catalyze dietary fibers and proteins to generate short-chain fatty acids and tryptophan to promote antiinflammatory cytokines, reduce epithelium permeability, reinforcing immunity in the gut mucosa, and regulating the systemic immune response. Herein, we review our overarching understanding of current applications of probiotics in amelioration of gut microbiome, and the improvement of gut barrier function and maintaining immune homeostasis. We also highlight clinical trials on probiotics with reported results for the treatment of inflammatory diseases. Additionally, the looming global Covid-19 pandemic makes it prudent to highlight the role of probiotics in both the innate and adaptive human immune responses, especially amid the Covid-19 vaccination paradigm.
publishDate 2022
dc.date.none.fl_str_mv 2022-01-01
2023-07-29T12:28:33Z
2023-07-29T12:28:33Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/bookPart
format bookPart
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/B978-0-12-823733-5.00024-6
Probiotics in the Prevention and Management of Human Diseases: A Scientific Perspective, p. 41-58.
http://hdl.handle.net/11449/245983
10.1016/B978-0-12-823733-5.00024-6
2-s2.0-85138917595
url http://dx.doi.org/10.1016/B978-0-12-823733-5.00024-6
http://hdl.handle.net/11449/245983
identifier_str_mv Probiotics in the Prevention and Management of Human Diseases: A Scientific Perspective, p. 41-58.
10.1016/B978-0-12-823733-5.00024-6
2-s2.0-85138917595
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Probiotics in the Prevention and Management of Human Diseases: A Scientific Perspective
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 41-58
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
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