A functional wound dressing as a potential treatment for cutaneous leishmaniasis

Detalhes bibliográficos
Autor(a) principal: Alexandrino-Junior, Francisco
Data de Publicação: 2019
Outros Autores: E Silva, Kattya Gyselle de Holanda, Freire, Marjorie Caroline Liberato Cavalcanti, Lione, Viviane de Oliveira Freitas, Cardoso, Elisama Azevedo, Marcelino, Henrique Rodrigues, Genre, Julieta, de Oliveira, Anselmo Gomes [UNESP], Do Egito, Eryvaldo Sócrates Tabosa
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.3390/pharmaceutics11050200
http://hdl.handle.net/11449/189209
Resumo: Cutaneous leishmaniasis (CL) is a parasitic disease characterized by progressive skin sores. Currently, treatments for CL are limited to parenteral administration of the drug, which presents severe adverse effects and low cure rates. Therefore, this study aimed to develop poly(vinyl-alcohol) (PVA) hydrogels containing Amphotericin B (AmB) intended for topical treatment of CL. Hydrogels were evaluated in vitro for their potential to eliminate promastigote forms of Leishmania spp., to prevent secondary infections, to maintain appropriate healing conditions, and to offer suitable biocompatibility. AmB was incorporated into the system in its non-crystalline state, allowing it to swell more and faster than the system without the drug. Furthermore, the AmB release profile showed a continuous and controlled behavior following Higuchi´s kinetic model. AmB-loaded-PVA-hydrogels (PVA–AmB) also showed efficient antifungal and leishmanicidal activity, no cytotoxic potential for VERO cells, microbial impermeability and water vapor permeability compatible with the healthy skin’s physiological needs. Indeed, these results revealed the potential of PVA–AmB to prevent secondary infections and to maintain a favorable environment for the healing process. Hence, these results suggest that PVA–AmB could be a suitable and efficient new therapeutic approach for the topical treatment of CL.
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spelling A functional wound dressing as a potential treatment for cutaneous leishmaniasisAmphotericin BControlled releaseCutaneous leishmaniasisHydrogelWound dressingCutaneous leishmaniasis (CL) is a parasitic disease characterized by progressive skin sores. Currently, treatments for CL are limited to parenteral administration of the drug, which presents severe adverse effects and low cure rates. Therefore, this study aimed to develop poly(vinyl-alcohol) (PVA) hydrogels containing Amphotericin B (AmB) intended for topical treatment of CL. Hydrogels were evaluated in vitro for their potential to eliminate promastigote forms of Leishmania spp., to prevent secondary infections, to maintain appropriate healing conditions, and to offer suitable biocompatibility. AmB was incorporated into the system in its non-crystalline state, allowing it to swell more and faster than the system without the drug. Furthermore, the AmB release profile showed a continuous and controlled behavior following Higuchi´s kinetic model. AmB-loaded-PVA-hydrogels (PVA–AmB) also showed efficient antifungal and leishmanicidal activity, no cytotoxic potential for VERO cells, microbial impermeability and water vapor permeability compatible with the healthy skin’s physiological needs. Indeed, these results revealed the potential of PVA–AmB to prevent secondary infections and to maintain a favorable environment for the healing process. Hence, these results suggest that PVA–AmB could be a suitable and efficient new therapeutic approach for the topical treatment of CL.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Universidade Federal do Rio Grande do Norte (UFRN)Faculdade de Farmácia Universidade Federal do Rio de Janeiro (UFRJ)Instituto de Física de São Carlos Universidade de São Paulo (USP)Departamento do Medicamento Universidade Federal da Bahia (UFBA)Faculdade de Farmácia Universidade Federal do Rio Grande do Norte (UFRN)Departamento de Fármacos e Medicamentos Universidade Estadual Paulista (UNESP)Laboratório de Sistemas Dispersos (LaSiD) Departamento de Farmácia Universidade Federal do Rio Grande do Norte (UFRN), Rua General Gustavo Cordeiro de Farias s/n, PetrópolisDepartamento de Fármacos e Medicamentos Universidade Estadual Paulista (UNESP)Universidade Federal do Rio Grande do Norte (UFRN)Universidade Federal do Rio de Janeiro (UFRJ)Universidade de São Paulo (USP)Universidade Federal da Bahia (UFBA)Universidade Estadual Paulista (Unesp)Alexandrino-Junior, FranciscoE Silva, Kattya Gyselle de HolandaFreire, Marjorie Caroline Liberato CavalcantiLione, Viviane de Oliveira FreitasCardoso, Elisama AzevedoMarcelino, Henrique RodriguesGenre, Julietade Oliveira, Anselmo Gomes [UNESP]Do Egito, Eryvaldo Sócrates Tabosa2019-10-06T16:33:27Z2019-10-06T16:33:27Z2019-05-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.3390/pharmaceutics11050200Pharmaceutics, v. 11, n. 5, 2019.1999-4923http://hdl.handle.net/11449/18920910.3390/pharmaceutics110502002-s2.0-85066791938Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengPharmaceuticsinfo:eu-repo/semantics/openAccess2024-06-24T13:45:06Zoai:repositorio.unesp.br:11449/189209Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T14:47:36.749513Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv A functional wound dressing as a potential treatment for cutaneous leishmaniasis
title A functional wound dressing as a potential treatment for cutaneous leishmaniasis
spellingShingle A functional wound dressing as a potential treatment for cutaneous leishmaniasis
Alexandrino-Junior, Francisco
Amphotericin B
Controlled release
Cutaneous leishmaniasis
Hydrogel
Wound dressing
title_short A functional wound dressing as a potential treatment for cutaneous leishmaniasis
title_full A functional wound dressing as a potential treatment for cutaneous leishmaniasis
title_fullStr A functional wound dressing as a potential treatment for cutaneous leishmaniasis
title_full_unstemmed A functional wound dressing as a potential treatment for cutaneous leishmaniasis
title_sort A functional wound dressing as a potential treatment for cutaneous leishmaniasis
author Alexandrino-Junior, Francisco
author_facet Alexandrino-Junior, Francisco
E Silva, Kattya Gyselle de Holanda
Freire, Marjorie Caroline Liberato Cavalcanti
Lione, Viviane de Oliveira Freitas
Cardoso, Elisama Azevedo
Marcelino, Henrique Rodrigues
Genre, Julieta
de Oliveira, Anselmo Gomes [UNESP]
Do Egito, Eryvaldo Sócrates Tabosa
author_role author
author2 E Silva, Kattya Gyselle de Holanda
Freire, Marjorie Caroline Liberato Cavalcanti
Lione, Viviane de Oliveira Freitas
Cardoso, Elisama Azevedo
Marcelino, Henrique Rodrigues
Genre, Julieta
de Oliveira, Anselmo Gomes [UNESP]
Do Egito, Eryvaldo Sócrates Tabosa
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Federal do Rio Grande do Norte (UFRN)
Universidade Federal do Rio de Janeiro (UFRJ)
Universidade de São Paulo (USP)
Universidade Federal da Bahia (UFBA)
Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Alexandrino-Junior, Francisco
E Silva, Kattya Gyselle de Holanda
Freire, Marjorie Caroline Liberato Cavalcanti
Lione, Viviane de Oliveira Freitas
Cardoso, Elisama Azevedo
Marcelino, Henrique Rodrigues
Genre, Julieta
de Oliveira, Anselmo Gomes [UNESP]
Do Egito, Eryvaldo Sócrates Tabosa
dc.subject.por.fl_str_mv Amphotericin B
Controlled release
Cutaneous leishmaniasis
Hydrogel
Wound dressing
topic Amphotericin B
Controlled release
Cutaneous leishmaniasis
Hydrogel
Wound dressing
description Cutaneous leishmaniasis (CL) is a parasitic disease characterized by progressive skin sores. Currently, treatments for CL are limited to parenteral administration of the drug, which presents severe adverse effects and low cure rates. Therefore, this study aimed to develop poly(vinyl-alcohol) (PVA) hydrogels containing Amphotericin B (AmB) intended for topical treatment of CL. Hydrogels were evaluated in vitro for their potential to eliminate promastigote forms of Leishmania spp., to prevent secondary infections, to maintain appropriate healing conditions, and to offer suitable biocompatibility. AmB was incorporated into the system in its non-crystalline state, allowing it to swell more and faster than the system without the drug. Furthermore, the AmB release profile showed a continuous and controlled behavior following Higuchi´s kinetic model. AmB-loaded-PVA-hydrogels (PVA–AmB) also showed efficient antifungal and leishmanicidal activity, no cytotoxic potential for VERO cells, microbial impermeability and water vapor permeability compatible with the healthy skin’s physiological needs. Indeed, these results revealed the potential of PVA–AmB to prevent secondary infections and to maintain a favorable environment for the healing process. Hence, these results suggest that PVA–AmB could be a suitable and efficient new therapeutic approach for the topical treatment of CL.
publishDate 2019
dc.date.none.fl_str_mv 2019-10-06T16:33:27Z
2019-10-06T16:33:27Z
2019-05-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.3390/pharmaceutics11050200
Pharmaceutics, v. 11, n. 5, 2019.
1999-4923
http://hdl.handle.net/11449/189209
10.3390/pharmaceutics11050200
2-s2.0-85066791938
url http://dx.doi.org/10.3390/pharmaceutics11050200
http://hdl.handle.net/11449/189209
identifier_str_mv Pharmaceutics, v. 11, n. 5, 2019.
1999-4923
10.3390/pharmaceutics11050200
2-s2.0-85066791938
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Pharmaceutics
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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