A functional wound dressing as a potential treatment for cutaneous leishmaniasis
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.3390/pharmaceutics11050200 http://hdl.handle.net/11449/189209 |
Resumo: | Cutaneous leishmaniasis (CL) is a parasitic disease characterized by progressive skin sores. Currently, treatments for CL are limited to parenteral administration of the drug, which presents severe adverse effects and low cure rates. Therefore, this study aimed to develop poly(vinyl-alcohol) (PVA) hydrogels containing Amphotericin B (AmB) intended for topical treatment of CL. Hydrogels were evaluated in vitro for their potential to eliminate promastigote forms of Leishmania spp., to prevent secondary infections, to maintain appropriate healing conditions, and to offer suitable biocompatibility. AmB was incorporated into the system in its non-crystalline state, allowing it to swell more and faster than the system without the drug. Furthermore, the AmB release profile showed a continuous and controlled behavior following Higuchi´s kinetic model. AmB-loaded-PVA-hydrogels (PVA–AmB) also showed efficient antifungal and leishmanicidal activity, no cytotoxic potential for VERO cells, microbial impermeability and water vapor permeability compatible with the healthy skin’s physiological needs. Indeed, these results revealed the potential of PVA–AmB to prevent secondary infections and to maintain a favorable environment for the healing process. Hence, these results suggest that PVA–AmB could be a suitable and efficient new therapeutic approach for the topical treatment of CL. |
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A functional wound dressing as a potential treatment for cutaneous leishmaniasisAmphotericin BControlled releaseCutaneous leishmaniasisHydrogelWound dressingCutaneous leishmaniasis (CL) is a parasitic disease characterized by progressive skin sores. Currently, treatments for CL are limited to parenteral administration of the drug, which presents severe adverse effects and low cure rates. Therefore, this study aimed to develop poly(vinyl-alcohol) (PVA) hydrogels containing Amphotericin B (AmB) intended for topical treatment of CL. Hydrogels were evaluated in vitro for their potential to eliminate promastigote forms of Leishmania spp., to prevent secondary infections, to maintain appropriate healing conditions, and to offer suitable biocompatibility. AmB was incorporated into the system in its non-crystalline state, allowing it to swell more and faster than the system without the drug. Furthermore, the AmB release profile showed a continuous and controlled behavior following Higuchi´s kinetic model. AmB-loaded-PVA-hydrogels (PVA–AmB) also showed efficient antifungal and leishmanicidal activity, no cytotoxic potential for VERO cells, microbial impermeability and water vapor permeability compatible with the healthy skin’s physiological needs. Indeed, these results revealed the potential of PVA–AmB to prevent secondary infections and to maintain a favorable environment for the healing process. Hence, these results suggest that PVA–AmB could be a suitable and efficient new therapeutic approach for the topical treatment of CL.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Universidade Federal do Rio Grande do Norte (UFRN)Faculdade de Farmácia Universidade Federal do Rio de Janeiro (UFRJ)Instituto de Física de São Carlos Universidade de São Paulo (USP)Departamento do Medicamento Universidade Federal da Bahia (UFBA)Faculdade de Farmácia Universidade Federal do Rio Grande do Norte (UFRN)Departamento de Fármacos e Medicamentos Universidade Estadual Paulista (UNESP)Laboratório de Sistemas Dispersos (LaSiD) Departamento de Farmácia Universidade Federal do Rio Grande do Norte (UFRN), Rua General Gustavo Cordeiro de Farias s/n, PetrópolisDepartamento de Fármacos e Medicamentos Universidade Estadual Paulista (UNESP)Universidade Federal do Rio Grande do Norte (UFRN)Universidade Federal do Rio de Janeiro (UFRJ)Universidade de São Paulo (USP)Universidade Federal da Bahia (UFBA)Universidade Estadual Paulista (Unesp)Alexandrino-Junior, FranciscoE Silva, Kattya Gyselle de HolandaFreire, Marjorie Caroline Liberato CavalcantiLione, Viviane de Oliveira FreitasCardoso, Elisama AzevedoMarcelino, Henrique RodriguesGenre, Julietade Oliveira, Anselmo Gomes [UNESP]Do Egito, Eryvaldo Sócrates Tabosa2019-10-06T16:33:27Z2019-10-06T16:33:27Z2019-05-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.3390/pharmaceutics11050200Pharmaceutics, v. 11, n. 5, 2019.1999-4923http://hdl.handle.net/11449/18920910.3390/pharmaceutics110502002-s2.0-85066791938Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengPharmaceuticsinfo:eu-repo/semantics/openAccess2024-06-24T13:45:06Zoai:repositorio.unesp.br:11449/189209Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T14:47:36.749513Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
A functional wound dressing as a potential treatment for cutaneous leishmaniasis |
title |
A functional wound dressing as a potential treatment for cutaneous leishmaniasis |
spellingShingle |
A functional wound dressing as a potential treatment for cutaneous leishmaniasis Alexandrino-Junior, Francisco Amphotericin B Controlled release Cutaneous leishmaniasis Hydrogel Wound dressing |
title_short |
A functional wound dressing as a potential treatment for cutaneous leishmaniasis |
title_full |
A functional wound dressing as a potential treatment for cutaneous leishmaniasis |
title_fullStr |
A functional wound dressing as a potential treatment for cutaneous leishmaniasis |
title_full_unstemmed |
A functional wound dressing as a potential treatment for cutaneous leishmaniasis |
title_sort |
A functional wound dressing as a potential treatment for cutaneous leishmaniasis |
author |
Alexandrino-Junior, Francisco |
author_facet |
Alexandrino-Junior, Francisco E Silva, Kattya Gyselle de Holanda Freire, Marjorie Caroline Liberato Cavalcanti Lione, Viviane de Oliveira Freitas Cardoso, Elisama Azevedo Marcelino, Henrique Rodrigues Genre, Julieta de Oliveira, Anselmo Gomes [UNESP] Do Egito, Eryvaldo Sócrates Tabosa |
author_role |
author |
author2 |
E Silva, Kattya Gyselle de Holanda Freire, Marjorie Caroline Liberato Cavalcanti Lione, Viviane de Oliveira Freitas Cardoso, Elisama Azevedo Marcelino, Henrique Rodrigues Genre, Julieta de Oliveira, Anselmo Gomes [UNESP] Do Egito, Eryvaldo Sócrates Tabosa |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal do Rio Grande do Norte (UFRN) Universidade Federal do Rio de Janeiro (UFRJ) Universidade de São Paulo (USP) Universidade Federal da Bahia (UFBA) Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Alexandrino-Junior, Francisco E Silva, Kattya Gyselle de Holanda Freire, Marjorie Caroline Liberato Cavalcanti Lione, Viviane de Oliveira Freitas Cardoso, Elisama Azevedo Marcelino, Henrique Rodrigues Genre, Julieta de Oliveira, Anselmo Gomes [UNESP] Do Egito, Eryvaldo Sócrates Tabosa |
dc.subject.por.fl_str_mv |
Amphotericin B Controlled release Cutaneous leishmaniasis Hydrogel Wound dressing |
topic |
Amphotericin B Controlled release Cutaneous leishmaniasis Hydrogel Wound dressing |
description |
Cutaneous leishmaniasis (CL) is a parasitic disease characterized by progressive skin sores. Currently, treatments for CL are limited to parenteral administration of the drug, which presents severe adverse effects and low cure rates. Therefore, this study aimed to develop poly(vinyl-alcohol) (PVA) hydrogels containing Amphotericin B (AmB) intended for topical treatment of CL. Hydrogels were evaluated in vitro for their potential to eliminate promastigote forms of Leishmania spp., to prevent secondary infections, to maintain appropriate healing conditions, and to offer suitable biocompatibility. AmB was incorporated into the system in its non-crystalline state, allowing it to swell more and faster than the system without the drug. Furthermore, the AmB release profile showed a continuous and controlled behavior following Higuchi´s kinetic model. AmB-loaded-PVA-hydrogels (PVA–AmB) also showed efficient antifungal and leishmanicidal activity, no cytotoxic potential for VERO cells, microbial impermeability and water vapor permeability compatible with the healthy skin’s physiological needs. Indeed, these results revealed the potential of PVA–AmB to prevent secondary infections and to maintain a favorable environment for the healing process. Hence, these results suggest that PVA–AmB could be a suitable and efficient new therapeutic approach for the topical treatment of CL. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-10-06T16:33:27Z 2019-10-06T16:33:27Z 2019-05-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.3390/pharmaceutics11050200 Pharmaceutics, v. 11, n. 5, 2019. 1999-4923 http://hdl.handle.net/11449/189209 10.3390/pharmaceutics11050200 2-s2.0-85066791938 |
url |
http://dx.doi.org/10.3390/pharmaceutics11050200 http://hdl.handle.net/11449/189209 |
identifier_str_mv |
Pharmaceutics, v. 11, n. 5, 2019. 1999-4923 10.3390/pharmaceutics11050200 2-s2.0-85066791938 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Pharmaceutics |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1808128418239217664 |