Bacterial cellulose/collagen hydrogel for wound healing

• Autor(a) principal: De Sousa Moraes, Paula Rodrigues Fontes
• Data de Publicação: 2016
• Outros Autores: Saska, Sybele [UNESP], Barud, Hernane [UNESP], De Lima, Lais Roncalho, Da Conceicao Amaro Martins, Virginia, De Guzzi Plepis, Ana Maria, Ribeiro, Sidney Jose Lima [UNESP], Gaspar, Ana Maria Minarelli [UNESP]
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://dx.doi.org/10.1590/1980-5373-MR-2015-0249; http://hdl.handle.net/11449/176915
• topic: Bacterial cellulose; Collagen; Hydrogel; Tissue repair; Wound dressing

This study compares a wound dressing based on bacterial cellulose/collagen (BC/COL) hydrogel in rat dorsum with commercial collagenase ointment and untreated wound. The hydrogel was characterized by Scanning Electron Microscopy (SEM), Thermogravimetric Analysis (TGA), Fourier transformed-Infrared spectroscopy (FT-IR) and X-ray diffraction (XRD). According to the In vivo test and macroscopic evaluation, BC/COL hydrogel showed a better repair of wounds and promoted statistically significant differences of tissue repair between treatments on the 7th day after surgery. Better quality, quantity and orientation evaluation of collagen fibers (p=0.0001) were observed in the BC/COL hydrogel and collagenase ointment groups in relation to the control group. The BC/COL hydrogel promoted better wound healing than collagenase and the control group, therefore, it can be considered a potential wound dressing for skin regeneration.