Crystal structure of Myotoxin-II: A myotoxic phospholipase A2 - homologue from Bothrops moojeni venom

• Autor(a) principal: De Azevedo, W. F. [UNESP]
• Data de Publicação: 1997
• Outros Autores: Ward, R. J. [UNESP], Lombardi, F. R. [UNESP], Giglio, J. R., Soares, A. M., Fontes, M. R.M. [UNESP], Arni, R. K. [UNESP]
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://hdl.handle.net/11449/223829

The crystal structure of Myotoxin-II (MjTX-II), a Lys49 PLA2-homologue from Bothrops moojeni venom has been determined and refined at 2.0 Å to a crystallographic residual of 19.7% (Rfree=28.1%). MjTX-II is a dimer in the crystal, with the monomers in the asymmetric unit related by a two-fold symmetry axis running through the dimer interface. The dimers of MjTX-II and the Lys49 PLA2 from B. asper venom are similar, however the relative orientations of the monomers suggests a flexible dimer interface, which serves as a hinge between the two molecules.