Influence of a periodized circuit training protocol on intermuscular adipose tissue of patients with knee osteoarthritis: Protocol for a randomized controlled trial
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1186/s12891-018-2325-y http://hdl.handle.net/11449/189933 |
Resumo: | Background: The objective of this study is to analyze the influence of a 14-week periodized circuit training protocol on patients with knee osteoarthritis (OA), in randomized intervention groups, on thigh intermuscular adipose tissue (interMAT), body composition, systemic inflammation, cartilage degradation, and its repercussion on pain, functional performance and quality of life. Methods: This study presents a protocol for a randomized controlled trial. Sixty selected participants diagnosed with knee OA grades II and III, 40-65 years old and BMI < 30 kg/m 2, will be randomly divided into three groups:periodized circuit training, strength training, and educational protocol. The circuit training and strength training protocols consist of 14-week training protocols conducted 3 times a week. The circuit training group will perform selected exercises previously stratified as light, moderate, and intense, arranged progressively in a circuit model, the strength group will perform regular strength exercises, and the educational protocol group will participate in a 14-week protocol with lectures twice a month about healthy lifestyles. Baseline and follow-up evaluations will be conducted for thigh interMAT (computed tomography), body composition (DXA), inflammation (IL-1β, IL-6, IL-10, TNF-α, leptin, and adiponectin), and joint degradation biomarkers (uCTX-II and sCOMP), performance-based tests (30s Chair Stand Test, 40 m Fast-paced Walk Test and Stair Climb Test), quadriceps and hamstring maximal isometric voluntary contraction (MIVC), and questionnaires (WOMAC and pain catastrophizing scale). Repeated measures ANOVA will be used to compare differences between groups (circuit training X strength training X educational protocol) at the different times of assessment (baseline x follow-up or baseline x during protocol x follow-up) for each of the dependent variables. When significant main effects were found, the pots hoc Bonferroni test will be used to identify statistical differences. A significance level of 5% (p < 0.05) will be adopted. Discussion: This will be the first randomized controlled trial to assess the effects of a circuit training protocol on patients with knee OA on thigh intermuscular adipose tissue (interMAT). Given the prevalence and impact of OA and the widespread availability of this intervention, assessing the efficacy of a low-cost, non-pharmacological, and non-invasive treatment for knee OA patients has the potential for immediate and high clinical impact. Trial registration: ClinicalTrials.gov, NCT02761590, registered in May 4, 2016. |
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Influence of a periodized circuit training protocol on intermuscular adipose tissue of patients with knee osteoarthritis: Protocol for a randomized controlled trialAdipokinesCircuit workoutsCT scanInflammationIntermuscular fatPhysical therapyQuadricepsRehabilitationBackground: The objective of this study is to analyze the influence of a 14-week periodized circuit training protocol on patients with knee osteoarthritis (OA), in randomized intervention groups, on thigh intermuscular adipose tissue (interMAT), body composition, systemic inflammation, cartilage degradation, and its repercussion on pain, functional performance and quality of life. Methods: This study presents a protocol for a randomized controlled trial. Sixty selected participants diagnosed with knee OA grades II and III, 40-65 years old and BMI < 30 kg/m 2, will be randomly divided into three groups:periodized circuit training, strength training, and educational protocol. The circuit training and strength training protocols consist of 14-week training protocols conducted 3 times a week. The circuit training group will perform selected exercises previously stratified as light, moderate, and intense, arranged progressively in a circuit model, the strength group will perform regular strength exercises, and the educational protocol group will participate in a 14-week protocol with lectures twice a month about healthy lifestyles. Baseline and follow-up evaluations will be conducted for thigh interMAT (computed tomography), body composition (DXA), inflammation (IL-1β, IL-6, IL-10, TNF-α, leptin, and adiponectin), and joint degradation biomarkers (uCTX-II and sCOMP), performance-based tests (30s Chair Stand Test, 40 m Fast-paced Walk Test and Stair Climb Test), quadriceps and hamstring maximal isometric voluntary contraction (MIVC), and questionnaires (WOMAC and pain catastrophizing scale). Repeated measures ANOVA will be used to compare differences between groups (circuit training X strength training X educational protocol) at the different times of assessment (baseline x follow-up or baseline x during protocol x follow-up) for each of the dependent variables. When significant main effects were found, the pots hoc Bonferroni test will be used to identify statistical differences. A significance level of 5% (p < 0.05) will be adopted. Discussion: This will be the first randomized controlled trial to assess the effects of a circuit training protocol on patients with knee OA on thigh intermuscular adipose tissue (interMAT). Given the prevalence and impact of OA and the widespread availability of this intervention, assessing the efficacy of a low-cost, non-pharmacological, and non-invasive treatment for knee OA patients has the potential for immediate and high clinical impact. Trial registration: ClinicalTrials.gov, NCT02761590, registered in May 4, 2016.Department of Physical Therapy Federal University of São Carlos (UFSCar), Km 235,Rod. Washington Luís-SP310Department of Physical Therapy São Paulo State University (UNESP) School of Sciences and Technology, 305, Roberto Simonsen St.Department of Physical Therapy São Paulo State University (UNESP) School of Sciences and Technology, 305, Roberto Simonsen St.Universidade Federal de São Carlos (UFSCar)Universidade Estadual Paulista (Unesp)De Almeida, Aline CastilhoPedroso, Maria GabrielaAily, Jessica BiancaGonçalves, Glaucia HelenaPastre, Carlos Marcelo [UNESP]Mattiello, Stela Marcia2019-10-06T16:56:55Z2019-10-06T16:56:55Z2018-11-30info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1186/s12891-018-2325-yBMC Musculoskeletal Disorders, v. 19, n. 1, 2018.1471-2474http://hdl.handle.net/11449/18993310.1186/s12891-018-2325-y2-s2.0-85057494938Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBMC Musculoskeletal Disordersinfo:eu-repo/semantics/openAccess2021-10-23T10:02:43Zoai:repositorio.unesp.br:11449/189933Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462021-10-23T10:02:43Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Influence of a periodized circuit training protocol on intermuscular adipose tissue of patients with knee osteoarthritis: Protocol for a randomized controlled trial |
title |
Influence of a periodized circuit training protocol on intermuscular adipose tissue of patients with knee osteoarthritis: Protocol for a randomized controlled trial |
spellingShingle |
Influence of a periodized circuit training protocol on intermuscular adipose tissue of patients with knee osteoarthritis: Protocol for a randomized controlled trial De Almeida, Aline Castilho Adipokines Circuit workouts CT scan Inflammation Intermuscular fat Physical therapy Quadriceps Rehabilitation |
title_short |
Influence of a periodized circuit training protocol on intermuscular adipose tissue of patients with knee osteoarthritis: Protocol for a randomized controlled trial |
title_full |
Influence of a periodized circuit training protocol on intermuscular adipose tissue of patients with knee osteoarthritis: Protocol for a randomized controlled trial |
title_fullStr |
Influence of a periodized circuit training protocol on intermuscular adipose tissue of patients with knee osteoarthritis: Protocol for a randomized controlled trial |
title_full_unstemmed |
Influence of a periodized circuit training protocol on intermuscular adipose tissue of patients with knee osteoarthritis: Protocol for a randomized controlled trial |
title_sort |
Influence of a periodized circuit training protocol on intermuscular adipose tissue of patients with knee osteoarthritis: Protocol for a randomized controlled trial |
author |
De Almeida, Aline Castilho |
author_facet |
De Almeida, Aline Castilho Pedroso, Maria Gabriela Aily, Jessica Bianca Gonçalves, Glaucia Helena Pastre, Carlos Marcelo [UNESP] Mattiello, Stela Marcia |
author_role |
author |
author2 |
Pedroso, Maria Gabriela Aily, Jessica Bianca Gonçalves, Glaucia Helena Pastre, Carlos Marcelo [UNESP] Mattiello, Stela Marcia |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal de São Carlos (UFSCar) Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
De Almeida, Aline Castilho Pedroso, Maria Gabriela Aily, Jessica Bianca Gonçalves, Glaucia Helena Pastre, Carlos Marcelo [UNESP] Mattiello, Stela Marcia |
dc.subject.por.fl_str_mv |
Adipokines Circuit workouts CT scan Inflammation Intermuscular fat Physical therapy Quadriceps Rehabilitation |
topic |
Adipokines Circuit workouts CT scan Inflammation Intermuscular fat Physical therapy Quadriceps Rehabilitation |
description |
Background: The objective of this study is to analyze the influence of a 14-week periodized circuit training protocol on patients with knee osteoarthritis (OA), in randomized intervention groups, on thigh intermuscular adipose tissue (interMAT), body composition, systemic inflammation, cartilage degradation, and its repercussion on pain, functional performance and quality of life. Methods: This study presents a protocol for a randomized controlled trial. Sixty selected participants diagnosed with knee OA grades II and III, 40-65 years old and BMI < 30 kg/m 2, will be randomly divided into three groups:periodized circuit training, strength training, and educational protocol. The circuit training and strength training protocols consist of 14-week training protocols conducted 3 times a week. The circuit training group will perform selected exercises previously stratified as light, moderate, and intense, arranged progressively in a circuit model, the strength group will perform regular strength exercises, and the educational protocol group will participate in a 14-week protocol with lectures twice a month about healthy lifestyles. Baseline and follow-up evaluations will be conducted for thigh interMAT (computed tomography), body composition (DXA), inflammation (IL-1β, IL-6, IL-10, TNF-α, leptin, and adiponectin), and joint degradation biomarkers (uCTX-II and sCOMP), performance-based tests (30s Chair Stand Test, 40 m Fast-paced Walk Test and Stair Climb Test), quadriceps and hamstring maximal isometric voluntary contraction (MIVC), and questionnaires (WOMAC and pain catastrophizing scale). Repeated measures ANOVA will be used to compare differences between groups (circuit training X strength training X educational protocol) at the different times of assessment (baseline x follow-up or baseline x during protocol x follow-up) for each of the dependent variables. When significant main effects were found, the pots hoc Bonferroni test will be used to identify statistical differences. A significance level of 5% (p < 0.05) will be adopted. Discussion: This will be the first randomized controlled trial to assess the effects of a circuit training protocol on patients with knee OA on thigh intermuscular adipose tissue (interMAT). Given the prevalence and impact of OA and the widespread availability of this intervention, assessing the efficacy of a low-cost, non-pharmacological, and non-invasive treatment for knee OA patients has the potential for immediate and high clinical impact. Trial registration: ClinicalTrials.gov, NCT02761590, registered in May 4, 2016. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-11-30 2019-10-06T16:56:55Z 2019-10-06T16:56:55Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1186/s12891-018-2325-y BMC Musculoskeletal Disorders, v. 19, n. 1, 2018. 1471-2474 http://hdl.handle.net/11449/189933 10.1186/s12891-018-2325-y 2-s2.0-85057494938 |
url |
http://dx.doi.org/10.1186/s12891-018-2325-y http://hdl.handle.net/11449/189933 |
identifier_str_mv |
BMC Musculoskeletal Disorders, v. 19, n. 1, 2018. 1471-2474 10.1186/s12891-018-2325-y 2-s2.0-85057494938 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
BMC Musculoskeletal Disorders |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1799965488331096064 |