Surto de botulismo tipo C em equinos no Rio Grande do Sul

Detalhes bibliográficos
Autor(a) principal: Argenta, Fernando F.
Data de Publicação: 2017
Outros Autores: Konradt, Guilherme, Bassuino, Daniele M., Caprioli, Rafaela A., Laisse, Cláudio J.M., Borsanelli, Ana Carolina [UNESP], Dutra, Iveraldo S. [UNESP], Driemeier, David
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1590/S0100-736X2017001200002
http://hdl.handle.net/11449/176035
Resumo: Botulism in domestic animals is a fatal poisoning caused by ingestion of Clostridium botulinum neurotoxin. This paper describes epidemiological, clinical and laboratorial aspects of a botulism type C outbreak in horses in a farm in Porto Alegre, Rio Grande do Sul. From a total of 20 horses, seven (35%) were affected and died, and one was euthanized after presenting poor prognosis. The horses, which were raised extensively, showed similar clinical signs, that included limited mobility, lethargy, progressive flaccid paralysis, muscle tremors, sweating, ataxia, and frequent falls. Four horses were necropsied and did not show significant macroscopic and microscopic lesions. Brain and spinal cord samples were analyzed by direct immunofluorescence and were negative for rabies. Liver fragments from the four necropsied horses, soil sediment samples, and suspect water from two reservoirs were evaluated by direct exam to verify the botulinum toxin and/or Clostridium botulinum spores presence. In the serum neutralization bioassay in mice, the type C botulinum toxin was detected in one liver sample, at the same time that the soil sediment and water samples were negative in all assays. Based on the epidemiological, clinical and laboratory data the etiological diagnosis of botulism was established by being caused by botulinum toxin type C, and it is suggested that the stagnant water of the dams is the likely source of the toxin.
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spelling Surto de botulismo tipo C em equinos no Rio Grande do SulOutbreak of type C botulism in horses in Rio Grande do SulBotulinum toxin type CBotulism type CClostridium botulinumHorsesPoisoningBotulism in domestic animals is a fatal poisoning caused by ingestion of Clostridium botulinum neurotoxin. This paper describes epidemiological, clinical and laboratorial aspects of a botulism type C outbreak in horses in a farm in Porto Alegre, Rio Grande do Sul. From a total of 20 horses, seven (35%) were affected and died, and one was euthanized after presenting poor prognosis. The horses, which were raised extensively, showed similar clinical signs, that included limited mobility, lethargy, progressive flaccid paralysis, muscle tremors, sweating, ataxia, and frequent falls. Four horses were necropsied and did not show significant macroscopic and microscopic lesions. Brain and spinal cord samples were analyzed by direct immunofluorescence and were negative for rabies. Liver fragments from the four necropsied horses, soil sediment samples, and suspect water from two reservoirs were evaluated by direct exam to verify the botulinum toxin and/or Clostridium botulinum spores presence. In the serum neutralization bioassay in mice, the type C botulinum toxin was detected in one liver sample, at the same time that the soil sediment and water samples were negative in all assays. Based on the epidemiological, clinical and laboratory data the etiological diagnosis of botulism was established by being caused by botulinum toxin type C, and it is suggested that the stagnant water of the dams is the likely source of the toxin.Setor de Patologia Veterinária Departamento de Patologia Clínica Veterinária Faculdade de Veterinária Universidade Federal do Rio Grande do Sul (UFRGS), Av. Bento Gonçalves 9090Departamento de Apoio Produção e Saúde Animal Faculdade de Medicina Veterinária de Araçatuba Universidade Estadual Paulista (Unesp), Rua Clovis Pestana 793, Jardim Dona Amelia, Cx. Postal 533Departamento de Apoio Produção e Saúde Animal Faculdade de Medicina Veterinária de Araçatuba Universidade Estadual Paulista (Unesp), Rua Clovis Pestana 793, Jardim Dona Amelia, Cx. Postal 533Universidade Federal do Rio Grande do Sul (UFRGS)Universidade Estadual Paulista (Unesp)Argenta, Fernando F.Konradt, GuilhermeBassuino, Daniele M.Caprioli, Rafaela A.Laisse, Cláudio J.M.Borsanelli, Ana Carolina [UNESP]Dutra, Iveraldo S. [UNESP]Driemeier, David2018-12-11T17:18:39Z2018-12-11T17:18:39Z2017-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1369-1372application/pdfhttp://dx.doi.org/10.1590/S0100-736X2017001200002Pesquisa Veterinaria Brasileira, v. 37, n. 12, p. 1369-1372, 2017.1678-51500100-736Xhttp://hdl.handle.net/11449/17603510.1590/S0100-736X2017001200002S0100-736X20170012013692-s2.0-85044214313S0100-736X2017001201369.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPporPesquisa Veterinaria Brasileirainfo:eu-repo/semantics/openAccess2024-09-04T19:15:39Zoai:repositorio.unesp.br:11449/176035Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-04T19:15:39Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Surto de botulismo tipo C em equinos no Rio Grande do Sul
Outbreak of type C botulism in horses in Rio Grande do Sul
title Surto de botulismo tipo C em equinos no Rio Grande do Sul
spellingShingle Surto de botulismo tipo C em equinos no Rio Grande do Sul
Argenta, Fernando F.
Botulinum toxin type C
Botulism type C
Clostridium botulinum
Horses
Poisoning
title_short Surto de botulismo tipo C em equinos no Rio Grande do Sul
title_full Surto de botulismo tipo C em equinos no Rio Grande do Sul
title_fullStr Surto de botulismo tipo C em equinos no Rio Grande do Sul
title_full_unstemmed Surto de botulismo tipo C em equinos no Rio Grande do Sul
title_sort Surto de botulismo tipo C em equinos no Rio Grande do Sul
author Argenta, Fernando F.
author_facet Argenta, Fernando F.
Konradt, Guilherme
Bassuino, Daniele M.
Caprioli, Rafaela A.
Laisse, Cláudio J.M.
Borsanelli, Ana Carolina [UNESP]
Dutra, Iveraldo S. [UNESP]
Driemeier, David
author_role author
author2 Konradt, Guilherme
Bassuino, Daniele M.
Caprioli, Rafaela A.
Laisse, Cláudio J.M.
Borsanelli, Ana Carolina [UNESP]
Dutra, Iveraldo S. [UNESP]
Driemeier, David
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Federal do Rio Grande do Sul (UFRGS)
Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Argenta, Fernando F.
Konradt, Guilherme
Bassuino, Daniele M.
Caprioli, Rafaela A.
Laisse, Cláudio J.M.
Borsanelli, Ana Carolina [UNESP]
Dutra, Iveraldo S. [UNESP]
Driemeier, David
dc.subject.por.fl_str_mv Botulinum toxin type C
Botulism type C
Clostridium botulinum
Horses
Poisoning
topic Botulinum toxin type C
Botulism type C
Clostridium botulinum
Horses
Poisoning
description Botulism in domestic animals is a fatal poisoning caused by ingestion of Clostridium botulinum neurotoxin. This paper describes epidemiological, clinical and laboratorial aspects of a botulism type C outbreak in horses in a farm in Porto Alegre, Rio Grande do Sul. From a total of 20 horses, seven (35%) were affected and died, and one was euthanized after presenting poor prognosis. The horses, which were raised extensively, showed similar clinical signs, that included limited mobility, lethargy, progressive flaccid paralysis, muscle tremors, sweating, ataxia, and frequent falls. Four horses were necropsied and did not show significant macroscopic and microscopic lesions. Brain and spinal cord samples were analyzed by direct immunofluorescence and were negative for rabies. Liver fragments from the four necropsied horses, soil sediment samples, and suspect water from two reservoirs were evaluated by direct exam to verify the botulinum toxin and/or Clostridium botulinum spores presence. In the serum neutralization bioassay in mice, the type C botulinum toxin was detected in one liver sample, at the same time that the soil sediment and water samples were negative in all assays. Based on the epidemiological, clinical and laboratory data the etiological diagnosis of botulism was established by being caused by botulinum toxin type C, and it is suggested that the stagnant water of the dams is the likely source of the toxin.
publishDate 2017
dc.date.none.fl_str_mv 2017-12-01
2018-12-11T17:18:39Z
2018-12-11T17:18:39Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S0100-736X2017001200002
Pesquisa Veterinaria Brasileira, v. 37, n. 12, p. 1369-1372, 2017.
1678-5150
0100-736X
http://hdl.handle.net/11449/176035
10.1590/S0100-736X2017001200002
S0100-736X2017001201369
2-s2.0-85044214313
S0100-736X2017001201369.pdf
url http://dx.doi.org/10.1590/S0100-736X2017001200002
http://hdl.handle.net/11449/176035
identifier_str_mv Pesquisa Veterinaria Brasileira, v. 37, n. 12, p. 1369-1372, 2017.
1678-5150
0100-736X
10.1590/S0100-736X2017001200002
S0100-736X2017001201369
2-s2.0-85044214313
S0100-736X2017001201369.pdf
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv Pesquisa Veterinaria Brasileira
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 1369-1372
application/pdf
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv repositoriounesp@unesp.br
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