Surto de botulismo tipo C em equinos no Rio Grande do Sul
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/S0100-736X2017001200002 http://hdl.handle.net/11449/176035 |
Resumo: | Botulism in domestic animals is a fatal poisoning caused by ingestion of Clostridium botulinum neurotoxin. This paper describes epidemiological, clinical and laboratorial aspects of a botulism type C outbreak in horses in a farm in Porto Alegre, Rio Grande do Sul. From a total of 20 horses, seven (35%) were affected and died, and one was euthanized after presenting poor prognosis. The horses, which were raised extensively, showed similar clinical signs, that included limited mobility, lethargy, progressive flaccid paralysis, muscle tremors, sweating, ataxia, and frequent falls. Four horses were necropsied and did not show significant macroscopic and microscopic lesions. Brain and spinal cord samples were analyzed by direct immunofluorescence and were negative for rabies. Liver fragments from the four necropsied horses, soil sediment samples, and suspect water from two reservoirs were evaluated by direct exam to verify the botulinum toxin and/or Clostridium botulinum spores presence. In the serum neutralization bioassay in mice, the type C botulinum toxin was detected in one liver sample, at the same time that the soil sediment and water samples were negative in all assays. Based on the epidemiological, clinical and laboratory data the etiological diagnosis of botulism was established by being caused by botulinum toxin type C, and it is suggested that the stagnant water of the dams is the likely source of the toxin. |
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Surto de botulismo tipo C em equinos no Rio Grande do SulOutbreak of type C botulism in horses in Rio Grande do SulBotulinum toxin type CBotulism type CClostridium botulinumHorsesPoisoningBotulism in domestic animals is a fatal poisoning caused by ingestion of Clostridium botulinum neurotoxin. This paper describes epidemiological, clinical and laboratorial aspects of a botulism type C outbreak in horses in a farm in Porto Alegre, Rio Grande do Sul. From a total of 20 horses, seven (35%) were affected and died, and one was euthanized after presenting poor prognosis. The horses, which were raised extensively, showed similar clinical signs, that included limited mobility, lethargy, progressive flaccid paralysis, muscle tremors, sweating, ataxia, and frequent falls. Four horses were necropsied and did not show significant macroscopic and microscopic lesions. Brain and spinal cord samples were analyzed by direct immunofluorescence and were negative for rabies. Liver fragments from the four necropsied horses, soil sediment samples, and suspect water from two reservoirs were evaluated by direct exam to verify the botulinum toxin and/or Clostridium botulinum spores presence. In the serum neutralization bioassay in mice, the type C botulinum toxin was detected in one liver sample, at the same time that the soil sediment and water samples were negative in all assays. Based on the epidemiological, clinical and laboratory data the etiological diagnosis of botulism was established by being caused by botulinum toxin type C, and it is suggested that the stagnant water of the dams is the likely source of the toxin.Setor de Patologia Veterinária Departamento de Patologia Clínica Veterinária Faculdade de Veterinária Universidade Federal do Rio Grande do Sul (UFRGS), Av. Bento Gonçalves 9090Departamento de Apoio Produção e Saúde Animal Faculdade de Medicina Veterinária de Araçatuba Universidade Estadual Paulista (Unesp), Rua Clovis Pestana 793, Jardim Dona Amelia, Cx. Postal 533Departamento de Apoio Produção e Saúde Animal Faculdade de Medicina Veterinária de Araçatuba Universidade Estadual Paulista (Unesp), Rua Clovis Pestana 793, Jardim Dona Amelia, Cx. Postal 533Universidade Federal do Rio Grande do Sul (UFRGS)Universidade Estadual Paulista (Unesp)Argenta, Fernando F.Konradt, GuilhermeBassuino, Daniele M.Caprioli, Rafaela A.Laisse, Cláudio J.M.Borsanelli, Ana Carolina [UNESP]Dutra, Iveraldo S. [UNESP]Driemeier, David2018-12-11T17:18:39Z2018-12-11T17:18:39Z2017-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1369-1372application/pdfhttp://dx.doi.org/10.1590/S0100-736X2017001200002Pesquisa Veterinaria Brasileira, v. 37, n. 12, p. 1369-1372, 2017.1678-51500100-736Xhttp://hdl.handle.net/11449/17603510.1590/S0100-736X2017001200002S0100-736X20170012013692-s2.0-85044214313S0100-736X2017001201369.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPporPesquisa Veterinaria Brasileirainfo:eu-repo/semantics/openAccess2024-09-04T19:15:39Zoai:repositorio.unesp.br:11449/176035Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-04T19:15:39Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Surto de botulismo tipo C em equinos no Rio Grande do Sul Outbreak of type C botulism in horses in Rio Grande do Sul |
title |
Surto de botulismo tipo C em equinos no Rio Grande do Sul |
spellingShingle |
Surto de botulismo tipo C em equinos no Rio Grande do Sul Argenta, Fernando F. Botulinum toxin type C Botulism type C Clostridium botulinum Horses Poisoning |
title_short |
Surto de botulismo tipo C em equinos no Rio Grande do Sul |
title_full |
Surto de botulismo tipo C em equinos no Rio Grande do Sul |
title_fullStr |
Surto de botulismo tipo C em equinos no Rio Grande do Sul |
title_full_unstemmed |
Surto de botulismo tipo C em equinos no Rio Grande do Sul |
title_sort |
Surto de botulismo tipo C em equinos no Rio Grande do Sul |
author |
Argenta, Fernando F. |
author_facet |
Argenta, Fernando F. Konradt, Guilherme Bassuino, Daniele M. Caprioli, Rafaela A. Laisse, Cláudio J.M. Borsanelli, Ana Carolina [UNESP] Dutra, Iveraldo S. [UNESP] Driemeier, David |
author_role |
author |
author2 |
Konradt, Guilherme Bassuino, Daniele M. Caprioli, Rafaela A. Laisse, Cláudio J.M. Borsanelli, Ana Carolina [UNESP] Dutra, Iveraldo S. [UNESP] Driemeier, David |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal do Rio Grande do Sul (UFRGS) Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Argenta, Fernando F. Konradt, Guilherme Bassuino, Daniele M. Caprioli, Rafaela A. Laisse, Cláudio J.M. Borsanelli, Ana Carolina [UNESP] Dutra, Iveraldo S. [UNESP] Driemeier, David |
dc.subject.por.fl_str_mv |
Botulinum toxin type C Botulism type C Clostridium botulinum Horses Poisoning |
topic |
Botulinum toxin type C Botulism type C Clostridium botulinum Horses Poisoning |
description |
Botulism in domestic animals is a fatal poisoning caused by ingestion of Clostridium botulinum neurotoxin. This paper describes epidemiological, clinical and laboratorial aspects of a botulism type C outbreak in horses in a farm in Porto Alegre, Rio Grande do Sul. From a total of 20 horses, seven (35%) were affected and died, and one was euthanized after presenting poor prognosis. The horses, which were raised extensively, showed similar clinical signs, that included limited mobility, lethargy, progressive flaccid paralysis, muscle tremors, sweating, ataxia, and frequent falls. Four horses were necropsied and did not show significant macroscopic and microscopic lesions. Brain and spinal cord samples were analyzed by direct immunofluorescence and were negative for rabies. Liver fragments from the four necropsied horses, soil sediment samples, and suspect water from two reservoirs were evaluated by direct exam to verify the botulinum toxin and/or Clostridium botulinum spores presence. In the serum neutralization bioassay in mice, the type C botulinum toxin was detected in one liver sample, at the same time that the soil sediment and water samples were negative in all assays. Based on the epidemiological, clinical and laboratory data the etiological diagnosis of botulism was established by being caused by botulinum toxin type C, and it is suggested that the stagnant water of the dams is the likely source of the toxin. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-12-01 2018-12-11T17:18:39Z 2018-12-11T17:18:39Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S0100-736X2017001200002 Pesquisa Veterinaria Brasileira, v. 37, n. 12, p. 1369-1372, 2017. 1678-5150 0100-736X http://hdl.handle.net/11449/176035 10.1590/S0100-736X2017001200002 S0100-736X2017001201369 2-s2.0-85044214313 S0100-736X2017001201369.pdf |
url |
http://dx.doi.org/10.1590/S0100-736X2017001200002 http://hdl.handle.net/11449/176035 |
identifier_str_mv |
Pesquisa Veterinaria Brasileira, v. 37, n. 12, p. 1369-1372, 2017. 1678-5150 0100-736X 10.1590/S0100-736X2017001200002 S0100-736X2017001201369 2-s2.0-85044214313 S0100-736X2017001201369.pdf |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
Pesquisa Veterinaria Brasileira |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
1369-1372 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
repositoriounesp@unesp.br |
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1810021397965045760 |