The protective effect of Artepillin C against lipid oxidation on simplified model membranes

Detalhes bibliográficos
Autor(a) principal: Pazin, Wallance Moreira [UNESP]
Data de Publicação: 2021
Outros Autores: Ruiz, Gilia Cristine Marques [UNESP], Ito, Amando Siuiti, Constantino, Carlos José Leopoldo [UNESP], Aoki, Pedro Henrique Benites [UNESP], Santos, Marcelo Jose dos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://hdl.handle.net/11449/202820
Resumo: Brazilian green propolis is a well-known therapeutic product, commonly used in folk medicine. Artepillin C is the major compound of propolis and has received considerable attention owing to its lipophilic affinity and antioxidant activity, enabling the use against lipid oxidation caused by free radicals, which is a first step before degenerative diseases. The protective effect of Artepillin C against lipid oxidation was evaluated here on simplified models of lipid membranes based on Langmuir monolayers and giant unilamellar vesicles (GUVs) formed of DOPC under oxidative stress induced by the photoactivated erythrosin. Our findings show that Artepillin C donates a hydrogen atom of the phenolic hydroxyl group to the lipid radical, avoiding the formation of truncated aldehyde lipids, playing a role in the termination step of lipid peroxidation generating hydroperoxides. The affinity of Artepillin C for lipid structures, together with its antioxidant potential, preclude the lipid peroxidation caused by reactive species.
id UNSP_d43fafd466da8715d8e1828fa5b604f2
oai_identifier_str oai:repositorio.unesp.br:11449/202820
network_acronym_str UNSP
network_name_str Repositório Institucional da UNESP
repository_id_str 2946
spelling The protective effect of Artepillin C against lipid oxidation on simplified model membranesGreen propolisArtepillin CAntioxidant activityModel membranesErythrosineBrazilian green propolis is a well-known therapeutic product, commonly used in folk medicine. Artepillin C is the major compound of propolis and has received considerable attention owing to its lipophilic affinity and antioxidant activity, enabling the use against lipid oxidation caused by free radicals, which is a first step before degenerative diseases. The protective effect of Artepillin C against lipid oxidation was evaluated here on simplified models of lipid membranes based on Langmuir monolayers and giant unilamellar vesicles (GUVs) formed of DOPC under oxidative stress induced by the photoactivated erythrosin. Our findings show that Artepillin C donates a hydrogen atom of the phenolic hydroxyl group to the lipid radical, avoiding the formation of truncated aldehyde lipids, playing a role in the termination step of lipid peroxidation generating hydroperoxides. The affinity of Artepillin C for lipid structures, together with its antioxidant potential, preclude the lipid peroxidation caused by reactive species.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)PostprintSão Paulo State University (UNESP), School of Technology and Applied Sciences, Presidente Prudente, SP, Brazil, 19060-900University of São Paulo USP), Faculty of Philosophy, Sciences and Letters of Ribeirão Preto, Ribeirão Preto, SP, Brazil, 14040-901São Paulo State University (UNESP), School of Sciences, Humanities and Languages, Assis, SP, Brazil, 19806-900FAPESP: 2016/09633-4FAPESP: 2018/16713-0CNPq: 304100/2018-8CNPq: 305771/2016-7FAPESP: 2018/22214-6ElsevierUniversidade Estadual Paulista (Unesp)Pazin, Wallance Moreira [UNESP]Ruiz, Gilia Cristine Marques [UNESP]Ito, Amando SiuitiConstantino, Carlos José Leopoldo [UNESP]Aoki, Pedro Henrique Benites [UNESP]Santos, Marcelo Jose dos2021-03-02T13:02:40Z2021-03-02T13:02:40Z2021-02-15info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdf0167-7322http://hdl.handle.net/11449/20282010.1016/j.molliq.2020.115089839412075652589280592082451480954724506319250767738416867453970261183259673198360000-0002-2157-59330000-0001-8623-178X0000-0003-4701-64080000-0003-4454-60320000-0002-5921-3161engJournal of Molecular Liquidsinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESP2024-06-13T15:14:04Zoai:repositorio.unesp.br:11449/202820Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T20:49:25.714513Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv The protective effect of Artepillin C against lipid oxidation on simplified model membranes
title The protective effect of Artepillin C against lipid oxidation on simplified model membranes
spellingShingle The protective effect of Artepillin C against lipid oxidation on simplified model membranes
Pazin, Wallance Moreira [UNESP]
Green propolis
Artepillin C
Antioxidant activity
Model membranes
Erythrosine
title_short The protective effect of Artepillin C against lipid oxidation on simplified model membranes
title_full The protective effect of Artepillin C against lipid oxidation on simplified model membranes
title_fullStr The protective effect of Artepillin C against lipid oxidation on simplified model membranes
title_full_unstemmed The protective effect of Artepillin C against lipid oxidation on simplified model membranes
title_sort The protective effect of Artepillin C against lipid oxidation on simplified model membranes
author Pazin, Wallance Moreira [UNESP]
author_facet Pazin, Wallance Moreira [UNESP]
Ruiz, Gilia Cristine Marques [UNESP]
Ito, Amando Siuiti
Constantino, Carlos José Leopoldo [UNESP]
Aoki, Pedro Henrique Benites [UNESP]
Santos, Marcelo Jose dos
author_role author
author2 Ruiz, Gilia Cristine Marques [UNESP]
Ito, Amando Siuiti
Constantino, Carlos José Leopoldo [UNESP]
Aoki, Pedro Henrique Benites [UNESP]
Santos, Marcelo Jose dos
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Pazin, Wallance Moreira [UNESP]
Ruiz, Gilia Cristine Marques [UNESP]
Ito, Amando Siuiti
Constantino, Carlos José Leopoldo [UNESP]
Aoki, Pedro Henrique Benites [UNESP]
Santos, Marcelo Jose dos
dc.subject.por.fl_str_mv Green propolis
Artepillin C
Antioxidant activity
Model membranes
Erythrosine
topic Green propolis
Artepillin C
Antioxidant activity
Model membranes
Erythrosine
description Brazilian green propolis is a well-known therapeutic product, commonly used in folk medicine. Artepillin C is the major compound of propolis and has received considerable attention owing to its lipophilic affinity and antioxidant activity, enabling the use against lipid oxidation caused by free radicals, which is a first step before degenerative diseases. The protective effect of Artepillin C against lipid oxidation was evaluated here on simplified models of lipid membranes based on Langmuir monolayers and giant unilamellar vesicles (GUVs) formed of DOPC under oxidative stress induced by the photoactivated erythrosin. Our findings show that Artepillin C donates a hydrogen atom of the phenolic hydroxyl group to the lipid radical, avoiding the formation of truncated aldehyde lipids, playing a role in the termination step of lipid peroxidation generating hydroperoxides. The affinity of Artepillin C for lipid structures, together with its antioxidant potential, preclude the lipid peroxidation caused by reactive species.
publishDate 2021
dc.date.none.fl_str_mv 2021-03-02T13:02:40Z
2021-03-02T13:02:40Z
2021-02-15
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv 0167-7322
http://hdl.handle.net/11449/202820
10.1016/j.molliq.2020.115089
8394120756525892
8059208245148095
4724506319250767
7384168674539702
6118325967319836
0000-0002-2157-5933
0000-0001-8623-178X
0000-0003-4701-6408
0000-0003-4454-6032
0000-0002-5921-3161
identifier_str_mv 0167-7322
10.1016/j.molliq.2020.115089
8394120756525892
8059208245148095
4724506319250767
7384168674539702
6118325967319836
0000-0002-2157-5933
0000-0001-8623-178X
0000-0003-4701-6408
0000-0003-4454-6032
0000-0002-5921-3161
url http://hdl.handle.net/11449/202820
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Journal of Molecular Liquids
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1808129254453411840

Registros relacionados