Estudio histológico del processo de reparación alveolar después de la aplicación tópica de la solucioón anestésica prilocaína 3 % con felipressina o,o3 ui/ml

• Autor(a) principal: Monnazzi, Marcelo Silva [UNESP]
• Data de Publicação: 2010
• Outros Autores: Dias-Ribeiro, Eduardo, Milanezi, Luis Al berto, Okamoto, Tetuo [UNESP], Gabrielli, Mário Francisco Real [UNESP], Chiarelli, Murilo [UNESP]
• Tipo de documento: Artigo
• Idioma: spa
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://www.actaodontologica.com/ediciones/2010/3/art6.asp; http://hdl.handle.net/11449/125615
• topic: Socket healing; Local anesthetics; Prilocaine; Topical application; Oral surgery; Reparación alveolar; Anestésicos locales; Aplicación tópica; Cirugía oral; Reparo alveolar; Anestésicos locais; Prilocaína; Aplicação tópica; Cirurgia oral

The aim of this study was to evaluate the local anesthetic solution, composed by Prilocaine 3% and felipressin 0,03 UI/ml, influence on the alveolar repair process in rats after dental extraction. This research was previously approved by the Ethic Committee in Research of the Masters Degree Program in Oral and Maxillofacial Surgery of the Marília University (UNIMAR), Marília, São Paulo, Brazil. It was an experimental, randomly controlled study, with bifactorial analysis (group control versus experimental group, in function of the postoperative times (2 X 4)). For the accomplishment of this study 32 rats were used (Rattus norvegicus, albinus, Wistar), males, adults, weighing between 280 and 320 grams. The animals were selected and divided into Group I (control) and Group II (Citocain 3%® - Prilocaine 3% with felipressin 0,03UI/ml) with 16 rats each; being four animals of the Group I and four of the Group II, destined to the euthanasia in the postoperative periods of 3rd, 7th, 15th and 24th days. The histological analysis with base in the developed methodology, allowed us to conclude that the anesthetic solution of Citocain 3%® applied with gauze compress on the surgical dental wound, produced tissue events that committed the basic biological principles, that are responsible for the regeneration of the gingival epithelium and the alveolar process repair in rats. The Group I presented better results in the alveolar repair when compared to the Group II.