Deregulation of VEGFR-2 and PDGFR expression and microvascular density in a triple-negative model of canine malignant mammary tumors with lymph node or lung metastasis
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.3390/VETSCI6010003 http://hdl.handle.net/11449/189453 |
Resumo: | Canine mammary tumors (CMT) represent the most common cancer in noncastrated female dogs. Interestingly, triple-negative tumors are the most common molecular subtype in female dogs. In this study, we proposed to evaluate the expression of vascular endothelial growth factor receptor 2 (VEGFR-2), Platelet-derived growth factor receptor (PDGFR), and microvascular density (MVD) in a group of metastatic and nonmetastatic triple-negative CMT and compare the expression based on clinical parameters. Twenty-six female dogs with triple-negative mammary tumors were divided into three groups: nonmetastatic tumors (NMT) (n = 11), tumors with lymph node metastasis (LNM) (n = 10), and tumors with lung metastasis (LM) (n = 5). We observed increased VEGFR-2 expression in LNM compared with NMT and a positive correlation between tumor grade and VEGFR-2 expression. A positive correlation was noted between VEGFR-2 and PDGFR expression. Regarding microvascular density (MVD), we identified a higher number of vessels in primary tumors with lymph node metastasis and lung metastasis compared with tumors with no metastasis. The primary tumors with lung metastasis exhibited an increased MVD compared with carcinoma with lymph node metastasis. Overall, our results suggest a deregulation of VEGFR-2 and PDGFR and high MVD in metastatic tumors, indicating a role for angiogenesis in tumor progression. |
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Deregulation of VEGFR-2 and PDGFR expression and microvascular density in a triple-negative model of canine malignant mammary tumors with lymph node or lung metastasisAngiogenesisMammary neoplasmMetastasisCanine mammary tumors (CMT) represent the most common cancer in noncastrated female dogs. Interestingly, triple-negative tumors are the most common molecular subtype in female dogs. In this study, we proposed to evaluate the expression of vascular endothelial growth factor receptor 2 (VEGFR-2), Platelet-derived growth factor receptor (PDGFR), and microvascular density (MVD) in a group of metastatic and nonmetastatic triple-negative CMT and compare the expression based on clinical parameters. Twenty-six female dogs with triple-negative mammary tumors were divided into three groups: nonmetastatic tumors (NMT) (n = 11), tumors with lymph node metastasis (LNM) (n = 10), and tumors with lung metastasis (LM) (n = 5). We observed increased VEGFR-2 expression in LNM compared with NMT and a positive correlation between tumor grade and VEGFR-2 expression. A positive correlation was noted between VEGFR-2 and PDGFR expression. Regarding microvascular density (MVD), we identified a higher number of vessels in primary tumors with lymph node metastasis and lung metastasis compared with tumors with no metastasis. The primary tumors with lung metastasis exhibited an increased MVD compared with carcinoma with lymph node metastasis. Overall, our results suggest a deregulation of VEGFR-2 and PDGFR and high MVD in metastatic tumors, indicating a role for angiogenesis in tumor progression.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Veterinary Science Graduate Program University of Franca (UNIFRAN)Department of Veterinary Surgery and Anesthesiology School of Veterinary Medicine and Animal Science São Paulo State University-UNESPSuperintendencia Unidade Hospitalar Veterinaria Universitaria Federal University of the Fronteira SulDepartment of Veterinary Surgery and Anesthesiology School of Veterinary Medicine and Animal Science São Paulo State University-UNESPUniversity of Franca (UNIFRAN)Universidade Estadual Paulista (Unesp)Federal University of the Fronteira Suldos Anjos, Denner SantosVital, Aline FernandesLainetti, Patrícia de Faria [UNESP]Leis-Filho, Antonio Fernando [UNESP]Dalmolin, FabiolaElias, FabianaCalazans, Sabryna GouveiaFonseca-Alves, Carlos Eduardo [UNESP]2019-10-06T16:41:12Z2019-10-06T16:41:12Z2019-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.3390/VETSCI6010003Veterinary Sciences, v. 6, n. 1, 2019.2306-7381http://hdl.handle.net/11449/18945310.3390/VETSCI60100032-s2.0-85069768312Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengVeterinary Sciencesinfo:eu-repo/semantics/openAccess2021-10-23T12:39:45Zoai:repositorio.unesp.br:11449/189453Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T21:33:06.561104Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Deregulation of VEGFR-2 and PDGFR expression and microvascular density in a triple-negative model of canine malignant mammary tumors with lymph node or lung metastasis |
title |
Deregulation of VEGFR-2 and PDGFR expression and microvascular density in a triple-negative model of canine malignant mammary tumors with lymph node or lung metastasis |
spellingShingle |
Deregulation of VEGFR-2 and PDGFR expression and microvascular density in a triple-negative model of canine malignant mammary tumors with lymph node or lung metastasis dos Anjos, Denner Santos Angiogenesis Mammary neoplasm Metastasis |
title_short |
Deregulation of VEGFR-2 and PDGFR expression and microvascular density in a triple-negative model of canine malignant mammary tumors with lymph node or lung metastasis |
title_full |
Deregulation of VEGFR-2 and PDGFR expression and microvascular density in a triple-negative model of canine malignant mammary tumors with lymph node or lung metastasis |
title_fullStr |
Deregulation of VEGFR-2 and PDGFR expression and microvascular density in a triple-negative model of canine malignant mammary tumors with lymph node or lung metastasis |
title_full_unstemmed |
Deregulation of VEGFR-2 and PDGFR expression and microvascular density in a triple-negative model of canine malignant mammary tumors with lymph node or lung metastasis |
title_sort |
Deregulation of VEGFR-2 and PDGFR expression and microvascular density in a triple-negative model of canine malignant mammary tumors with lymph node or lung metastasis |
author |
dos Anjos, Denner Santos |
author_facet |
dos Anjos, Denner Santos Vital, Aline Fernandes Lainetti, Patrícia de Faria [UNESP] Leis-Filho, Antonio Fernando [UNESP] Dalmolin, Fabiola Elias, Fabiana Calazans, Sabryna Gouveia Fonseca-Alves, Carlos Eduardo [UNESP] |
author_role |
author |
author2 |
Vital, Aline Fernandes Lainetti, Patrícia de Faria [UNESP] Leis-Filho, Antonio Fernando [UNESP] Dalmolin, Fabiola Elias, Fabiana Calazans, Sabryna Gouveia Fonseca-Alves, Carlos Eduardo [UNESP] |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
University of Franca (UNIFRAN) Universidade Estadual Paulista (Unesp) Federal University of the Fronteira Sul |
dc.contributor.author.fl_str_mv |
dos Anjos, Denner Santos Vital, Aline Fernandes Lainetti, Patrícia de Faria [UNESP] Leis-Filho, Antonio Fernando [UNESP] Dalmolin, Fabiola Elias, Fabiana Calazans, Sabryna Gouveia Fonseca-Alves, Carlos Eduardo [UNESP] |
dc.subject.por.fl_str_mv |
Angiogenesis Mammary neoplasm Metastasis |
topic |
Angiogenesis Mammary neoplasm Metastasis |
description |
Canine mammary tumors (CMT) represent the most common cancer in noncastrated female dogs. Interestingly, triple-negative tumors are the most common molecular subtype in female dogs. In this study, we proposed to evaluate the expression of vascular endothelial growth factor receptor 2 (VEGFR-2), Platelet-derived growth factor receptor (PDGFR), and microvascular density (MVD) in a group of metastatic and nonmetastatic triple-negative CMT and compare the expression based on clinical parameters. Twenty-six female dogs with triple-negative mammary tumors were divided into three groups: nonmetastatic tumors (NMT) (n = 11), tumors with lymph node metastasis (LNM) (n = 10), and tumors with lung metastasis (LM) (n = 5). We observed increased VEGFR-2 expression in LNM compared with NMT and a positive correlation between tumor grade and VEGFR-2 expression. A positive correlation was noted between VEGFR-2 and PDGFR expression. Regarding microvascular density (MVD), we identified a higher number of vessels in primary tumors with lymph node metastasis and lung metastasis compared with tumors with no metastasis. The primary tumors with lung metastasis exhibited an increased MVD compared with carcinoma with lymph node metastasis. Overall, our results suggest a deregulation of VEGFR-2 and PDGFR and high MVD in metastatic tumors, indicating a role for angiogenesis in tumor progression. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-10-06T16:41:12Z 2019-10-06T16:41:12Z 2019-01-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.3390/VETSCI6010003 Veterinary Sciences, v. 6, n. 1, 2019. 2306-7381 http://hdl.handle.net/11449/189453 10.3390/VETSCI6010003 2-s2.0-85069768312 |
url |
http://dx.doi.org/10.3390/VETSCI6010003 http://hdl.handle.net/11449/189453 |
identifier_str_mv |
Veterinary Sciences, v. 6, n. 1, 2019. 2306-7381 10.3390/VETSCI6010003 2-s2.0-85069768312 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Veterinary Sciences |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129334145187840 |