Subarachnoid injection of ifenprodil and ketamine association improves the anti-hyperalgesic action of ketamine in dogs

Detalhes bibliográficos
Autor(a) principal: Rondon, E. S.
Data de Publicação: 2015
Outros Autores: Valadão, C. A.A. [UNESP], Parada, C. A.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1590/1678-4162-8057
http://hdl.handle.net/11449/168249
Resumo: To test clinically whether a small dose of ifenprodil can enhance the anti-hyperalgesic effect of ketamine in dogs, a prospective randomized cross-over study was done with eight mongrel dogs (weighing 16.9 ± 3.7kg). Animals received two distinct treatments: Ketamine (0.3mg kg-1; KT) and an ifenprodil plus ketamine combination (0.03mg kg-1 and 0.3mg kg-1, respectively; IKT). Dogs were anesthetized with propofol (5mg kg-1 intravenously) and a subarachnoid needle was placed between the 5th and 6th lumbar vertebrae. Five minutes after subarachnoid injection of KT or IKT, an incision including cutaneous and subcutaneous tissues was made on the common pad of one hind limb and was immediately closed with a simple interrupted suture pattern. The dogs were treated again 20 days later, using the contralateral pad and the opposite treatment. Sedation score (SS), lameness score (LS), heart rate (HR), respiratory rate (fR), and mechanical nociceptive threshold using von Frey filaments, were evaluated before anesthesia and at 1, 1.5, 2, 3, 4, 8, 12, and 24 hours after subarachnoid injection. There were no differences in SS, LS, HR or fR between treatments. The intensity of hyperalgesia was higher in KT than in IKT for 24 hours. The anti-hyperalgesic effect of IKT remained without statistical significant difference between 1 and 24 h. Prior subarachnoid administration of ifenprodil enhances the anti-hyperalgesic effect of subarachnoid ketamine in dogs. Ifenprodil can be co-administrated with ketamine to enhance its antihyperalgesic effect and to reduce acute post-incisional hyperalgesia without motor impairment and sedation.
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spelling Subarachnoid injection of ifenprodil and ketamine association improves the anti-hyperalgesic action of ketamine in dogsAnalgesiaInflammatory painNMDAPainSubarachnoidTo test clinically whether a small dose of ifenprodil can enhance the anti-hyperalgesic effect of ketamine in dogs, a prospective randomized cross-over study was done with eight mongrel dogs (weighing 16.9 ± 3.7kg). Animals received two distinct treatments: Ketamine (0.3mg kg-1; KT) and an ifenprodil plus ketamine combination (0.03mg kg-1 and 0.3mg kg-1, respectively; IKT). Dogs were anesthetized with propofol (5mg kg-1 intravenously) and a subarachnoid needle was placed between the 5th and 6th lumbar vertebrae. Five minutes after subarachnoid injection of KT or IKT, an incision including cutaneous and subcutaneous tissues was made on the common pad of one hind limb and was immediately closed with a simple interrupted suture pattern. The dogs were treated again 20 days later, using the contralateral pad and the opposite treatment. Sedation score (SS), lameness score (LS), heart rate (HR), respiratory rate (fR), and mechanical nociceptive threshold using von Frey filaments, were evaluated before anesthesia and at 1, 1.5, 2, 3, 4, 8, 12, and 24 hours after subarachnoid injection. There were no differences in SS, LS, HR or fR between treatments. The intensity of hyperalgesia was higher in KT than in IKT for 24 hours. The anti-hyperalgesic effect of IKT remained without statistical significant difference between 1 and 24 h. Prior subarachnoid administration of ifenprodil enhances the anti-hyperalgesic effect of subarachnoid ketamine in dogs. Ifenprodil can be co-administrated with ketamine to enhance its antihyperalgesic effect and to reduce acute post-incisional hyperalgesia without motor impairment and sedation.Faculdade de Medicina Veterinária e Zootecnia Universidade Federal de Mato Grosso do Sul FAMEZ-UFMSFaculdade de Ciências Agrárias e Veterinárias Universidade Estadual Paulista Júlio de Mesquita FilhoInstituto de Biologia Universidade Estadual de Campinas UNICAMPFaculdade de Ciências Agrárias e Veterinárias Universidade Estadual Paulista Júlio de Mesquita FilhoUniversidade Federal de Mato Grosso do Sul (UFMS)Universidade Estadual Paulista (Unesp)Universidade Estadual de Campinas (UNICAMP)Rondon, E. S.Valadão, C. A.A. [UNESP]Parada, C. A.2018-12-11T16:40:25Z2018-12-11T16:40:25Z2015-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1539-1546application/pdfhttp://dx.doi.org/10.1590/1678-4162-8057Arquivo Brasileiro de Medicina Veterinaria e Zootecnia, v. 67, n. 6, p. 1539-1546, 2015.1678-41620102-0935http://hdl.handle.net/11449/16824910.1590/1678-4162-8057S0102-093520150006015392-s2.0-84951973697S0102-09352015000601539.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengArquivo Brasileiro de Medicina Veterinaria e Zootecnia0,248info:eu-repo/semantics/openAccess2023-12-03T06:18:05Zoai:repositorio.unesp.br:11449/168249Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T19:25:49.180075Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Subarachnoid injection of ifenprodil and ketamine association improves the anti-hyperalgesic action of ketamine in dogs
title Subarachnoid injection of ifenprodil and ketamine association improves the anti-hyperalgesic action of ketamine in dogs
spellingShingle Subarachnoid injection of ifenprodil and ketamine association improves the anti-hyperalgesic action of ketamine in dogs
Rondon, E. S.
Analgesia
Inflammatory pain
NMDA
Pain
Subarachnoid
title_short Subarachnoid injection of ifenprodil and ketamine association improves the anti-hyperalgesic action of ketamine in dogs
title_full Subarachnoid injection of ifenprodil and ketamine association improves the anti-hyperalgesic action of ketamine in dogs
title_fullStr Subarachnoid injection of ifenprodil and ketamine association improves the anti-hyperalgesic action of ketamine in dogs
title_full_unstemmed Subarachnoid injection of ifenprodil and ketamine association improves the anti-hyperalgesic action of ketamine in dogs
title_sort Subarachnoid injection of ifenprodil and ketamine association improves the anti-hyperalgesic action of ketamine in dogs
author Rondon, E. S.
author_facet Rondon, E. S.
Valadão, C. A.A. [UNESP]
Parada, C. A.
author_role author
author2 Valadão, C. A.A. [UNESP]
Parada, C. A.
author2_role author
author
dc.contributor.none.fl_str_mv Universidade Federal de Mato Grosso do Sul (UFMS)
Universidade Estadual Paulista (Unesp)
Universidade Estadual de Campinas (UNICAMP)
dc.contributor.author.fl_str_mv Rondon, E. S.
Valadão, C. A.A. [UNESP]
Parada, C. A.
dc.subject.por.fl_str_mv Analgesia
Inflammatory pain
NMDA
Pain
Subarachnoid
topic Analgesia
Inflammatory pain
NMDA
Pain
Subarachnoid
description To test clinically whether a small dose of ifenprodil can enhance the anti-hyperalgesic effect of ketamine in dogs, a prospective randomized cross-over study was done with eight mongrel dogs (weighing 16.9 ± 3.7kg). Animals received two distinct treatments: Ketamine (0.3mg kg-1; KT) and an ifenprodil plus ketamine combination (0.03mg kg-1 and 0.3mg kg-1, respectively; IKT). Dogs were anesthetized with propofol (5mg kg-1 intravenously) and a subarachnoid needle was placed between the 5th and 6th lumbar vertebrae. Five minutes after subarachnoid injection of KT or IKT, an incision including cutaneous and subcutaneous tissues was made on the common pad of one hind limb and was immediately closed with a simple interrupted suture pattern. The dogs were treated again 20 days later, using the contralateral pad and the opposite treatment. Sedation score (SS), lameness score (LS), heart rate (HR), respiratory rate (fR), and mechanical nociceptive threshold using von Frey filaments, were evaluated before anesthesia and at 1, 1.5, 2, 3, 4, 8, 12, and 24 hours after subarachnoid injection. There were no differences in SS, LS, HR or fR between treatments. The intensity of hyperalgesia was higher in KT than in IKT for 24 hours. The anti-hyperalgesic effect of IKT remained without statistical significant difference between 1 and 24 h. Prior subarachnoid administration of ifenprodil enhances the anti-hyperalgesic effect of subarachnoid ketamine in dogs. Ifenprodil can be co-administrated with ketamine to enhance its antihyperalgesic effect and to reduce acute post-incisional hyperalgesia without motor impairment and sedation.
publishDate 2015
dc.date.none.fl_str_mv 2015-01-01
2018-12-11T16:40:25Z
2018-12-11T16:40:25Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/1678-4162-8057
Arquivo Brasileiro de Medicina Veterinaria e Zootecnia, v. 67, n. 6, p. 1539-1546, 2015.
1678-4162
0102-0935
http://hdl.handle.net/11449/168249
10.1590/1678-4162-8057
S0102-09352015000601539
2-s2.0-84951973697
S0102-09352015000601539.pdf
url http://dx.doi.org/10.1590/1678-4162-8057
http://hdl.handle.net/11449/168249
identifier_str_mv Arquivo Brasileiro de Medicina Veterinaria e Zootecnia, v. 67, n. 6, p. 1539-1546, 2015.
1678-4162
0102-0935
10.1590/1678-4162-8057
S0102-09352015000601539
2-s2.0-84951973697
S0102-09352015000601539.pdf
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Arquivo Brasileiro de Medicina Veterinaria e Zootecnia
0,248
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 1539-1546
application/pdf
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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