Subarachnoid injection of ifenprodil and ketamine association improves the anti-hyperalgesic action of ketamine in dogs
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/1678-4162-8057 http://hdl.handle.net/11449/168249 |
Resumo: | To test clinically whether a small dose of ifenprodil can enhance the anti-hyperalgesic effect of ketamine in dogs, a prospective randomized cross-over study was done with eight mongrel dogs (weighing 16.9 ± 3.7kg). Animals received two distinct treatments: Ketamine (0.3mg kg-1; KT) and an ifenprodil plus ketamine combination (0.03mg kg-1 and 0.3mg kg-1, respectively; IKT). Dogs were anesthetized with propofol (5mg kg-1 intravenously) and a subarachnoid needle was placed between the 5th and 6th lumbar vertebrae. Five minutes after subarachnoid injection of KT or IKT, an incision including cutaneous and subcutaneous tissues was made on the common pad of one hind limb and was immediately closed with a simple interrupted suture pattern. The dogs were treated again 20 days later, using the contralateral pad and the opposite treatment. Sedation score (SS), lameness score (LS), heart rate (HR), respiratory rate (fR), and mechanical nociceptive threshold using von Frey filaments, were evaluated before anesthesia and at 1, 1.5, 2, 3, 4, 8, 12, and 24 hours after subarachnoid injection. There were no differences in SS, LS, HR or fR between treatments. The intensity of hyperalgesia was higher in KT than in IKT for 24 hours. The anti-hyperalgesic effect of IKT remained without statistical significant difference between 1 and 24 h. Prior subarachnoid administration of ifenprodil enhances the anti-hyperalgesic effect of subarachnoid ketamine in dogs. Ifenprodil can be co-administrated with ketamine to enhance its antihyperalgesic effect and to reduce acute post-incisional hyperalgesia without motor impairment and sedation. |
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Subarachnoid injection of ifenprodil and ketamine association improves the anti-hyperalgesic action of ketamine in dogsAnalgesiaInflammatory painNMDAPainSubarachnoidTo test clinically whether a small dose of ifenprodil can enhance the anti-hyperalgesic effect of ketamine in dogs, a prospective randomized cross-over study was done with eight mongrel dogs (weighing 16.9 ± 3.7kg). Animals received two distinct treatments: Ketamine (0.3mg kg-1; KT) and an ifenprodil plus ketamine combination (0.03mg kg-1 and 0.3mg kg-1, respectively; IKT). Dogs were anesthetized with propofol (5mg kg-1 intravenously) and a subarachnoid needle was placed between the 5th and 6th lumbar vertebrae. Five minutes after subarachnoid injection of KT or IKT, an incision including cutaneous and subcutaneous tissues was made on the common pad of one hind limb and was immediately closed with a simple interrupted suture pattern. The dogs were treated again 20 days later, using the contralateral pad and the opposite treatment. Sedation score (SS), lameness score (LS), heart rate (HR), respiratory rate (fR), and mechanical nociceptive threshold using von Frey filaments, were evaluated before anesthesia and at 1, 1.5, 2, 3, 4, 8, 12, and 24 hours after subarachnoid injection. There were no differences in SS, LS, HR or fR between treatments. The intensity of hyperalgesia was higher in KT than in IKT for 24 hours. The anti-hyperalgesic effect of IKT remained without statistical significant difference between 1 and 24 h. Prior subarachnoid administration of ifenprodil enhances the anti-hyperalgesic effect of subarachnoid ketamine in dogs. Ifenprodil can be co-administrated with ketamine to enhance its antihyperalgesic effect and to reduce acute post-incisional hyperalgesia without motor impairment and sedation.Faculdade de Medicina Veterinária e Zootecnia Universidade Federal de Mato Grosso do Sul FAMEZ-UFMSFaculdade de Ciências Agrárias e Veterinárias Universidade Estadual Paulista Júlio de Mesquita FilhoInstituto de Biologia Universidade Estadual de Campinas UNICAMPFaculdade de Ciências Agrárias e Veterinárias Universidade Estadual Paulista Júlio de Mesquita FilhoUniversidade Federal de Mato Grosso do Sul (UFMS)Universidade Estadual Paulista (Unesp)Universidade Estadual de Campinas (UNICAMP)Rondon, E. S.Valadão, C. A.A. [UNESP]Parada, C. A.2018-12-11T16:40:25Z2018-12-11T16:40:25Z2015-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1539-1546application/pdfhttp://dx.doi.org/10.1590/1678-4162-8057Arquivo Brasileiro de Medicina Veterinaria e Zootecnia, v. 67, n. 6, p. 1539-1546, 2015.1678-41620102-0935http://hdl.handle.net/11449/16824910.1590/1678-4162-8057S0102-093520150006015392-s2.0-84951973697S0102-09352015000601539.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengArquivo Brasileiro de Medicina Veterinaria e Zootecnia0,248info:eu-repo/semantics/openAccess2023-12-03T06:18:05Zoai:repositorio.unesp.br:11449/168249Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T19:25:49.180075Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Subarachnoid injection of ifenprodil and ketamine association improves the anti-hyperalgesic action of ketamine in dogs |
title |
Subarachnoid injection of ifenprodil and ketamine association improves the anti-hyperalgesic action of ketamine in dogs |
spellingShingle |
Subarachnoid injection of ifenprodil and ketamine association improves the anti-hyperalgesic action of ketamine in dogs Rondon, E. S. Analgesia Inflammatory pain NMDA Pain Subarachnoid |
title_short |
Subarachnoid injection of ifenprodil and ketamine association improves the anti-hyperalgesic action of ketamine in dogs |
title_full |
Subarachnoid injection of ifenprodil and ketamine association improves the anti-hyperalgesic action of ketamine in dogs |
title_fullStr |
Subarachnoid injection of ifenprodil and ketamine association improves the anti-hyperalgesic action of ketamine in dogs |
title_full_unstemmed |
Subarachnoid injection of ifenprodil and ketamine association improves the anti-hyperalgesic action of ketamine in dogs |
title_sort |
Subarachnoid injection of ifenprodil and ketamine association improves the anti-hyperalgesic action of ketamine in dogs |
author |
Rondon, E. S. |
author_facet |
Rondon, E. S. Valadão, C. A.A. [UNESP] Parada, C. A. |
author_role |
author |
author2 |
Valadão, C. A.A. [UNESP] Parada, C. A. |
author2_role |
author author |
dc.contributor.none.fl_str_mv |
Universidade Federal de Mato Grosso do Sul (UFMS) Universidade Estadual Paulista (Unesp) Universidade Estadual de Campinas (UNICAMP) |
dc.contributor.author.fl_str_mv |
Rondon, E. S. Valadão, C. A.A. [UNESP] Parada, C. A. |
dc.subject.por.fl_str_mv |
Analgesia Inflammatory pain NMDA Pain Subarachnoid |
topic |
Analgesia Inflammatory pain NMDA Pain Subarachnoid |
description |
To test clinically whether a small dose of ifenprodil can enhance the anti-hyperalgesic effect of ketamine in dogs, a prospective randomized cross-over study was done with eight mongrel dogs (weighing 16.9 ± 3.7kg). Animals received two distinct treatments: Ketamine (0.3mg kg-1; KT) and an ifenprodil plus ketamine combination (0.03mg kg-1 and 0.3mg kg-1, respectively; IKT). Dogs were anesthetized with propofol (5mg kg-1 intravenously) and a subarachnoid needle was placed between the 5th and 6th lumbar vertebrae. Five minutes after subarachnoid injection of KT or IKT, an incision including cutaneous and subcutaneous tissues was made on the common pad of one hind limb and was immediately closed with a simple interrupted suture pattern. The dogs were treated again 20 days later, using the contralateral pad and the opposite treatment. Sedation score (SS), lameness score (LS), heart rate (HR), respiratory rate (fR), and mechanical nociceptive threshold using von Frey filaments, were evaluated before anesthesia and at 1, 1.5, 2, 3, 4, 8, 12, and 24 hours after subarachnoid injection. There were no differences in SS, LS, HR or fR between treatments. The intensity of hyperalgesia was higher in KT than in IKT for 24 hours. The anti-hyperalgesic effect of IKT remained without statistical significant difference between 1 and 24 h. Prior subarachnoid administration of ifenprodil enhances the anti-hyperalgesic effect of subarachnoid ketamine in dogs. Ifenprodil can be co-administrated with ketamine to enhance its antihyperalgesic effect and to reduce acute post-incisional hyperalgesia without motor impairment and sedation. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-01-01 2018-12-11T16:40:25Z 2018-12-11T16:40:25Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/1678-4162-8057 Arquivo Brasileiro de Medicina Veterinaria e Zootecnia, v. 67, n. 6, p. 1539-1546, 2015. 1678-4162 0102-0935 http://hdl.handle.net/11449/168249 10.1590/1678-4162-8057 S0102-09352015000601539 2-s2.0-84951973697 S0102-09352015000601539.pdf |
url |
http://dx.doi.org/10.1590/1678-4162-8057 http://hdl.handle.net/11449/168249 |
identifier_str_mv |
Arquivo Brasileiro de Medicina Veterinaria e Zootecnia, v. 67, n. 6, p. 1539-1546, 2015. 1678-4162 0102-0935 10.1590/1678-4162-8057 S0102-09352015000601539 2-s2.0-84951973697 S0102-09352015000601539.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Arquivo Brasileiro de Medicina Veterinaria e Zootecnia 0,248 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
1539-1546 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1808129066106093568 |