Ethylcelullose microspheres containing sodium diclofenac: Development and characterization

Detalhes bibliográficos
Autor(a) principal: Baccarin, Marcelo A.
Data de Publicação: 2006
Outros Autores: Evangelista, Raul C. [UNESP], Lucinda-Silva, Ruth M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://www.latamjpharm.org/trabajos/25/3/LAJOP_25_3_1_13_2CNJSSC48S.pdf
http://hdl.handle.net/11449/68975
Resumo: The objective of the present study was the development and characterization of ethylcellulose microspheres containing diclofenac and the determination of the in vitro drug release profile. Microspheres were prepared by emulsification/solvent evaporation method using ethyl acetate as solvent for the polymer and water as non solvent. The microspheres were characterized by morphologic and granulometric analyses. The amount of encapsulated drug as well as its release profile in vitro were also determined. The product obtained was microparticles with smooth surface and narrow size distribution, about 50% of the particles being smaller than 5 μm. The methodology used allowed drug encapsulation with a good yield and the system provided a controlled release of diclofenac.
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spelling Ethylcelullose microspheres containing sodium diclofenac: Development and characterizationDiclofenacEthylcelluloseMicroencapsulationdiclofenacethyl cellulosemicrospheredrug delivery systemdrug releaseemulsionin vitro studymethodologymicroencapsulationmorphologyThe objective of the present study was the development and characterization of ethylcellulose microspheres containing diclofenac and the determination of the in vitro drug release profile. Microspheres were prepared by emulsification/solvent evaporation method using ethyl acetate as solvent for the polymer and water as non solvent. The microspheres were characterized by morphologic and granulometric analyses. The amount of encapsulated drug as well as its release profile in vitro were also determined. The product obtained was microparticles with smooth surface and narrow size distribution, about 50% of the particles being smaller than 5 μm. The methodology used allowed drug encapsulation with a good yield and the system provided a controlled release of diclofenac.NIQFAR Curso de Farmácia UNIVALI, R. Uruguai, 458, CP 360, Itajaí, SC, 88302-202Faculdade de Ciências Farmacêuticas UNESP, Rod. Araraquara-Jaú, km 01, Araraquara, SP, 14801-902Faculdade de Ciências Farmacêuticas UNESP, Rod. Araraquara-Jaú, km 01, Araraquara, SP, 14801-902UNIVALIUniversidade Estadual Paulista (Unesp)Baccarin, Marcelo A.Evangelista, Raul C. [UNESP]Lucinda-Silva, Ruth M.2014-05-27T11:21:54Z2014-05-27T11:21:54Z2006-07-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article401-404http://www.latamjpharm.org/trabajos/25/3/LAJOP_25_3_1_13_2CNJSSC48S.pdfActa Farmaceutica Bonaerense, v. 25, n. 3, p. 401-404, 2006.0326-2383http://hdl.handle.net/11449/689752-s2.0-33845466134Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengActa Farmaceutica Bonaerense0.4010,152info:eu-repo/semantics/openAccess2021-10-23T10:26:43Zoai:repositorio.unesp.br:11449/68975Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462021-10-23T10:26:43Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Ethylcelullose microspheres containing sodium diclofenac: Development and characterization
title Ethylcelullose microspheres containing sodium diclofenac: Development and characterization
spellingShingle Ethylcelullose microspheres containing sodium diclofenac: Development and characterization
Baccarin, Marcelo A.
Diclofenac
Ethylcellulose
Microencapsulation
diclofenac
ethyl cellulose
microsphere
drug delivery system
drug release
emulsion
in vitro study
methodology
microencapsulation
morphology
title_short Ethylcelullose microspheres containing sodium diclofenac: Development and characterization
title_full Ethylcelullose microspheres containing sodium diclofenac: Development and characterization
title_fullStr Ethylcelullose microspheres containing sodium diclofenac: Development and characterization
title_full_unstemmed Ethylcelullose microspheres containing sodium diclofenac: Development and characterization
title_sort Ethylcelullose microspheres containing sodium diclofenac: Development and characterization
author Baccarin, Marcelo A.
author_facet Baccarin, Marcelo A.
Evangelista, Raul C. [UNESP]
Lucinda-Silva, Ruth M.
author_role author
author2 Evangelista, Raul C. [UNESP]
Lucinda-Silva, Ruth M.
author2_role author
author
dc.contributor.none.fl_str_mv UNIVALI
Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Baccarin, Marcelo A.
Evangelista, Raul C. [UNESP]
Lucinda-Silva, Ruth M.
dc.subject.por.fl_str_mv Diclofenac
Ethylcellulose
Microencapsulation
diclofenac
ethyl cellulose
microsphere
drug delivery system
drug release
emulsion
in vitro study
methodology
microencapsulation
morphology
topic Diclofenac
Ethylcellulose
Microencapsulation
diclofenac
ethyl cellulose
microsphere
drug delivery system
drug release
emulsion
in vitro study
methodology
microencapsulation
morphology
description The objective of the present study was the development and characterization of ethylcellulose microspheres containing diclofenac and the determination of the in vitro drug release profile. Microspheres were prepared by emulsification/solvent evaporation method using ethyl acetate as solvent for the polymer and water as non solvent. The microspheres were characterized by morphologic and granulometric analyses. The amount of encapsulated drug as well as its release profile in vitro were also determined. The product obtained was microparticles with smooth surface and narrow size distribution, about 50% of the particles being smaller than 5 μm. The methodology used allowed drug encapsulation with a good yield and the system provided a controlled release of diclofenac.
publishDate 2006
dc.date.none.fl_str_mv 2006-07-01
2014-05-27T11:21:54Z
2014-05-27T11:21:54Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.latamjpharm.org/trabajos/25/3/LAJOP_25_3_1_13_2CNJSSC48S.pdf
Acta Farmaceutica Bonaerense, v. 25, n. 3, p. 401-404, 2006.
0326-2383
http://hdl.handle.net/11449/68975
2-s2.0-33845466134
url http://www.latamjpharm.org/trabajos/25/3/LAJOP_25_3_1_13_2CNJSSC48S.pdf
http://hdl.handle.net/11449/68975
identifier_str_mv Acta Farmaceutica Bonaerense, v. 25, n. 3, p. 401-404, 2006.
0326-2383
2-s2.0-33845466134
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Acta Farmaceutica Bonaerense
0.401
0,152
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 401-404
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1803046734719352832

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