Ethylcelullose microspheres containing sodium diclofenac: Development and characterization
Autor(a) principal: | |
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Data de Publicação: | 2006 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://www.latamjpharm.org/trabajos/25/3/LAJOP_25_3_1_13_2CNJSSC48S.pdf http://hdl.handle.net/11449/68975 |
Resumo: | The objective of the present study was the development and characterization of ethylcellulose microspheres containing diclofenac and the determination of the in vitro drug release profile. Microspheres were prepared by emulsification/solvent evaporation method using ethyl acetate as solvent for the polymer and water as non solvent. The microspheres were characterized by morphologic and granulometric analyses. The amount of encapsulated drug as well as its release profile in vitro were also determined. The product obtained was microparticles with smooth surface and narrow size distribution, about 50% of the particles being smaller than 5 μm. The methodology used allowed drug encapsulation with a good yield and the system provided a controlled release of diclofenac. |
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Ethylcelullose microspheres containing sodium diclofenac: Development and characterizationDiclofenacEthylcelluloseMicroencapsulationdiclofenacethyl cellulosemicrospheredrug delivery systemdrug releaseemulsionin vitro studymethodologymicroencapsulationmorphologyThe objective of the present study was the development and characterization of ethylcellulose microspheres containing diclofenac and the determination of the in vitro drug release profile. Microspheres were prepared by emulsification/solvent evaporation method using ethyl acetate as solvent for the polymer and water as non solvent. The microspheres were characterized by morphologic and granulometric analyses. The amount of encapsulated drug as well as its release profile in vitro were also determined. The product obtained was microparticles with smooth surface and narrow size distribution, about 50% of the particles being smaller than 5 μm. The methodology used allowed drug encapsulation with a good yield and the system provided a controlled release of diclofenac.NIQFAR Curso de Farmácia UNIVALI, R. Uruguai, 458, CP 360, Itajaí, SC, 88302-202Faculdade de Ciências Farmacêuticas UNESP, Rod. Araraquara-Jaú, km 01, Araraquara, SP, 14801-902Faculdade de Ciências Farmacêuticas UNESP, Rod. Araraquara-Jaú, km 01, Araraquara, SP, 14801-902UNIVALIUniversidade Estadual Paulista (Unesp)Baccarin, Marcelo A.Evangelista, Raul C. [UNESP]Lucinda-Silva, Ruth M.2014-05-27T11:21:54Z2014-05-27T11:21:54Z2006-07-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article401-404http://www.latamjpharm.org/trabajos/25/3/LAJOP_25_3_1_13_2CNJSSC48S.pdfActa Farmaceutica Bonaerense, v. 25, n. 3, p. 401-404, 2006.0326-2383http://hdl.handle.net/11449/689752-s2.0-33845466134Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengActa Farmaceutica Bonaerense0.4010,152info:eu-repo/semantics/openAccess2021-10-23T10:26:43Zoai:repositorio.unesp.br:11449/68975Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T19:10:03.804053Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Ethylcelullose microspheres containing sodium diclofenac: Development and characterization |
title |
Ethylcelullose microspheres containing sodium diclofenac: Development and characterization |
spellingShingle |
Ethylcelullose microspheres containing sodium diclofenac: Development and characterization Baccarin, Marcelo A. Diclofenac Ethylcellulose Microencapsulation diclofenac ethyl cellulose microsphere drug delivery system drug release emulsion in vitro study methodology microencapsulation morphology |
title_short |
Ethylcelullose microspheres containing sodium diclofenac: Development and characterization |
title_full |
Ethylcelullose microspheres containing sodium diclofenac: Development and characterization |
title_fullStr |
Ethylcelullose microspheres containing sodium diclofenac: Development and characterization |
title_full_unstemmed |
Ethylcelullose microspheres containing sodium diclofenac: Development and characterization |
title_sort |
Ethylcelullose microspheres containing sodium diclofenac: Development and characterization |
author |
Baccarin, Marcelo A. |
author_facet |
Baccarin, Marcelo A. Evangelista, Raul C. [UNESP] Lucinda-Silva, Ruth M. |
author_role |
author |
author2 |
Evangelista, Raul C. [UNESP] Lucinda-Silva, Ruth M. |
author2_role |
author author |
dc.contributor.none.fl_str_mv |
UNIVALI Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Baccarin, Marcelo A. Evangelista, Raul C. [UNESP] Lucinda-Silva, Ruth M. |
dc.subject.por.fl_str_mv |
Diclofenac Ethylcellulose Microencapsulation diclofenac ethyl cellulose microsphere drug delivery system drug release emulsion in vitro study methodology microencapsulation morphology |
topic |
Diclofenac Ethylcellulose Microencapsulation diclofenac ethyl cellulose microsphere drug delivery system drug release emulsion in vitro study methodology microencapsulation morphology |
description |
The objective of the present study was the development and characterization of ethylcellulose microspheres containing diclofenac and the determination of the in vitro drug release profile. Microspheres were prepared by emulsification/solvent evaporation method using ethyl acetate as solvent for the polymer and water as non solvent. The microspheres were characterized by morphologic and granulometric analyses. The amount of encapsulated drug as well as its release profile in vitro were also determined. The product obtained was microparticles with smooth surface and narrow size distribution, about 50% of the particles being smaller than 5 μm. The methodology used allowed drug encapsulation with a good yield and the system provided a controlled release of diclofenac. |
publishDate |
2006 |
dc.date.none.fl_str_mv |
2006-07-01 2014-05-27T11:21:54Z 2014-05-27T11:21:54Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://www.latamjpharm.org/trabajos/25/3/LAJOP_25_3_1_13_2CNJSSC48S.pdf Acta Farmaceutica Bonaerense, v. 25, n. 3, p. 401-404, 2006. 0326-2383 http://hdl.handle.net/11449/68975 2-s2.0-33845466134 |
url |
http://www.latamjpharm.org/trabajos/25/3/LAJOP_25_3_1_13_2CNJSSC48S.pdf http://hdl.handle.net/11449/68975 |
identifier_str_mv |
Acta Farmaceutica Bonaerense, v. 25, n. 3, p. 401-404, 2006. 0326-2383 2-s2.0-33845466134 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Acta Farmaceutica Bonaerense 0.401 0,152 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
401-404 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129028179099648 |