Analysis of the chronic intake of and withdrawal from diazepam on emotional reactivity and sensory information processing in rats

Detalhes bibliográficos
Autor(a) principal: De Ross, Jana Batista [UNESP]
Data de Publicação: 2009
Tipo de documento: Trabalho de conclusão de curso
Idioma: por
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://hdl.handle.net/11449/118852
Resumo: It has been demonstrated that, on abrupt withdrawal, patients with chronic exposure can experience a number of symptoms indicative of a dependent state. In clinical patients, the earliest to arise and most persistent signal of withdrawal from chronic benzodiazepine (Bzp) treatment is anxiety. In laboratory animals, anxiety-like effects following abrupt interruption of chronic Bzp treatment can also be reproduced. In fact, signs that oscillate from irritability to extreme fear behaviours and seizures have been described already. As anxiety remains one of the most important symptoms of Bzp withdrawal, in this study we evaluated the anxiety levels of rats withdrawn from diazepam. Also studied were the effects on the motor performance and preattentive sensory gating process of rats under diazepam chronic treatment and upon 48-h withdrawal on three animal models of anxiety, the elevated plus-maze (EPM), ultrasonic vocalizations (USV) and startle + prepulse inhibition tests. Data obtained showed an anxiolytic- and anxiogenic-like profile of the chronic intake of and withdrawal from diazepam regimen in the EPM test, 22-KHz USV and startle reflex. Diazepam chronic effects or its withdrawal were ineffective in promoting any alteration in the prepulse inhibition (PPI). However, an increase of PPI was achieved in both sucrose and diazepam pretreated rats on 48-h withdrawal, suggesting a procedural rather than a specific effect of withdrawal on sensory gating processes. It is also possible that the prepulse can function as a conditioned stimulus to informing the delivery of an aversive event, as the auditory startling-eliciting stimulus. All these findings are indicative of a sensitization of the neural substrates of aversion in diazepam withdrawn animals without concomitant changes on the processing of sensory information
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spelling Analysis of the chronic intake of and withdrawal from diazepam on emotional reactivity and sensory information processing in ratsDiazepamFarmacologiaAnsiedadeIt has been demonstrated that, on abrupt withdrawal, patients with chronic exposure can experience a number of symptoms indicative of a dependent state. In clinical patients, the earliest to arise and most persistent signal of withdrawal from chronic benzodiazepine (Bzp) treatment is anxiety. In laboratory animals, anxiety-like effects following abrupt interruption of chronic Bzp treatment can also be reproduced. In fact, signs that oscillate from irritability to extreme fear behaviours and seizures have been described already. As anxiety remains one of the most important symptoms of Bzp withdrawal, in this study we evaluated the anxiety levels of rats withdrawn from diazepam. Also studied were the effects on the motor performance and preattentive sensory gating process of rats under diazepam chronic treatment and upon 48-h withdrawal on three animal models of anxiety, the elevated plus-maze (EPM), ultrasonic vocalizations (USV) and startle + prepulse inhibition tests. Data obtained showed an anxiolytic- and anxiogenic-like profile of the chronic intake of and withdrawal from diazepam regimen in the EPM test, 22-KHz USV and startle reflex. Diazepam chronic effects or its withdrawal were ineffective in promoting any alteration in the prepulse inhibition (PPI). However, an increase of PPI was achieved in both sucrose and diazepam pretreated rats on 48-h withdrawal, suggesting a procedural rather than a specific effect of withdrawal on sensory gating processes. It is also possible that the prepulse can function as a conditioned stimulus to informing the delivery of an aversive event, as the auditory startling-eliciting stimulus. All these findings are indicative of a sensitization of the neural substrates of aversion in diazepam withdrawn animals without concomitant changes on the processing of sensory informationNão disponívelUniversidade Estadual Paulista (Unesp)Nobre, Manoel Jorge [UNESP]Universidade Estadual Paulista (Unesp)De Ross, Jana Batista [UNESP]2015-03-23T15:13:27Z2015-03-23T15:13:27Z2009info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/bachelorThesisapplication/pdfDE ROSS, Jana Batista. Analysis of the chronic intake of and withdrawal from diazepam on emotional reactivity and sensory information processing in rats. 2009. 1 CD-ROM. Trabalho de conclusão de curso (bacharelado -Ciências Biológicas) - Universidade Estadual Paulista, Instituto de Biociências de Botucatu, 2009.http://hdl.handle.net/11449/118852000634619deross_jb_tcc_botib.pdfAlephreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPporinfo:eu-repo/semantics/openAccess2023-12-09T06:21:24Zoai:repositorio.unesp.br:11449/118852Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T19:51:39.445241Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Analysis of the chronic intake of and withdrawal from diazepam on emotional reactivity and sensory information processing in rats
title Analysis of the chronic intake of and withdrawal from diazepam on emotional reactivity and sensory information processing in rats
spellingShingle Analysis of the chronic intake of and withdrawal from diazepam on emotional reactivity and sensory information processing in rats
De Ross, Jana Batista [UNESP]
Diazepam
Farmacologia
Ansiedade
title_short Analysis of the chronic intake of and withdrawal from diazepam on emotional reactivity and sensory information processing in rats
title_full Analysis of the chronic intake of and withdrawal from diazepam on emotional reactivity and sensory information processing in rats
title_fullStr Analysis of the chronic intake of and withdrawal from diazepam on emotional reactivity and sensory information processing in rats
title_full_unstemmed Analysis of the chronic intake of and withdrawal from diazepam on emotional reactivity and sensory information processing in rats
title_sort Analysis of the chronic intake of and withdrawal from diazepam on emotional reactivity and sensory information processing in rats
author De Ross, Jana Batista [UNESP]
author_facet De Ross, Jana Batista [UNESP]
author_role author
dc.contributor.none.fl_str_mv Nobre, Manoel Jorge [UNESP]
Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv De Ross, Jana Batista [UNESP]
dc.subject.por.fl_str_mv Diazepam
Farmacologia
Ansiedade
topic Diazepam
Farmacologia
Ansiedade
description It has been demonstrated that, on abrupt withdrawal, patients with chronic exposure can experience a number of symptoms indicative of a dependent state. In clinical patients, the earliest to arise and most persistent signal of withdrawal from chronic benzodiazepine (Bzp) treatment is anxiety. In laboratory animals, anxiety-like effects following abrupt interruption of chronic Bzp treatment can also be reproduced. In fact, signs that oscillate from irritability to extreme fear behaviours and seizures have been described already. As anxiety remains one of the most important symptoms of Bzp withdrawal, in this study we evaluated the anxiety levels of rats withdrawn from diazepam. Also studied were the effects on the motor performance and preattentive sensory gating process of rats under diazepam chronic treatment and upon 48-h withdrawal on three animal models of anxiety, the elevated plus-maze (EPM), ultrasonic vocalizations (USV) and startle + prepulse inhibition tests. Data obtained showed an anxiolytic- and anxiogenic-like profile of the chronic intake of and withdrawal from diazepam regimen in the EPM test, 22-KHz USV and startle reflex. Diazepam chronic effects or its withdrawal were ineffective in promoting any alteration in the prepulse inhibition (PPI). However, an increase of PPI was achieved in both sucrose and diazepam pretreated rats on 48-h withdrawal, suggesting a procedural rather than a specific effect of withdrawal on sensory gating processes. It is also possible that the prepulse can function as a conditioned stimulus to informing the delivery of an aversive event, as the auditory startling-eliciting stimulus. All these findings are indicative of a sensitization of the neural substrates of aversion in diazepam withdrawn animals without concomitant changes on the processing of sensory information
publishDate 2009
dc.date.none.fl_str_mv 2009
2015-03-23T15:13:27Z
2015-03-23T15:13:27Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/bachelorThesis
format bachelorThesis
status_str publishedVersion
dc.identifier.uri.fl_str_mv DE ROSS, Jana Batista. Analysis of the chronic intake of and withdrawal from diazepam on emotional reactivity and sensory information processing in rats. 2009. 1 CD-ROM. Trabalho de conclusão de curso (bacharelado -Ciências Biológicas) - Universidade Estadual Paulista, Instituto de Biociências de Botucatu, 2009.
http://hdl.handle.net/11449/118852
000634619
deross_jb_tcc_botib.pdf
identifier_str_mv DE ROSS, Jana Batista. Analysis of the chronic intake of and withdrawal from diazepam on emotional reactivity and sensory information processing in rats. 2009. 1 CD-ROM. Trabalho de conclusão de curso (bacharelado -Ciências Biológicas) - Universidade Estadual Paulista, Instituto de Biociências de Botucatu, 2009.
000634619
deross_jb_tcc_botib.pdf
url http://hdl.handle.net/11449/118852
dc.language.iso.fl_str_mv por
language por
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade Estadual Paulista (Unesp)
publisher.none.fl_str_mv Universidade Estadual Paulista (Unesp)
dc.source.none.fl_str_mv Aleph
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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