ACUTE-PHASE REACTIONS, INCLUDING CYTOKINES, IN PATIENTS BITTEN BY BOTHROPS AND CROTALUS SNAKES IN BRAZIL

Detalhes bibliográficos
Autor(a) principal: Barraviera, B. [UNESP]
Data de Publicação: 1995
Outros Autores: Lomonte, B., Tarkowski, A., Hanson, L. Å., Meira, D.a. [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
DOI: 10.1590/S0104-79301995000100003
Texto Completo: http://dx.doi.org/10.1590/S0104-79301995000100003
http://hdl.handle.net/11449/212319
Resumo: Thirty-one patients bitten by venomous snakes in Botucatu area (State of São Paulo - Brazil), sixteen by Bothrops spp. and fifteen by Crotalus durissus terrificus, were studied. The group comprised twenty-nine males and two females, ranging from fourteen to sixty-three years of age (mean 33 ± 15). Leukocytosis with neutrophilia and lymphopenia, increase of mucoproteins and C-reactive protein, decrease of total serum protein and albumin, were observed on the first day after the accident. In addition, increased serum levels of the cytokines IL-6 and IL-8, but not of IL-1b and TNF-a, were observed. The alterations were generally more intense in patients bitten by Crotalus durissus terrificus than by Bothrops spp. It is concluded that these snakebite envenomations closely resemble an acute trauma, inducing a typical acute-phase response.
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spelling ACUTE-PHASE REACTIONS, INCLUDING CYTOKINES, IN PATIENTS BITTEN BY BOTHROPS AND CROTALUS SNAKES IN BRAZILsnake venomacute-phase reactionscytokinesC-reactive proteininflammationThirty-one patients bitten by venomous snakes in Botucatu area (State of São Paulo - Brazil), sixteen by Bothrops spp. and fifteen by Crotalus durissus terrificus, were studied. The group comprised twenty-nine males and two females, ranging from fourteen to sixty-three years of age (mean 33 ± 15). Leukocytosis with neutrophilia and lymphopenia, increase of mucoproteins and C-reactive protein, decrease of total serum protein and albumin, were observed on the first day after the accident. In addition, increased serum levels of the cytokines IL-6 and IL-8, but not of IL-1b and TNF-a, were observed. The alterations were generally more intense in patients bitten by Crotalus durissus terrificus than by Bothrops spp. It is concluded that these snakebite envenomations closely resemble an acute trauma, inducing a typical acute-phase response.University of Göteborg, SwedenUniversidad de Costa Rica, Instituto Clodomiro Picado, Facultad de Microbiologia, Department of Clinical ImmunologySchool of Medicine of Botucatu, Department of Tropical DiseasesCEVAP-UNESP, Center for the Study of Venoms and Venomous AnimalsCEVAP-UNESP, Center for the Study of Venoms and Venomous AnimalsCentro de Estudos de Venenos e Animais Peçonhentos - CEVAP, Universidade Estadual Paulista - UNESPUniversity of Göteborg, SwedenUniversidad de Costa RicaSchool of Medicine of BotucatuUniversidade Estadual Paulista (Unesp)Barraviera, B. [UNESP]Lomonte, B.Tarkowski, A.Hanson, L. Å.Meira, D.a. [UNESP]2021-07-14T10:38:01Z2021-07-14T10:38:01Z1995info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article11-22http://dx.doi.org/10.1590/S0104-79301995000100003Journal of Venomous Animals and Toxins. Botucatu, SP, Brazil: Centro de Estudos de Venenos e Animais Peçonhentos - CEVAP, Universidade Estadual Paulista - UNESP, v. 1, n. 1, p. 11-22, 1995.0104-79301678-4936http://hdl.handle.net/11449/21231910.1590/S0104-79301995000100003S0104-79301995000100003S0104-79301995000100003.pdfSciELOreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Venomous Animals and Toxinsinfo:eu-repo/semantics/openAccess2024-04-11T15:28:17Zoai:repositorio.unesp.br:11449/212319Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T17:53:54.873149Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv ACUTE-PHASE REACTIONS, INCLUDING CYTOKINES, IN PATIENTS BITTEN BY BOTHROPS AND CROTALUS SNAKES IN BRAZIL
title ACUTE-PHASE REACTIONS, INCLUDING CYTOKINES, IN PATIENTS BITTEN BY BOTHROPS AND CROTALUS SNAKES IN BRAZIL
spellingShingle ACUTE-PHASE REACTIONS, INCLUDING CYTOKINES, IN PATIENTS BITTEN BY BOTHROPS AND CROTALUS SNAKES IN BRAZIL
ACUTE-PHASE REACTIONS, INCLUDING CYTOKINES, IN PATIENTS BITTEN BY BOTHROPS AND CROTALUS SNAKES IN BRAZIL
Barraviera, B. [UNESP]
snake venom
acute-phase reactions
cytokines
C-reactive protein
inflammation
Barraviera, B. [UNESP]
snake venom
acute-phase reactions
cytokines
C-reactive protein
inflammation
title_short ACUTE-PHASE REACTIONS, INCLUDING CYTOKINES, IN PATIENTS BITTEN BY BOTHROPS AND CROTALUS SNAKES IN BRAZIL
title_full ACUTE-PHASE REACTIONS, INCLUDING CYTOKINES, IN PATIENTS BITTEN BY BOTHROPS AND CROTALUS SNAKES IN BRAZIL
title_fullStr ACUTE-PHASE REACTIONS, INCLUDING CYTOKINES, IN PATIENTS BITTEN BY BOTHROPS AND CROTALUS SNAKES IN BRAZIL
ACUTE-PHASE REACTIONS, INCLUDING CYTOKINES, IN PATIENTS BITTEN BY BOTHROPS AND CROTALUS SNAKES IN BRAZIL
title_full_unstemmed ACUTE-PHASE REACTIONS, INCLUDING CYTOKINES, IN PATIENTS BITTEN BY BOTHROPS AND CROTALUS SNAKES IN BRAZIL
ACUTE-PHASE REACTIONS, INCLUDING CYTOKINES, IN PATIENTS BITTEN BY BOTHROPS AND CROTALUS SNAKES IN BRAZIL
title_sort ACUTE-PHASE REACTIONS, INCLUDING CYTOKINES, IN PATIENTS BITTEN BY BOTHROPS AND CROTALUS SNAKES IN BRAZIL
author Barraviera, B. [UNESP]
author_facet Barraviera, B. [UNESP]
Barraviera, B. [UNESP]
Lomonte, B.
Tarkowski, A.
Hanson, L. Å.
Meira, D.a. [UNESP]
Lomonte, B.
Tarkowski, A.
Hanson, L. Å.
Meira, D.a. [UNESP]
author_role author
author2 Lomonte, B.
Tarkowski, A.
Hanson, L. Å.
Meira, D.a. [UNESP]
author2_role author
author
author
author
dc.contributor.none.fl_str_mv University of Göteborg, Sweden
Universidad de Costa Rica
School of Medicine of Botucatu
Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Barraviera, B. [UNESP]
Lomonte, B.
Tarkowski, A.
Hanson, L. Å.
Meira, D.a. [UNESP]
dc.subject.por.fl_str_mv snake venom
acute-phase reactions
cytokines
C-reactive protein
inflammation
topic snake venom
acute-phase reactions
cytokines
C-reactive protein
inflammation
description Thirty-one patients bitten by venomous snakes in Botucatu area (State of São Paulo - Brazil), sixteen by Bothrops spp. and fifteen by Crotalus durissus terrificus, were studied. The group comprised twenty-nine males and two females, ranging from fourteen to sixty-three years of age (mean 33 ± 15). Leukocytosis with neutrophilia and lymphopenia, increase of mucoproteins and C-reactive protein, decrease of total serum protein and albumin, were observed on the first day after the accident. In addition, increased serum levels of the cytokines IL-6 and IL-8, but not of IL-1b and TNF-a, were observed. The alterations were generally more intense in patients bitten by Crotalus durissus terrificus than by Bothrops spp. It is concluded that these snakebite envenomations closely resemble an acute trauma, inducing a typical acute-phase response.
publishDate 1995
dc.date.none.fl_str_mv 1995
2021-07-14T10:38:01Z
2021-07-14T10:38:01Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S0104-79301995000100003
Journal of Venomous Animals and Toxins. Botucatu, SP, Brazil: Centro de Estudos de Venenos e Animais Peçonhentos - CEVAP, Universidade Estadual Paulista - UNESP, v. 1, n. 1, p. 11-22, 1995.
0104-7930
1678-4936
http://hdl.handle.net/11449/212319
10.1590/S0104-79301995000100003
S0104-79301995000100003
S0104-79301995000100003.pdf
url http://dx.doi.org/10.1590/S0104-79301995000100003
http://hdl.handle.net/11449/212319
identifier_str_mv Journal of Venomous Animals and Toxins. Botucatu, SP, Brazil: Centro de Estudos de Venenos e Animais Peçonhentos - CEVAP, Universidade Estadual Paulista - UNESP, v. 1, n. 1, p. 11-22, 1995.
0104-7930
1678-4936
10.1590/S0104-79301995000100003
S0104-79301995000100003
S0104-79301995000100003.pdf
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Journal of Venomous Animals and Toxins
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 11-22
dc.publisher.none.fl_str_mv Centro de Estudos de Venenos e Animais Peçonhentos - CEVAP, Universidade Estadual Paulista - UNESP
publisher.none.fl_str_mv Centro de Estudos de Venenos e Animais Peçonhentos - CEVAP, Universidade Estadual Paulista - UNESP
dc.source.none.fl_str_mv SciELO
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1822182325990981632
dc.identifier.doi.none.fl_str_mv 10.1590/S0104-79301995000100003

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