Tissue alterations in the Guinea pig lateral prostate following antiandrogen flutamide therapy

Detalhes bibliográficos
Autor(a) principal: Cordeiro, R. S.
Data de Publicação: 2004
Outros Autores: Scarano, W. R., Goes, R. M., Taboga, SR
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://www.scielo.org.ar/scielo.php?pid=S0327-95452004000100003&script=sci_arttext
http://hdl.handle.net/11449/21375
Resumo: The flutamide antiandrogenic effects oil the Guinea pig male prostate morphology in puberal, post-puberal and adult ages were evaluated in the present study. Daily-treated group animals received flutamide Subcutaneous injection at a dose of 10 mg/Kg body weight for 10 days. The control group animals received a pharmacological vehicle under the same conditions. The lateral prostate was removed, fixed and processed for light and transmission electron microscopy. The results revealed all increase of the acinus diameter in the treated puberal animals and straitness in the stromal compartment around the acini. The epithelial cells exhibited cubic phenotype. In the post-puberal and adult animals, a decrease of the acinus diameter was observed, as well as an increase of the smooth muscle layer and presence of the folds at epithelium. The ultrastructural evaluation of the secretory cells in the treated group demonstrated endomembrane enlargement, mainly in the rough endoplasmic reticulum and Golgi apparatus. In addition, a decrease of the microvilli and alterations in the distribution patterns and density of the stromal fibrillar components were observed. In Conclusion, the flutamide treatment exerts tissue effects oil the lateral prostate, promoting stroma/epithelium alterations.
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spelling Tissue alterations in the Guinea pig lateral prostate following antiandrogen flutamide therapylateral prostateflutamideantiandrogensecretory cellsThe flutamide antiandrogenic effects oil the Guinea pig male prostate morphology in puberal, post-puberal and adult ages were evaluated in the present study. Daily-treated group animals received flutamide Subcutaneous injection at a dose of 10 mg/Kg body weight for 10 days. The control group animals received a pharmacological vehicle under the same conditions. The lateral prostate was removed, fixed and processed for light and transmission electron microscopy. The results revealed all increase of the acinus diameter in the treated puberal animals and straitness in the stromal compartment around the acini. The epithelial cells exhibited cubic phenotype. In the post-puberal and adult animals, a decrease of the acinus diameter was observed, as well as an increase of the smooth muscle layer and presence of the folds at epithelium. The ultrastructural evaluation of the secretory cells in the treated group demonstrated endomembrane enlargement, mainly in the rough endoplasmic reticulum and Golgi apparatus. In addition, a decrease of the microvilli and alterations in the distribution patterns and density of the stromal fibrillar components were observed. In Conclusion, the flutamide treatment exerts tissue effects oil the lateral prostate, promoting stroma/epithelium alterations.UNESP, IBILCE, Dept Biol, Lab Microscopy & Microanal, BR-15054000 Sao Jose do Rio Preto, SP, BrazilUNICAMP, Inst Biol, Dept Cell Biol, BR-13084971 Campinas, SP, BrazilUNESP, IBILCE, Dept Biol, Lab Microscopy & Microanal, BR-15054000 Sao Jose do Rio Preto, SP, BrazilInst Histol Embriol-conicetUniversidade Estadual Paulista (Unesp)Universidade Estadual de Campinas (UNICAMP)Cordeiro, R. S.Scarano, W. R.Goes, R. M.Taboga, SR2014-05-20T14:00:26Z2014-05-20T14:00:26Z2004-04-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article21-30application/pdfhttp://www.scielo.org.ar/scielo.php?pid=S0327-95452004000100003&script=sci_arttextBiocell. Mendoza: Inst Histol Embriol-conicet, v. 28, n. 1, p. 21-30, 2004.0327-9545http://hdl.handle.net/11449/21375S0327-95452004000100003WOS:000221459400003WOS000221459400003.pdf371373299682735109471933473121570000-0002-0970-42880000-0002-3622-460XWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBiocell0.1180,116info:eu-repo/semantics/openAccess2024-04-11T19:33:50Zoai:repositorio.unesp.br:11449/21375Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T15:49:40.911364Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Tissue alterations in the Guinea pig lateral prostate following antiandrogen flutamide therapy
title Tissue alterations in the Guinea pig lateral prostate following antiandrogen flutamide therapy
spellingShingle Tissue alterations in the Guinea pig lateral prostate following antiandrogen flutamide therapy
Cordeiro, R. S.
lateral prostate
flutamide
antiandrogen
secretory cells
title_short Tissue alterations in the Guinea pig lateral prostate following antiandrogen flutamide therapy
title_full Tissue alterations in the Guinea pig lateral prostate following antiandrogen flutamide therapy
title_fullStr Tissue alterations in the Guinea pig lateral prostate following antiandrogen flutamide therapy
title_full_unstemmed Tissue alterations in the Guinea pig lateral prostate following antiandrogen flutamide therapy
title_sort Tissue alterations in the Guinea pig lateral prostate following antiandrogen flutamide therapy
author Cordeiro, R. S.
author_facet Cordeiro, R. S.
Scarano, W. R.
Goes, R. M.
Taboga, SR
author_role author
author2 Scarano, W. R.
Goes, R. M.
Taboga, SR
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
Universidade Estadual de Campinas (UNICAMP)
dc.contributor.author.fl_str_mv Cordeiro, R. S.
Scarano, W. R.
Goes, R. M.
Taboga, SR
dc.subject.por.fl_str_mv lateral prostate
flutamide
antiandrogen
secretory cells
topic lateral prostate
flutamide
antiandrogen
secretory cells
description The flutamide antiandrogenic effects oil the Guinea pig male prostate morphology in puberal, post-puberal and adult ages were evaluated in the present study. Daily-treated group animals received flutamide Subcutaneous injection at a dose of 10 mg/Kg body weight for 10 days. The control group animals received a pharmacological vehicle under the same conditions. The lateral prostate was removed, fixed and processed for light and transmission electron microscopy. The results revealed all increase of the acinus diameter in the treated puberal animals and straitness in the stromal compartment around the acini. The epithelial cells exhibited cubic phenotype. In the post-puberal and adult animals, a decrease of the acinus diameter was observed, as well as an increase of the smooth muscle layer and presence of the folds at epithelium. The ultrastructural evaluation of the secretory cells in the treated group demonstrated endomembrane enlargement, mainly in the rough endoplasmic reticulum and Golgi apparatus. In addition, a decrease of the microvilli and alterations in the distribution patterns and density of the stromal fibrillar components were observed. In Conclusion, the flutamide treatment exerts tissue effects oil the lateral prostate, promoting stroma/epithelium alterations.
publishDate 2004
dc.date.none.fl_str_mv 2004-04-01
2014-05-20T14:00:26Z
2014-05-20T14:00:26Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.scielo.org.ar/scielo.php?pid=S0327-95452004000100003&script=sci_arttext
Biocell. Mendoza: Inst Histol Embriol-conicet, v. 28, n. 1, p. 21-30, 2004.
0327-9545
http://hdl.handle.net/11449/21375
S0327-95452004000100003
WOS:000221459400003
WOS000221459400003.pdf
3713732996827351
0947193347312157
0000-0002-0970-4288
0000-0002-3622-460X
url http://www.scielo.org.ar/scielo.php?pid=S0327-95452004000100003&script=sci_arttext
http://hdl.handle.net/11449/21375
identifier_str_mv Biocell. Mendoza: Inst Histol Embriol-conicet, v. 28, n. 1, p. 21-30, 2004.
0327-9545
S0327-95452004000100003
WOS:000221459400003
WOS000221459400003.pdf
3713732996827351
0947193347312157
0000-0002-0970-4288
0000-0002-3622-460X
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Biocell
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eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 21-30
application/pdf
dc.publisher.none.fl_str_mv Inst Histol Embriol-conicet
publisher.none.fl_str_mv Inst Histol Embriol-conicet
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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