Anti-coagulase-negative Staphylococcus activity of ethanolic extracts of propolis from two Brazilian regions and synergism with antimicrobial drugs by the E-test method

Detalhes bibliográficos
Autor(a) principal: Mantovani, R. P. [UNESP]
Data de Publicação: 2008
Outros Autores: Rall, V. L.M. [UNESP], Batalha, J. E.N. [UNESP], Fernandes, A. A.H. [UNESP], Fernandes Jr., Ary [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1590/S1678-91992008000200012
http://hdl.handle.net/11449/225184
Resumo: Propolis is a natural resinous substance collected by bees from vegetal sources and its therapeutic properties have been investigated. In this work, we evaluated the inhibitory activity of ethanolic extracts of propolis (EEP) from the Southeast and South of Brazil on coagulase-negative Staphylococcus (CNS) growth as well as the EEP in vitro synergism with antimicrobial drugs by using the diffusion method (E-test). The EEP chemical characteristics (dry weight, pH, flavonoid and phenolic compounds) were determined. Seven drugs were tested, and synergism was observed between three drugs and Southeast EEP, six drugs and South EEP, and one drug and ethanol control. Ethanolic extracts of propolis from the South of Brazil presented the greatest flavonoid content and synergism rate, while EEP from the Southeast presented the greatest anti-CNS activity and phenolic compound content. Results showed the correlation among anti-CNS activity, synergism rate and chemical characteristics of propolis.
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spelling Anti-coagulase-negative Staphylococcus activity of ethanolic extracts of propolis from two Brazilian regions and synergism with antimicrobial drugs by the E-test methodAntimicrobial drugsBrazilian propolisCoagulase-negative StaphylococcusE-testSynergismPropolis is a natural resinous substance collected by bees from vegetal sources and its therapeutic properties have been investigated. In this work, we evaluated the inhibitory activity of ethanolic extracts of propolis (EEP) from the Southeast and South of Brazil on coagulase-negative Staphylococcus (CNS) growth as well as the EEP in vitro synergism with antimicrobial drugs by using the diffusion method (E-test). The EEP chemical characteristics (dry weight, pH, flavonoid and phenolic compounds) were determined. Seven drugs were tested, and synergism was observed between three drugs and Southeast EEP, six drugs and South EEP, and one drug and ethanol control. Ethanolic extracts of propolis from the South of Brazil presented the greatest flavonoid content and synergism rate, while EEP from the Southeast presented the greatest anti-CNS activity and phenolic compound content. Results showed the correlation among anti-CNS activity, synergism rate and chemical characteristics of propolis.Department of Microbiology and Immunology Botucatu Institute of Biosciences São Paulo State University, Botucatu, São Paulo StateDepartment of Chemistry and Biochemistry IBB UNESP, Botucatu, São Paulo StateDepartamento de Microbiologia e Imunologia Instituto de Biociências Campus de Botucatu, SPDepartment of Microbiology and Immunology Botucatu Institute of Biosciences São Paulo State University, Botucatu, São Paulo StateDepartment of Chemistry and Biochemistry IBB UNESP, Botucatu, São Paulo StateUniversidade Estadual Paulista (UNESP)Instituto de BiociênciasMantovani, R. P. [UNESP]Rall, V. L.M. [UNESP]Batalha, J. E.N. [UNESP]Fernandes, A. A.H. [UNESP]Fernandes Jr., Ary [UNESP]2022-04-28T20:41:59Z2022-04-28T20:41:59Z2008-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article357-365http://dx.doi.org/10.1590/S1678-91992008000200012Journal of Venomous Animals and Toxins Including Tropical Diseases, v. 14, n. 2, p. 357-365, 2008.1678-9199http://hdl.handle.net/11449/22518410.1590/S1678-919920080002000122-s2.0-45349101030Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Venomous Animals and Toxins Including Tropical Diseasesinfo:eu-repo/semantics/openAccess2022-04-28T20:41:59Zoai:repositorio.unesp.br:11449/225184Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T14:46:33.162254Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Anti-coagulase-negative Staphylococcus activity of ethanolic extracts of propolis from two Brazilian regions and synergism with antimicrobial drugs by the E-test method
title Anti-coagulase-negative Staphylococcus activity of ethanolic extracts of propolis from two Brazilian regions and synergism with antimicrobial drugs by the E-test method
spellingShingle Anti-coagulase-negative Staphylococcus activity of ethanolic extracts of propolis from two Brazilian regions and synergism with antimicrobial drugs by the E-test method
Mantovani, R. P. [UNESP]
Antimicrobial drugs
Brazilian propolis
Coagulase-negative Staphylococcus
E-test
Synergism
title_short Anti-coagulase-negative Staphylococcus activity of ethanolic extracts of propolis from two Brazilian regions and synergism with antimicrobial drugs by the E-test method
title_full Anti-coagulase-negative Staphylococcus activity of ethanolic extracts of propolis from two Brazilian regions and synergism with antimicrobial drugs by the E-test method
title_fullStr Anti-coagulase-negative Staphylococcus activity of ethanolic extracts of propolis from two Brazilian regions and synergism with antimicrobial drugs by the E-test method
title_full_unstemmed Anti-coagulase-negative Staphylococcus activity of ethanolic extracts of propolis from two Brazilian regions and synergism with antimicrobial drugs by the E-test method
title_sort Anti-coagulase-negative Staphylococcus activity of ethanolic extracts of propolis from two Brazilian regions and synergism with antimicrobial drugs by the E-test method
author Mantovani, R. P. [UNESP]
author_facet Mantovani, R. P. [UNESP]
Rall, V. L.M. [UNESP]
Batalha, J. E.N. [UNESP]
Fernandes, A. A.H. [UNESP]
Fernandes Jr., Ary [UNESP]
author_role author
author2 Rall, V. L.M. [UNESP]
Batalha, J. E.N. [UNESP]
Fernandes, A. A.H. [UNESP]
Fernandes Jr., Ary [UNESP]
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (UNESP)
Instituto de Biociências
dc.contributor.author.fl_str_mv Mantovani, R. P. [UNESP]
Rall, V. L.M. [UNESP]
Batalha, J. E.N. [UNESP]
Fernandes, A. A.H. [UNESP]
Fernandes Jr., Ary [UNESP]
dc.subject.por.fl_str_mv Antimicrobial drugs
Brazilian propolis
Coagulase-negative Staphylococcus
E-test
Synergism
topic Antimicrobial drugs
Brazilian propolis
Coagulase-negative Staphylococcus
E-test
Synergism
description Propolis is a natural resinous substance collected by bees from vegetal sources and its therapeutic properties have been investigated. In this work, we evaluated the inhibitory activity of ethanolic extracts of propolis (EEP) from the Southeast and South of Brazil on coagulase-negative Staphylococcus (CNS) growth as well as the EEP in vitro synergism with antimicrobial drugs by using the diffusion method (E-test). The EEP chemical characteristics (dry weight, pH, flavonoid and phenolic compounds) were determined. Seven drugs were tested, and synergism was observed between three drugs and Southeast EEP, six drugs and South EEP, and one drug and ethanol control. Ethanolic extracts of propolis from the South of Brazil presented the greatest flavonoid content and synergism rate, while EEP from the Southeast presented the greatest anti-CNS activity and phenolic compound content. Results showed the correlation among anti-CNS activity, synergism rate and chemical characteristics of propolis.
publishDate 2008
dc.date.none.fl_str_mv 2008-01-01
2022-04-28T20:41:59Z
2022-04-28T20:41:59Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S1678-91992008000200012
Journal of Venomous Animals and Toxins Including Tropical Diseases, v. 14, n. 2, p. 357-365, 2008.
1678-9199
http://hdl.handle.net/11449/225184
10.1590/S1678-91992008000200012
2-s2.0-45349101030
url http://dx.doi.org/10.1590/S1678-91992008000200012
http://hdl.handle.net/11449/225184
identifier_str_mv Journal of Venomous Animals and Toxins Including Tropical Diseases, v. 14, n. 2, p. 357-365, 2008.
1678-9199
10.1590/S1678-91992008000200012
2-s2.0-45349101030
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Journal of Venomous Animals and Toxins Including Tropical Diseases
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 357-365
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1808128415679643648

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