Citotoxicity and immune response induced by organopalladium(II) compounds in mice bearing Ehrlich ascites tumour
Autor(a) principal: | |
---|---|
Data de Publicação: | 2007 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/S0103-50532007000800004 http://hdl.handle.net/11449/70062 |
Resumo: | Cyclometallated palladium(II) complexes are reactive inorganic compounds employed in several biological studies because of their antitumour potential and interaction with immune system. In the present study, the immune and citotoxic response induced by two organopalladated complexes: [{Pd(N,C-dmba)} 2(μ-NCS) 2] (1), [Pd(C-dmba)(NCS)(dppp)] (2) [dmba = N,N′-dimethylbenzylamine, dppp = 1,3-bis(diphenylphosphino)propane] and cisplatin (cis-DDP), as standard, were investigated in mice bearing Ehrlich ascites tumour. The mice were divided into five groups and inoculated with the compounds (1) or (2) or cisplatin, or only vehicle or phosphate-buffered saline (PBS). Many parameters were evaluated, such as tumour cell percentage in the peritoneal exsudate, levels of seric nitric oxide (NO) and tumour necrosis factor-alpha (TNF-α) and increase in life span. Analysis of all data revealed, for compound (2), an activity similar to that presented by cisplatin, resulting in increased life span, lower levels of seric TNF-α and increase in NO production. ©2007 Sociedade Brasileira de Química. |
id |
UNSP_f5c1a79d383c7f71c2ea72ed6f151c3f |
---|---|
oai_identifier_str |
oai:repositorio.unesp.br:11449/70062 |
network_acronym_str |
UNSP |
network_name_str |
Repositório Institucional da UNESP |
repository_id_str |
2946 |
spelling |
Citotoxicity and immune response induced by organopalladium(II) compounds in mice bearing Ehrlich ascites tumourEhrlich ascites tumourMacrophagesNitric oxidePalladium(II) complexesTumour necrosis factor-alphaCyclometallated palladium(II) complexes are reactive inorganic compounds employed in several biological studies because of their antitumour potential and interaction with immune system. In the present study, the immune and citotoxic response induced by two organopalladated complexes: [{Pd(N,C-dmba)} 2(μ-NCS) 2] (1), [Pd(C-dmba)(NCS)(dppp)] (2) [dmba = N,N′-dimethylbenzylamine, dppp = 1,3-bis(diphenylphosphino)propane] and cisplatin (cis-DDP), as standard, were investigated in mice bearing Ehrlich ascites tumour. The mice were divided into five groups and inoculated with the compounds (1) or (2) or cisplatin, or only vehicle or phosphate-buffered saline (PBS). Many parameters were evaluated, such as tumour cell percentage in the peritoneal exsudate, levels of seric nitric oxide (NO) and tumour necrosis factor-alpha (TNF-α) and increase in life span. Analysis of all data revealed, for compound (2), an activity similar to that presented by cisplatin, resulting in increased life span, lower levels of seric TNF-α and increase in NO production. ©2007 Sociedade Brasileira de Química.Departamento de Análises Clínicas Faculdade de Ciências Farmacêuticas de Araraquara Universidade Estadual Paulista, CP 502, 14801-902 Araraquara-SPDepartamento de Química Geral e Inorgânica Instituto de Química de Araraquara Universidade Estadual Paulista, CP 355, 14801-970 Araraquara-SPDepartamento de Ciências Exatas Universidade Federal de Alfenas, 31130-000 Alfenas-MGDepartamento de Análises Clínicas Faculdade de Ciências Farmacêuticas de Araraquara Universidade Estadual Paulista, CP 502, 14801-902 Araraquara-SPDepartamento de Química Geral e Inorgânica Instituto de Química de Araraquara Universidade Estadual Paulista, CP 355, 14801-970 Araraquara-SPUniversidade Estadual Paulista (Unesp)Universidade Federal de Alfenas (UNIFAL)Rocha, Michelle C. da [UNESP]Santana, Anderson M. [UNESP]Ananias, Sandra R. [UNESP]Almeida, Eduardo T. deMauro, Antonio Eduardo [UNESP]Placeres, Marisa C. P. [UNESP]Carlos, Iracilda Z. [UNESP]2014-05-27T11:22:40Z2014-05-27T11:22:40Z2007-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1473-1480application/pdfhttp://dx.doi.org/10.1590/S0103-50532007000800004Journal of the Brazilian Chemical Society, v. 18, n. 8, p. 1473-1480, 2007.0103-50531678-4790http://hdl.handle.net/11449/7006210.1590/S0103-50532007000800004S0103-50532007000800004WOS:0002528597000042-s2.0-375490374682-s2.0-37549037468.pdf3300223970814448Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of the Brazilian Chemical Society1.4440,3570,357info:eu-repo/semantics/openAccess2024-01-09T06:28:41Zoai:repositorio.unesp.br:11449/70062Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-01-09T06:28:41Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Citotoxicity and immune response induced by organopalladium(II) compounds in mice bearing Ehrlich ascites tumour |
title |
Citotoxicity and immune response induced by organopalladium(II) compounds in mice bearing Ehrlich ascites tumour |
spellingShingle |
Citotoxicity and immune response induced by organopalladium(II) compounds in mice bearing Ehrlich ascites tumour Rocha, Michelle C. da [UNESP] Ehrlich ascites tumour Macrophages Nitric oxide Palladium(II) complexes Tumour necrosis factor-alpha |
title_short |
Citotoxicity and immune response induced by organopalladium(II) compounds in mice bearing Ehrlich ascites tumour |
title_full |
Citotoxicity and immune response induced by organopalladium(II) compounds in mice bearing Ehrlich ascites tumour |
title_fullStr |
Citotoxicity and immune response induced by organopalladium(II) compounds in mice bearing Ehrlich ascites tumour |
title_full_unstemmed |
Citotoxicity and immune response induced by organopalladium(II) compounds in mice bearing Ehrlich ascites tumour |
title_sort |
Citotoxicity and immune response induced by organopalladium(II) compounds in mice bearing Ehrlich ascites tumour |
author |
Rocha, Michelle C. da [UNESP] |
author_facet |
Rocha, Michelle C. da [UNESP] Santana, Anderson M. [UNESP] Ananias, Sandra R. [UNESP] Almeida, Eduardo T. de Mauro, Antonio Eduardo [UNESP] Placeres, Marisa C. P. [UNESP] Carlos, Iracilda Z. [UNESP] |
author_role |
author |
author2 |
Santana, Anderson M. [UNESP] Ananias, Sandra R. [UNESP] Almeida, Eduardo T. de Mauro, Antonio Eduardo [UNESP] Placeres, Marisa C. P. [UNESP] Carlos, Iracilda Z. [UNESP] |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Universidade Federal de Alfenas (UNIFAL) |
dc.contributor.author.fl_str_mv |
Rocha, Michelle C. da [UNESP] Santana, Anderson M. [UNESP] Ananias, Sandra R. [UNESP] Almeida, Eduardo T. de Mauro, Antonio Eduardo [UNESP] Placeres, Marisa C. P. [UNESP] Carlos, Iracilda Z. [UNESP] |
dc.subject.por.fl_str_mv |
Ehrlich ascites tumour Macrophages Nitric oxide Palladium(II) complexes Tumour necrosis factor-alpha |
topic |
Ehrlich ascites tumour Macrophages Nitric oxide Palladium(II) complexes Tumour necrosis factor-alpha |
description |
Cyclometallated palladium(II) complexes are reactive inorganic compounds employed in several biological studies because of their antitumour potential and interaction with immune system. In the present study, the immune and citotoxic response induced by two organopalladated complexes: [{Pd(N,C-dmba)} 2(μ-NCS) 2] (1), [Pd(C-dmba)(NCS)(dppp)] (2) [dmba = N,N′-dimethylbenzylamine, dppp = 1,3-bis(diphenylphosphino)propane] and cisplatin (cis-DDP), as standard, were investigated in mice bearing Ehrlich ascites tumour. The mice were divided into five groups and inoculated with the compounds (1) or (2) or cisplatin, or only vehicle or phosphate-buffered saline (PBS). Many parameters were evaluated, such as tumour cell percentage in the peritoneal exsudate, levels of seric nitric oxide (NO) and tumour necrosis factor-alpha (TNF-α) and increase in life span. Analysis of all data revealed, for compound (2), an activity similar to that presented by cisplatin, resulting in increased life span, lower levels of seric TNF-α and increase in NO production. ©2007 Sociedade Brasileira de Química. |
publishDate |
2007 |
dc.date.none.fl_str_mv |
2007-12-01 2014-05-27T11:22:40Z 2014-05-27T11:22:40Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S0103-50532007000800004 Journal of the Brazilian Chemical Society, v. 18, n. 8, p. 1473-1480, 2007. 0103-5053 1678-4790 http://hdl.handle.net/11449/70062 10.1590/S0103-50532007000800004 S0103-50532007000800004 WOS:000252859700004 2-s2.0-37549037468 2-s2.0-37549037468.pdf 3300223970814448 |
url |
http://dx.doi.org/10.1590/S0103-50532007000800004 http://hdl.handle.net/11449/70062 |
identifier_str_mv |
Journal of the Brazilian Chemical Society, v. 18, n. 8, p. 1473-1480, 2007. 0103-5053 1678-4790 10.1590/S0103-50532007000800004 S0103-50532007000800004 WOS:000252859700004 2-s2.0-37549037468 2-s2.0-37549037468.pdf 3300223970814448 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of the Brazilian Chemical Society 1.444 0,357 0,357 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
1473-1480 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799965568687669248 |