Changes in minor salivary glands during 4-nitroquinoline 1-oxide-induced rat tongue carcinogenesis

Detalhes bibliográficos
Autor(a) principal: Ribeiro, D. A.
Data de Publicação: 2004
Outros Autores: Silva, R. N., Darros, B. R., Salvadori, Daisy Maria Favero [UNESP], Marques, MEA
Tipo de documento: Artigo de conferência
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://hdl.handle.net/11449/12742
Resumo: We investigated the changes of minor salivary glands during 4NQO-induced rat tongue carcinogenesis. Histopathological examinations of serous and mucous tongue salivary glands of 30 male Wistar rats were performed after 4, 12 and 20 weeks of 50 ppm 4NQO chronicle administration in drinking water. Ten rats were used as control. Morphometric results were expressed as volume density (Vv %) of each of the components. Histopathological and morphometric changes in the salivary glands were evident only at 20 weeks following 4NQO administration and they included a significant (P < 0.05) decreased in the mean Vv of the serous acini compared with the control group accompanied by abnormal acini (Vv=14 %). Neither mucous acini nor ducts demonstrated significant changes. In conclusion, minor salivary glands are involved in the progression of 4NQO-induced carcinoma.
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spelling Changes in minor salivary glands during 4-nitroquinoline 1-oxide-induced rat tongue carcinogenesisWe investigated the changes of minor salivary glands during 4NQO-induced rat tongue carcinogenesis. Histopathological examinations of serous and mucous tongue salivary glands of 30 male Wistar rats were performed after 4, 12 and 20 weeks of 50 ppm 4NQO chronicle administration in drinking water. Ten rats were used as control. Morphometric results were expressed as volume density (Vv %) of each of the components. Histopathological and morphometric changes in the salivary glands were evident only at 20 weeks following 4NQO administration and they included a significant (P < 0.05) decreased in the mean Vv of the serous acini compared with the control group accompanied by abnormal acini (Vv=14 %). Neither mucous acini nor ducts demonstrated significant changes. In conclusion, minor salivary glands are involved in the progression of 4NQO-induced carcinoma.Univ Estadual Paulista Julio Mesquita Filho, TOXICAN, Dept Patol, Botucatu, SP, BrazilUniv Estadual Paulista Julio Mesquita Filho, TOXICAN, Dept Patol, Botucatu, SP, BrazilMedimond Publishing CoUniversidade Estadual Paulista (Unesp)Ribeiro, D. A.Silva, R. N.Darros, B. R.Salvadori, Daisy Maria Favero [UNESP]Marques, MEA2014-05-20T13:36:58Z2014-05-20T13:36:58Z2004-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObject43-48Ii Intercontinental Congress of Pathology. Bologna: Medimond Publishing Co, p. 43-48, 2004.http://hdl.handle.net/11449/12742WOS:0002255604000105051118752980903Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengIi Intercontinental Congress of Pathologyinfo:eu-repo/semantics/openAccess2024-09-03T13:19:09Zoai:repositorio.unesp.br:11449/12742Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-03T13:19:09Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Changes in minor salivary glands during 4-nitroquinoline 1-oxide-induced rat tongue carcinogenesis
title Changes in minor salivary glands during 4-nitroquinoline 1-oxide-induced rat tongue carcinogenesis
spellingShingle Changes in minor salivary glands during 4-nitroquinoline 1-oxide-induced rat tongue carcinogenesis
Ribeiro, D. A.
title_short Changes in minor salivary glands during 4-nitroquinoline 1-oxide-induced rat tongue carcinogenesis
title_full Changes in minor salivary glands during 4-nitroquinoline 1-oxide-induced rat tongue carcinogenesis
title_fullStr Changes in minor salivary glands during 4-nitroquinoline 1-oxide-induced rat tongue carcinogenesis
title_full_unstemmed Changes in minor salivary glands during 4-nitroquinoline 1-oxide-induced rat tongue carcinogenesis
title_sort Changes in minor salivary glands during 4-nitroquinoline 1-oxide-induced rat tongue carcinogenesis
author Ribeiro, D. A.
author_facet Ribeiro, D. A.
Silva, R. N.
Darros, B. R.
Salvadori, Daisy Maria Favero [UNESP]
Marques, MEA
author_role author
author2 Silva, R. N.
Darros, B. R.
Salvadori, Daisy Maria Favero [UNESP]
Marques, MEA
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Ribeiro, D. A.
Silva, R. N.
Darros, B. R.
Salvadori, Daisy Maria Favero [UNESP]
Marques, MEA
description We investigated the changes of minor salivary glands during 4NQO-induced rat tongue carcinogenesis. Histopathological examinations of serous and mucous tongue salivary glands of 30 male Wistar rats were performed after 4, 12 and 20 weeks of 50 ppm 4NQO chronicle administration in drinking water. Ten rats were used as control. Morphometric results were expressed as volume density (Vv %) of each of the components. Histopathological and morphometric changes in the salivary glands were evident only at 20 weeks following 4NQO administration and they included a significant (P < 0.05) decreased in the mean Vv of the serous acini compared with the control group accompanied by abnormal acini (Vv=14 %). Neither mucous acini nor ducts demonstrated significant changes. In conclusion, minor salivary glands are involved in the progression of 4NQO-induced carcinoma.
publishDate 2004
dc.date.none.fl_str_mv 2004-01-01
2014-05-20T13:36:58Z
2014-05-20T13:36:58Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/conferenceObject
format conferenceObject
status_str publishedVersion
dc.identifier.uri.fl_str_mv Ii Intercontinental Congress of Pathology. Bologna: Medimond Publishing Co, p. 43-48, 2004.
http://hdl.handle.net/11449/12742
WOS:000225560400010
5051118752980903
identifier_str_mv Ii Intercontinental Congress of Pathology. Bologna: Medimond Publishing Co, p. 43-48, 2004.
WOS:000225560400010
5051118752980903
url http://hdl.handle.net/11449/12742
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Ii Intercontinental Congress of Pathology
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 43-48
dc.publisher.none.fl_str_mv Medimond Publishing Co
publisher.none.fl_str_mv Medimond Publishing Co
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv repositoriounesp@unesp.br
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