Evaluation of peptidylarginine deiminase 4 and PADI4 polymorphisms in sepsis-induced acute kidney injury

Detalhes bibliográficos
Autor(a) principal: Costa, Nara Aline
Data de Publicação: 2021
Outros Autores: Polegato, Bertha Furlan [UNESP], Pereira, Amanda Gomes [UNESP], de Paiva, Sérgio Alberto Rupp [UNESP], Gut, Ana Lúcia [UNESP], Balbi, André Luís [UNESP], Ponce, Daniela [UNESP], Zornoff, Leonardo Antonio Mamede [UNESP], Azevedo, Paula Schmidt [UNESP], Minicucci, Marcos Ferreira [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1590/1806-9282.66.11.1515
http://hdl.handle.net/11449/208234
Resumo: BACKGROUND: The aim of this study is to evaluate the peptidylarginine deiminase 4 (PAD 4) concentration and PADI4 polymorphisms as predictors of acute kidney injury (AKI) development, the need for renal replacement therapy (RRT), and mortality in patients with septic shock. METHODS: We included all individuals aged ≥ 18 years, with a diagnosis of septic shock at ICU admission. Blood samples were taken within the first 24 hours of the patient's admission to determine serum PAD4 concentration and its PADI4 polymorphism (rs11203367) and (rs874881). Patients were monitored during their ICU stay and the development of SAKI was evaluated. Among the patients in whom SAKI developed, mortality and the need for RRT were also evaluated. RESULTS: There were 99 patients, 51.5% of whom developed SAKI and of these, 21.5% needed RRT and 80% died in the ICU. There was no difference between PAD4 concentration (p = 0.116) and its polymorphisms rs11203367 (p = 0.910) and rs874881 (p = 0.769) in patients in whom SAKI did or did not develop. However, PAD4 had a positive correlation with plasma urea concentration (r = 0.269 and p = 0.007) and creatinine (r = 0.284 and p = 0.004). The PAD4 concentration and PADI4 polymorphisms were also not associated with RRT and with mortality in patients with SAKI. CONCLUSION: PAD4 concentration and its polymorphisms were not associated with SAKI development, the need for RRT, or mortality in patients with septic shock. However, PAD4 concentrations were associated with creatinine and urea levels in these patients.
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spelling Evaluation of peptidylarginine deiminase 4 and PADI4 polymorphisms in sepsis-induced acute kidney injuryAcute kidney injuryDialysisMortalityProtein-arginine deiminase type 4SepsisBACKGROUND: The aim of this study is to evaluate the peptidylarginine deiminase 4 (PAD 4) concentration and PADI4 polymorphisms as predictors of acute kidney injury (AKI) development, the need for renal replacement therapy (RRT), and mortality in patients with septic shock. METHODS: We included all individuals aged ≥ 18 years, with a diagnosis of septic shock at ICU admission. Blood samples were taken within the first 24 hours of the patient's admission to determine serum PAD4 concentration and its PADI4 polymorphism (rs11203367) and (rs874881). Patients were monitored during their ICU stay and the development of SAKI was evaluated. Among the patients in whom SAKI developed, mortality and the need for RRT were also evaluated. RESULTS: There were 99 patients, 51.5% of whom developed SAKI and of these, 21.5% needed RRT and 80% died in the ICU. There was no difference between PAD4 concentration (p = 0.116) and its polymorphisms rs11203367 (p = 0.910) and rs874881 (p = 0.769) in patients in whom SAKI did or did not develop. However, PAD4 had a positive correlation with plasma urea concentration (r = 0.269 and p = 0.007) and creatinine (r = 0.284 and p = 0.004). The PAD4 concentration and PADI4 polymorphisms were also not associated with RRT and with mortality in patients with SAKI. CONCLUSION: PAD4 concentration and its polymorphisms were not associated with SAKI development, the need for RRT, or mortality in patients with septic shock. However, PAD4 concentrations were associated with creatinine and urea levels in these patients.Faculdade de Nutrição Universidade Federal de Goiás - UFGFaculdade de Medicina de Botucatu UnespAluna do Programa de Pós-graduação em Fisiopatologia em Clínica Médica UnespMédica Livre-docente e Coordenadora Programa de Pós-graduação em Fisiopatologia em Clínica Médica UnespFaculdade de Nutrição Universidade Federal de Goiás (UFG) Setor Leste Universitário, Rua 227, quadra 68 s/nFaculdade de Medicina de Botucatu UnespAluna do Programa de Pós-graduação em Fisiopatologia em Clínica Médica UnespMédica Livre-docente e Coordenadora Programa de Pós-graduação em Fisiopatologia em Clínica Médica UnespUniversidade Federal de Goiás (UFG)Universidade Estadual Paulista (Unesp)Costa, Nara AlinePolegato, Bertha Furlan [UNESP]Pereira, Amanda Gomes [UNESP]de Paiva, Sérgio Alberto Rupp [UNESP]Gut, Ana Lúcia [UNESP]Balbi, André Luís [UNESP]Ponce, Daniela [UNESP]Zornoff, Leonardo Antonio Mamede [UNESP]Azevedo, Paula Schmidt [UNESP]Minicucci, Marcos Ferreira [UNESP]2021-06-25T11:08:39Z2021-06-25T11:08:39Z2021-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1515-1520application/pdfhttp://dx.doi.org/10.1590/1806-9282.66.11.1515Revista da Associacao Medica Brasileira, v. 66, n. 11, p. 1515-1520, 2021.1806-92820104-4230http://hdl.handle.net/11449/20823410.1590/1806-9282.66.11.1515S0104-423020200011015152-s2.0-85097517873S0104-42302020001101515.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengRevista da Associacao Medica Brasileirainfo:eu-repo/semantics/openAccess2024-08-14T17:23:32Zoai:repositorio.unesp.br:11449/208234Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-14T17:23:32Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Evaluation of peptidylarginine deiminase 4 and PADI4 polymorphisms in sepsis-induced acute kidney injury
title Evaluation of peptidylarginine deiminase 4 and PADI4 polymorphisms in sepsis-induced acute kidney injury
spellingShingle Evaluation of peptidylarginine deiminase 4 and PADI4 polymorphisms in sepsis-induced acute kidney injury
Costa, Nara Aline
Acute kidney injury
Dialysis
Mortality
Protein-arginine deiminase type 4
Sepsis
title_short Evaluation of peptidylarginine deiminase 4 and PADI4 polymorphisms in sepsis-induced acute kidney injury
title_full Evaluation of peptidylarginine deiminase 4 and PADI4 polymorphisms in sepsis-induced acute kidney injury
title_fullStr Evaluation of peptidylarginine deiminase 4 and PADI4 polymorphisms in sepsis-induced acute kidney injury
title_full_unstemmed Evaluation of peptidylarginine deiminase 4 and PADI4 polymorphisms in sepsis-induced acute kidney injury
title_sort Evaluation of peptidylarginine deiminase 4 and PADI4 polymorphisms in sepsis-induced acute kidney injury
author Costa, Nara Aline
author_facet Costa, Nara Aline
Polegato, Bertha Furlan [UNESP]
Pereira, Amanda Gomes [UNESP]
de Paiva, Sérgio Alberto Rupp [UNESP]
Gut, Ana Lúcia [UNESP]
Balbi, André Luís [UNESP]
Ponce, Daniela [UNESP]
Zornoff, Leonardo Antonio Mamede [UNESP]
Azevedo, Paula Schmidt [UNESP]
Minicucci, Marcos Ferreira [UNESP]
author_role author
author2 Polegato, Bertha Furlan [UNESP]
Pereira, Amanda Gomes [UNESP]
de Paiva, Sérgio Alberto Rupp [UNESP]
Gut, Ana Lúcia [UNESP]
Balbi, André Luís [UNESP]
Ponce, Daniela [UNESP]
Zornoff, Leonardo Antonio Mamede [UNESP]
Azevedo, Paula Schmidt [UNESP]
Minicucci, Marcos Ferreira [UNESP]
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Federal de Goiás (UFG)
Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Costa, Nara Aline
Polegato, Bertha Furlan [UNESP]
Pereira, Amanda Gomes [UNESP]
de Paiva, Sérgio Alberto Rupp [UNESP]
Gut, Ana Lúcia [UNESP]
Balbi, André Luís [UNESP]
Ponce, Daniela [UNESP]
Zornoff, Leonardo Antonio Mamede [UNESP]
Azevedo, Paula Schmidt [UNESP]
Minicucci, Marcos Ferreira [UNESP]
dc.subject.por.fl_str_mv Acute kidney injury
Dialysis
Mortality
Protein-arginine deiminase type 4
Sepsis
topic Acute kidney injury
Dialysis
Mortality
Protein-arginine deiminase type 4
Sepsis
description BACKGROUND: The aim of this study is to evaluate the peptidylarginine deiminase 4 (PAD 4) concentration and PADI4 polymorphisms as predictors of acute kidney injury (AKI) development, the need for renal replacement therapy (RRT), and mortality in patients with septic shock. METHODS: We included all individuals aged ≥ 18 years, with a diagnosis of septic shock at ICU admission. Blood samples were taken within the first 24 hours of the patient's admission to determine serum PAD4 concentration and its PADI4 polymorphism (rs11203367) and (rs874881). Patients were monitored during their ICU stay and the development of SAKI was evaluated. Among the patients in whom SAKI developed, mortality and the need for RRT were also evaluated. RESULTS: There were 99 patients, 51.5% of whom developed SAKI and of these, 21.5% needed RRT and 80% died in the ICU. There was no difference between PAD4 concentration (p = 0.116) and its polymorphisms rs11203367 (p = 0.910) and rs874881 (p = 0.769) in patients in whom SAKI did or did not develop. However, PAD4 had a positive correlation with plasma urea concentration (r = 0.269 and p = 0.007) and creatinine (r = 0.284 and p = 0.004). The PAD4 concentration and PADI4 polymorphisms were also not associated with RRT and with mortality in patients with SAKI. CONCLUSION: PAD4 concentration and its polymorphisms were not associated with SAKI development, the need for RRT, or mortality in patients with septic shock. However, PAD4 concentrations were associated with creatinine and urea levels in these patients.
publishDate 2021
dc.date.none.fl_str_mv 2021-06-25T11:08:39Z
2021-06-25T11:08:39Z
2021-01-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/1806-9282.66.11.1515
Revista da Associacao Medica Brasileira, v. 66, n. 11, p. 1515-1520, 2021.
1806-9282
0104-4230
http://hdl.handle.net/11449/208234
10.1590/1806-9282.66.11.1515
S0104-42302020001101515
2-s2.0-85097517873
S0104-42302020001101515.pdf
url http://dx.doi.org/10.1590/1806-9282.66.11.1515
http://hdl.handle.net/11449/208234
identifier_str_mv Revista da Associacao Medica Brasileira, v. 66, n. 11, p. 1515-1520, 2021.
1806-9282
0104-4230
10.1590/1806-9282.66.11.1515
S0104-42302020001101515
2-s2.0-85097517873
S0104-42302020001101515.pdf
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Revista da Associacao Medica Brasileira
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 1515-1520
application/pdf
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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