Antioxidant and anti-inflammatory properties of gamma- oryzanol attenuates insulin resistance by increasing GLUT- 4 expression in skeletal muscle of obese animals
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.mce.2021.111423 http://hdl.handle.net/11449/222230 |
Resumo: | Background: Skeletal muscle is the most important organ for whole-body glucose homeostasis. However, it has been suggested that obesity-related inflammation could be involved in insulin resistance and diabetes mellitus type 2 (DM2) development due several mechanisms, among them, the reduced expression of the glucose transporter type 4 (GLUT-4). Gamma-oryzanol (γOz) is a compound present in the whole grain of rice that presents anti-inflammatory and antioxidant activities. The aim of this study was to verify if the effect antioxidant and anti-inflammatory of yOz attenuate insulin resistance in skeletal muscle of obese rats by increasing GLUT- 4 expression. Methods: Male Wistar rats (±187 g) were initially randomly distributed into 2 experimental groups (control, n = 6, and high sugar-fat diet (HSF), n = 12) for 20 weeks. At week 20th of this study, once obesity and insulin resistance were detected in the HSF group, animals were divided to begin the treatment with γOz or continue receiving HSF for 10 more weeks. At the end it was analyzed nutritional, metabolic, inflammatory and oxidative stress parameters and GLUT-4 protein expression. Results: The treatment improved insulin resistance, reduced inflammation, increased antioxidant response and GLUT-4 expression. Conclusion: It is possible to conclude that the antioxidant and anti-inflammatory activity of yOz attenuates insulin resistance by increasing GLUT-4 expression in skeletal muscle of obese animals. |
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Antioxidant and anti-inflammatory properties of gamma- oryzanol attenuates insulin resistance by increasing GLUT- 4 expression in skeletal muscle of obese animalsGamma- oryzanolInflammationInsulin resistanceObesityOxidative stressBackground: Skeletal muscle is the most important organ for whole-body glucose homeostasis. However, it has been suggested that obesity-related inflammation could be involved in insulin resistance and diabetes mellitus type 2 (DM2) development due several mechanisms, among them, the reduced expression of the glucose transporter type 4 (GLUT-4). Gamma-oryzanol (γOz) is a compound present in the whole grain of rice that presents anti-inflammatory and antioxidant activities. The aim of this study was to verify if the effect antioxidant and anti-inflammatory of yOz attenuate insulin resistance in skeletal muscle of obese rats by increasing GLUT- 4 expression. Methods: Male Wistar rats (±187 g) were initially randomly distributed into 2 experimental groups (control, n = 6, and high sugar-fat diet (HSF), n = 12) for 20 weeks. At week 20th of this study, once obesity and insulin resistance were detected in the HSF group, animals were divided to begin the treatment with γOz or continue receiving HSF for 10 more weeks. At the end it was analyzed nutritional, metabolic, inflammatory and oxidative stress parameters and GLUT-4 protein expression. Results: The treatment improved insulin resistance, reduced inflammation, increased antioxidant response and GLUT-4 expression. Conclusion: It is possible to conclude that the antioxidant and anti-inflammatory activity of yOz attenuates insulin resistance by increasing GLUT-4 expression in skeletal muscle of obese animals.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)São Paulo State University (UNESP) Medical SchoolSão Paulo State University (UNESP) Institute of BiosciencesSão Paulo State University (UNESP) Medical SchoolSão Paulo State University (UNESP) Institute of BiosciencesFAPESP: #2015/10626-0FAPESP: #2017/24689-9Universidade Estadual Paulista (UNESP)Mattei, Letícia [UNESP]Francisqueti-Ferron, Fabiane Valentini [UNESP]Garcia, Jéssica Leite [UNESP]Ferron, Artur Junio Togneri [UNESP]Silva, Carol Cristina Vágula de Almeida [UNESP]Gregolin, Cristina Schmitt [UNESP]Nakandakare-Maia, Erika Tiemi [UNESP]Silva, Janaína das Chagas Paixão [UNESP]Moreto, Fernando [UNESP]Minatel, Igor Otávio [UNESP]Corrêa, Camila Renata [UNESP]2022-04-28T19:43:31Z2022-04-28T19:43:31Z2021-11-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.mce.2021.111423Molecular and Cellular Endocrinology, v. 537.1872-80570303-7207http://hdl.handle.net/11449/22223010.1016/j.mce.2021.1114232-s2.0-85112739775Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengMolecular and Cellular Endocrinologyinfo:eu-repo/semantics/openAccess2022-04-28T19:43:31Zoai:repositorio.unesp.br:11449/222230Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T16:04:44.285241Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Antioxidant and anti-inflammatory properties of gamma- oryzanol attenuates insulin resistance by increasing GLUT- 4 expression in skeletal muscle of obese animals |
title |
Antioxidant and anti-inflammatory properties of gamma- oryzanol attenuates insulin resistance by increasing GLUT- 4 expression in skeletal muscle of obese animals |
spellingShingle |
Antioxidant and anti-inflammatory properties of gamma- oryzanol attenuates insulin resistance by increasing GLUT- 4 expression in skeletal muscle of obese animals Mattei, Letícia [UNESP] Gamma- oryzanol Inflammation Insulin resistance Obesity Oxidative stress |
title_short |
Antioxidant and anti-inflammatory properties of gamma- oryzanol attenuates insulin resistance by increasing GLUT- 4 expression in skeletal muscle of obese animals |
title_full |
Antioxidant and anti-inflammatory properties of gamma- oryzanol attenuates insulin resistance by increasing GLUT- 4 expression in skeletal muscle of obese animals |
title_fullStr |
Antioxidant and anti-inflammatory properties of gamma- oryzanol attenuates insulin resistance by increasing GLUT- 4 expression in skeletal muscle of obese animals |
title_full_unstemmed |
Antioxidant and anti-inflammatory properties of gamma- oryzanol attenuates insulin resistance by increasing GLUT- 4 expression in skeletal muscle of obese animals |
title_sort |
Antioxidant and anti-inflammatory properties of gamma- oryzanol attenuates insulin resistance by increasing GLUT- 4 expression in skeletal muscle of obese animals |
author |
Mattei, Letícia [UNESP] |
author_facet |
Mattei, Letícia [UNESP] Francisqueti-Ferron, Fabiane Valentini [UNESP] Garcia, Jéssica Leite [UNESP] Ferron, Artur Junio Togneri [UNESP] Silva, Carol Cristina Vágula de Almeida [UNESP] Gregolin, Cristina Schmitt [UNESP] Nakandakare-Maia, Erika Tiemi [UNESP] Silva, Janaína das Chagas Paixão [UNESP] Moreto, Fernando [UNESP] Minatel, Igor Otávio [UNESP] Corrêa, Camila Renata [UNESP] |
author_role |
author |
author2 |
Francisqueti-Ferron, Fabiane Valentini [UNESP] Garcia, Jéssica Leite [UNESP] Ferron, Artur Junio Togneri [UNESP] Silva, Carol Cristina Vágula de Almeida [UNESP] Gregolin, Cristina Schmitt [UNESP] Nakandakare-Maia, Erika Tiemi [UNESP] Silva, Janaína das Chagas Paixão [UNESP] Moreto, Fernando [UNESP] Minatel, Igor Otávio [UNESP] Corrêa, Camila Renata [UNESP] |
author2_role |
author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) |
dc.contributor.author.fl_str_mv |
Mattei, Letícia [UNESP] Francisqueti-Ferron, Fabiane Valentini [UNESP] Garcia, Jéssica Leite [UNESP] Ferron, Artur Junio Togneri [UNESP] Silva, Carol Cristina Vágula de Almeida [UNESP] Gregolin, Cristina Schmitt [UNESP] Nakandakare-Maia, Erika Tiemi [UNESP] Silva, Janaína das Chagas Paixão [UNESP] Moreto, Fernando [UNESP] Minatel, Igor Otávio [UNESP] Corrêa, Camila Renata [UNESP] |
dc.subject.por.fl_str_mv |
Gamma- oryzanol Inflammation Insulin resistance Obesity Oxidative stress |
topic |
Gamma- oryzanol Inflammation Insulin resistance Obesity Oxidative stress |
description |
Background: Skeletal muscle is the most important organ for whole-body glucose homeostasis. However, it has been suggested that obesity-related inflammation could be involved in insulin resistance and diabetes mellitus type 2 (DM2) development due several mechanisms, among them, the reduced expression of the glucose transporter type 4 (GLUT-4). Gamma-oryzanol (γOz) is a compound present in the whole grain of rice that presents anti-inflammatory and antioxidant activities. The aim of this study was to verify if the effect antioxidant and anti-inflammatory of yOz attenuate insulin resistance in skeletal muscle of obese rats by increasing GLUT- 4 expression. Methods: Male Wistar rats (±187 g) were initially randomly distributed into 2 experimental groups (control, n = 6, and high sugar-fat diet (HSF), n = 12) for 20 weeks. At week 20th of this study, once obesity and insulin resistance were detected in the HSF group, animals were divided to begin the treatment with γOz or continue receiving HSF for 10 more weeks. At the end it was analyzed nutritional, metabolic, inflammatory and oxidative stress parameters and GLUT-4 protein expression. Results: The treatment improved insulin resistance, reduced inflammation, increased antioxidant response and GLUT-4 expression. Conclusion: It is possible to conclude that the antioxidant and anti-inflammatory activity of yOz attenuates insulin resistance by increasing GLUT-4 expression in skeletal muscle of obese animals. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-11-01 2022-04-28T19:43:31Z 2022-04-28T19:43:31Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.mce.2021.111423 Molecular and Cellular Endocrinology, v. 537. 1872-8057 0303-7207 http://hdl.handle.net/11449/222230 10.1016/j.mce.2021.111423 2-s2.0-85112739775 |
url |
http://dx.doi.org/10.1016/j.mce.2021.111423 http://hdl.handle.net/11449/222230 |
identifier_str_mv |
Molecular and Cellular Endocrinology, v. 537. 1872-8057 0303-7207 10.1016/j.mce.2021.111423 2-s2.0-85112739775 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Molecular and Cellular Endocrinology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128604859531264 |