Intravascular lymphomatosis in the central nervous system of dogs: Immunohistochemical investigation in two cases

Detalhes bibliográficos
Autor(a) principal: Machado, Gisele Fabrino [UNESP]
Data de Publicação: 2011
Outros Autores: Castro, Márcio B., Melo, Guilherme D. [UNESP], Ferreira, Wagner Luis [UNESP], Aylon, Eliana G., Alessi, Antonio C. [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://www.abpv.vet.br/upload/documentos/DOWNLOAD-FULL-ARTICLE-09-20881_2011_3_16_8_11.pdf
http://hdl.handle.net/11449/72385
Resumo: We report here two postmortem cases of dogs with intravascular lymphomatosis affecting the central nervous system. Intravascular lymphomatosis is represented by an exclusively intravascular proliferation of neoplastic lymphoid cells. To characterize the origin of the neoplastic cells, we have proceeded with immunohistochemical analysis to identify B and T lymphocytes and endothelial cells. The results showed predominance of cells from the T cell lineage, and no evidence of B cell origin was found. Few cells from one dog also exhibited cytoplasmatic staining for vimentin and Von Willebrand factor. Although in one case some immunophenotype diversity was observed, the massive presence of CD3 positive cells confirmed these neoplasms as intravascular lymphomatosis of T cell origin.
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spelling Intravascular lymphomatosis in the central nervous system of dogs: Immunohistochemical investigation in two casesCell markerImmunohistochemistryLymphoproliferative disorderNeoplasiaNeuropathologyT cellCanis familiarisWe report here two postmortem cases of dogs with intravascular lymphomatosis affecting the central nervous system. Intravascular lymphomatosis is represented by an exclusively intravascular proliferation of neoplastic lymphoid cells. To characterize the origin of the neoplastic cells, we have proceeded with immunohistochemical analysis to identify B and T lymphocytes and endothelial cells. The results showed predominance of cells from the T cell lineage, and no evidence of B cell origin was found. Few cells from one dog also exhibited cytoplasmatic staining for vimentin and Von Willebrand factor. Although in one case some immunophenotype diversity was observed, the massive presence of CD3 positive cells confirmed these neoplasms as intravascular lymphomatosis of T cell origin.Departamento de Clínica, Cirurgia e Reprodução Animal FMV-Universidade Estadual Paulista (UNESP), Araçatuba, SPDepartamento de Anatomofisiologia e Reprodução FAV-UNB - Univ de Brasília, Brasília, DFUNIFRAN - Univ de Franca, Franca, SPDepartamento de Patologia Veterinária FCAV-Universidade Estadual Paulista (UNESP), Jaboticabal, SPDepartamento de Clínica, Cirurgia e Reprodução Animal FMV-Universidade Estadual Paulista (UNESP), Araçatuba, SPDepartamento de Patologia Veterinária FCAV-Universidade Estadual Paulista (UNESP), Jaboticabal, SPUniversidade Estadual Paulista (Unesp)Universidade de Brasília (UnB)UNIFRAN - Univ de FrancaMachado, Gisele Fabrino [UNESP]Castro, Márcio B.Melo, Guilherme D. [UNESP]Ferreira, Wagner Luis [UNESP]Aylon, Eliana G.Alessi, Antonio C. [UNESP]2014-05-27T11:25:51Z2014-05-27T11:25:51Z2011-04-18info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article47-51http://www.abpv.vet.br/upload/documentos/DOWNLOAD-FULL-ARTICLE-09-20881_2011_3_16_8_11.pdfBrazilian Journal of Veterinary Pathology, v. 4, n. 1, p. 47-51, 2011.1983-0246http://hdl.handle.net/11449/723852-s2.0-7995384199303104055581256347515150042015756Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBrazilian Journal of Veterinary Pathology0,162info:eu-repo/semantics/openAccess2021-10-23T10:40:56Zoai:repositorio.unesp.br:11449/72385Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462021-10-23T10:40:56Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Intravascular lymphomatosis in the central nervous system of dogs: Immunohistochemical investigation in two cases
title Intravascular lymphomatosis in the central nervous system of dogs: Immunohistochemical investigation in two cases
spellingShingle Intravascular lymphomatosis in the central nervous system of dogs: Immunohistochemical investigation in two cases
Machado, Gisele Fabrino [UNESP]
Cell marker
Immunohistochemistry
Lymphoproliferative disorder
Neoplasia
Neuropathology
T cell
Canis familiaris
title_short Intravascular lymphomatosis in the central nervous system of dogs: Immunohistochemical investigation in two cases
title_full Intravascular lymphomatosis in the central nervous system of dogs: Immunohistochemical investigation in two cases
title_fullStr Intravascular lymphomatosis in the central nervous system of dogs: Immunohistochemical investigation in two cases
title_full_unstemmed Intravascular lymphomatosis in the central nervous system of dogs: Immunohistochemical investigation in two cases
title_sort Intravascular lymphomatosis in the central nervous system of dogs: Immunohistochemical investigation in two cases
author Machado, Gisele Fabrino [UNESP]
author_facet Machado, Gisele Fabrino [UNESP]
Castro, Márcio B.
Melo, Guilherme D. [UNESP]
Ferreira, Wagner Luis [UNESP]
Aylon, Eliana G.
Alessi, Antonio C. [UNESP]
author_role author
author2 Castro, Márcio B.
Melo, Guilherme D. [UNESP]
Ferreira, Wagner Luis [UNESP]
Aylon, Eliana G.
Alessi, Antonio C. [UNESP]
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
Universidade de Brasília (UnB)
UNIFRAN - Univ de Franca
dc.contributor.author.fl_str_mv Machado, Gisele Fabrino [UNESP]
Castro, Márcio B.
Melo, Guilherme D. [UNESP]
Ferreira, Wagner Luis [UNESP]
Aylon, Eliana G.
Alessi, Antonio C. [UNESP]
dc.subject.por.fl_str_mv Cell marker
Immunohistochemistry
Lymphoproliferative disorder
Neoplasia
Neuropathology
T cell
Canis familiaris
topic Cell marker
Immunohistochemistry
Lymphoproliferative disorder
Neoplasia
Neuropathology
T cell
Canis familiaris
description We report here two postmortem cases of dogs with intravascular lymphomatosis affecting the central nervous system. Intravascular lymphomatosis is represented by an exclusively intravascular proliferation of neoplastic lymphoid cells. To characterize the origin of the neoplastic cells, we have proceeded with immunohistochemical analysis to identify B and T lymphocytes and endothelial cells. The results showed predominance of cells from the T cell lineage, and no evidence of B cell origin was found. Few cells from one dog also exhibited cytoplasmatic staining for vimentin and Von Willebrand factor. Although in one case some immunophenotype diversity was observed, the massive presence of CD3 positive cells confirmed these neoplasms as intravascular lymphomatosis of T cell origin.
publishDate 2011
dc.date.none.fl_str_mv 2011-04-18
2014-05-27T11:25:51Z
2014-05-27T11:25:51Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.abpv.vet.br/upload/documentos/DOWNLOAD-FULL-ARTICLE-09-20881_2011_3_16_8_11.pdf
Brazilian Journal of Veterinary Pathology, v. 4, n. 1, p. 47-51, 2011.
1983-0246
http://hdl.handle.net/11449/72385
2-s2.0-79953841993
0310405558125634
7515150042015756
url http://www.abpv.vet.br/upload/documentos/DOWNLOAD-FULL-ARTICLE-09-20881_2011_3_16_8_11.pdf
http://hdl.handle.net/11449/72385
identifier_str_mv Brazilian Journal of Veterinary Pathology, v. 4, n. 1, p. 47-51, 2011.
1983-0246
2-s2.0-79953841993
0310405558125634
7515150042015756
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Brazilian Journal of Veterinary Pathology
0,162
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 47-51
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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